Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献_第4页

New Approaches to Eye-Tracking Analysis in Autism Research 自闭症研究中眼动追踪分析的新方法。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2025-01-01 DOI: 10.1016/j.bpsc.2024.11.009

Terje Falck-Ytter

引用次数: 0

Navigating Exploitative Traps: Unveiling the Uncontrollable Reward Seeking of Individuals With Internet Gaming Disorder 探索剥削陷阱：揭开网络游戏障碍者无法控制的奖励追求。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2025-01-01 DOI: 10.1016/j.bpsc.2024.05.005

Lin Zuo , Kedan Ai , Weili Liu , Bensheng Qiu , Rui Tang , Jiaxin Fu , Ping Yang , Zhuo Kong , Hongwen Song , Xiaoyu Zhu , Xiaochu Zhang

Background

Internet gaming disorder (IGD) involves an imbalance in the brain’s dual system, characterized by heightened reward seeking and diminished cognitive control, which lead to decision-making challenges. The exploration-exploitation strategy is key to decision making, but how IGD affects this process is unclear.

Methods

To investigate the impact of IGD on decision making, a modified version of the 2-armed bandit task was employed. Participants included 41 individuals with IGD and 44 healthy control individuals. The study assessed the strategies used by participants in the task, particularly focusing on the exploitation-exploration strategy. Additionally, functional magnetic resonance imaging was used to examine brain activation patterns during decision-making and estimation phases.

Results

The study found that individuals with IGD demonstrated greater reliance on exploitative strategies in decision making due to their elevated value-seeking tendencies and decreased cognitive control. Individuals with IGD also displayed heightened activation in the presupplementary motor area and the ventral striatum compared with the healthy control group in both decision-making and estimation phases. Meanwhile, the prefrontal cortex showed more inhibition in individuals with IGD than in the healthy control group during exploitative strategies. This inhibition decreased as cognitive control diminished.

Conclusions

The imbalance in the development of the dual system in individuals with IGD may lead to an overreliance on exploitative strategies. This imbalance, marked by increased reward seeking and reduced cognitive control, contributes to difficulties in decision making and value-related behavioral processes in individuals with IGD.

背景：网络游戏障碍（IGD）涉及大脑双系统的失衡，其特点是追求奖励的欲望增强，而认知控制能力减弱，从而导致决策难题。探索-开发策略是决策的关键，但 IGD 如何影响这一过程尚不清楚：为了研究 IGD 对决策的影响，我们采用了一种改进版的双臂强盗任务。参与者包括 41 名 IGD 患者和 44 名健康对照组 (HC) 患者。研究对参与者在任务中使用的策略进行了评估，尤其侧重于开发-探索策略。此外，研究还使用功能磁共振成像（fMRI）检查了决策和估计阶段的大脑激活模式：研究发现，IGD 患者在决策过程中更依赖于探索策略，这是因为他们的价值追求倾向增强，认知控制能力下降。与 HC 组相比，IGD 患者在决策和估计阶段的前辅助运动区（pre-SMA）和腹侧纹状体（VS）的激活程度也有所提高。同时，在利用策略阶段，IGD 患者的前额叶皮层（PFC）比 HC 组表现出更多的抑制。这种抑制作用会随着认知控制能力的减弱而减弱：研究得出结论，IGD 患者双系统发展的不平衡可能会导致他们过度依赖剥削策略。这种失衡的特点是追求回报的行为增多，而认知控制能力下降，从而导致 IGD 患者在决策和与价值相关的行为过程中遇到困难。

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引用次数: 0

A Reproducible Pipeline for Parcellation of the Anterior Limb of the Internal Capsule 内囊前缘切口的可重复管道。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.07.008

Karianne Sretavan , Henry Braun , Zoe Liu , Daniel Bullock , Tara Palnitkar , Remi Patriat , Jayashree Chandrasekaran , Samuel Brenny , Matthew D. Johnson , Alik S. Widge , Noam Harel , Sarah R. Heilbronner

Background

The anterior limb of the internal capsule (ALIC) is a white matter structure that connects the prefrontal cortex (PFC) to the brainstem, thalamus, and subthalamic nucleus. It is a target for deep brain stimulation for obsessive-compulsive disorder. There is strong interest in improving deep brain stimulation targeting by using diffusion tractography to reconstruct and target specific ALIC fiber pathways, but this methodology is susceptible to errors and lacks validation. To address these limitations, we developed a novel diffusion tractography pipeline that generates reliable and biologically validated ALIC white matter reconstructions.

