Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(24)00361-6","DOIUrl":"10.1016/S2451-9022(24)00361-6","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Losing Control: Prefrontal Emotion Regulation Is Related to Symptom Severity and Predicts Treatment-Related Symptom Change in Adolescent Girls With Conduct Disorder","authors":"Nora Maria Raschle ,&nbsp;Réka Borbás ,&nbsp;Plamina Dimanova ,&nbsp;Eva Unternaehrer ,&nbsp;Gregor Kohls ,&nbsp;Stephane De Brito ,&nbsp;Graeme Fairchild ,&nbsp;Christine M. Freitag ,&nbsp;Kerstin Konrad ,&nbsp;Christina Stadler","doi":"10.1016/j.bpsc.2024.08.005","DOIUrl":"10.1016/j.bpsc.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Emotion regulation skills are linked to corticolimbic brain activity (e.g., dorsolateral prefrontal cortex [dlPFC] and limbic regions) and enable an individual to control their emotional experiences, thus allowing healthy social functioning. Disruptions in emotion regulation skills are reported in neuropsychiatric disorders, including conduct disorder or oppositional defiant disorder (CD/ODD). Clinically recognized means to ameliorate emotion regulation deficits observed in CD/ODD include cognitive or dialectical behavioral skills therapy as implemented in the START NOW program. However, the role of emotion regulation and its neural substrates in symptom severity and prognosis following treatment of adolescent CD/ODD has not been investigated.</div></div><div><h3>Methods</h3><div>Cross-sectional data including functional magnetic resonance imaging responses during emotion regulation (<em>N</em> = 114; average age = 15 years), repeated-measures assessments of symptom severity (pretreatment, posttreatment, long-term follow-up), and functional magnetic resonance imaging data collected prior to and following the START NOW randomized controlled trial (<em>n</em> = 44) for female adolescents with CD/ODD were analyzed using group comparisons and multiple regression.</div></div><div><h3>Results</h3><div>First, behavioral and neural correlates of emotion regulation were disrupted in female adolescents with CD/ODD. Second, ODD symptom severity was negatively associated with dlPFC/precentral gyrus activity during regulation. Third, treatment-related symptom changes were predicted by pretreatment ODD symptom severity and regulatory dlPFC/precentral activity. Additionally, pretreatment dlPFC/precentral activity and ODD symptom severity predicted long-term reductions in symptom severity following treatment for participants who received the START NOW treatment.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate the important role that emotion regulation skills play in the characteristics of CD/ODD and show that regulatory dlPFC/precentral activity is positively associated with treatment response in female adolescents with CD/ODD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 80-93"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Activation and Aberrant Effective Connectivity in the Mentalizing Network of Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder","authors":"Lotte Veddum ,&nbsp;Vibeke Bliksted ,&nbsp;Yuan Zhou ,&nbsp;Anna Krogh Andreassen ,&nbsp;Christina Bruun Knudsen ,&nbsp;Aja Neergaard Greve ,&nbsp;Nanna Lawaetz Steffensen ,&nbsp;Merete Birk ,&nbsp;Nicoline Hemager ,&nbsp;Julie Marie Brandt ,&nbsp;Maja Gregersen ,&nbsp;Line Korsgaard Johnsen ,&nbsp;Kit Melissa Larsen ,&nbsp;William Frans Christiaan Baaré ,&nbsp;Kathrine Skak Madsen ,&nbsp;Hartwig Roman Siebner ,&nbsp;Kerstin Jessica Plessen ,&nbsp;Anne Amalie Elgaard Thorup ,&nbsp;Leif Østergaard ,&nbsp;Merete Nordentoft ,&nbsp;Martin Dietz","doi":"10.1016/j.bpsc.2024.08.004","DOIUrl":"10.1016/j.bpsc.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia and bipolar disorder are characterized by social cognitive impairments, and recent research has identified alterations of the social brain. However, it is unknown whether familial high risk (FHR) of these disorders is associated with neurobiological alterations already present in childhood.</div></div><div><h3>Methods</h3><div>As part of the Danish High Risk and Resilience Study–VIA 11, we examined children at FHR of schizophrenia (<em>n</em> = 121, 50% female) or bipolar disorder (<em>n</em> = 75, 47% female) and population-based control children (PBCs) (<em>n</em> = 128, 48% female). Using functional magnetic resonance imaging and dynamic causal modeling, we investigated brain activation and effective connectivity during the social cognition paradigm from the Human Connectome Project.