Pub Date : 2022-03-04DOI: 10.58397/ashkmdc.v27i1.541
Muhammad Abid, Saima Quareshi, Tazeen Zehra
Objectives: To compare the efficacy of natural Honey (10%) and chlorhexidine mouthwash (0.12%) on the dental plaque levels. Moreover, to evaluate the efficacy of natural Honey and chlorhexidine mouthwash on the level of dental plaque. Methods: This study was a single-centered randomized controlled trial conducted on participants attending the Dental OPD of Dar-ul-Sehat hospital in Karachi. A total of 60 participants were included in the trial from June 2020 to December 2020. The sample size was calculated using openepi after entering the mean and SD of the honey and chlorhexidine groups. The study included sixty male and female participants ranging in age from 18 to 25 years, and those with medical illness, missing teeth, and antimicrobial history were excluded from the study. The subjects were randomly assigned to two groups: Natural Honey or Chlorhexidine gluconate mouthwash. The data was collected at the baseline and 14th day; the plaque was revealed using a disclosing solution. Their scores were recorded at four sites per tooth using the Silness-Loe plaque index criteria. Later, statistical analysis was performed to compare the effects of the two groups. P ? 0.05 was considered statistically significant. Results: Our findings revealed that both groups effectively lowered the plaque score. However, it showed a more significant reduction in plaque indices in the honey group on Day 14 when compared to chlorhexidine mouthwash. Conclusion: Honey has been identified as a potent antibacterial agent with therapeutic properties. Based on the findings of this study, it is possible to conclude that gargling with the original honey 10% solution is effective in lowering dental plaque score. Honey can be used in relation to conventional treatments to protect dental plaque and gingivitis. More research will be needed to back up these preliminary findings. Moreover, the synergistic effect of Chlorhexidine with natural Honey must be investigated
{"title":"Comparative efficacy of the Antiplaque Effect of Natural Honey Mouthwash and Chlorhexidine Mouthwash. A randomized controlled trial","authors":"Muhammad Abid, Saima Quareshi, Tazeen Zehra","doi":"10.58397/ashkmdc.v27i1.541","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.541","url":null,"abstract":"Objectives: To compare the efficacy of natural Honey (10%) and chlorhexidine mouthwash (0.12%) on the dental plaque levels. Moreover, to evaluate the efficacy of natural Honey and chlorhexidine mouthwash on the level of dental plaque. \u0000Methods: This study was a single-centered randomized controlled trial conducted on participants attending the Dental OPD of Dar-ul-Sehat hospital in Karachi. A total of 60 participants were included in the trial from June 2020 to December 2020. The sample size was calculated using openepi after entering the mean and SD of the honey and chlorhexidine groups. The study included sixty male and female participants ranging in age from 18 to 25 years, and those with medical illness, missing teeth, and antimicrobial history were excluded from the study. The subjects were randomly assigned to two groups: Natural Honey or Chlorhexidine gluconate mouthwash. The data was collected at the baseline and 14th day; the plaque was revealed using a disclosing solution. Their scores were recorded at four sites per tooth using the Silness-Loe plaque index criteria. Later, statistical analysis was performed to compare the effects of the two groups. P ? 