J. A. Calderón-Chagualá, Miguel Á. Montilla-García, M. Gómez, Julián E. Ospina-Viña, Jennifer C. Triana-Martínez, Laura C. Vargas-Martínez
Palabras clave: Daño cerebral adquirido. Rehabilitación neuropsicológica. Realidad virtual. Rehabilitación tradicional. Rehabilitación. Fisioterapia. Abstract Neuropsychological rehabilitation is the discipline in charge of treating the cognitive, emotional and behavioral disorders that origi-nate as a result of brain damage, due to traumatic brain injury, hypoxia, stroke or tumors. We made a review of the tools for traditional and virtual neuropsychological rehabilitation, to determine the influence of each in the process of neuropsychological rehabilitation. The results revealed that two methods are reliable and valid in the processes of intervention for these kind of patients; however at the moment the virtual rehabilitation is generating easier access to this system, due to the creation of software specialized in rehabilitation. In conclusion, the review established that the two modalities are adequate, but the virtual modality has been developed for more integration of technological and scientific advances, resulting in improvement in a short time and with less cost.
{"title":"Rehabilitación neuropsicológica en daño cerebral: uso de herramientas tradicionales y realidad virtual","authors":"J. A. Calderón-Chagualá, Miguel Á. Montilla-García, M. Gómez, Julián E. Ospina-Viña, Jennifer C. Triana-Martínez, Laura C. Vargas-Martínez","doi":"10.24875/rmn.m22000089","DOIUrl":"https://doi.org/10.24875/rmn.m22000089","url":null,"abstract":"Palabras clave: Daño cerebral adquirido. Rehabilitación neuropsicológica. Realidad virtual. Rehabilitación tradicional. Rehabilitación. Fisioterapia. Abstract Neuropsychological rehabilitation is the discipline in charge of treating the cognitive, emotional and behavioral disorders that origi-nate as a result of brain damage, due to traumatic brain injury, hypoxia, stroke or tumors. We made a review of the tools for traditional and virtual neuropsychological rehabilitation, to determine the influence of each in the process of neuropsychological rehabilitation. The results revealed that two methods are reliable and valid in the processes of intervention for these kind of patients; however at the moment the virtual rehabilitation is generating easier access to this system, due to the creation of software specialized in rehabilitation. In conclusion, the review established that the two modalities are adequate, but the virtual modality has been developed for more integration of technological and scientific advances, resulting in improvement in a short time and with less cost.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47793967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypoxia-induced factor 1 (HIF-1) plays a fundamental role in the response to low oxygen tension, since it regulates the expression of a wide variety of genes, whose products participate in processes such as angiogenesis, energy metabolism, erythropoiesis, and cell proliferation as well as in the process of neurogenesis, which involves various stages, such as proliferation of neuronal stem cells, migration, differentiation, survival of new neurons, and integration of the same. Among the many intrinsic and extrinsic molecular signals that regulate the production of new neurons from progenitor cells in the adult in the central nervous system (CNS), hypoxic damage plays an important role in the maintenance and function of stem cells in development and disease.
{"title":"Role of the hypoxia-inducible factor (HIF) in the process of neurogenesis at the hippocampal level","authors":"Clara L. Ramirez-Rincón","doi":"10.24875/rmn.21000020","DOIUrl":"https://doi.org/10.24875/rmn.21000020","url":null,"abstract":"Hypoxia-induced factor 1 (HIF-1) plays a fundamental role in the response to low oxygen tension, since it regulates the expression of a wide variety of genes, whose products participate in processes such as angiogenesis, energy metabolism, erythropoiesis, and cell proliferation as well as in the process of neurogenesis, which involves various stages, such as proliferation of neuronal stem cells, migration, differentiation, survival of new neurons, and integration of the same. Among the many intrinsic and extrinsic molecular signals that regulate the production of new neurons from progenitor cells in the adult in the central nervous system (CNS), hypoxic damage plays an important role in the maintenance and function of stem cells in development and disease.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43833004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alma Y Galvez-Contreras, Jorge Guzman-Muñiz, N. Moy-López, Ó. González-Pérez
Background: In Latin America, research in neuroscience and psychology has had a continuous development; however, the magnitude of this development and its impact on the comparison to other regions or countries has not been well studied. Objective: The objective of the study was to carry out a bibliometric analysis of scientific productivity in neuroscience and psychology in Latin America. Methods: We consulted the Scimago Journal and Country Rank database to obtain the clas-sification of the Latin American countries in these knowledge disciplines, during the period from 2015 to 2020. Results: We found 32 Latin American countries with citable documents in these disciplines. Notably, 90% of Latin American scientific productivity is concentrated in five countries: Brazil, Mexico, Argentina, Chile, and Colombia, with Brazil being the leading country in all cases. Conclusions: Research in neuroscience and psychology in Latin America has had a sustained and moderate growth. However, it is highly circumscribed in these five countries.
