S. Manna, S. H. Kombathula, Sanjib Gayen, Sonal Varshney, P. Pareek
Abstract Background: This study was conducted to assess the dosimetric impact of FFF beam plans on high-grade brain neoplasms using the VMAT technique when compared with FF beam plans. Material and Methods: Thirty patients with high-grade brain neoplasms, who had received radiotherapy using VMAT technique retrospectively were selected for this study. All the patients were planned for VMAT using 6MV_FF beam and the same plan was re-optimized using 6MV_FFF beam keeping the same dose constraint. Radiotherapy dose distribution on planning target volume (PTV) and organs at risk (OAR), target conformity index (CI), Homogeneity Index (HI), Low dose volume in the patient (V5, V10, V20, and V30), and Integral dose to the whole body in both plans were compared. Results: The PTV coverage and OAR’s showed no significant differences in dose distribution between the FFF and FF beam VMAT planning. There was a reduction of the average maximum dose in the right eye, left eye, right optic nerve, and left optic nerve using FFF beams. The reduction in average low dose volume was observed in V5, V10, V20, V30, and Mean Dose. Also, a significant reduction was observed in the integral dose to the whole body using the FFF beam. Conclusions: Using FFF beams with VMAT is doable for the treatment of high-grade brain neoplasms, and the delivery mode of the FFF beam in VMAT may yield similar results to FF beam which should be confirmed in a large scale prospective clinical trial.
{"title":"Dosimetric impact of FFF over FF beam using VMAT for brain neoplasms treated with radiotherapy","authors":"S. Manna, S. H. Kombathula, Sanjib Gayen, Sonal Varshney, P. Pareek","doi":"10.2478/pjmpe-2021-0023","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0023","url":null,"abstract":"Abstract Background: This study was conducted to assess the dosimetric impact of FFF beam plans on high-grade brain neoplasms using the VMAT technique when compared with FF beam plans. Material and Methods: Thirty patients with high-grade brain neoplasms, who had received radiotherapy using VMAT technique retrospectively were selected for this study. All the patients were planned for VMAT using 6MV_FF beam and the same plan was re-optimized using 6MV_FFF beam keeping the same dose constraint. Radiotherapy dose distribution on planning target volume (PTV) and organs at risk (OAR), target conformity index (CI), Homogeneity Index (HI), Low dose volume in the patient (V5, V10, V20, and V30), and Integral dose to the whole body in both plans were compared. Results: The PTV coverage and OAR’s showed no significant differences in dose distribution between the FFF and FF beam VMAT planning. There was a reduction of the average maximum dose in the right eye, left eye, right optic nerve, and left optic nerve using FFF beams. The reduction in average low dose volume was observed in V5, V10, V20, V30, and Mean Dose. Also, a significant reduction was observed in the integral dose to the whole body using the FFF beam. Conclusions: Using FFF beams with VMAT is doable for the treatment of high-grade brain neoplasms, and the delivery mode of the FFF beam in VMAT may yield similar results to FF beam which should be confirmed in a large scale prospective clinical trial.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"43 1","pages":"191 - 199"},"PeriodicalIF":0.4,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79509013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The analysis involved thermograms of the lower limbs of a patient suffering from symptomatic L-S segment discopathy with spinal root compression syndrome (symptomatic lumbar discopathy) qualified for surgical treatment. The thermograms were obtained using the Flir Ebx 50 camera. They were developed with the use of the software included with the Flir Ebx 50 camera, as well as the Origin Pro 2020 data analysis and graphing software. ROIs (Regions of Interest) were specified and analyzed in terms of temperature (average, maximum or minimum) temperature distributions, isotherms, and specified surface areas limited by selected isotherms. According to the analysis of the thermograms, the images obtained with Origin Pro 2020 enable a more advanced presentation of the temperature distribution, by taking into account the isotherms with selected temperatures and by calculating the area limited by a given isotherm (or between two isotherms) they allow to introduce an additional surface parameter related to specific isotherms. It provides additional information (parameter) in comparison with analogous ROIs on healthy and pathologic limbs in the same patient.
