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Sigma-Metric Analysis to Evaluate Quality Management of Analytical Processes Using RCA and QGI in a Clinical Biochemistry Laboratory, South India 西格玛-度量分析评价使用RCA和QGI在印度南部临床生物化学实验室的分析过程的质量管理
Pub Date : 2023-06-13 DOI: 10.55691/2278-344x.1035
S. Nilakantam, Kusuma Kasapura Shivashankar, Akila Prashant, Melanahalli Dayananda, Suma M. Nataraj, Namratha G Dayananda
Introduction : This study aimed to identify laboratory errors at the earliest through Sigma-metric analysis and to evaluate quality management of analytical processes. Methods : Sigma-metrics and Quality Goal Index (QGI) were calculated by harvesting the IQC and EQC data of an accredited laboratory for 31 biochemical parameters run on Roche Cobas6000 and e411. Those with Sigma (cid:1) 2 were further analysed by applying the various Westgard rules, as suggested Results : Nearly 13 chemistry analytes showed world-class performance with Sigma > 6 and most of the immunoassay parameters showed marginal performance with sigma > 2 (cid:1) 6. Sodium, Chloride, Total T4, Beta-HCG and TSH were found to have Sigma < 2 indicating unacceptable performance. A signi fi cant improvement was observed in the Sigma-metrics analysis after performing the root cause analysis Conclusion : Sigma-metric analyses the quality management of various analytical processes in biochemistry. The poor assay performance will be picked up by the Root cause analysis and Quality Goal Indices calculation. With the help of RCA and QGI, we plan to increase the resource management by decreasing the frequency of QC runs.
本研究旨在通过西格玛-度量分析尽早发现实验室错误,并评价分析过程的质量管理。方法:收集认可实验室在罗氏Cobas6000和e411上运行的31项生化参数的IQC和EQC数据,计算Sigma-metrics和质量目标指数(QGI)。结果:近13种化学分析物在Sigma bbb6 (cid:1)下表现为世界级水平,大部分免疫测定参数在Sigma > (cid:1) 6下表现为边缘性水平。钠、氯化物、总T4、β - hcg和TSH的Sigma < 2表明表现不佳。在进行根本原因分析后,西格玛计量分析有了显著的改善。结论:西格玛计量分析了生物化学各分析过程的质量管理。通过根本原因分析和质量目标指标的计算,找出分析结果不佳的地方。在RCA和QGI的帮助下,我们计划通过减少QC运行的频率来增加资源管理。
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引用次数: 0
Treatment burden, not health risk attitude associated with adherence in patients with mental illness in South India 南印度精神疾病患者治疗负担而非健康风险态度与依从性相关
Pub Date : 2023-06-13 DOI: 10.55691/2278-344x.1033
D. Ram, Neethu Benny, Shruthy Kv
Background : Attitude towards health risks and treatment burden may mediate treatment adherence in therapeutic care. There is a paucity of study examining the levels and relationships of these variables in patients with mental illness. Objective : This study was conducted to know the relationships of health risk attitude & treatment burden and medication adherence in patients with mental illness. Settings and design : Cross-sectional, Hospital-based study. Methods and material : One hundred seventy consecutive participants in remission of mental illness were recruited. The patient ' s details were assessed with Sociodemographic proforma while attitude towards health risk was assessed with Health-Risk Attitude Scale (HRAS). To evaluate the burden of treatment, the Treatment Burden Questionnaire (TBQ) was used while medication adherence was rated with the Medication Adherence Rating Scale (MARS). Statistical analysis used : Descriptive statistics, Kruskal e Wallis H, Linear regression analysis. Results : Mean score on MARS was 4.9 (SD ± 1.7) while HRAS and TBQ were 62.2 (SD ± 8.6) and 44.2 (SD ± 23). On linear regression analysis scores of TBQ were statistically signi fi cant positively linked to HRAS score (R 2 ¼ .35, df ¼ 1, F ¼ 94.2, p ¼ 0.001), While Scores on MARS were statistically signi fi cant negatively linked TBQ and HRAS score (R 2 ¼ .53, df ¼ 2, F ¼ 97.1, p ¼ 001). Conclusions : Health risk aversion and treatment burden may upraise in mentally ill, and linked to poor medication adherence.
