Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

英文中文

Eigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis 特征向量中心性图谱揭示了抗NMDA受体脑炎中大脑功能动态的波动性。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.021

Tim J. Hartung , Nina von Schwanenflug , Stephan Krohn , Tommy A.A. Broeders , Harald Prüss , Menno M. Schoonheim , Carsten Finke

Background

Anti-NMDA receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxelwise and time-resolved estimation of network importance—beyond changes in classical static functional connectivity.

Methods

To assess changes in functional brain network organization, we applied EC mapping in 73 patients with NMDARE and 73 matched healthy control participants. Areas with significant group differences were further investigated using 1) spatial clustering analyses, 2) time series correlation to assess synchronicity between the hippocampus and cortical brain regions, and 3) correlation with cognitive and clinical parameters.

Results

Dynamic, time-resolved EC showed significantly higher variability in 13 cortical areas (familywise error p < .05) in patients with NMDARE compared with healthy control participants. Areas with dynamic EC group differences were spatially organized in centrality clusters resembling resting-state networks. Importantly, variability of dynamic EC in the frontotemporal cluster was associated with impaired verbal episodic memory in patients (r = −0.25, p = .037). EC synchronicity between the hippocampus and the medial prefrontal cortex was reduced in patients compared with healthy control participants (familywise error p < .05, t_max = 3.76) and associated with verbal episodic memory in patients (r = 0.28, p = .019). Static EC analyses showed group differences in only one brain region (left intracalcarine cortex).

Conclusions

Widespread changes in network dynamics and reduced hippocampal-medial prefrontal synchronicity were associated with verbal episodic memory deficits and may thus represent a functional neural correlate of cognitive dysfunction in NMDARE. Importantly, dynamic EC detected substantially more network alterations than traditional static approaches, highlighting the potential of this method to explain long-term deficits in NMDARE.

背景：抗N-甲基-D-天冬氨酸受体脑炎（NMDARE）会导致与功能连接性改变相关的长期认知障碍。特征向量中心性（EC）绘图是一种功能强大的新方法，可通过数据驱动的体素和时间分辨来估计网络的重要性--超越了经典的 "静态 "功能连通性的变化：为了评估大脑功能网络组织的变化，我们对 73 名 NMDARE 患者和 73 名匹配的健康对照者进行了 EC 映射。结果：动态、时间分辨 EC 显示，海马区和皮质脑区之间的同步性与认知和临床参数相关：动态、时间分辨EC在13个皮质区域显示出明显较高的变异性（p(FWE)(FWE)(max)=3.76），并与患者的言语外显记忆相关（r=0.28，p=0.019）。静态EC分析显示，只有一个脑区（左侧钙内皮层）存在群体差异：网络动态的广泛变化和海马-内侧前额叶同步性的降低与言语表观记忆缺陷有关，因此可能代表了 NMDARE 认知功能障碍的功能神经相关性。重要的是，与传统的静态方法相比，动态EC检测到的网络改变要多得多，这凸显了这种方法在解释NMDARE长期缺陷方面的潜力。

{"title":"Eigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis","authors":"Tim J. Hartung , Nina von Schwanenflug , Stephan Krohn , Tommy A.A. Broeders , Harald Prüss , Menno M. Schoonheim , Carsten Finke","doi":"10.1016/j.bpsc.2024.07.021","DOIUrl":"10.1016/j.bpsc.2024.07.021","url":null,"abstract":"<div><h3>Background</h3><div>Anti-NMDA receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxelwise and time-resolved estimation of network importance—beyond changes in classical static functional connectivity.</div></div><div><h3>Methods</h3><div>To assess changes in functional brain network organization, we applied EC mapping in 73 patients with NMDARE and 73 matched healthy control participants. Areas with significant group differences were further investigated using 1) spatial clustering analyses, 2) time series correlation to assess synchronicity between the hippocampus and cortical brain regions, and 3) correlation with cognitive and clinical parameters.</div></div><div><h3>Results</h3><div>Dynamic, time-resolved EC showed significantly higher variability in 13 cortical areas (familywise error <em>p</em> < .05) in patients with NMDARE compared with healthy control participants. Areas with dynamic EC group differences were spatially organized in centrality clusters resembling resting-state networks. Importantly, variability of dynamic EC in the frontotemporal cluster was associated with impaired verbal episodic memory in patients (<em>r =</em> −0.25, <em>p =</em> .037). EC synchronicity between the hippocampus and the medial prefrontal cortex was reduced in patients compared with healthy control participants (familywise error <em>p</em> < .05, <em>t</em><sub>max</sub> = 3.76) and associated with verbal episodic memory in patients (<em>r =</em> 0.28, <em>p =</em> .019). Static EC analyses showed group differences in only one brain region (left intracalcarine cortex).</div></div><div><h3>Conclusions</h3><div>Widespread changes in network dynamics and reduced hippocampal-medial prefrontal synchronicity were associated with verbal episodic memory deficits and may thus represent a functional neural correlate of cognitive dysfunction in NMDARE. Importantly, dynamic EC detected substantially more network alterations than traditional static approaches, highlighting the potential of this method to explain long-term deficits in NMDARE.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1222-1229"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairment of Visual Fixation and Preparatory Saccade Control in Borderline Personality Disorder With and Without Comorbid Attention-Deficit/Hyperactivity Disorder 伴有或不伴有注意力缺陷/多动障碍的边缘型人格障碍患者的视线固定和准备性跳跃控制能力受损。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.003

