Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献_第10页

Family Environment Modulates Linkage of Transdiagnostic Psychiatric Phenotypes and Dissociable Brain Features in the Developing Brain 家庭环境调节发育期大脑中跨诊断精神病表型与可分离大脑特征之间的联系。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsc.2024.03.003

Background

Family environment has long been known for shaping brain function and psychiatric phenotypes, especially during childhood and adolescence. Accumulating neuroimaging evidence suggests that across different psychiatric disorders, common phenotypes may share common neural bases, indicating latent brain-behavior relationships beyond diagnostic categories. However, the influence of family environment on the brain-behavior relationship from a transdiagnostic perspective remains unknown.

Methods

We included a community-based sample of 699 participants (ages 5–22 years) and applied partial least squares regression analysis to determine latent brain-behavior relationships from whole-brain functional connectivity and comprehensive phenotypic measures. Comparisons were made between diagnostic and nondiagnostic groups to help interpret the latent brain-behavior relationships. A moderation model was introduced to examine the potential moderating role of family factors in the estimated brain-behavior associations.

Results

Four significant latent brain-behavior pairs were identified that reflected the relationship of dissociable brain network and general behavioral problems, cognitive and language skills, externalizing problems, and social dysfunction, respectively. The group comparisons exhibited interpretable variations across different diagnostic groups. A warm family environment was found to moderate the brain-behavior relationship of core symptoms in internalizing disorders. However, in neurodevelopmental disorders, family factors were not found to moderate the brain-behavior relationship of core symptoms, but they were found to affect the brain-behavior relationship in other domains.

Conclusions

Our findings leveraged a transdiagnostic analysis to investigate the moderating effects of family factors on brain-behavior associations, emphasizing the different roles that family factors play during this developmental period across distinct diagnostic groups.

背景：众所周知，家庭环境会塑造大脑功能和精神病表型，尤其是在儿童和青少年时期。不断积累的神经影像学证据表明，在不同的精神疾病中，共同的表型可能具有共同的神经基础，这表明大脑与行为之间存在着超越诊断类别的潜在关系。然而，从跨诊断的角度来看，家庭环境对大脑行为关系的影响仍是未知数：方法：我们以社区为基础，对 699 名受试者（5-22 岁）进行了抽样调查，并应用偏最小二乘法回归分析，从全脑功能连接和综合表型测量中确定大脑与行为之间的潜在关系。在诊断组和非诊断组之间进行比较，以帮助解释潜在的大脑行为关系。研究还引入了一个调节模型，以检验家庭因素在估计的大脑行为关联中的潜在调节作用：结果：研究发现了四个重要的潜在大脑行为对，分别反映了可分离大脑网络与一般行为问题、认知和语言技能、外化问题和社会功能障碍之间的关系。小组比较显示了不同诊断小组之间可解释的差异。研究发现，温暖的家庭环境可以缓和内化障碍核心症状的大脑行为关系。然而，在神经发育障碍中，没有发现家庭因素能调节核心症状的大脑行为关系，但发现家庭因素会影响其他领域的大脑行为关系：我们的研究结果利用了跨诊断分析，调查了家庭因素对大脑与行为关系的调节作用，强调了家庭因素在不同诊断群体的发展时期所起的不同作用。

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引用次数: 0

Associations Among Birth Weight, Adrenarche, Brain Morphometry, and Cognitive Function in Preterm Children Ages 9 to 11 Years 9-11 岁早产儿出生体重、肾上腺初潮、大脑形态测量和认知功能之间的关系。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsc.2024.02.012

Background

Preterm infants with low birth weight are at heightened risk of developmental sequelae, including neurological and cognitive dysfunction that can persist into adolescence or adulthood. In addition, preterm birth and low birth weight can provoke changes in endocrine and metabolic processes that likely impact brain health throughout development. However, few studies have examined associations among birth weight, pubertal endocrine processes, and long-term neurological and cognitive development.

Methods

We investigated the associations between birth weight and brain morphometry, cognitive function, and onset of adrenarche assessed 9 to 11 years later in 3571 preterm and full-term children using the ABCD (Adolescent Brain Cognitive Development) Study dataset.