摘要:本文分析了一例症状性L-S节段脱位合并脊髓根压迫综合征(症状性腰椎脱位)患者的下肢热像图，该患者适合手术治疗。热像图使用Flir Ebx 50相机获得。它们是使用Flir Ebx 50相机附带的软件以及Origin Pro 2020数据分析和绘图软件开发的。根据温度(平均、最高或最低)温度分布、等温线和受选定等温线限制的指定表面积来指定和分析roi(兴趣区域)。根据对热图的分析，使用Origin Pro 2020获得的图像可以更高级地呈现温度分布，通过考虑选定温度下的等温线，并通过计算给定等温线(或两个等温线之间)限制的面积，它们可以引入与特定等温线相关的额外表面参数。它提供了额外的信息(参数)，比较类似的roi在同一患者的健康和病理肢体。
{"title":"New possibilities of graphics software in the analysis of thermograms of patient’s lower limbs – a technical note","authors":"Monika Wideł, S. Grzegorczyn","doi":"10.2478/pjmpe-2021-0021","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0021","url":null,"abstract":"Abstract The analysis involved thermograms of the lower limbs of a patient suffering from symptomatic L-S segment discopathy with spinal root compression syndrome (symptomatic lumbar discopathy) qualified for surgical treatment. The thermograms were obtained using the Flir Ebx 50 camera. They were developed with the use of the software included with the Flir Ebx 50 camera, as well as the Origin Pro 2020 data analysis and graphing software. ROIs (Regions of Interest) were specified and analyzed in terms of temperature (average, maximum or minimum) temperature distributions, isotherms, and specified surface areas limited by selected isotherms. According to the analysis of the thermograms, the images obtained with Origin Pro 2020 enable a more advanced presentation of the temperature distribution, by taking into account the isotherms with selected temperatures and by calculating the area limited by a given isotherm (or between two isotherms) they allow to introduce an additional surface parameter related to specific isotherms. It provides additional information (parameter) in comparison with analogous ROIs on healthy and pathologic limbs in the same patient.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"15 1","pages":"175 - 180"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87300109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farshid Mahmoudi, D. Shahbazi-Gahrouei, N. Chegeni
Abstract Spatially fractionated radiation therapy (SFRT) refers to the delivery of a single large dose of radiation within the target volume in a heterogeneous pattern using either a custom GRID block, multileaf collimators, and virtual methods such as helical tomotherapy or synchrotron-based microbeams. The potential impact of this technique on the regression of bulky deep-seated tumors that do not respond well to conventional radiotherapy has been remarkable. To date, a large number of patients have been treated using the SFRT techniques. However, there are yet many technical and medical challenges that have limited their routine use to a handful of clinics, most commonly for palliative intent. There is also a poor understanding of the biological mechanisms underlying the clinical efficacy of this approach. In this article, the methods of SFRT delivery together with its potential biological mechanisms are presented. Furthermore, technical challenges and clinical achievements along with the radiobiological models used to evaluate the efficacy and safety of SFRT are highlighted.
{"title":"The role of the spatially fractionated radiation therapy in the management of advanced bulky tumors","authors":"Farshid Mahmoudi, D. Shahbazi-Gahrouei, N. Chegeni","doi":"10.2478/pjmpe-2021-0015","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0015","url":null,"abstract":"Abstract Spatially fractionated radiation therapy (SFRT) refers to the delivery of a single large dose of radiation within the target volume in a heterogeneous pattern using either a custom GRID block, multileaf collimators, and virtual methods such as helical tomotherapy or synchrotron-based microbeams. The potential impact of this technique on the regression of bulky deep-seated tumors that do not respond well to conventional radiotherapy has been remarkable. To date, a large number of patients have been treated using the SFRT techniques. However, there are yet many technical and medical challenges that have limited their routine use to a handful of clinics, most commonly for palliative intent. There is also a poor understanding of the biological mechanisms underlying the clinical efficacy of this approach. In this article, the methods of SFRT delivery together with its potential biological mechanisms are presented. Furthermore, technical challenges and clinical achievements along with the radiobiological models used to evaluate the efficacy and safety of SFRT are highlighted.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"23 1","pages":"123 - 135"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81720997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Bencheikh, A. Maghnouj, J. Tajmouati, Abdessamad DIDI, A. Lamrabet
Abstract External photon beam radiotherapy is often used in tumor treatment. The photons are generated from the target which had stricken by the primary electron beam (incident particles). The photon beam contains the primary photons coming directly from the target and secondary photons coming from the photon interactions with head component materials (scattered photons). Altogether is thereafter used in radiotherapy treatment. This Monte Carlo study aims to investigate and evaluate the secondary radiations (photons) in terms of fluence, energy fluence, spectral distribution, mean energy and angular spread distribution. The secondary photons, which contributed in radiotherapy treatment, are examined and evaluated in number (fluence) and energy. At the phantom surface, the secondary photons originated in the whole linac head are mainly coming from the primary collimator. In 0.45% of secondary photons coming from the whole linac head, the primary collimator contributes by 86% and they are more energetic. However, the flattening filter and the secondary collimator contribute together by less than 14% and their photons are less energetic and then can deteriorate the beam dosimetry quality. To improve the radiotherapy treatment quality, the number of photons of low energy should be as low as possible in the clinical beam. Our work can be a basic investigation to use in the improvement of linac head configuration and specially the beam modifiers.