Methods

Following algorithm development and refinement, we analyzed 43 control participants, each with 2 sets of 3T magnetic resonance imaging data and a subset of 5 control participants with 7T data from the Human Connectome Project. We generated 22 segmented ALIC fiber bundles (11 per hemisphere) based on PFC regions of interest, and we analyzed the relationships among bundles.

Results

We successfully reproduced the topographies established by previous anatomical work using images acquired at both 3T and 7T. Quantitative assessment demonstrated significantly smaller intraparticipant variability than interparticipant variability for both test and retest groups across all but one PFC region. We examined the overlap between fibers from different PFC regions and a response tract for obsessive-compulsive disorder deep brain stimulation, and we reconstructed the PFC hyperdirect pathway using a modified version of our pipeline.

Conclusions

Our diffusion magnetic resonance imaging algorithm reliably generates biologically validated ALIC white matter reconstructions, thereby allowing for more precise modeling of fibers for neuromodulation therapies.

背景：内囊前肢（ALIC）是连接前额叶皮质（PFC）与脑干、丘脑和丘脑下核的白质结构。它是治疗强迫症的脑深部刺激（DBS）靶点。人们对通过使用弥散束成像技术重建和定位特定的 ALIC 纤维通路来改善 DBS 定位有浓厚的兴趣，但这种方法容易出错，而且缺乏验证。为了解决这些局限性，我们开发了一种新型扩散束成像管道，可生成可靠且经过生物学验证的 ALIC 白质重建：在算法开发和改进之后，我们分析了 43 名对照组受试者的 2 组 3T MRI 数据，以及 5 名对照组受试者的子集，这些数据来自人类连接组计划的 7T 数据。我们根据感兴趣的前额叶 PFC 区域生成了 22 个分段 ALIC 纤维束（每个半球 11 个），并分析了纤维束之间的关系：结果：我们利用 3T 和 7T 获取的图像，成功地再现了先前解剖学工作所建立的拓扑图。定量评估结果表明，除一个前脑功能区外，测试组和复测组的受试者内变异性明显小于受试者间变异性。我们检查了来自不同 PFC 区域的纤维与强迫症深部脑刺激反应束之间的重叠情况，并使用我们管道的改进版本重建了 PFC 超直达通路：我们的 dMRI 算法能可靠地生成经过生物学验证的 ALIC 白质重建，从而为神经调控疗法提供更精确的纤维建模。

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引用次数: 0

Editorial Board Page

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/S2451-9022(24)00318-5

引用次数: 0

Efficacy of Deep Brain Stimulation for Treatment-Resistant Depression: Systematic Review and Meta-Analysis 脑深部刺激治疗耐药性抑郁症的疗效：系统回顾和荟萃分析。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.08.013

Sandesh Reddy , Katherine E. Kabotyanski , Samad Hirani , Tommy Liu , Zain Naqvi , Nisha Giridharan , Mohammed Hasen , Nicole R. Provenza , Garrett P. Banks , Sanjay J. Mathew , Wayne K. Goodman , Sameer A. Sheth

Background

Treatment-resistant depression affects about 30% of individuals with major depressive disorder. Deep brain stimulation is an investigational intervention for treatment-resistant depression with varied results. We undertook this meta-analysis to synthesize outcome data across trial designs, anatomical targets, and institutions to better establish efficacy and side-effect profiles.