</div></div><div><h3>Results</h3><div>We found similar activation of the mentalizing network across groups, including visual area V5, the dorsomedial prefrontal cortex, and the posterior superior temporal sulcus (pSTS). Nonetheless, both FHR groups showed aberrant brain connectivity in the form of increased feedforward connectivity from left V5 to pSTS compared with PBCs. Children at FHR of schizophrenia had reduced intrinsic connectivity in bilateral V5 compared with PBCs, whereas children at FHR of bipolar disorder showed increased reciprocal connectivity between the left dorsomedial prefrontal cortex and the pSTS, increased intrinsic connectivity in the right pSTS, and reduced feedforward connectivity from the right pSTS to the dorsomedial prefrontal cortex compared with PBCs.</div></div><div><h3>Conclusions</h3><div>Our results provide first-time evidence of aberrant brain connectivity in the mentalizing network of children at FHR of schizophrenia or FHR of bipolar disorder. Longitudinal research is warranted to clarify whether aberrant brain connectivity during mentalizing constitutes an endophenotype associated with the development of a mental disorder later in life.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 68-79"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression","authors":"Helmet T. Karim ,&nbsp;Andrew Gerlach ,&nbsp;Meryl A. Butters ,&nbsp;Robert Krafty ,&nbsp;Brian D. Boyd ,&nbsp;Layla Banihashemi ,&nbsp;Bennett A. Landman ,&nbsp;Olusola Ajilore ,&nbsp;Warren D. Taylor ,&nbsp;Carmen Andreescu","doi":"10.1016/j.bpsc.2024.09.009","DOIUrl":"10.1016/j.bpsc.2024.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression (LLD) has been associated cross-sectionally with lower brain structural volumes and accelerated brain aging compared with healthy control participants (HCs). There are few longitudinal studies on the neurobiological predictors of recurrence in LLD. We tested a machine learning brain age model and its prospective association with LLD recurrence risk.</div></div><div><h3>Methods</h3><div>We recruited individuals with LLD (<em>n</em> = 102) and HCs (<em>n</em> = 43) into a multisite, 2-year longitudinal study. Individuals with LLD were enrolled within 4 months of remission. Remitted participants with LLD underwent baseline neuroimaging and longitudinal clinical follow-up. Over 2 years, 43 participants with LLD relapsed and 59 stayed in remission. We used a previously developed machine learning brain age algorithm to compute brain age at baseline, and we evaluated brain age group differences (HC vs. LLD and HC vs. remitted LLD vs. relapsed LLD). We conducted a Cox proportional hazards model to evaluate whether baseline brain age predicted time to relapse.</div></div><div><h3>Results</h3><div>We found that brain age did not significantly differ between the HC and LLD groups or between the HC, remitted LLD, and relapsed LLD groups. Brain age did not significantly predict time to relapse.</div></div><div><h3>Conclusions</h3><div>In contrast to our hypothesis, we found that brain age did not differ between control participants without depression and individuals with remitted LLD, and brain age was not associated with subsequent recurrence. This is in contrast to existing literature which has identified baseline brain age differences in late life but consistent with work that has shown no differences between people who do and do not relapse on gross structural measures.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 103-110"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis","authors":"Tyler A. Lesh ,&nbsp;Daniel Bergé ,&nbsp;Jason Smucny ,&nbsp;Joyce Guo ,&nbsp;Cameron S. Carter","doi":"10.1016/j.bpsc.2024.09.014","DOIUrl":"10.1016/j.bpsc.2024.09.014","url":null,"abstract":"<div><h3>Background</h3><div>Despite the diverse nature of clinical trajectories after a first episode of psychosis, few baseline characteristics have been predictive of clinical improvement, and the neurobiological underpinnings of this heterogeneity remain largely unknown. Elevated extracellular free water (FW) in the brain is a diffusion imaging measure that has been consistently reported in different phases of psychosis that may indicate a neuroinflammatory state. However, its predictive capacity in terms of clinical outcomes is unknown.</div></div><div><h3>Methods</h3><div>We used diffusion imaging to determine FW and tissue-specific fractional anisotropy (FA-t) in first-episode psychosis. Forty-seven participants were categorized as clinical improvers (<em>n</em> = 26) if they achieved a 20% decrease in total Brief Psychiatric Rating Scale score at 12 months. To determine the predictive capacity of FW and FA-t, these measures were introduced in a stepwise logistic regression model to predict clinical improvement. For measures that survived the model, regional between-group differences were also investigated in cortical surface or white matter tracts, as applicable.