{"title":"Detailed Monte Carlo analysis of the secondary photons coming out of the therapeutic X-ray beam of linear accelerator","authors":"M. Bencheikh, A. Maghnouj, J. Tajmouati, Abdessamad DIDI, A. Lamrabet","doi":"10.2478/pjmpe-2021-0018","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0018","url":null,"abstract":"Abstract External photon beam radiotherapy is often used in tumor treatment. The photons are generated from the target which had stricken by the primary electron beam (incident particles). The photon beam contains the primary photons coming directly from the target and secondary photons coming from the photon interactions with head component materials (scattered photons). Altogether is thereafter used in radiotherapy treatment. This Monte Carlo study aims to investigate and evaluate the secondary radiations (photons) in terms of fluence, energy fluence, spectral distribution, mean energy and angular spread distribution. The secondary photons, which contributed in radiotherapy treatment, are examined and evaluated in number (fluence) and energy. At the phantom surface, the secondary photons originated in the whole linac head are mainly coming from the primary collimator. In 0.45% of secondary photons coming from the whole linac head, the primary collimator contributes by 86% and they are more energetic. However, the flattening filter and the secondary collimator contribute together by less than 14% and their photons are less energetic and then can deteriorate the beam dosimetry quality. To improve the radiotherapy treatment quality, the number of photons of low energy should be as low as possible in the clinical beam. Our work can be a basic investigation to use in the improvement of linac head configuration and specially the beam modifiers.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"39 1","pages":"151 - 156"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88388272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominika J. Plaza, Klaudia M. Orzechowska, K. Slosarek
Abstract Introduction: The aim of the study was to evaluate the influence of flattening filter (FF) and flattening filter-free (FFF) beams on small-field and large-field dose distribution using the VMAT treatment plan. Material and methods: Dose distribution calculations were performed for the VMAT technique in two locations: the larynx (small irradiation field; average 30.1 cm2) and gynecology (large irradiation field; average 173.1 cm2) using X-6MV flattening filter (FF) and flattening filter-free (FFF) beams. The following values were compared: the number of monitor units, minimum doses, average doses in PTV and maximum average doses in OaR (spinal cord – in larynx radiotherapy, bladder and rectum - in gynecological radiotherapy) and RPI (Radiation Planning Index) coefficient. Results and Discussion: The performed statistical tests indicate that there is a significant difference (p <0.05) between the number of monitor units in the irradiation of large (gynecological) fields between the FF and FFF beams. The dose distributions show no statistically significant differences between the flattening filter and flattening-free filter beams (regardless of the field size). Conclusions: Due to the smaller number of monitor units, it is recommended to use flattening filter beams (FF) for large-field radiotherapy.