Methods

We conducted a systematic PubMed review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven randomized controlled trials (n = 198) and 8 open-label trials (n = 77) were included spanning 2009 to 2020. Outcome measures included Hamilton Depression Rating Scale or Montgomery–Åsberg Depression Rating Scale scores, as well as response and remission rates over time. Outcomes were tracked at the last follow-up and quantified as a time course using model-based network meta-analysis. Linear mixed models were fit to individual patient data to identify covariates.

Results

Deep brain stimulation achieved 47% improvement in long-term depression scale scores, with an estimated time to reach 50% improvement of around 23 months. There were no significant subgroup effects of stimulation target, time of last follow-up, sex, age of disease onset, or duration of disease, but open-label trials showed significantly greater treatment effects than randomized controlled trials. Long-term (12–60 month) response and remission rates were 48% and 35%, respectively. The time course of improvement with active stimulation could not be adequately distinguished from that with sham stimulation, when available.

Conclusions

Deep brain stimulation produces significant chronic improvement in symptoms of treatment-resistant depression. However, the limited sham-controlled data do not demonstrate significant improvement over placebo. Future advancements in stimulation optimization and careful blinding and placebo schemes are important next steps for this therapy.

背景：约有 30% 的重度抑郁症患者会出现治疗耐受性抑郁症（TRD）。脑深部刺激（DBS）是一种针对TRD的研究性干预措施，其结果各不相同。我们进行了这项荟萃分析，以综合不同试验设计、解剖靶点和机构的结果数据，从而更好地确定疗效和副作用情况：我们按照 PRISMA 指南在 PubMed 上进行了系统性综述。共纳入 7 项随机对照试验（n=198）和 8 项开放标签试验（n=77），时间跨度为 2009-2020 年。结果测量包括汉密尔顿抑郁量表或蒙哥马利-奥斯伯格抑郁量表评分，以及随时间变化的反应率和缓解率。在最后一次随访时对结果进行跟踪，并使用基于模型的网络荟萃分析将结果量化为一个时间过程。线性混合模型适用于单个患者数据，以确定协变量：结果：DBS使长期抑郁量表评分提高了47%，估计达到50%的提高需要23个月左右。刺激目标、最后一次随访时间、性别、发病年龄或病程没有明显的亚组效应，但开放标签试验的治疗效果明显高于随机对照试验。长期（12-60 个月）反应率和缓解率分别为 48% 和 35%。在有假性刺激的情况下，活性刺激与假性刺激的改善时间过程无法充分区分：结论：DBS能显著改善TRD的慢性症状。结论：DBS 对 TRD 症状有明显的慢性改善作用，但有限的假性对照数据并未显示出与安慰剂相比有明显改善。未来在刺激优化、仔细盲法和安慰剂方案方面取得进展是该疗法下一步的重要工作。

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引用次数: 0

Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness 阿尔法调节功能失调是严重精神疾病患者工作记忆受损的机制之一。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.07.022

Molly A. Erickson , Megan A. Boudewyn , Kurt Winsler , Charlotte Li , Deanna M. Barch , Cameron S. Carter , Michael J. Frank , James M. Gold , Angus W. MacDonald III , John D. Ragland , Steven M. Silverstein , Andrew Yonelinas , Steven J. Luck

Background

People with psychosis and mood disorders experience disruptions in working memory; however, the underlying mechanism remains unknown. We focused on 2 potential mechanisms: poor attentional engagement should be associated with elevated levels of prestimulus alpha-band activity within the electroencephalogram (EEG), whereas impaired working memory encoding should be associated with reduced poststimulus alpha suppression.

Methods

We collected EEG data from 68 people with schizophrenia, 43 people with bipolar disorder with a history of psychosis, 53 people with major depressive disorder, and 90 healthy comparison subjects while they completed a spatial working memory task. We quantified attention lapsing, memory precision, and memory capacity from the behavioral responses, and we quantified alpha using traditional wavelet analysis as well as a novel approach for isolating oscillatory alpha power from aperiodic elements of the EEG signal.

Results

We found that 1) greater prestimulus alpha power estimated using traditional wavelet analysis predicted behavioral errors; 2) poststimulus alpha suppression was reduced in the patient groups; and 3) reduced suppression was associated with a lower likelihood of memory storage. However, we also observed that the prestimulus alpha was larger among healthy control participants than patients, and single-trial analyses showed that it was the aperiodic elements of the prestimulus EEG—not oscillatory alpha—that predicted behavioral errors.