0.05 was considered statistically significant. \u0000Results: Our findings revealed that both groups effectively lowered the plaque score. However, it showed a more significant reduction in plaque indices in the honey group on Day 14 when compared to chlorhexidine mouthwash. \u0000Conclusion: Honey has been identified as a potent antibacterial agent with therapeutic properties. Based on the findings of this study, it is possible to conclude that gargling with the original honey 10% solution is effective in lowering dental plaque score. Honey can be used in relation to conventional treatments to protect dental plaque and gingivitis. More research will be needed to back up these preliminary findings. Moreover, the synergistic effect of Chlorhexidine with natural Honey must be investigated","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78922715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.247
Badaruddin Sahito, J. Khaskheli, Dileep Kumar, M. T. Lakho, Muhammad Younis, Arsalan Khalil Ayub
Objectives: To assess the functional outcome of dynamic condylar screws to treat subtrochanteric fractures in adult patients. Methods: The prospective descriptive study was conducted at the department of orthopedic surgery, Dr. Ruth KM Pfau civil hospital Karachi, Pakistan, from March 2016 to October 2019. A total of 47 patients of 18 to 60 years of either gender with subtrochanteric fractures treated with dynamic condylar screw were included in the study. After consent and counseling, patients were operated on by a consultant orthopedic surgeon and fixed with a dynamic condylar screw. Postoperatively patients were regularly followed at 2nd, 6th, 12th, 16th, 20th weeks, and onwards monthly for at least one year. Functional outcomes such as infection, union, failure of fixation were observed in all patients. SPSS software version 23 was used to analyze data. Mean and SD was reported for numeric variables, whereas frequency and percentage were reported for categorical variables. A Chi-square test was used to assess the association between variables. Results: The mean age was estimated as 37.53±12.31 years. Most of the patients were male (74.5%), and 25.5% were females. About 27 patients had a fracture on the right side (57.4%) and 20 on the left side (42.6%). Out 47 cases, 3 were lost to follow, 33 patients showed excellent outcomes, 6 cases had a good outcome, 3 cases had fair outcomes, and 2 cases had poor functional outcomes. During the follow-up, 42 cases showed union, 3 lost to follow-up, 1 died, and 1 patient had implant break. About 2 patients had infections in post- operative duration because of fracture. Conclusion: Subtrochanteric femur fractures are challenging to operate, especially in our society where extensive trauma becomes more frequent. Dynamic condylar screws showed overall acceptable results. It is simple, locally made, readily available, and cheap, with almost the same result as other implants around proximal femur fractures.
目的:评价动态髁螺钉治疗成人粗隆下骨折的功能效果。方法:前瞻性描述性研究于2016年3月至2019年10月在巴基斯坦卡拉奇市Ruth KM Pfau民用医院骨科进行。共有47例18 - 60岁的患者接受动力髁螺钉治疗转子下骨折。经同意和咨询后，患者由骨科顾问医生进行手术，并使用动态髁螺钉固定。术后定期随访2、6、12、16、20周，每月随访至少1年。所有患者均观察到感染、愈合、固定失败等功能结果。采用SPSS软件23版进行数据分析。数值变量报告平均值和标准差，而分类变量报告频率和百分比。采用卡方检验评估变量之间的相关性。结果:患者平均年龄为37.53±12.31岁。男性占74.5%，女性占25.5%。右侧骨折27例(57.4%)，左侧骨折20例(42.6%)。47例患者中失访3例，预后优良者33例，预后良好者6例，预后一般者3例，功能预后差者2例。随访中42例愈合，3例失访，1例死亡，1例种植体断裂。2例患者术后因骨折发生感染。结论:股骨粗隆下骨折是一项具有挑战性的手术，特别是在我们的社会，广泛的创伤变得更加频繁。动态髁螺钉显示总体可接受的结果。它简单、本地制造、容易获得、便宜，与其他股骨近端骨折植入物的效果几乎相同。
{"title":"Subtrochanteric fractures treated with dynamic condylar screw","authors":"Badaruddin Sahito, J. Khaskheli, Dileep Kumar, M. T. Lakho, Muhammad Younis, Arsalan Khalil Ayub","doi":"10.58397/ashkmdc.v27i1.247","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.247","url":null,"abstract":"Objectives: To assess the functional outcome of dynamic condylar screws to treat subtrochanteric fractures in adult patients. \u0000Methods: The prospective descriptive study was conducted at the department of orthopedic surgery, Dr. Ruth KM Pfau civil hospital Karachi, Pakistan, from March 2016 to October 2019. A total of 47 patients of 18 to 60 years of either gender with