Results

The preterm children showed lower birth weight and early adrenarche, as expected. Birth weight was positively associated with cognitive function (all Cohen’s d > 0.154, p < .005), global brain volumes (all Cohen’s d > 0.170, p < .008), and regional volumes in frontal, temporal, and parietal cortices in preterm and full-term children (all Cohen’s d > 0.170, p < .0007); cortical volume in the lateral orbitofrontal cortex partially mediated the effect of low birth weight on cognitive function in preterm children. In addition, adrenal score and cortical volume in the lateral orbitofrontal cortex mediated the associations between birth weight and cognitive function only in preterm children.

Conclusions

These findings highlight the impact of low birth weight on long-term brain structural and cognitive function development and show important associations with early onset of adrenarche during the puberty. This understanding may help with prevention and treatment.

背景：出生体重过轻的早产儿出现发育后遗症（包括神经和认知功能障碍）的风险较高，这些后遗症可能会持续到青春期或成年期。此外，早产和低出生体重会引起内分泌和新陈代谢过程的变化，从而可能影响整个发育过程中的大脑健康。然而，很少有研究对出生体重、青春期内分泌过程、长期神经和认知发育之间的关系进行研究：方法：我们利用青少年大脑认知发展数据集调查了 3571 名早产儿和足月儿的出生体重与大脑形态测量、认知功能以及 9 至 11 年后评估的肾上腺初潮之间的关系：结果：早产儿的出生体重较低，肾上腺初潮也较早，这是意料之中的。出生体重与早产儿和足月儿的认知功能（所有︱Cohen's d︱>0.154，P <0.005）、整体脑容量（所有︱Cohen's d︱>0.170，P <0.008）以及额叶、颞叶和顶叶皮层的区域容量呈正相关（所有︱Cohen's d︱>0.170，P＜0.0007）；外侧眶额皮层（lOFC）的皮质体积部分介导了低出生体重对早产儿认知功能的影响。此外，肾上腺评分和眶额叶外侧皮质体积只对早产儿出生体重和认知功能之间的关联起中介作用：这些研究结果凸显了低出生体重对大脑结构和认知功能长期发展的影响，并显示出与青春期肾上腺早发育的重要关联。这种认识可能有助于预防和治疗。

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引用次数: 0

Identifying and Using Psychotic-Like Experiences in Clinical Practice and Public Policy 在临床实践和公共政策中识别和使用类似精神病的经历。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsc.2024.07.006

Lorna Staines , John Hoey , Mary Cannon

引用次数: 0

Mindfulness Meditation Training Reduces Gaming Cravings by Reshaping the Functional Connectivity Between the Default Mode Network and Executive Control–Related Brain Regions 正念冥想训练通过重塑默认模式网络和执行控制相关脑区之间的功能连接，减少对游戏的渴望。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.04.011

Background

Internet gaming disorder (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders. In this study, MM was used to intervene in IGD and to explore its neural mechanism.

Methods

Eighty participants were recruited through advertisements. Eventually, 61 completed the 1-month training (MM group, n = 31; progressive muscle relaxation [PMR] group, n = 30), including a pretest, 8 training sessions, and a posttest. Regional homogeneity and degree centrality were calculated, and the tests (pre- and post-) and group (MM and PMR) analysis of variance was performed. The overlapping results were obtained as region of interest for functional connectivity (FC) analyses. Behavioral data and neurotransmitter availability maps were correlated with FC.

Results

Compared with PMR, MM decreased the severity of addiction and game craving in IGD. Brain imaging results showed that the FC between and within the executive control and default mode networks/reward-related regions were enhanced. Significant negative correlations were observed between FC and dopamine receptor D₂, dopamine transporter, and vesicular acetylcholine transporter. Significant positive correlations were observed between FCs and serotonin and aminobutyric acid receptors.

Conclusions

This study confirmed the effectiveness of MM in treating IGD. MM altered the default mode and enhanced top-down control over game cravings. These findings were revealed by the correlations between brain regions and behavioral and biochemical effects. The results show the neural mechanism of MM in reducing IGD and lay the foundation for future research.