Discussion

These results suggest that working memory impairments in serious mental illness primarily reflect an impairment in the poststimulus encoding processes rather than reduced attentional engagement prior to stimulus onset.

背景：精神病和情绪障碍患者的工作记忆会受到干扰，但其潜在机制仍不清楚。我们重点研究了两种潜在机制：首先，注意力不集中应与脑电图中刺激前阿尔法波段活动水平升高有关，而工作记忆编码受损应与刺激后阿尔法抑制减少有关：我们收集了 68 名精神分裂症患者、43 名有精神病史的双相情感障碍患者、53 名重度抑郁症患者以及 90 名健康对比受试者（HCS）在完成空间工作记忆任务时的脑电图数据。我们从行为反应中量化了注意力缺失、记忆精确度和记忆容量，并使用传统的小波分析和一种从脑电信号非周期性元素中分离出振荡α功率的新方法量化了α：我们发现：(1) 使用传统小波分析法估测的刺激前 alpha 功率越大，预测行为错误越大；(2) 患者组中刺激后 alpha 抑制减少；(3) 抑制减少与记忆存储可能性降低有关。然而，我们还观察到，与患者相比，刺激前α在高危人群中更大，单次试验分析表明，预测行为错误的是刺激前脑电的非周期性元素，而不是振荡α：这些结果表明，重性精神病患者的工作记忆障碍主要反映了刺激后编码过程的障碍，而不是刺激开始前注意参与的减少。

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引用次数: 0

Torture Exposure Modulates Cognitive Control and Attention Neural Network Connectivity During a Go/NoGo Task 酷刑暴露会调节 "走/停 "任务中的认知控制和注意力神经网络连接性

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.07.025

Belinda J. Liddell , Pritha Das , Gin S. Malhi , Kim L. Felmingham , Mirjana Askovic , Angela Nickerson , Jorge Aroche , Mariano Coello , Tim Outhred , Richard A. Bryant

Background

Torture trauma is characterized by intentional uncontrollable acts, but the long-term effects of torture exposure on cognitive control brain mechanisms are unknown.

Methods

A final sample of 33 torture survivors (TSs) and 44 non-TSs, all with a refugee background, completed a Go/NoGo response inhibition task during functional magnetic resonance imaging scanning. Data-driven independent component analysis identified active networks across the task and on Go, NoGo, and error of commission trials. Groups were compared on within-/between-network connectivity while controlling for demographic and psychological symptom covariates. Secondary analyses investigated whether network connectivity moderated the associations between torture exposure and severity on fear (e.g., re-experiencing) and dysphoria (e.g., anhedonia) posttraumatic stress disorder symptoms.

Results

The TS group exhibited decreased connectivity (compared with the non-TS control group) within the posterior default mode network (specifically the left precuneus) and auditory-motor network (specifically the right superior temporal gyrus) and reduced connectivity between the dorsomedial frontal network and dorsal attention network across the Go/NoGo task. The TS group also showed more negative ventral attention network connectivity during NoGo (i.e., inhibition) trials. No behavioral effects were observed. Secondary analyses revealed that the association between torture exposure and elevated posttraumatic stress dysphoria (not fear) symptoms was moderated by reduced connectivity in the right superior temporal gyrus and between the dorsomedial frontal network and the dorsal attention network.

Conclusions

Response inhibition, attention, and motor networks appear to be less connected in TSs, which may be specifically linked to a posttraumatic stress dysphoria symptom profile. The findings suggest that targeting cognitive control processes may hold promise for alleviating posttraumatic symptoms among survivors of torture.