背景:对健康风险和治疗负担的态度可能影响治疗护理的治疗依从性。关于这些变量在精神疾病患者中的水平和关系的研究很少。目的:了解精神疾病患者健康风险态度、治疗负担与药物依从性的关系。设置和设计:横断面,医院为基础的研究。方法和材料:连续招募170名精神疾病缓解的参与者。采用社会人口学量表评估患者的详细情况,采用健康风险态度量表(HRAS)评估患者对健康风险的态度。治疗负担评价采用治疗负担问卷(TBQ),依从性评定采用依从性评定量表(MARS)。采用的统计分析:描述性统计,Kruskal e Wallis H,线性回归分析。结果:MARS评分为4.9 (SD±1.7)分,HRAS评分为62.2 (SD±8.6)分,TBQ评分为44.2 (SD±23)分。线性回归分析TBQ评分与HRAS评分呈显著正相关(R 2.35, df 1, F 94.2, p 0.001),而MARS评分与TBQ评分呈显著负相关(R 2.53, df 2, F 97.1, p 0.001)。结论:精神疾病患者的健康风险规避和治疗负担可能升高,并与较差的药物依从性有关。
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引用次数: 0
Effect Of Fenugreek And Curry Leaves Powder On Dyslipidemia- A Randomized Controlled Pilot Study 胡芦巴和咖喱叶粉对血脂异常的影响——一项随机对照的初步研究
Pub Date : 2023-06-13 DOI: 10.55691/2278-344x.1031
Syeda Farha S, Shivani Agarwal, Vanitha Reddy P
Background: Dyslipidemias, a disorder of lipid metabolism, is widely established as an independent major and modifiable risk factor of cardiovascular disease (CVD). The conditions are common worldwide and a leading cause of death in India, and has even riven the age bar swaying in young people too. The significant effect of an increase in dyslipidemias depends on diabetes and hypertension. Nutraceuticals, derived from food sources serve as an alternative therapy for the management of dyslipidemia. India is home to multitudinous medicinal plants, of which many remain underutilized. Murraya Koenigii (curry leaf) and Trigonella foenum-graecum (fenugreek leaves) are well-proven as good sources of nutraceutical and functional foods. Objectives: To study the effect of fenugreek and curry leaves powder on dyslipidemia and also the dietary habits of dyslipidemic subjects. Materials and methods: 31 subjects aged between 40 and 70 years were recruited based on inclusion and exclusion criteria, and grouped into group 1(hypertensive with dyslipidemia), group 2 (diabetic with dyslipidemia), and group 3 (only dyslipidemia) supplemented with the mixture of fenugreek and curry leaf powder for 3 months. Results: Reduction in total cholesterol and triglyceride levels were observed in group 2 (DM þ DLP) and group 1 (HTN þ DLP) i.e 221.2 ± 29 and 193 ± 72.4 respectively. The HDL levels increased in all three groups. Reduced VLDL and FBS levels were observed in all three groups. Conclusion: Our findings showed that fenugreek and curry leaf powder supplementation, as a phenolic-rich herb can be effective in the reduction of some lipid profiles in dyslipidemic patients suggesting their potential neutraceutical role in treating CVD.
背景:血脂异常是一种脂质代谢紊乱,被广泛认为是心血管疾病(CVD)的一个独立的、主要的、可改变的危险因素。这种情况在世界范围内很常见,也是印度的主要死亡原因,甚至还使年轻人的年龄界限摇摆不定。血脂异常增加的显著影响取决于糖尿病和高血压。从食物中提取的营养保健品是治疗血脂异常的一种替代疗法。印度是众多药用植物的家园,其中许多仍未得到充分利用。Murraya Koenigii(咖喱叶)和Trigonella foenum-graecum(葫芦巴叶)已被证明是营养保健和功能性食品的良好来源。目的:研究胡芦巴咖喱叶粉对血脂异常的影响及血脂异常人群的饮食习惯。材料与方法:根据纳入和排除标准,招募年龄在40 ~ 70岁之间的31名受试者,分为1组(高血压合并血脂异常)、2组(糖尿病合并血脂异常)和3组(仅血脂异常),并辅以胡芦巴咖喱叶粉合剂,疗程3个月。结果:2组(DM + DLP)和1组(HTN + DLP)总胆固醇和甘油三酯水平分别降低221.2±29和193±72.4。三组的高密度脂蛋白水平均有所上升。三组均观察到VLDL和FBS水平降低。结论:我们的研究结果表明,胡芦巴和咖喱叶粉作为一种富含酚类物质的草药,可以有效地降低血脂异常患者的一些脂质谱,这表明它们在治疗心血管疾病方面具有潜在的中性作用。
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引用次数: 0
COVID-19: An impetus to reform paediatrics curriculum for undergraduate medical students in Iraq 2019冠状病毒病:推动伊拉克医科本科学生儿科课程改革
Pub Date : 2023-06-13 DOI: 10.55691/2278-344x.1037
M. Al-Mendalawi
The beginning of COVID-19 infection in late 2019 in China and its global spread represent one of the stressful events of recent times. Apart from posing risks to the health, living, society, and economy, the COVID-19 pandemic has devastated various aspects of medical education. In this article, we have highlighted the journey of paediatrics curricular reform in Iraq with a special emphasis on the need to reform in the era of the pandemic. The reform is essential to arm undergraduate medical students with the necessary competency to deliver adequate paediatric healthcare to the community should COVID-19 infection comes roaring back.