背景：网络游戏障碍（IGD）会导致心理问题并引发个人行为问题。传统的干预措施在治疗网络游戏障碍方面效果不佳。与此同时，正念冥想（MM）是一种新兴的方法，已被证明对治疗精神障碍有效。本研究采用正念冥想干预IGD，并探索其神经机制：方法：通过广告招募了 80 名参与者。最终，61人完成了为期一个月的训练（MM/渐进式肌肉放松：31/30），包括一次前测、八次训练和一次后测。计算了区域同质性和度中心性，并进行了测试（测试前和测试后）和分组（MM 和 PMR）方差分析。重叠结果作为功能连接（FC）分析的 ROI。行为数据和神经递质与功能连接相关：结果：与PMR相比，MM能降低IGD的成瘾严重程度和游戏渴求。脑成像结果显示，执行控制和默认模式网络（DMN）/奖励相关区域之间和内部的FC增强了。FC与多巴胺受体D2、多巴胺转运体（DAT）和乙酰胆碱受体VAChT之间呈显著负相关。FC与血清素和氨基丁酸受体之间呈显著正相关：本研究证实了 MM 治疗 IGD 的有效性。MM改变了默认模式，增强了自上而下对游戏渴望的控制。脑区与行为和生化效应之间的相关性揭示了这些发现。这些结果显示了 MM 在减少 IGD 方面的神经机制，为今后的研究奠定了基础。

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引用次数: 0

Direction and Directionality: The Neural Effects of Transcranial Magnetic Stimulation Coil Orientation and Pulse Waveform 方向与指向性：经颅磁刺激线圈方向和脉冲波形的神经效应。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.06.010

Angel V. Peterchev

引用次数: 0

Training in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder 认知重评训练可使边缘型人格障碍患者的全脑情绪调节指数正常化。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.03.007

Background

Borderline personality disorder (BPD) is the prototypical disorder of emotion dysregulation. We have previously shown that patients with BPD are impaired in their capacity to engage cognitive reappraisal, a frequently employed adaptive emotion regulation strategy.

Methods

Here, we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in patients with BPD. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 participants with BPD (14 female) and 22 healthy control participants (13 female) received training in psychological distancing and then completed a widely used picture-based reappraisal task. Self-reported negative affect ratings and functional magnetic resonance imaging data were acquired at the first and fifth sessions. In addition to behavioral analyses, we performed whole-brain pattern expression analyses using independently defined patterns for negative affect and cognitive reappraisal implementation for each session.

Results

Patients with BPD showed a decrease in negative affect pattern expression following reappraisal training, reflecting a normalization in neural activity. However, they did not show significant change in behavioral self-reports.

Conclusions

To our knowledge, this study represents the first longitudinal functional magnetic resonance imaging examination of task-based cognitive reappraisal training. Using a brief, proof-of-concept design, the results suggest a potential role for reappraisal training in the treatment of patients with BPD.

背景边缘型人格障碍（BPD）是典型的情绪调节障碍。方法在此，我们报告了认知重评纵向训练对加强 BPD 患者情绪调节的效果。具体来说，培训以心理疏导为目标，这是一种重新评估策略，通过这种策略，人们可以冷静地看待负面刺激，就像一个客观、公正的观察者所经历的那样。在为期两周的 5 次训练中，22 名患有 BPD 的参与者（14 名女性）和 22 名健康对照组参与者（13 名女性）分别接受了心理疏导训练，然后完成了一项广泛使用的基于图片的再评价任务。在第一和第五次训练中，他们获得了自我报告的负面情绪评分和功能磁共振成像数据。除了行为分析外，我们还使用独立定义的负性情绪模式和认知重评实施模式对每个疗程进行了全脑模式表达分析。结果BPD患者在接受重评训练后，负性情绪模式表达有所减少，反映出神经活动趋于正常。结论据我们所知，这项研究是对基于任务的认知重评训练进行的首次纵向功能磁共振成像检查。通过简短的概念验证设计，研究结果表明重评训练在治疗 BPD 患者方面具有潜在的作用。

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引用次数: 0

Rumination and Overrecruitment of Cognitive Control Circuits in Depression 抑郁症患者的反刍和认知控制回路的过度招募

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.04.013

Background

Rumination is associated with greater cognitive dysfunction and treatment resistance in major depressive disorder (MDD), but its underlying neural mechanisms are not well understood. Because rumination is characterized by difficulty in controlling negative thoughts, the current study investigated whether rumination was associated with aberrant cognitive control in the absence of negative emotional information.