</div></div><div><h3>Results</h3><div>Both higher gray matter FW (odds ratio 1.698; 95% CI, 1.134–2.542) and FA-t (odds ratio, 1.358; 95% CI, 0.905–2.038) predicted improver status. FW in gray matter was also linearly correlated with the Brief Psychiatric Rating Scale total score at the 12-month follow-up. When we examined regional specificity, we found that improvers showed greater FW predominantly in temporal regions and higher FA-t values in several white matter tracts, including the bilateral longitudinal superior fasciculus.</div></div><div><h3>Conclusions</h3><div>Our results show that elevated FW in gray matter and FA-t predict further clinical improvement during the initial phases of psychosis. The potential roles of brain inflammatory processes in predicting clinical improvement are discussed.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 111-119"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Effort Discounting Reveals Domain-General and Social-Specific Motivation Components","authors":"Chloe M. Savage ,&nbsp;Greer E. Prettyman ,&nbsp;Adrianna C. Jenkins ,&nbsp;Joseph W. Kable ,&nbsp;Paige R. Didier ,&nbsp;Luis Fernando Viegas de Moraes Leme ,&nbsp;Daniel H. Wolf","doi":"10.1016/j.bpsc.2024.07.020","DOIUrl":"10.1016/j.bpsc.2024.07.020","url":null,"abstract":"<div><h3>Background</h3><div>Social motivation is crucial for healthy interpersonal connections and is impaired in a subset of the general population and across many psychiatric disorders. However, compared with nonsocial (e.g., monetary) motivation, social motivation has been understudied in quantitative behavioral work, especially regarding willingness to exert social effort. We developed a novel social effort discounting task, paired with a monetary task to examine motivational specificity. We expected that social task performance would relate to general motivation and also show selective relationships with self-reported avoidance tendencies and with sociality.</div></div><div><h3>Methods</h3><div>An analyzed sample of 397 participants performed the social and nonsocial effort discounting task online, along with self-report measures of various aspects of motivation and psychiatric symptomatology.</div></div><div><h3>Results</h3><div>Social and nonsocial task motivation correlated strongly (ρ = 0.71, <em>p</em> &lt; .001). Both social and nonsocial task motivation related similarly to self-reported general motivation (social, β = 0.16; nonsocial, β = 0.13) and to self-reported approach motivation (social, β = 0.14; nonsocial, β = 0.11), with this common effect captured by a significant main effect across social and nonsocial conditions. Significant condition interaction effects supported a selective relationship of social task motivation with self-reported sociality and also with avoidance motivation.</div></div><div><h3>Conclusions</h3><div>Our novel social effort discounting task revealed both domain-general and social-specific components of motivation. In combination with other measures, this approach can facilitate further investigation of common and dissociable neurobehavioral mechanisms to better characterize normative and pathological variation and develop personalized interventions targeting specific contributors to social impairment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 37-44"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(24)00365-3","DOIUrl":"10.1016/S2451-9022(24)00365-3","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Neural Signature for Reappraisal as an Emotion Regulation Strategy: Relationship to Stress-Related Suicidal Ideation and Negative Affect in Major Depression","authors":"Sarah Herzog ,&nbsp;Noam Schneck ,&nbsp;Hanga Galfalvy ,&nbsp;Tse Hwei-Choo ,&nbsp;Mike Schmidt ,&nbsp;Christina A. Michel ,&nbsp;M. Elizabeth Sublette ,&nbsp;Ainsley Burke ,&nbsp;Kevin Ochsner ,&nbsp;J. John Mann ,&nbsp;Maria A. Oquendo ,&nbsp;Barbara H. Stanley","doi":"10.1016/j.bpsc.2024.08.011","DOIUrl":"10.1016/j.bpsc.2024.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Impaired emotion regulation (ER) contributes to major depression and suicidal ideation and behavior. ER is typically studied by explicitly directing participants to regulate, but this may not capture spontaneous tendencies of individuals with depression to engage ER in daily life.