2019年底,新冠肺炎在中国开始感染,并在全球蔓延,这是近年来令人紧张的事件之一。除了给健康、生活、社会、经济带来风险外,新冠肺炎疫情还对医学教育的各个方面造成了破坏。在这篇文章中,我们强调了伊拉克儿科课程改革的历程,特别强调了在大流行病时代进行改革的必要性。这项改革对于让医科本科生具备必要的能力,以便在COVID-19感染卷土重来时为社区提供足够的儿科医疗服务至关重要。
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引用次数: 0
Bed utilization pattern of intensive care units affiliated to Ministry of Health: a national study in Egypt prior to the COVID-19 pandemic 卫生部附属重症监护病房床位利用模式:2019冠状病毒病大流行前埃及的一项全国性研究
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1021
A. El-Gilany, Abeer El Ashry, M. Khafagy, Noha El Adawi, M. Bahgat
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引用次数: 0
Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries 亚洲不同地区番茄黄卷叶病毒(TYLCV)密码子使用指标、进化模型和系统地理重构的新信息学框架
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1022
Mamathashree Mn, Kuralyanapalya Putta, Honnappa Suresh, Sharanagouda S Patil, Uma Bharathi Indrabalan, Mallikarjun S Beelagi, Sushma Pradeep, Krishnamoorthy Paramanandham, Siju Susan Jacob, Chandrashekar Srinivasa, Shiva Prasad Kollur, Raghu Ram Achar, Ashwini Prasad, Shashanka K Prasad, Chandan Shivamallu
: Tomato yellow leaf curl virus (TYLCV) is a major devastating viral disease, majorly affecting the tomato production globally. The disease is majorly transmitted by the Whitefly. The Begomovirus (TYLCV) having a six major protein coding genes, among them the C1/AC1 is evidently associated with viral replication. Owing to immense role of C1/AC1 gene, the present study is an initial effort to elucidate the factors shaping the codon usage bias and evolutionary pattern of TYLCV-C1/AC1 gene in five major Asian countries. Based on publically available nucleotide sequence data the Codon usage pattern, Evolutionary and Phylogeographic reconstruction was carried out. The study revealed the presence of significant variation between the codon bias indices in all the selected regions. Implying that the codon usage pattern indices (eNC, CAI, RCDI, GRAVY, Aromo) are seriously affected by selection and mutational pressure, taking a supremacy in shaping the codon usage bias of viral gene. Further, the tMRCA age was 1853, 1939, 1855, 1944, 1828 for China, India, Iran, Oman and South Korea, respectively for TYLCV-C1/AC1 gene. The integrated analysis of Codon usage bias, Evolutionary rate and Phylogeography analysis in viruses signifies the positive role of selection and mutational pressure among the selected regions for TYLCV (C1/AC1) gene.