{"title":"Contributions of Latin America to scientific research in neuroscience and psychology","authors":"Alma Y Galvez-Contreras, Jorge Guzman-Muñiz, N. Moy-López, Ó. González-Pérez","doi":"10.24875/rmn.21000034","DOIUrl":"https://doi.org/10.24875/rmn.21000034","url":null,"abstract":"Background: In Latin America, research in neuroscience and psychology has had a continuous development; however, the magnitude of this development and its impact on the comparison to other regions or countries has not been well studied. Objective: The objective of the study was to carry out a bibliometric analysis of scientific productivity in neuroscience and psychology in Latin America. Methods: We consulted the Scimago Journal and Country Rank database to obtain the clas-sification of the Latin American countries in these knowledge disciplines, during the period from 2015 to 2020. Results: We found 32 Latin American countries with citable documents in these disciplines. Notably, 90% of Latin American scientific productivity is concentrated in five countries: Brazil, Mexico, Argentina, Chile, and Colombia, with Brazil being the leading country in all cases. Conclusions: Research in neuroscience and psychology in Latin America has had a sustained and moderate growth. However, it is highly circumscribed in these five countries.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47467451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Rebolledo-García, J. C. Diestel-Bautista, P. González-Vargas, G. García-Ramos
Acute neuromuscular failure (ANF) has become a common issue in emergency rooms worldwide. A systematic research was done in multiple data sources. A total of 350 articles were found, exclusion criteria were: not-neurological acute respiratory failure, case reports, duplication, and written in languages other than English or Spanish. One hundred and six abstracts of articles that included definition, epidemiology, etiology, physiopathology, and ANF diagnosis were considered, 70 were re-viewed. Finally, 32 articles focused on decision-making by non-neurological medical staff were taken. Guillain-Barré syndrome seems to be the most common etiology for ANF in Mexico. Myasthenia gravis, autoimmune and oncologic diseases are also common causes for ANF. The clinical signs for an imminent neuromuscular failure are drop head, faltering speech, nasal voice, and sialorrhea. Early diagnosis of ANF leads to better ANF outcomes; it is necessary to establish an approach for the diagnosis in Mexico.
{"title":"Acute neuromuscular failure acquired in the community: A state-of-the-art review","authors":"Daniel Rebolledo-García, J. C. Diestel-Bautista, P. González-Vargas, G. García-Ramos","doi":"10.24875/rmn.21000007","DOIUrl":"https://doi.org/10.24875/rmn.21000007","url":null,"abstract":"Acute neuromuscular failure (ANF) has become a common issue in emergency rooms worldwide. A systematic research was done in multiple data sources. A total of 350 articles were found, exclusion criteria were: not-neurological acute respiratory failure, case reports, duplication, and written in languages other than English or Spanish. One hundred and six abstracts of articles that included definition, epidemiology, etiology, physiopathology, and ANF diagnosis were considered, 70 were re-viewed. Finally, 32 articles focused on decision-making by non-neurological medical staff were taken. Guillain-Barré syndrome seems to be the most common etiology for ANF in Mexico. Myasthenia gravis, autoimmune and oncologic diseases are also common causes for ANF. The clinical signs for an imminent neuromuscular failure are drop head, faltering speech, nasal voice, and sialorrhea. Early diagnosis of ANF leads to better ANF outcomes; it is necessary to establish an approach for the diagnosis in Mexico.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47609515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebeca Vindas-Smith, Andrey Sequeira-Cordero, I. Castro-Volio, Patricia Jiménez-González, P. Cuenca, Manuel Saborio-Rocafort, Marietha Fallas, Melissa Vásquez
Objective: We aimed to determine the distribution of intermediate and expanded FMR1 alleles in Costa Rican individuals diagnosed with autism. Materials and methods: A total of 212 autism spectrum disorder (ASD) cases of Costa Rican individuals and 943 male newborn controls were screened by means of polymerase chain reaction to determine the frequency of intermediate, premutation, and full mutation FMR1 alleles. Full mutation suspected cases were confirmed by Southern blot analyses. Frequencies of FMR1 alleles in the case group were compared with frequencies observed in a population-based sample of male newborn controls. Results: A significant excess of intermediate allele carriers was found in ASD individuals as compared to controls ( χ 2 test, p < 0.001). Four, out of 188 males in the case group, were identified as full mutation carriers. Conclusions: Our results suggest a possible involvement of the gray zone or intermediate alleles in ASD.