Methods

Individuals with MDD (n = 176) and healthy control individuals (n = 52) completed the stop signal task with varied stop signal difficulty during functional magnetic resonance imaging. In the task, a longer stop signal asynchrony made stopping difficult (hard stop), whereas a shorter stop signal asynchrony allowed more time for stopping (easy stop).

Results

In participants with MDD, higher rumination intensity was associated with greater neural activity in response to difficult inhibitory control in the frontoparietal regions. Greater activation for difficult inhibitory control associated with rumination was also positively related to state fear. The imaging results provide compelling evidence for the neural basis of inhibitory control difficulties in individuals with MDD with high rumination.

Conclusions

The association between higher rumination intensity and greater neural activity in regions involved in difficult inhibitory control tasks may provide treatment targets for interventions aimed at improving inhibitory control and reducing rumination in this population.

背景：反刍与重度抑郁障碍（MDD）患者的认知功能障碍和治疗抵抗有关，但其潜在的神经机制尚不十分清楚。由于反刍的特点是难以控制消极想法，本研究调查了反刍是否与没有消极情绪信息时的异常认知控制有关：方法：患有 MDD 的患者（人数=176）和健康志愿者（人数=52）在功能磁共振成像中完成不同停止信号难度的停止信号任务。在该任务中，较长的停止信号不同步会使停止变得困难（硬停止），而较短的停止信号不同步会使停止有更多的时间（易停止）：在 MDD 参与者中，反刍强度越高，前顶叶区域对困难抑制控制的神经活动越多。与反刍相关的高难度抑制控制激活也与状态恐惧呈正相关。成像结果提供了令人信服的证据，证明了反刍强度高的 MDD 患者抑制控制困难的神经基础：结论：反刍强度越高，参与困难抑制控制任务的区域的神经活动越强，这两者之间的关联可能会为旨在改善该人群抑制控制和减少反刍的干预措施提供治疗目标。

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引用次数: 0

Guide for Authors 作者指南

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/S2451-9022(24)00180-0

引用次数: 0

Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders 情感障碍和精神障碍中的功能连接动态变化

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.02.013

Background

Patients with psychosis and patients with depression exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC) allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders.

Methods

We report the analysis of dFC in a large sample including 127 patients at clinical high risk for psychosis, 142 patients with recent-onset psychosis, 134 patients with recent-onset depression, and 256 healthy control participants. A sliding window–based technique was used to calculate the time-dependent FC in resting-state magnetic resonance imaging data, followed by clustering to reveal recurrent FC states in each diagnostic group.

Results

We identified 5 unique FC states, which could be identified in all groups with high consistency (mean r = 0.889 [SD = 0.116]). Analysis of dynamic parameters of these states showed a characteristic increase in the lifetime and frequency of a weakly connected FC state in patients with recent-onset depression (p < .0005) compared with the other groups and a common increase in the lifetime of an FC state characterized by high sensorimotor and cingulo-opercular connectivities in all patient groups compared with the healthy control group (p < .0002). Canonical correlation analysis revealed a mode that exhibited significant correlations between dFC parameters and clinical variables (r = 0.617, p < .0029), which was associated with positive psychosis symptom severity and several dFC parameters.

Conclusions

Our findings indicate diagnosis-specific alterations of dFC and underline the potential of dynamic analysis to characterize disorders such as depression and psychosis and clinical risk states.