{"title":"Effects of flattening filter (FF) and flattening filter-free (FFF) beams on small-field and large-field dose distribution using the VMAT treatment plan","authors":"Dominika J. Plaza, Klaudia M. Orzechowska, K. Slosarek","doi":"10.2478/pjmpe-2021-0016","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0016","url":null,"abstract":"Abstract Introduction: The aim of the study was to evaluate the influence of flattening filter (FF) and flattening filter-free (FFF) beams on small-field and large-field dose distribution using the VMAT treatment plan. Material and methods: Dose distribution calculations were performed for the VMAT technique in two locations: the larynx (small irradiation field; average 30.1 cm2) and gynecology (large irradiation field; average 173.1 cm2) using X-6MV flattening filter (FF) and flattening filter-free (FFF) beams. The following values were compared: the number of monitor units, minimum doses, average doses in PTV and maximum average doses in OaR (spinal cord – in larynx radiotherapy, bladder and rectum - in gynecological radiotherapy) and RPI (Radiation Planning Index) coefficient. Results and Discussion: The performed statistical tests indicate that there is a significant difference (p <0.05) between the number of monitor units in the irradiation of large (gynecological) fields between the FF and FFF beams. The dose distributions show no statistically significant differences between the flattening filter and flattening-free filter beams (regardless of the field size). Conclusions: Due to the smaller number of monitor units, it is recommended to use flattening filter beams (FF) for large-field radiotherapy.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"42 1","pages":"137 - 141"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89919898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kostyshyn, M. Gzhegotskyi, L. Kostyshyn, O. Yarova, Y. Kulyk, S. Mudry
Abstract Sedentary lifestyle and physiological menopause are among the risk factors of osteopenia, especially in elderly people. However, bone mineral density decrease can also be observed in young individuals, for instance, due to deficiency of female sex hormones after surgical interventions, particularly ovariectomy. Our research enabled us to assess the efficacy of whole-body vibration in preventing the loss of bone mineral density in the ovariectomy rat osteopenia model. Thus, whole-body vibration with acceleration level 0.3 g and frequency 50 Hz was used on young female rats, which had been subjected to ovariectomy (n = 18). It had been conducted for 24 weeks, exposure time – 30 minutes per day, 5 times a week. Assessment of mineral component loss of the tibia was performed by means of X-ray diffraction. Bone remodeling was assessed by determining hormones: parathyroid hormone and calcitonin, Ca and P in the blood. X-ray diffraction is an effective method, which enables the evaluation a nanocomposites structure of the bone tissue in the experiment. In the article, we applied this method to determine the loss of bone mineral mass after ovariectomy and the impact of whole-body vibration under such conditions. In the ovariectomy group, the volume of a mineral component significantly decreased starting already from the 16th week (р<0.05) versus control. However, in the group with ovariectomy + whole-body vibration, the loss of a mineral component was insignificant during 8-16 weeks of the investigation, compared with the control group. On the 24th day, the spectrums almost did not differ from ovariectomized rats group. Meanwhile, hormone levels changed in ovariectomized rats group. It should be emphasized that the aforementioned whole-body vibration parameters do not cause severe bone damage or further negative consequences.
{"title":"Using X-ray diffraction in characterization of bone remodeling and nanocomposites in ovariectomized rats osteopenia model","authors":"N. Kostyshyn, M. Gzhegotskyi, L. Kostyshyn, O. Yarova, Y. Kulyk, S. Mudry","doi":"10.2478/pjmpe-2021-0019","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0019","url":null,"abstract":"Abstract Sedentary lifestyle and physiological menopause are among the risk factors of osteopenia, especially in elderly people. However, bone mineral density decrease can also be observed in young individuals, for instance, due to deficiency of female sex hormones after surgical interventions, particularly ovariectomy. Our research enabled us to assess the efficacy of whole-body vibration in preventing the loss of bone mineral density in the ovariectomy rat osteopenia model. Thus, whole-body vibration with acceleration level 0.3 g and frequency 50 Hz was used on young female rats, which had been subjected to ovariectomy (n = 18). It had been conducted for 24 weeks, exposure time – 30 minutes per day, 5 times a week. Assessment of mineral component loss of the tibia was performed by means of X-ray diffraction. Bone remodeling was assessed by determining hormones: parathyroid hormone and calcitonin, Ca and P in the blood. X-ray diffraction is an effective method, which enables the evaluation a nanocomposites structure of the bone tissue in the experiment. In the article, we applied this method to determine the loss of bone mineral mass after ovariectomy and the impact of whole-body vibration under such conditions. In the ovariectomy group, the volume of a mineral component significantly decreased starting already from the 16th week (р<0.05) versus control. However, in the group with ovariectomy + whole-body vibration, the loss of a mineral component was insignificant during 8-16 weeks of the investigation, compared with the control group. On the 24th day, the spectrums almost did not differ from ovariectomized rats group. Meanwhile, hormone levels changed in ovariectomized rats group. It should be emphasized that the aforementioned whole-body vibration parameters do not cause severe bone damage or further negative consequences.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"98 1","pages":"157 - 163"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83591104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna Kidoń, K. Polaczek-Grelik, K. Golba, W. Wojakowski, A. Ochała