{"title":"Intermediate and expanded FMR1 alleles in an autistic Costa Rican population","authors":"Rebeca Vindas-Smith, Andrey Sequeira-Cordero, I. Castro-Volio, Patricia Jiménez-González, P. Cuenca, Manuel Saborio-Rocafort, Marietha Fallas, Melissa Vásquez","doi":"10.24875/rmn.21000044","DOIUrl":"https://doi.org/10.24875/rmn.21000044","url":null,"abstract":"Objective: We aimed to determine the distribution of intermediate and expanded FMR1 alleles in Costa Rican individuals diagnosed with autism. Materials and methods: A total of 212 autism spectrum disorder (ASD) cases of Costa Rican individuals and 943 male newborn controls were screened by means of polymerase chain reaction to determine the frequency of intermediate, premutation, and full mutation FMR1 alleles. Full mutation suspected cases were confirmed by Southern blot analyses. Frequencies of FMR1 alleles in the case group were compared with frequencies observed in a population-based sample of male newborn controls. Results: A significant excess of intermediate allele carriers was found in ASD individuals as compared to controls ( χ 2 test, p < 0.001). Four, out of 188 males in the case group, were identified as full mutation carriers. Conclusions: Our results suggest a possible involvement of the gray zone or intermediate alleles in ASD.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46119279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lilia G. Aguilar-Parra, Karla Rodríguez-Jiménez, Adib J. de-Saráchaga, Anna L. Bazán-Rodríguez, Eunice Martínez-Jiménez, J. Galnares-Olalde, N. Kerik-Rotenberg, J. Calleja-Castillo, E. León-Manríquez, E. S. Vargas-Cañas, J. C. López-Hernández
Background: Bickerstaff brainstem encephalitis (BBE) presents with consciousness impairment, ataxia, ophthalmoplegia, and areflexia. Objective: We aim to describe the clinical, paraclinical, and imaging features of patients with BBE from a tertiary-re-ferral neurological center. Methods: A case series was conducted from an ambispective cohort of patients with Guillain-Barré syndrome (GBS) from 2016 to 2021. Subjects ≥ 18 years and who met Odaka et al. BBE criteria were eligible. Data collected included: age, gender, prior infection, Guillain-Barré disability score (GDS score), time from symptom onset to diagnosis, altered mental state, time from symptom onset to altered mental state, cranial nerve involvement, deep tendon reflexes, ataxia, invasive mechanical ventilation (IMV) requirement, treatment, inpatient delirium, length of stay (days), and protein levels in CSF analysis. Nerve conduction studies (NCS) were performed, as well as neuroimaging (brain magnetic resonance imaging [MRI] and F 18-fluorodeoxyglucose PET-CT). Antiganglioside antibodies panel including anti-GQ1b was solicited. Results: Four patients (1.7%) met the inclusion criteria. Two patients manifested stupor and two showed somnolence throughout the course of the disease. Three patients required IMV due to bulbar dysfunction. None of the NCS met the criteria for any GBS electrophysiological variant. One patient was positive for IgM GM2 antibodies. One patient underwent 18F-FDG PET-CT, showing gene-ralized cortical hypometabolism. Conclusion: The frequency of BBE in our population is very low (1.7%). IgM GM2 is another anti-ganglioside antibody related to BBE. Imaging studies such as MRI frequently do not present abnormalities and [ F 18-FDG-PET scan might be a useful study to describe a metabolism pattern to aid the diagnosis of BBE.