subtrochanteric fractures treated with dynamic condylar screw were included in the study. After consent and counseling, patients were operated on by a consultant orthopedic surgeon and fixed with a dynamic condylar screw. Postoperatively patients were regularly followed at 2nd, 6th, 12th, 16th, 20th weeks, and onwards monthly for at least one year. Functional outcomes such as infection, union, failure of fixation were observed in all patients. SPSS software version 23 was used to analyze data. Mean and SD was reported for numeric variables, whereas frequency and percentage were reported for categorical variables. A Chi-square test was used to assess the association between variables. \u0000Results: The mean age was estimated as 37.53±12.31 years. Most of the patients were male (74.5%), and 25.5% were females. About 27 patients had a fracture on the right side (57.4%) and 20 on the left side (42.6%). Out 47 cases, 3 were lost to follow, 33 patients showed excellent outcomes, 6 cases had a good outcome, 3 cases had fair outcomes, and 2 cases had poor functional outcomes. During the follow-up, 42 cases showed union, 3 lost to follow-up, 1 died, and 1 patient had implant break. About 2 patients had infections in post- operative duration because of fracture. \u0000Conclusion: Subtrochanteric femur fractures are challenging to operate, especially in our society where extensive trauma becomes more frequent. Dynamic condylar screws showed overall acceptable results. It is simple, locally made, readily available, and cheap, with almost the same result as other implants around proximal femur fractures.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84374269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.550
Syed Muhammad Zulfiqar Hyder Naqvi, Syed Imtiaz Ahmed Jafry
Objectives: To assess the frequency of self-medication and its associated factors among outpatients. Methods: A cross-sectional study was conducted at the outpatient department of Fatima Hospital, Baqai Medical University, from May 2019 to September 2019. After checking eligibility, a total of 360 outpatients were included in the study using the convenience sampling technique. Being aged 18 years or above and belonging to either gender were the study's inclusion criteria, whereas refusal to give verbal informed consent was the exclusion criterion of the study. The data was collected by interviewing the study participants using a structured questionnaire. Statistical package for social sciences version 21 was used for data analysis, while inferential analysis was performed using univariate and multivariable binary logistic regression. Results: The study results showed that 118 (32.8%) of the participants were suffering from a chronic illness, 240 (66.7%) of them kept medicines at their houses, 235 (65.3%) of them self-medicated, whereas the mean duration of their self-medication was found to be 9.90 ± 8.51 years. Moreover, age, educational status, employment status, and keeping medicines at the house were significantly associated with self-medication of the participants were those who were aged 50 years or above (AOR,7.83; 95% CI,2.27-27.04; p=0.001), able to read and write (AOR, 4.36; 95% CI, 1.58-11.98; p=0.004) and kept medicines at the house (AOR, 46.35; 95% CI, 20.07-107.06; p<0.001) had significantly higher odds of self-medication than those who were aged up to 30 years, were illiterate or did not keep medicines at house respectively whereas those who were employed/self-employed (AOR, 0.30; 95% CI, 0.10-0.88; p=0.028) had significantly lower odds of self- medication than those who were unemployed. Conclusion: Almost two-thirds of the participants were found to be self-medicating. Moreover, age, educational status, employment status, and keeping medicines at the house were significantly associated with the self-medication of the respondents.