Abstract Introduction: The purpose of the study was the calibration of Gafchromic films in clinical interventional radiology conditions and the assessment of the influence of dose range, the shape of the fitting curve, and its practical application. The aim of the work was to show how practically perform calibration in a wide range of doses. Material and methods: Gafchromic XR–RV3 films were included in the study. The calibration was performed for A and B film series separately. Doses from the range of 0 – 8 Gy were used. Film dosimeters were read out in reflective mode with a commercial flatbed scanner. Results: Among various degrees of a polynomial function, the best fit, which fulfilled the chosen criterion of 95% agreement between measured and reconstructed doses and simple equation criterion, was observed for third-degree polynomial. The fitting curve where the dose is the function of optical density (logMPV) was demonstrated to be more precise than the fitting curve based on MPV only. To minimize the difference between dose absorbed by the film and dose reconstructed from the fitting curve below 5% it is necessary to divide the calibration range of 0 – 8 Gy into two subranges for use in interventional radiology. This difference was set at a maximum level of 3.8% and 1.9% for the lowand high-dose range, respectively. Each series of films may have a slightly different calibration curve, especially for the low dose range. A deviation of up to 36% between two batches of Gafchromic film was observed. Conclusions: For the third-degree polynomial fitting function (one of the recommended in the literature) calibration should be done into low and high dose ranges and for each batch separately. A systematic error higher than 20% could be introduced when the fitting curve from one film batch is applied to the other film batch.
{"title":"Calibration of Gafchromic XR-RV3 film under interventional radiology conditions","authors":"Joanna Kidoń, K. Polaczek-Grelik, K. Golba, W. Wojakowski, A. Ochała","doi":"10.2478/pjmpe-2021-0020","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0020","url":null,"abstract":"Abstract Introduction: The purpose of the study was the calibration of Gafchromic films in clinical interventional radiology conditions and the assessment of the influence of dose range, the shape of the fitting curve, and its practical application. The aim of the work was to show how practically perform calibration in a wide range of doses. Material and methods: Gafchromic XR–RV3 films were included in the study. The calibration was performed for A and B film series separately. Doses from the range of 0 – 8 Gy were used. Film dosimeters were read out in reflective mode with a commercial flatbed scanner. Results: Among various degrees of a polynomial function, the best fit, which fulfilled the chosen criterion of 95% agreement between measured and reconstructed doses and simple equation criterion, was observed for third-degree polynomial. The fitting curve where the dose is the function of optical density (logMPV) was demonstrated to be more precise than the fitting curve based on MPV only. To minimize the difference between dose absorbed by the film and dose reconstructed from the fitting curve below 5% it is necessary to divide the calibration range of 0 – 8 Gy into two subranges for use in interventional radiology. This difference was set at a maximum level of 3.8% and 1.9% for the lowand high-dose range, respectively. Each series of films may have a slightly different calibration curve, especially for the low dose range. A deviation of up to 36% between two batches of Gafchromic film was observed. Conclusions: For the third-degree polynomial fitting function (one of the recommended in the literature) calibration should be done into low and high dose ranges and for each batch separately. A systematic error higher than 20% could be introduced when the fitting curve from one film batch is applied to the other film batch.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"40 1","pages":"165 - 173"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84456544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Purpose: The aim of this study is to compare the dosimetric results of Helical Tomotherapy (HT) and Multi-field IMRT treatment plans using a Simultaneous Integrated Boost (SIB) technique in the treatment of High-Risk Prostate Cancer (HRPCa) with pelvic nodal radiation. Methods: Seventeen patients planned with HT and 7,8 and 9 fields IMRT were investigated. All plans were designed with the prescribed dose of 54.0 Gy to the PTVln while simultaneously delivering 74.0 Gy to the PTVPS in 30 fractions. Dosimetric data of PTV and OARs were compared. Results: HT gives a better CI and HI of PTVPS compared to multi-field IMRT plans. HT plans significantly improved target coverage (HT:0.95 vs multi-field IMRT: 0.52, 0.49 and 0.49 respectively, p < 0.001). Bladder mean dose(Gy) (HT: 45.6 vs multi-field IMRT: 53.6, 53.3 and 52.7 respectively, p = 0.004) and D66%(Gy) dose (HT: 35.3 vs multi-field IMRT: 46.7, 47.0 and 44.9 respectively, p = 0.006) were lower in HT. But multi-field IMRT plans significantly reduced the rectum volume receiving more than 75 Gy; (HT V75% (%) 2.7 vs multi-field IMRT 0.8, 1.4 and 0.9 respectively, p = 0.008). HT provided better sparing of the right and left femoral head receiving a mean dose. The penile bulb and small bowel doses were the highest in HT compared with multi-field IMRT. Conclusions: HT achieved better dose distribution to target compared to multi-field IMRT. This study suggests HT as a reasonable option for the treatment of HRPCa patients.