Olivia G. Calancie , Ashley C. Parr , Don C. Brien , Brian C. Coe , Linda Booij , Sarosh Khalid-Khan , Doug P. Munoz

Background

Borderline personality disorder (BPD) is associated with heightened impulsivity, evidenced by increased substance abuse, self-harm, and suicide attempts. Addressing impulsivity in individuals with BPD is a therapeutic objective, but its underlying neural basis in this clinical population remains unclear, partly due to its frequent comorbidity with attention-deficit/hyperactivity disorder (ADHD).

Methods

We used a response inhibition paradigm—the interleaved pro-/antisaccade task—among adolescents diagnosed with BPD with and without comorbid ADHD (n = 25 and n = 24, respectively) during concomitant video-based eye tracking. We quantified various eye movement response parameters reflective of impulsive action during the task, including delay to fixation acquisition, fixation breaks, anticipatory saccades, and direction errors with express saccade (saccade reaction time: 90–140 ms) and regular saccade latencies (saccade reaction time > 140 ms).

Results

Individuals with BPD exhibited deficient response preparation, as evidenced by reduced visual fixation on task cues and greater variability of saccade responses (i.e., saccade reaction time and peak velocity). The ADHD/BPD group shared these traits and made more anticipatory responses and direction errors with express saccade latencies and reduced error correction.

Conclusions

Saccadic deficits in BPD and ADHD/BPD stemmed not from an inability to execute antisaccades but rather from inadequate preparation for the upcoming task set. These distinctions may arise due to abnormal signaling in cortical areas like the frontal eye fields, posterior parietal cortex, and anterior cingulate cortex. Understanding these mechanisms could provide insights into targeted interventions focusing on task set preparation to manage response inhibition deficits in BPD and ADHD/BPD.

背景：边缘型人格障碍（BPD）与冲动性增强有关，表现为药物滥用、自残和自杀企图增多。解决 BPD 患者的冲动问题是一项治疗目标；但在这一临床人群中，其潜在的神经基础仍不清楚，部分原因是它经常与注意力缺陷/多动障碍（ADHD）共病：我们采用了一种反应抑制范式--交错前/反回旋任务（IPAST）--在同时进行视频眼动追踪的过程中，对被诊断为伴有或不伴有多动症的青少年（分别为 25 人和 24 人）进行了研究。我们对任务中反映冲动性动作的各种眼动反应参数进行了量化，包括获得定点的延迟、定点中断、预期性囊回以及快速囊回的方向错误（囊回反应时间 [SRT]：90-140 毫秒）和常规囊回延迟（SRT > 140 毫秒）：结果：患有 BPD 的个体表现出反应准备不足，具体表现为对任务线索的视觉固定减少，以及囊回反应（即 SRT 和峰值速度）的变异性更大。ADHD/BPD组也具有这些特征，同时还表现出更高频率的预期反应和方向错误，囊回延迟更快，错误纠正更少：结论：BPD和ADHD/BPD的回闪缺陷并非源于无法执行反回闪，而是源于对即将到来的任务准备不足。这些区别可能是由于额叶眼区、后顶叶皮层和前扣带回皮层等皮层区域的信号异常造成的。了解这些机制可以为有针对性的干预措施提供启示，这些干预措施侧重于任务集准备，以控制BPD和ADHD/BPD的反应抑制缺陷。