{"title":"Frequency of Self-Medication and Its Associated Factors among Outpatients","authors":"Syed Muhammad Zulfiqar Hyder Naqvi, Syed Imtiaz Ahmed Jafry","doi":"10.58397/ashkmdc.v27i1.550","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.550","url":null,"abstract":"Objectives: To assess the frequency of self-medication and its associated factors among outpatients. \u0000Methods: A cross-sectional study was conducted at the outpatient department of Fatima Hospital, Baqai Medical University, from May 2019 to September 2019. After checking eligibility, a total of 360 outpatients were included in the study using the convenience sampling technique. Being aged 18 years or above and belonging to either gender were the study's inclusion criteria, whereas refusal to give verbal informed consent was the exclusion criterion of the study. The data was collected by interviewing the study participants using a structured questionnaire. Statistical package for social sciences version 21 was used for data analysis, while inferential analysis was performed using univariate and multivariable binary logistic regression. \u0000Results: The study results showed that 118 (32.8%) of the participants were suffering from a chronic illness, 240 (66.7%) of them kept medicines at their houses, 235 (65.3%) of them self-medicated, whereas the mean duration of their self-medication was found to be 9.90 ± 8.51 years. Moreover, age, educational status, employment status, and keeping medicines at the house were significantly associated with self-medication of the participants were those who were aged 50 years or above (AOR,7.83; 95% CI,2.27-27.04; p=0.001), able to read and write (AOR, 4.36; 95% CI, 1.58-11.98; p=0.004) and kept medicines at the house (AOR, 46.35; 95% CI, 20.07-107.06; p<0.001) had significantly higher odds of self-medication than those who were aged up to 30 years, were illiterate or did not keep medicines at house respectively whereas those who were employed/self-employed (AOR, 0.30; 95% CI, 0.10-0.88; p=0.028) had significantly lower odds of self- medication than those who were unemployed. \u0000Conclusion: Almost two-thirds of the participants were found to be self-medicating. Moreover, age, educational status, employment status, and keeping medicines at the house were significantly associated with the self-medication of the respondents.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81912944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.310
F. Ali, Tazeen Fatima Munim, Shabnum Nadeem, A. Khatoon, Zubaida Masood
ABSTRACT Objective: To assess the experience (during and post procedure) of women after immediate postpartum and post placental Insertion of intrauterine contraceptive device (IUCD), a long acting reversible contraceptive (LARC). Methods: This prospective and longitudinal study was conducted during February 2019 to September 2019 in Gynae and Obstetrics department Unit 1 at Abbasi Shaheed Hospital. All 141 booked and non-booked patients who delivered in the hospital and received immediate postpartum intrauterine contraceptive device (PPIUCD),either post placental, intra cesarean or within 48 hours after delivery were included in the study regardless of the mode of delivery either intra-cesarean or spontaneous vaginal delivery. Written consent was taken for the contraceptive device insertion and verbal consent was taken to fill the proforma which included basic demographic information, their overall experience with postpartum intrauterine contraceptive device. Immediate experience was measured by assessing the pain during procedure and post insertion period. Further all participants were followed at six weeks and 6 months to collect information about any complains removal of IUCD and overall experience. Results: The mean age was 27.3 years with a standard deviation (SD) of 4.42. Among all the participants, 77(54.6%) had Cesarean section and 64(45.4%) had vaginal delivery. During procedure only 5(3.5%) had complain of mild pain and no immediate post procedural complains was recorded. 86(73.5%) participants at 6 weeks and 78(69.03%) participants at 6 months had no complained. Overall experience was found satisfactory in 86(73.5%) participants. Conclusion: Postpartum intrauterine contraceptive device (PPIUCD) provided satisfactory experience to majority of the women. So we recommend its use for better maternal and child health.
{"title":"Experience of Women after Immediate Postpartum Insertion of Intrauterine Contraceptive Device (PPIUCD), a Long-Acting Reversible Contraception","authors":"F. Ali, Tazeen Fatima Munim, Shabnum Nadeem, A. Khatoon, Zubaida Masood","doi":"10.58397/ashkmdc.v27i1.310","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.310","url":null,"abstract":"ABSTRACT \u0000Objective: To assess the experience (during and post procedure) of women after immediate postpartum and post placental Insertion of intrauterine contraceptive device (IUCD), a long acting reversible contraceptive (LARC). \u0000Methods: This prospective and longitudinal study was conducted during February 2019 to September 2019 in Gynae and Obstetrics department Unit 1 at Abbasi Shaheed Hospital. All 141 booked and non-booked patients who delivered in the hospital and received immediate postpartum intrauterine contraceptive device (PPIUCD),either post placental, intra cesarean or within 48 hours after delivery were included in the study regardless of the mode of delivery either intra-cesarean or spontaneous vaginal delivery. Written consent was taken for the contraceptive device insertion and verbal consent was taken to fill the proforma which included basic demographic information, their overall experience with postpartum intrauterine contraceptive device. Immediate experience was measured by assessing the pain during procedure and post insertion period. Further all participants were followed at six weeks and 6 months to collect information about any complains removal of IUCD and overall experience. \u0000Results: The mean age was 27.3 years with a standard deviation (SD) of 4.42. Among all the participants, 77(54.6%) had Cesarean section and 64(45.4%) had vaginal delivery. During procedure only 5(3.5%) had complain of mild pain and no immediate post procedural complains was recorded. 