{"title":"Comparison of helical tomotherapy with multi-field intensity-modulated radiotherapy treatment plans using simultaneous integrated boost in high-risk prostate cancer","authors":"H. Başaran, S. Karaca, T. Koca, Y. Gündoğdu","doi":"10.2478/pjmpe-2021-0017","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0017","url":null,"abstract":"Abstract Purpose: The aim of this study is to compare the dosimetric results of Helical Tomotherapy (HT) and Multi-field IMRT treatment plans using a Simultaneous Integrated Boost (SIB) technique in the treatment of High-Risk Prostate Cancer (HRPCa) with pelvic nodal radiation. Methods: Seventeen patients planned with HT and 7,8 and 9 fields IMRT were investigated. All plans were designed with the prescribed dose of 54.0 Gy to the PTVln while simultaneously delivering 74.0 Gy to the PTVPS in 30 fractions. Dosimetric data of PTV and OARs were compared. Results: HT gives a better CI and HI of PTVPS compared to multi-field IMRT plans. HT plans significantly improved target coverage (HT:0.95 vs multi-field IMRT: 0.52, 0.49 and 0.49 respectively, p < 0.001). Bladder mean dose(Gy) (HT: 45.6 vs multi-field IMRT: 53.6, 53.3 and 52.7 respectively, p = 0.004) and D66%(Gy) dose (HT: 35.3 vs multi-field IMRT: 46.7, 47.0 and 44.9 respectively, p = 0.006) were lower in HT. But multi-field IMRT plans significantly reduced the rectum volume receiving more than 75 Gy; (HT V75% (%) 2.7 vs multi-field IMRT 0.8, 1.4 and 0.9 respectively, p = 0.008). HT provided better sparing of the right and left femoral head receiving a mean dose. The penile bulb and small bowel doses were the highest in HT compared with multi-field IMRT. Conclusions: HT achieved better dose distribution to target compared to multi-field IMRT. This study suggests HT as a reasonable option for the treatment of HRPCa patients.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"435 1","pages":"143 - 149"},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85517297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rakhma Noviliawati, C. Anam, H. Sutanto, G. Dougherty, M. Mak’ruf
Abstract The purpose of this study was to develop an automatic method for validating the computed tomography gantry tilt. A head polymethyl methacrylate phantom with a diameter of 16 cm was used. Gantry tilt angles were measured both manually and automatically. Manual measurements were performed by measuring the length of the anteroposterior and lateral diameters from acquired images using electronic calipers. Automatic measurements consisted of a number of steps: phantom segmentation, determination of the center of the phantom, measurement of the anteroposterior and lateral diameters, and computation of the gantry tilt angle. The method was implemented on the gantry angles from 0° to 15°. The proposed method of measuring gantry angles produced accurate gantry tilt angles. The differences with the angles displayed on the gantry were less than 1°. The results of the automatic method were the same as those of the manual method (R2 > 0.98).