{"title":"Frequency, clinical, and paraclinical characteristics of patients with Bickerstaff brainstem encephalitis in a tertiary-referral neurological center","authors":"Lilia G. Aguilar-Parra, Karla Rodríguez-Jiménez, Adib J. de-Saráchaga, Anna L. Bazán-Rodríguez, Eunice Martínez-Jiménez, J. Galnares-Olalde, N. Kerik-Rotenberg, J. Calleja-Castillo, E. León-Manríquez, E. S. Vargas-Cañas, J. C. López-Hernández","doi":"10.24875/rmn.21000050","DOIUrl":"https://doi.org/10.24875/rmn.21000050","url":null,"abstract":"Background: Bickerstaff brainstem encephalitis (BBE) presents with consciousness impairment, ataxia, ophthalmoplegia, and areflexia. Objective: We aim to describe the clinical, paraclinical, and imaging features of patients with BBE from a tertiary-re-ferral neurological center. Methods: A case series was conducted from an ambispective cohort of patients with Guillain-Barré syndrome (GBS) from 2016 to 2021. Subjects ≥ 18 years and who met Odaka et al. BBE criteria were eligible. Data collected included: age, gender, prior infection, Guillain-Barré disability score (GDS score), time from symptom onset to diagnosis, altered mental state, time from symptom onset to altered mental state, cranial nerve involvement, deep tendon reflexes, ataxia, invasive mechanical ventilation (IMV) requirement, treatment, inpatient delirium, length of stay (days), and protein levels in CSF analysis. Nerve conduction studies (NCS) were performed, as well as neuroimaging (brain magnetic resonance imaging [MRI] and F 18-fluorodeoxyglucose PET-CT). Antiganglioside antibodies panel including anti-GQ1b was solicited. Results: Four patients (1.7%) met the inclusion criteria. Two patients manifested stupor and two showed somnolence throughout the course of the disease. Three patients required IMV due to bulbar dysfunction. None of the NCS met the criteria for any GBS electrophysiological variant. One patient was positive for IgM GM2 antibodies. One patient underwent 18F-FDG PET-CT, showing gene-ralized cortical hypometabolism. Conclusion: The frequency of BBE in our population is very low (1.7%). IgM GM2 is another anti-ganglioside antibody related to BBE. Imaging studies such as MRI frequently do not present abnormalities and [ F 18-FDG-PET scan might be a useful study to describe a metabolism pattern to aid the diagnosis of BBE.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41957186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental enrichment and intellectual disability: Systematic review of neurocognitive effects in children and adolescents","authors":"Orlando Villouta-Gutiérrez, Cristhian Pérez-Villalobos, Romina Rojas-Ponce, Fabiola Sáez-Delgado","doi":"10.24875/rmn.21000012","DOIUrl":"https://doi.org/10.24875/rmn.21000012","url":null,"abstract":"","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48990718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jahaziel Molina-Del-Rio, R. M. Hidalgo-Aguirre, Alondra Camacho-Vázquez, María G. Ayón-Rubio
Background: When we experience an emotion, a personal evaluation of stimuli and physiological responses occurs, based on the previous exposure. Anger can be triggered when we feel upset by movies, and those more realistic as videos of the internet can be even more arousing. Measures can be obtained to estimate synchronous participation between two brain areas during the processing of emotions. Objective: We compare brain activity in response to fictional visual stimuli taken from a movie bank versus real internet videos. Methods: We recorded subjective responses, and electrophysiological parameters to compare the functional connectivity patterns of 26 young women divided into two groups. Results: Results showed differences of functional connectivity revealed a characteristic pattern associated with each type of video observed, with an increased electroencephalographic (EEG) correlation during observation of the internet videos and a decreased EEG correlation while watching the movie clips, between frontal and temporal regions in slow and fast bands. Conclusion: Functional connectivity EEG analysis, together with the subjetive physiological assessment, allow for a closer approach to the study of the cognitive processing of emotions.