86(73.5%) participants at 6 weeks and 78(69.03%) participants at 6 months had no complained. Overall experience was found satisfactory in 86(73.5%) participants. \u0000Conclusion: Postpartum intrauterine contraceptive device (PPIUCD) provided satisfactory experience to majority of the women. So we recommend its use for better maternal and child health.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73175497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.544
Zahir Hussain, Shabbir Ahmed, A. Serafi, Samir Mohammed Abdulfattah Attia, Sumera Sohail, Nuvair Zia
Objective: The purpose of the present study was to determine the correlation of age with serum homocysteine (Hcy) levels in male nonobese epilepsy (Ep) patients and nonobese male control (C) subjects. Methods: This case-control study was conducted in non-obese male epilepsy patients (Ep; n: 44; age: 26-40 years) having predominant grand mal (generalized tonic-clonic) seizures, and in control subjects (C; n: 42; age: 26-40 years). The Ep and C subjects were further subdivided into age-based subgroups: 26-30, 31-35, 36-40 years. Determination of serum Hcy was carried out by enzyme linked immunosorbent assay (ELISA). SPSS software version 24 was used for the purpose of data entry/ statistical analysis. Results: The mean± SD values for serum Hcy (?mol/L) in male Ep (n:44) and male C subjects (n:42) were 12.34±3.34 and 9.16±3.38 respectively, that showed highly significant increase in the level of Hcy (p< 0.001) in Ep compared to C subjects. Serum Hcy levels showed significant increased serum levels of Hcy, and positive linear correlation in all age groups (26-30, 31-35, 36-40, 26-40) in Ep subjects compared to control subjects. However, significantly elevated serum Hcy and lesser association (though significant) of Hcy with age in Ep group as compared to C subjects was found in the present report. Conclusion: Present study provides evidence of the significant impact of age on serum homocysteine levels in nonobese epilepsy patients. However, it is essentially required to carry out well controlled studies comprising wider age range data, and large number of samples in each age subgroup to have better idea about the potential impact of Hcy in epilepsy, and to investigate the comparative effects of AEDs and dosages of AEDs on serum levels of Hcy and vice versa.
{"title":"Age Related Homocysteine Serum Levels Elevate in Men with Epilepsy","authors":"Zahir Hussain, Shabbir Ahmed, A. Serafi, Samir Mohammed Abdulfattah Attia, Sumera Sohail, Nuvair Zia","doi":"10.58397/ashkmdc.v27i1.544","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.544","url":null,"abstract":"Objective: The purpose of the present study was to determine the correlation of age with serum homocysteine (Hcy) levels in male nonobese epilepsy (Ep) patients and nonobese male control (C) subjects. \u0000Methods: This case-control study was conducted in non-obese male epilepsy patients (Ep; n: 44; age: 26-40 years) having predominant grand mal (generalized tonic-clonic) seizures, and in control subjects (C; n: 42; age: 26-40 years). The Ep and C subjects were further subdivided into age-based subgroups: 26-30, 31-35, 36-40 years. Determination of serum Hcy was carried out by enzyme linked immunosorbent assay (ELISA). SPSS software version 24 was used for the purpose of data entry/ statistical analysis. \u0000Results: The mean± SD values for serum Hcy (?mol/L) in male Ep (n:44) and male C subjects (n:42) were 12.34±3.34 and 9.16±3.38 respectively, that showed highly significant increase in the level of Hcy (p< 0.001) in Ep compared to C subjects. Serum Hcy levels showed significant increased serum levels of Hcy, and positive linear correlation in all age groups (26-30, 31-35, 36-40, 26-40) in Ep subjects compared to control subjects. However, significantly elevated serum Hcy and lesser association (though significant) of Hcy with age in Ep group as compared to C subjects was found in the present report. \u0000Conclusion: Present study provides evidence of the significant impact of age on serum homocysteine levels in nonobese epilepsy patients. However, it is essentially required to carry out well controlled studies comprising wider age range data, and large number of samples in each age subgroup to have better idea about the potential impact of Hcy in epilepsy, and to investigate the comparative effects of AEDs and dosages of AEDs on serum levels of Hcy and vice versa.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91031070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.542
Shahan Waheed
Learning resuscitation in emergency medicine is sought with many challenges like; recall, anxiety, stress and human factors. In the current editorial an innovative learning method has been proposed for LMICs to improve resuscitation outcomes through improve practice.