背景：精神病和抑郁症患者表现出广泛的神经生物学异常。通过分析动态功能连接（dFC），可以检测复杂大脑活动模式的变化，从而深入了解这些疾病的共同和独特过程：在本研究中，我们报告了对127名临床高危患者（CHR）、142名新近发病的精神病患者（ROP）、134名新近发病的抑郁症患者（ROD）和256名健康对照者（HC）等大样本患者的动态功能连通性分析。我们采用基于滑动窗口的技术计算静息态磁共振成像数据中随时间变化的FC，然后进行聚类以揭示每个诊断组中反复出现的FC状态：结果：我们发现了五种独特的 FC 状态，这些状态在所有组别中都能被识别，且一致性很高（rmean = 0.889，sd = 0.116）。对这些状态的动态参数分析表明，与大多数其他组别相比，ROD 患者弱连接 FC 状态的持续时间和频率增加（p < 0.0005），与 HC 组相比，所有患者组别中以高感觉运动和丘脑-小脑连接为特征的 FC 状态的持续时间普遍增加（p < 0.0002）。典型相关性分析表明，dFC参数与临床变量之间存在显著相关性（r = 0.617，p < 0.0029），该模式与阳性精神病症状严重程度和多个dFC参数相关：我们的研究结果表明，dFC的改变与诊断有关，并强调了动态分析在描述抑郁症、精神病和临床风险状态等疾病特征方面的潜力。

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引用次数: 0

Emotion-Induced Frontal Alpha Asymmetry as a Candidate Predictor of Relapse After Discontinuation of Antidepressant Medication 情绪诱导的额叶α不对称是预测停用抗抑郁药物后复发的候选指标。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-08-01 DOI: 10.1016/j.bpsc.2024.05.001

Background

One in 3 patients relapse after antidepressant discontinuation. Thus, the prevention of relapse after achieving remission is an important component in the long-term management of major depressive disorder. However, no clinical or other predictors are established. Frontal reactivity to sad mood as measured by functional magnetic resonance imaging has been reported to relate to relapse independently of antidepressant discontinuation and is an interesting candidate predictor.

Methods

Patients (n = 56) who had remitted from a depressive episode while taking antidepressants underwent electroencephalography (EEG) recording during a sad mood induction procedure prior to gradually discontinuing their medication. Relapse was assessed over a 6-month follow-up period. Thirty five healthy control participants were also tested. Current source density of the EEG power in the alpha band (8–13 Hz) was extracted and alpha asymmetry was computed by comparing the power across 2 hemispheres at frontal electrodes (F5 and F6).

Results

Sad mood induction was robust across all groups. Reactivity of alpha asymmetry to sad mood did not distinguish healthy control participants from patients with remitted major depressive disorder on medication. However, the 14 (25%) patients who relapsed during the follow-up period after discontinuing medication showed significantly reduced reactivity in alpha asymmetry compared with patients who remained well. This EEG signal provided predictive power (69% out-of-sample balanced accuracy and a positive predictive value of 0.75).

Conclusions

A simple EEG-based measure of emotional reactivity may have potential to contribute to clinical prediction models of antidepressant discontinuation. Given the very small sample size, this finding must be interpreted with caution and requires replication in a larger study.

背景：三分之一的患者在停用抗抑郁药后会复发。因此，在获得缓解后防止复发是重度抑郁障碍（MDD）长期治疗的重要组成部分。然而，目前尚无临床或其他预测因素。有报道称，fMRI测量的额叶对悲伤情绪的反应与复发有关，与停用抗抑郁药无关，是一个有趣的候选预测指标：方法：服用抗抑郁药期间抑郁发作缓解的患者（n=56）在逐渐停药前接受了悲伤情绪诱导过程中的脑电图记录。在六个月的随访期间对复发情况进行了评估。同时还对 35 名健康对照者进行了测试。提取了α波段（8-13Hz）脑电图功率的电流源密度，并通过比较额部电极（F5和F6）两个半球的功率来计算α不对称：所有组的悲伤情绪诱导都很强烈。α-不对称性对悲伤情绪的反应性并未将健康对照组与药物治疗的缓解型 MDD 患者区分开来。然而，在停药后的随访期间，14 名（25%）复发患者的 α-不对称性反应性明显低于仍然良好的患者。该脑电图信号具有预测能力（样本外平衡准确率为 69%，阳性预测值为 0.75）：基于脑电图的简单情绪反应测量方法可能有助于建立抗抑郁药停药的临床预测模型。鉴于样本量非常小，必须谨慎解释这一发现，并需要在更大范围的研究中进行复制。

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引用次数: 0