{"title":"Automatic validation of the gantry tilt in a computed tomography scanner using a head polymethyl methacrylate phantom","authors":"Rakhma Noviliawati, C. Anam, H. Sutanto, G. Dougherty, M. Mak’ruf","doi":"10.2478/pjmpe-2021-0008","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0008","url":null,"abstract":"Abstract The purpose of this study was to develop an automatic method for validating the computed tomography gantry tilt. A head polymethyl methacrylate phantom with a diameter of 16 cm was used. Gantry tilt angles were measured both manually and automatically. Manual measurements were performed by measuring the length of the anteroposterior and lateral diameters from acquired images using electronic calipers. Automatic measurements consisted of a number of steps: phantom segmentation, determination of the center of the phantom, measurement of the anteroposterior and lateral diameters, and computation of the gantry tilt angle. The method was implemented on the gantry angles from 0° to 15°. The proposed method of measuring gantry angles produced accurate gantry tilt angles. The differences with the angles displayed on the gantry were less than 1°. The results of the automatic method were the same as those of the manual method (R2 > 0.98).","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"99 5","pages":"57 - 62"},"PeriodicalIF":0.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72546918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edyta Michaś, Michał Dorosz, Karolina Wójciuk, K. Tymińska, M. Wiliński, M. Maciak, S. Domański, G. Wojtania, Łukasz Bartosik, A. Małkiewicz, J. Lechniak, M. Gryziński
Abstract National Centre for Nuclear Research, NCBJ is one of the biggest research institutes in Poland, in which scientists deal with basic research in the various fields of subatomic physics, development of nuclear technologies and practical applications of nuclear physics methods, including those for nuclear medicine and radiotherapy. NCBJ operates the only Polish nuclear research reactor MARIA, around which a Reactor Laboratory for Biomedical Research, RLBR has been built in the last 4 years. One of the main aims of the RLBR team is to adapt the H2 channel, one of the eight MARIA’s horizontal channels, to a specific irradiation facility delivering a high flux thermal/epithermal neutron beam. The beam derived from the channel will be a tool for biological, physical and material studies for Boron Neutron Capture Therapy, BNCT. While NCBJ is focused on building a neutron research facility, the Polish scientific community expressed its interest in BNCT development and implementation as an alternative therapy for cancer treatment. Through the working group meetings organized in the form of regular scientific workshops since 2015, it led to the establishment of a national scientific consortium dedicated to BNCT. Polish Consortium for Boron Neutron Capture Therapy agreement was initially signed by twelve institutions including scientific institutes, universities and oncological centres in October 2019. National Centre for Nuclear Research was appointed the leader of the consortium. A year later the consortium was enlarged by two more institutions.
{"title":"Reactor Laboratory for Biomedical Research in National Centre for Nuclear Research in Poland","authors":"Edyta Michaś, Michał Dorosz, Karolina Wójciuk, K. Tymińska, M. Wiliński, M. Maciak, S. Domański, G. Wojtania, Łukasz Bartosik, A. Małkiewicz, J. Lechniak, M. Gryziński","doi":"10.2478/pjmpe-2021-0014","DOIUrl":"https://doi.org/10.2478/pjmpe-2021-0014","url":null,"abstract":"Abstract National Centre for Nuclear Research, NCBJ is one of the biggest research institutes in Poland, in which scientists deal with basic research in the various fields of subatomic physics, development of nuclear technologies and practical applications of nuclear physics methods, including those for nuclear medicine and radiotherapy. NCBJ operates the only Polish nuclear research reactor MARIA, around which a Reactor Laboratory for Biomedical Research, RLBR has been built in the last 4 years. One of the main aims of the RLBR team is to adapt the H2 channel, one of the eight MARIA’s horizontal channels, to a specific irradiation facility delivering a high flux thermal/epithermal neutron beam. The beam derived from the channel will be a tool for biological, physical and material studies for Boron Neutron Capture Therapy, BNCT. While NCBJ is focused on building a neutron research facility, the Polish scientific community expressed its interest in BNCT development and implementation as an alternative therapy for cancer treatment. Through the working group meetings organized in the form of regular scientific workshops since 2015, it led to the establishment of a national scientific consortium dedicated to BNCT. Polish Consortium for Boron Neutron Capture Therapy agreement was initially signed by twelve institutions including scientific institutes, universities and oncological centres in October 2019. National Centre for Nuclear Research was appointed the leader of the consortium. A year later the consortium was enlarged by two more institutions.","PeriodicalId":53955,"journal":{"name":"Polish Journal of Medical Physics and Engineering","volume":"13 6 1","pages":"119 - 122"},"PeriodicalIF":0.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78302490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：