{"title":"Resuscitation Ladder–An Innovative Method of Learning Resuscitation","authors":"Shahan Waheed","doi":"10.58397/ashkmdc.v27i1.542","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.542","url":null,"abstract":"Learning resuscitation in emergency medicine is sought with many challenges like; recall, anxiety, stress and human factors. In the current editorial an innovative learning method has been proposed for LMICs to improve resuscitation outcomes through improve practice.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83592050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.531
Sadia Iqbal, U. Hameed, Muhammad Kamran, Lubna Faisal, S. Moeen, Nasarul Huda
Objectives: This study aimed to evaluate the anti-oxidative potential of ascorbic acid on methylphenidate induced decreased spermatogenesis and decreased testosterone levels in male Albino rats. Methods: This experimental study was performed on twelve-week-old Albino male rats selected through randomized sampling technique divided into three groups. Only healthy male rats of the same age and weighing between 180 to 200 gms were included, and any rat was appearing sick or had less weight than 180gms and aged less than 12 weeks were excluded. Control group A received 2 ml of normal saline for 50 days. Group B was given 2mg/day methylphenidate per oral for 50 days, and Group C received 2mg /day methylphenidate for 50 days, then ascorbic acid 50mg/day for 10 days. After 60 days, rats were dissected, testes were removed and histologically examined for spermatogenesis by Johnson's scoring, and blood samples were collected to evaluate testosterone levels. Results: On histological examination, the testes of animals of Group B showed a statistically significant decrease in Johnson's score (p-value < 0.001) with disruption of germinal epithelium and absence of mature sperms. These findings were associated with reduced levels of serum testosterone in this group. Administration of Ascorbic acid (AA) to group C showed statistically improved Johnson score and testosterone levels compared to group B. Conclusion: It has been concluded that administering Ascorbic Acid can improve decreased spermatogenesis and serum testosterone levels induced by methylphenidater
{"title":"Effect of Ascorbic Acid on Methylphenidate Induced Decreased Spermatogenesis in Albino Rats","authors":"Sadia Iqbal, U. Hameed, Muhammad Kamran, Lubna Faisal, S. Moeen, Nasarul Huda","doi":"10.58397/ashkmdc.v27i1.531","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.531","url":null,"abstract":"Objectives: This study aimed to evaluate the anti-oxidative potential of ascorbic acid on methylphenidate induced decreased spermatogenesis and decreased testosterone levels in male Albino rats. \u0000Methods: This experimental study was performed on twelve-week-old Albino male rats selected through randomized sampling technique divided into three groups. Only healthy male rats of the same age and weighing between 180 to 200 gms were included, and any rat was appearing sick or had less weight than 180gms and aged less than 12 weeks were excluded. Control group A received 2 ml of normal saline for 50 days. Group B was given 2mg/day methylphenidate per oral for 50 days, and Group C received 2mg /day methylphenidate for 50 days, then ascorbic acid 50mg/day for 10 days. After 60 days, rats were dissected, testes were removed and histologically examined for spermatogenesis by Johnson's scoring, and blood samples were collected to evaluate testosterone levels. \u0000Results: On histological examination, the testes of animals of Group B showed a statistically significant decrease in Johnson's score (p-value < 0.001) with disruption of germinal epithelium and absence of mature sperms. These findings were associated with reduced levels of serum testosterone in this group. Administration of Ascorbic acid (AA) to group C showed statistically improved Johnson score and testosterone levels compared to group B. \u0000Conclusion: It has been concluded that administering Ascorbic Acid can improve decreased spermatogenesis and serum testosterone levels induced by methylphenidater","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"159 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86990549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.535