{"title":"The observation of real videos and movie clips with anger content induces different cortical connectivity patterns in young women","authors":"Jahaziel Molina-Del-Rio, R. M. Hidalgo-Aguirre, Alondra Camacho-Vázquez, María G. Ayón-Rubio","doi":"10.24875/rmn.21000047","DOIUrl":"https://doi.org/10.24875/rmn.21000047","url":null,"abstract":"Background: When we experience an emotion, a personal evaluation of stimuli and physiological responses occurs, based on the previous exposure. Anger can be triggered when we feel upset by movies, and those more realistic as videos of the internet can be even more arousing. Measures can be obtained to estimate synchronous participation between two brain areas during the processing of emotions. Objective: We compare brain activity in response to fictional visual stimuli taken from a movie bank versus real internet videos. Methods: We recorded subjective responses, and electrophysiological parameters to compare the functional connectivity patterns of 26 young women divided into two groups. Results: Results showed differences of functional connectivity revealed a characteristic pattern associated with each type of video observed, with an increased electroencephalographic (EEG) correlation during observation of the internet videos and a decreased EEG correlation while watching the movie clips, between frontal and temporal regions in slow and fast bands. Conclusion: Functional connectivity EEG analysis, together with the subjetive physiological assessment, allow for a closer approach to the study of the cognitive processing of emotions.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46200508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"We leave a year behind, and we start a new one","authors":"Ildefonso Rodríguez-Leyva","doi":"10.24875/rmn.m21000085","DOIUrl":"https://doi.org/10.24875/rmn.m21000085","url":null,"abstract":"","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44972815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcela García-Villa, Raúl Leal-Cantú, Rosa G. Madrigal-Salas, Ildefonso Rodríguez-Leyva, Mariana A. Quintana-Díaz, C. L. González-García
Objective: This work is the first registry focused on knowing patients’ characteristics with Parkinson’s disease (PD), evolution and treatment used in the state of Michoacán. Methods: 68 patients with PD from the neurology consultation of the General Hospital “Dr. Miguel Silva” from October 1, 2019, to December 31, 2019, who fulfilled the UKPDSBB criteria, were studied. Sociodemographic data, disease duration, and severity according to the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Hoehn and Yahr Scale were collected. Results: A total of 68 patients were included in the study. Seven of them were eliminated for not meeting the inclusion criteria. Of the 61 evaluated, 31 (50.8%) were women, the mean age was 68 years (± 9.8) and the age of diagnosis was 61 years (± 12.6). The predominant comorbidities were diabetes mellitus (16.4%), systemic arterial hypertension (44.3%), and depression (70.5%). The dominant phenotype was rigid-akinetic, with absence or slight tremor in 50.8%. About 36.1% had between 5 and 10 years of suffering from the disease. 36.1% had exposure to pesticides; 31.1% had a history of head trauma. There were 24.6% smoking and 31.1% alcoholism. The drugs most used for motor manifestations were levodopa/carbidopa in 83.6% and pramipexole in 31.1 %. In part I of the MDS-UPDRS scale, the mean score was 9.8 ± 6.0; part II 14.37 ± 9.6; part III 21.22 ± 12.4 and part IV 3.2 ± 3.69. HY, I occupied 37.7%; II 26.2%; III 23%; IV 9.8% and V 3.3%. Conclusions: In this population, the disease occurred without distinction of gender. The only treatment was pharmacological. Rehabilitation, the support of the psychiatrist and nutritionists, is essential for comprehensive management.
{"title":"Parkinson’s disease in the state of Michoacan, evolution, and treatment","authors":"Marcela García-Villa, Raúl Leal-Cantú, Rosa G. Madrigal-Salas, Ildefonso Rodríguez-Leyva, Mariana A. Quintana-Díaz, C. L. González-García","doi":"10.24875/rmn.21000018","DOIUrl":"https://doi.org/10.24875/rmn.21000018","url":null,"abstract":"Objective: This work is the first registry focused on knowing patients’ characteristics with Parkinson’s disease (PD), evolution and treatment used in the state of Michoacán. Methods: 68 patients with PD from the neurology consultation of the General Hospital “Dr. Miguel Silva” from October 1, 2019, to December 31, 2019, who fulfilled the UKPDSBB criteria, were studied. Sociodemographic data, disease duration, and severity according to the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Hoehn and Yahr Scale were collected. Results: A total of 68 patients were included in the study. Seven of them were eliminated for not meeting the inclusion criteria. Of the 61 evaluated, 31 (50.8%) were women, the mean age was 68 years (± 9.8) and the age of diagnosis was 61 years (± 12.6). The predominant comorbidities were diabetes mellitus (16.4%), systemic arterial hypertension (44.3%), and depression (70.5%). The dominant phenotype was rigid-akinetic, with absence or slight tremor in 50.8%. About 36.1% had between 5 and 10 years of suffering from the disease. 36.1% had exposure to pesticides; 31.1% had a history of head trauma. There were 24.6% smoking and 31.1% alcoholism. The drugs most used for motor manifestations were levodopa/carbidopa in 83.6% and pramipexole in 31.1 %. In part I of the MDS-UPDRS scale, the mean score was 9.8 ± 6.0; part II 14.37 ± 9.6; part III 21.22 ± 12.4 and part IV 3.2 ± 3.69. HY, I occupied 37.7%; II 26.2%; III 23%; IV 9.8% and V 3.3%. Conclusions: In this population, the disease occurred without distinction of gender. The only treatment was pharmacological. Rehabilitation, the support of the psychiatrist and nutritionists, is essential for comprehensive management.","PeriodicalId":53921,"journal":{"name":"Revista Mexicana de Neurociencia","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42954600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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