番茄黄卷叶病毒(TYLCV)是一种严重危害番茄生产的病毒性疾病。这种疾病主要由白蝇传播。begomvirus (TYLCV)有6个主要的蛋白编码基因,其中C1/AC1与病毒复制明显相关。由于C1/AC1基因的巨大作用,本研究是对亚洲5个主要国家TYLCV-C1/AC1基因密码子使用偏好及其进化模式形成因素的初步研究。基于公开的核苷酸序列数据,进行了密码子使用模式、进化和系统地理重构。结果表明,在所选区域的密码子偏倚指数之间存在显著差异。说明密码子使用模式指数(eNC、CAI、RCDI、GRAVY、Aromo)受到选择和突变压力的严重影响,在病毒基因密码子使用偏好的形成中占主导地位。TYLCV-C1/AC1基因在中国、印度、伊朗、阿曼和韩国的tMRCA年龄分别为1853年、1939年、1855年、1944年、1828年。通过对病毒密码子使用偏差、进化率和系统地理分析的综合分析,揭示了TYLCV (C1/AC1)基因在选择区域中的选择和突变压力的积极作用。
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引用次数: 0
In silico examination of peptides containing selenium and ebselen Backbone To Assess Their Tumoricidal Potential 含硒和乙硒主链肽的计算机检测以评估其杀肿瘤潜能
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1029
Smitha S Bhat, Sushma Pradeep, Greeshma Jadhav, Devananda Devegowda, Sarana Rose Sommano, Chandan Shivamallu, Shiva Prasad Kollur, Shashanka K Prasad
Introduction: Cancer has been one of the highest causes of morbidity and mortality in the world for decades. Owing to improved therapeutics along with detection, breast cancer mortality has been slowly reducing. The incidence of breast cancer, on the other hand, has increased gradually. More than 100 types of cancer have been identified with a wide range of treatment protocols comprising of chemotherapy, radiation therapy, hormone therapy, etc. In an attempt to curb the serious deleterious effects caused by the chemotherapeutic drugs, numerous peptide molecules are currently popular as alternatives to the standard chemotherapeutic drugs. Methods: In this study, we have carried out in silico investigations to ascertain the anti-proliferative potential of novel peptides based on selenium and ebselen, i.e. Eb-Trp-Asp, 13, Eb-Trp-Glu, 14, and Eb-Trp-Lys, 15. Analysis of protein-ligand interactions, resulting in protein-ligand complex formation, has been carried out using the AutoDockVina in PyRx aided molecular docking technique, which may be an essential indication of druggability of the test peptides. Results: The molecular docking results revealed that the screened ligands had extraordinarily strong binding interactions and affinity for the target. Conclusion: Findings suggested that novel peptide molecule Eb-Trp-Glu, 14 may be a potent anticancer agent.
导读:几十年来,癌症一直是世界上发病率和死亡率最高的原因之一。由于治疗方法的改进和检测,乳腺癌死亡率一直在缓慢下降。另一方面,乳腺癌的发病率逐渐增加。超过100种类型的癌症已经确定了广泛的治疗方案,包括化疗,放射治疗,激素治疗等。为了抑制化疗药物的严重毒副作用,目前流行大量肽分子作为标准化疗药物的替代品。方法:在这项研究中,我们进行了硅实验,以确定基于硒和硒的新型肽的抗增殖潜力,即Eb-Trp-Asp, 13, Eb-Trp-Glu, 14和Eb-Trp-Lys, 15。利用AutoDockVina in PyRx辅助分子对接技术,分析了蛋白质-配体相互作用导致蛋白质-配体复合物形成的过程,这可能是测试肽的可药物性的重要指标。结果:分子对接结果显示,筛选的配体对靶标具有极强的结合相互作用和亲和力。结论:新型肽分子Eb-Trp-Glu, 14可能是一种有效的抗癌药物。
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引用次数: 2
Elevated serum Homocysteine levels a possible non-invasive diagnostic biomarker in patients with Non-alcoholic fatty liver disease 血清同型半胱氨酸水平升高是非酒精性脂肪肝患者可能的非侵入性诊断生物标志物
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1025
Panchami H.K., K. M, Varsha D. Shiragannanavar, Nirmala G. Sannappagowda, Shreyas H. Karunakara, Lakshana D. Puttahanumantharayappa, Kusuma K.S., Swetha N.K., Sumalatha. M.N, Prasanna K. Santhekadur
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引用次数: 0
Antioxidant effect of Morus indica L against paraquat-induced oxidative stress in Drosophila melanogaster 桑对百草枯诱导的黑腹果蝇氧化应激的抗氧化作用
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1026
M. S, Syeda Farha S, M. Reddy, S. Cs, S. A
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引用次数: 0
Perceptual and Acoustical assessment of voice in children with cleft lip and palate 唇腭裂儿童声音的知觉和声学评价
Pub Date : 2023-03-28 DOI: 10.55691/2278-344x.1027
Indu Thammaiah, Meenakshi S, R. N, R. Ramu
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引用次数: 0
期刊
International Journal of Health and Allied Sciences
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