Syeda Arzoo Azeem, S. Haider, Z. Abbasi, Z. Abbas, Hoor u lain Iqbal
Abstract Objective: To compare general quality of life of youths having repaired non-syndromic CLP with controls using a generic quality of life instrument, Youth Quality of Life – Research Version (YQOL-R). Methods: case control study was conducted from January, 2017 to December, 2018. Inclusion criteria was patients having repaired non syndromic Cleft Lip and Palate, age 15 to 29 years, of either gender while controls were healthy individuals of similar age. Quality of life was measured using validated YQOL-R instrument. Data of 62 cases and 107 healthy controls, consented for study was analysed using statistical software, SPSS version 20. Results:. Mean age was 22.09+5.04. Cronbach’s alpha for domains of sense of self was 0.630, relationship domain (0.795), environmental domain (0.826) and general quality of life domain was 0.688 and for YQOL-R was 0.866. Significant difference was observed for self care domain (63.10 vs. 73.50; p-value = 0.001), relationship domain (79.5 vs. 83.73; p-value = 0.013), environmental domain (70.89 vs. 84.60; p-value = 0.001), general quality of life domain (79.80 vs. 86.04; p-value = 0.012) and percent score of total perceptual score between cases and controls (73.32 vs. 81.97; p-value = 0.001). Conclusion: Compared to cases healthy controls had a better quality of life as they have significantly better results in self care, relationship, environment and general quality of life domains along with mean perceptual percentage.
摘要目的:采用通用生活质量量表青年生活质量-研究版(YQOL-R)比较修复无综合征CLP青年与对照组的一般生活质量。方法:于2017年1月至2018年12月进行病例对照研究。纳入标准为15至29岁的无综合征性唇腭裂修复患者，男女不限，对照组为年龄相近的健康个体。使用经验证的YQOL-R仪器测量生活质量。采用SPSS version 20统计软件对同意研究的62例病例和107例健康对照进行数据分析。结果:。平均年龄22.09+5.04。自我意识领域的Cronbach 's alpha为0.630，关系领域为0.795，环境领域为0.826，一般生活质量领域为0.688,YQOL-R为0.866。自我护理领域差异有统计学意义(63.10比73.50;p值= 0.001)，关系域(79.5 vs. 83.73;p值= 0.013)，环境领域(70.89 vs. 84.60;p值= 0.001)，总体生活质量域(79.80 vs. 86.04;p值= 0.012)和病例与对照组的总知觉得分百分比(73.32 vs. 81.97;p值= 0.001)。结论:与健康对照组相比，健康对照组在生活自理、人际关系、环境、总体生活质量等方面均有显著改善。
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Pub Date : 2022-02-28DOI: 10.58397/ashkmdc.v27i1.522
Muhammad Kamran, Naheed Khan, Hina Jabeen, Nasrul Huda Uda, Sadia Iqbal, Ashhad Mazhar Siddiqi
ABSTRACT Objectives: The present study evaluated the protective effect of Crocus Sativus against Amikacin-induced Nephrotoxicity. Methods: The prospective descriptive study was conducted at the department of orthopedic surgery, Dr. Ruth KM Pfau Adult laboratory albino rats of the Wistar strain were used in this experimental study. In this study, 75 albino rats were subdivided into 3 groups, including experimental groups B and C. The control group (A) received normal saline intraperitoneally, group (B) received Amikacin 30mg/kg body weight intraperitoneally and Group (C) received Crocus sativus 50 mg/kg body weight orally and vitamin E orally in a dose of 50mg/kg of body weight. Kidneys of rats obtained after dissection were processed, sectioned, and stained in PAS Hematoxylin and Gomoris Methenamine Silver stains. The present study was conducted at Dow University of Health Sciences in the Institute of Biomedical Sciences and Animal House of Dow University and Dow Diagnostic Research and Reference Laboratory. The duration of the study was Three months. Inclusion criteria were Albino rats of both sexes, kidneys of either side (right & left), rats with an approximate weight of 140 to 180 grams were included in the study. Exclusion criteria were overweight rats and pregnant rats. Results: A significant increase in kidney weight was observed in group B. A considerable addition was observed in proximal tubular in groups B and C. A considerable increase was also observed in the number of intact proximal tubule nuclei and the nuclear diameter of groups B & C. Conclusion: The study provides evidence that Crocus Sativus has protective effects in Amikacin-induced nephrotoxicity, comparable to widely used Antioxidant Vitamin E. The study recommends the addition of Crocus Sativus in dietary supplements after further evaluation in human subjects.