背景：酷刑创伤的特点是故意做出无法控制的行为，但酷刑对大脑认知控制机制的长期影响尚不清楚：33名酷刑幸存者（TS）和44名非酷刑幸存者（NTS）（均有难民背景）在fMRI扫描过程中完成了Go/NoGo反应抑制任务。数据驱动的独立成分分析确定了整个任务以及围棋、NoGo 和委托错误试验中的活跃网络。在控制人口统计学和心理症状协变量的情况下，比较了各组内部/之间的网络连通性。二次分析研究了网络连通性是否调节了酷刑暴露和严重程度对创伤后应激障碍（PTSD）症状的恐惧（如再体验）和失调（如失乐症）之间的关联：与NTS对照组相比，TS组在后部默认模式网络（特别是左侧楔前回）和听觉-运动网络（特别是右侧颞上回）中的连接性降低，在Go/NoGo任务中背内侧额叶网络（dmFN）和背侧注意力网络（dAN）之间的连接性降低。在NoGo（即抑制）试验中，TS组还表现出更多的腹侧负注意网络连接。没有观察到行为效应。辅助分析表明，酷刑暴露与创伤后应激障碍焦虑症（而非恐惧）症状升高之间的关联因右侧STG和dmFN-dAN之间的连接性降低而有所缓和：结论：酷刑幸存者的反应抑制、注意力和运动网络连接较少，这可能与创伤后应激障碍的焦虑症状特征有特定联系。研究结果表明，以认知控制过程为目标可能有望缓解酷刑幸存者的创伤后症状。

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引用次数: 0

Neurocomputational Mechanisms Underlying Differential Reinforcement Learning From Wins and Losses in Obesity With and Without Binge Eating 肥胖症患者在暴饮暴食和不暴饮暴食时从输赢中进行不同强化学习的神经计算机制。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.06.002

Maria Waltmann , Nadine Herzog , Andrea M.F. Reiter , Arno Villringer , Annette Horstmann , Lorenz Deserno

Background

Binge-eating disorder (BED) is thought of as a disorder of cognitive control, but evidence regarding its neurocognitive mechanisms is inconclusive. Key limitations of previous research include a lack of consistent separation between effects of BED and obesity and a disregard for self-report evidence suggesting that neurocognitive alterations may emerge primarily in loss- or harm-avoidance contexts.

Methods

To address these gaps, in this longitudinal study we investigated behavioral flexibility and its underlying neurocomputational processes in reward-seeking and loss-avoidance contexts. Obese participants with BED, obese participants without BED, and healthy normal-weight participants (n = 96) performed a probabilistic reversal learning task during functional imaging, with different blocks focused on obtaining wins or avoiding losses. They were reinvited for a 6-month follow-up assessment.

Results

Analyses informed by computational models of reinforcement learning showed that unlike obese participants with BED, obese participants without BED performed worse in the win than in the loss condition. Computationally, this was explained by differential learning sensitivities in the win versus loss conditions in the groups. In the brain, this was echoed in differential neural learning signals in the ventromedial prefrontal cortex per condition. The differences were subtle but scaled with BED symptoms, such that more severe BED symptoms were associated with increasing bias toward improved learning from wins versus losses. Across conditions, obese participants with BED switched more between choice options than healthy normal-weight participants. This was reflected in diminished representation of choice certainty in the ventromedial prefrontal cortex.

Conclusions

Our study highlights the importance of distinguishing between obesity with and without BED to identify unique neurocomputational alterations underlying different styles of maladaptive eating behavior.

背景：暴饮暴食症（BED）被认为是一种认知控制障碍，但有关其神经认知机制的证据尚无定论。以往研究的主要局限性在于，BED的影响与肥胖之间缺乏一致的区分，而且忽视了自我报告的证据，这些证据表明，神经认知的改变可能主要出现在避免损失或伤害的情况下：为了弥补这些不足，这项纵向研究调查了行为灵活性及其在寻求奖赏和避免损失情境下的潜在神经计算过程。有肥胖症的参与者（BED）、无肥胖症的参与者（OB）和体重正常的健康参与者（NW）（总人数=96）在功能成像过程中执行了一项概率反转学习任务，不同的区块侧重于获得胜利或避免损失。他们被再次邀请进行为期6个月的随访：结果：根据强化学习计算模型进行的分析表明，与 BED 不同，OB 在获胜条件下的表现比失败条件下差。从计算角度看，这是因为不同组别在获胜与失败条件下的学习敏感性不同。在大脑中，每种条件下腹外侧前额叶皮层（vmPFC）的不同神经学习信号也反映了这一点。这种差异是微妙的，但会随着 BED 症状的变化而变化。在所有条件下，OB 比 NW 更多地在选择选项之间切换。这反映在大脑前部皮质中枢（vmPFC）对选择确定性的表征减弱：我们的研究强调了区分肥胖症伴有和不伴有BED的重要性，以确定不同风格的适应不良饮食行为背后独特的神经计算改变。