</div></div><div><h3>Methods</h3><div>In 82 participants with major depressive disorder, we examined the relationship of spontaneous engagement of ER to real-world responses to stress. We used a machine learning–derived neural signature reflecting neural systems that underlie cognitive reappraisal (an ER strategy) to identify reappraisal-related activity while participants recalled negative autobiographical memories under the following conditions: 1) unstructured recall; 2) distanced recall, a form of reappraisal; and 3) immersed recall (comparison condition). Participants also completed a week of ecological momentary assessment measuring daily stressors, suicidal ideation, and negative affect.</div></div><div><h3>Results</h3><div>Higher reappraisal signature output for the unstructured period, a proxy for the spontaneous tendency to engage ER, was associated with greater increases in suicidal ideation following stressors (<em>b</em> = 0.083, <em>p</em> = .041). Higher signature output for distanced recall, a proxy for the capacity to engage ER when directed, was associated with lower negative affect following stressors (<em>b</em> = −0.085, <em>p</em> = .029). Output for the immerse period was not associated with ecological momentary assessment outcomes.</div></div><div><h3>Conclusions</h3><div>Findings suggest that in major depressive disorder, the spontaneous tendency to react to negative memories with attempts to reappraise may indicate greater reactivity to negative cues, while intact capacity to use reappraisal when directed may be associated with more adaptive responses to stress. These data have implications for understanding stress-related increases in suicide risk in depression.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 94-102"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of Peripartum Depression Moderates the Association Between Estradiol Polygenic Risk Scores and Basal Ganglia Volumes in Major Depressive Disorder","authors":"Yasmin A. Harrington ,&nbsp;Marco Paolini ,&nbsp;Lidia Fortaner-Uyà ,&nbsp;Melania Maccario ,&nbsp;Elisa M.T. Melloni ,&nbsp;Sara Poletti ,&nbsp;Cristina Lorenzi ,&nbsp;Raffaella Zanardi ,&nbsp;Cristina Colombo ,&nbsp;Francesco Benedetti","doi":"10.1016/j.bpsc.2024.09.011","DOIUrl":"10.1016/j.bpsc.2024.09.011","url":null,"abstract":"<div><h3>Background</h3><div>The neurobiological differences between women who have experienced a peripartum episode and those who have only had episodes outside of this period are not well understood.</div></div><div><h3>Methods</h3><div>Sixty-four parous female patients with major depressive disorder who had either a positive (<em>n</em> = 30) or negative (<em>n</em> = 34) history of peripartum depression (PPD) underwent magnetic resonance imaging acquisition to obtain structural brain images. An independent 2-sample <em>t</em> test comparing patients with and without a history of PPD was performed using voxel-based morphometry analysis. Additionally, polygenic risk scores for estradiol were calculated, and a moderation analysis was conducted between 3 estradiol polygenic risk scores and PPD history status on extracted cluster volumes using IBM SPSS PROCESS macro.</div></div><div><h3>Results</h3><div>The voxel-based morphometry analysis identified larger gray matter volumes in bilateral clusters encompassing the putamen, pallidum, caudate, and thalamus in patients with a PPD history than in patients without a history. The moderation analysis identified a significant interaction effect between 2 estradiol polygenic risk scores and PPD history on gray matter cluster volumes, with a positive effect in women with PPD and a negative effect in women with no history of PPD.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that women who have experienced a peripartum episode are neurobiologically distinct from women who have no history of PPD in a cluster within the basal ganglia, an area important for motivation, decision making, and emotional processing. Furthermore, we show that the genetic load for estradiol has a differing effect in this area based on PPD status, which supports the claim that PPD is associated with sensitivity to sex steroid hormones.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 7-16"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Signature of Reappraisal: Tendency Versus Capacity","authors":"Agnieszka Zuberer","doi":"10.1016/j.bpsc.2024.11.016","DOIUrl":"10.1016/j.bpsc.2024.11.016","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 5-6"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}