【摘要】目的:研究西红花对阿米卡星肾毒性的保护作用。方法:前瞻性描述性研究在骨科进行，Ruth KM Pfau博士采用Wistar品系成年实验室白化大鼠进行实验研究。本研究将75只白化大鼠再分为实验B、C组，对照组(A组)腹腔注射生理盐水，B组(B组)腹腔注射阿米卡星30mg/kg体重，C组(C组)口服藏红花50mg/kg体重，并口服维生素E 50mg/kg体重。对解剖后的大鼠肾脏进行处理、切片，用PAS苏木精和Gomoris甲基苯丙胺银染色。本研究由陶氏健康科学大学生物医学科学研究所和陶氏大学动物馆以及陶氏诊断研究和参考实验室进行。研究的持续时间为三个月。纳入标准为雌雄白化大鼠，左右两侧肾脏，体重约为140 ~ 180克的大鼠纳入研究。排除标准为超重大鼠和怀孕大鼠。结果:B组肾脏重量明显增加，B、c组近端肾小管数量明显增加，B、c组近端肾小管完整核数量和核直径均明显增加。该研究提供的证据表明，藏红花对阿米卡辛引起的肾毒性具有保护作用，可与广泛使用的抗氧化剂维生素e相媲美。在对人类受试者进行进一步评估后，研究建议在膳食补充剂中添加藏红花。
{"title":"Comparison of Antioxidant Effect of Crocus Sativus and Vitamin E on Amakicin Induced Nephrotoxicity in Albino Rats","authors":"Muhammad Kamran, Naheed Khan, Hina Jabeen, Nasrul Huda Uda, Sadia Iqbal, Ashhad Mazhar Siddiqi","doi":"10.58397/ashkmdc.v27i1.522","DOIUrl":"https://doi.org/10.58397/ashkmdc.v27i1.522","url":null,"abstract":"ABSTRACT \u0000Objectives: The present study evaluated the protective effect of Crocus Sativus against Amikacin-induced Nephrotoxicity. \u0000Methods: The prospective descriptive study was conducted at the department of orthopedic surgery, Dr. Ruth KM Pfau Adult laboratory albino rats of the Wistar strain were used in this experimental study. In this study, 75 albino rats were subdivided into 3 groups, including experimental groups B and C. The control group (A) received normal saline intraperitoneally, group (B) received Amikacin 30mg/kg body weight intraperitoneally and Group (C) received Crocus sativus 50 mg/kg body weight orally and vitamin E orally in a dose of 50mg/kg of body weight. Kidneys of rats obtained after dissection were processed, sectioned, and stained in PAS Hematoxylin and Gomoris Methenamine Silver stains. The present study was conducted at Dow University of Health Sciences in the Institute of Biomedical Sciences and Animal House of Dow University and Dow Diagnostic Research and Reference Laboratory. The duration of the study was Three months. Inclusion criteria were Albino rats of both sexes, kidneys of either side (right & left), rats with an approximate weight of 140 to 180 grams were included in the study. Exclusion criteria were overweight rats and pregnant rats. \u0000Results: A significant increase in kidney weight was observed in group B. A considerable addition was observed in proximal tubular in groups B and C. A considerable increase was also observed in the number of intact proximal tubule nuclei and the nuclear diameter of groups B & C. \u0000Conclusion: The study provides evidence that Crocus Sativus has protective effects in Amikacin-induced nephrotoxicity, comparable to widely used Antioxidant Vitamin E. The study recommends the addition of Crocus Sativus in dietary supplements after further evaluation in human subjects.","PeriodicalId":53838,"journal":{"name":"Annals Abbasi Shaheed Hospital & Karachi Medical & Dental College","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80269764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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