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引用次数: 0

Working Memory Training Is Good for Your World View and for Your Cortical Connectivity, Too 工作记忆训练对你的世界观和大脑皮层连通性也有好处。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.10.005

Philip D. Harvey

引用次数: 0

Change in Resting-State Functional Connectivity Following Working Memory Training in Individuals With Repetitive Negative Thinking 重复负面思维患者接受工作记忆训练后静息状态功能连接的变化。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-12-01 DOI: 10.1016/j.bpsc.2024.04.017

Jessica Bomyea , Shirley Feng , Raeanne C. Moore , Alan N. Simmons , Michael L. Thomas

Background

Repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts, are common in individuals with mood, anxiety, and traumatic stress disorders. Inability to regulate the contents of working memory is a hypothesized etiological factor in RNT, which suggests that training to improve working memory may be beneficial. This study examined the effects of working memory training on resting-state functional connectivity (rsFC) in individuals with elevated RNT and whether such changes would be associated with clinical improvement.

Methods

We conducted a secondary analysis of pre-post resting-state data collected as part of a randomized controlled trial (NCT04912089) of working memory training interventions (n = 42) compared with a waitlist control group (n = 23). We hypothesized that individuals who completed training would show increased rsFC between the 2 key intrinsic connectivity networks—the default mode network (posterior cingulate cortex) and the frontoparietal network (dorsolateral prefrontal cortex). We explored whether the magnitude of rsFC change was associated with change in RNT symptom severity.

Results

rsFC increased between the posterior cingulate cortex and regions including the frontal and parietal cortex in the training group compared with the waitlist group. Increased connectivity between the posterior cingulate cortex and superior frontal cortex was associated with RNT symptom reduction.

Conclusions

These data provide evidence that working memory training can modulate neural circuitry at rest in individuals with RNT. Results are consistent with accounts of working memory training effects on large-scale neurocircuitry changes and suggest that these changes may contribute to clinical promise of this type of intervention on transdiagnostic RNT symptoms.

背景：重复性消极思维（RNT）症状以普遍存在、无法控制的消极想法为特征，常见于情绪、焦虑和创伤应激障碍患者。无法调节工作记忆的内容是 RNT 的一个假设病因，这表明改善工作记忆的训练可能是有益的。本研究探讨了工作记忆训练对 RNT 升高患者静息状态功能连接（rsFC）的影响，以及这种变化是否与临床改善相关：我们对作为工作记忆训练干预随机对照试验[NCT04912089]一部分所收集的静息状态前数据（42 人）与等待对照组（23 人）进行了二次分析。我们假设，完成训练的个体将在两个关键的内在连接网络--默认模式网络（后扣带回皮层；PCC）和顶额叶网络（背外侧前额叶皮层；dlPFC）之间显示出更高的rsFC。我们探讨了 rsFC 的变化幅度是否与 RNT 症状严重程度的变化有关。结果：与候补表相比，训练组 PCC 与包括额叶和顶叶皮层在内的区域之间的 rsFC 增加了。PCC与上额叶皮层之间连接的增加与RNT症状的减轻有关：这些数据证明，工作记忆训练可以调节RNT患者静息状态下的神经回路。这些结果与工作记忆训练对大规模神经回路变化产生影响的说法一致，并表明这些变化可能有助于实现此类干预对跨诊断 RNT 症状的临床前景。

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引用次数: 0