{"title":"Impairment of Visual Fixation and Preparatory Saccade Control in Borderline Personality Disorder With and Without Comorbid Attention-Deficit/Hyperactivity Disorder","authors":"Olivia G. Calancie , Ashley C. Parr , Don C. Brien , Brian C. Coe , Linda Booij , Sarosh Khalid-Khan , Doug P. Munoz","doi":"10.1016/j.bpsc.2024.07.003","DOIUrl":"10.1016/j.bpsc.2024.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is associated with heightened impulsivity, evidenced by increased substance abuse, self-harm, and suicide attempts. Addressing impulsivity in individuals with BPD is a therapeutic objective, but its underlying neural basis in this clinical population remains unclear, partly due to its frequent comorbidity with attention-deficit/hyperactivity disorder (ADHD).</div></div><div><h3>Methods</h3><div>We used a response inhibition paradigm—the interleaved pro-/antisaccade task—among adolescents diagnosed with BPD with and without comorbid ADHD (<em>n</em> = 25 and <em>n</em> = 24, respectively) during concomitant video-based eye tracking. We quantified various eye movement response parameters reflective of impulsive action during the task, including delay to fixation acquisition, fixation breaks, anticipatory saccades, and direction errors with express saccade (saccade reaction time: 90–140 ms) and regular saccade latencies (saccade reaction time > 140 ms).</div></div><div><h3>Results</h3><div>Individuals with BPD exhibited deficient response preparation, as evidenced by reduced visual fixation on task cues and greater variability of saccade responses (i.e., saccade reaction time and peak velocity). The ADHD/BPD group shared these traits and made more anticipatory responses and direction errors with express saccade latencies and reduced error correction.</div></div><div><h3>Conclusions</h3><div>Saccadic deficits in BPD and ADHD/BPD stemmed not from an inability to execute antisaccades but rather from inadequate preparation for the upcoming task set. These distinctions may arise due to abnormal signaling in cortical areas like the frontal eye fields, posterior parietal cortex, and anterior cingulate cortex. Understanding these mechanisms could provide insights into targeted interventions focusing on task set preparation to manage response inhibition deficits in BPD and ADHD/BPD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1178-1187"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peak Alpha Frequency in Schizophrenia, Bipolar Disorder, and Healthy Volunteers: Associations With Visual Information Processing and Cognition 精神分裂症、双相情感障碍和健康志愿者的α峰频率：与视觉信息处理和认知的关联。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.06.004

Background

Schizophrenia (SCZ) and bipolar disorder (BD) are associated with information processing abnormalities, including visual perceptual and cognitive impairments, that impact daily functioning. Recent work with healthy samples suggests that peak alpha frequency (PAF) is an electrophysiological index of visual information processing speed that is correlated with cognitive ability. There is evidence that PAF is slowed in SCZ, but it remains unclear whether PAF is reduced in BD or whether slower PAF is associated with impaired visual perception and cognition in these clinical disorders.

Methods

We recorded resting-state brain activity (both eyes open and closed) with electroencephalography in 90 participants with SCZ, 62 participants with BD, and 69 healthy control participants. Most participants also performed a visual perception task (backward masking) and cognitive testing (MATRICS Concensus Cognitive Battery).

Results

We replicated previous findings of reduced PAF in patients with SCZ compared with healthy control participants. In contrast, PAF in patients with BD did not differ significantly from that in healthy control participants. Furthermore, PAF was significantly correlated with performance on the perceptual and cognitive measures in SCZ but not BD. PAF was also correlated with visual perception in the healthy control group and showed a trend-level correlation with cognition.

Conclusions

Together, these results suggest that PAF deficits characterize SCZ, but not BD, and that individual differences in PAF are related to abnormalities in visual information processing and cognition in SCZ.

背景：精神分裂症（SCZ）和双相情感障碍（BD）与信息处理异常有关，包括视觉感知和认知障碍，这影响了日常功能。最近在健康样本中进行的研究表明，α峰频率（PAF）是视觉信息处理速度的电生理指标，也与认知能力相关。有证据表明SCZ患者的α峰频率减慢，但目前仍不清楚BD患者的α峰频率是否减慢，也不清楚α峰频率减慢是否与这些临床疾病的视觉感知和认知能力受损有关：本研究通过脑电图（EEG）记录了90名SCZ参与者、62名BD参与者和69名健康对照者的静息状态大脑活动（睁眼和闭眼）。大多数参与者还进行了视觉感知任务（后向遮蔽）和认知测试（MATRICS共识认知测试）：结果：与健康对照组相比，我们重复了之前的研究结果，即 SCZ 患者的 PAF 减少了。相比之下，BD 患者的 PAF 与健康对照组没有明显差异。此外，PAF 与 SCZ 的知觉和认知测量结果有明显的相关性，但与 BD 的相关性不大。在健康对照组中，PAF也与视觉感知相关，并与认知能力呈趋势性相关：这些结果表明，PAF 缺陷是 SCZ 的特征，而不是 BD 的特征，PAF 的个体差异与 SCZ 的视觉信息处理和认知异常有关。

{"title":"Peak Alpha Frequency in Schizophrenia, Bipolar Disorder, and Healthy Volunteers: Associations With Visual Information Processing and Cognition","authors":"","doi":"10.1016/j.bpsc.2024.06.004","DOIUrl":"10.1016/j.bpsc.2024.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) and bipolar disorder (BD) are associated with information processing abnormalities, including visual perceptual and cognitive impairments, that impact daily functioning. Recent work with healthy samples suggests that peak alpha frequency (PAF) is an electrophysiological index of visual information processing speed that is correlated with cognitive ability. There is evidence that PAF is slowed in SCZ, but it remains unclear whether PAF is reduced in BD or whether slower PAF is associated with impaired visual perception and cognition in these clinical disorders.</div></div><div><h3>Methods</h3><div>We recorded resting-state brain activity (both eyes open and closed) with electroencephalography in 90 participants with SCZ, 62 participants with BD, and 69 healthy control participants. Most participants also performed a visual perception task (backward masking) and cognitive testing (MATRICS Concensus Cognitive Battery).</div></div><div><h3>Results</h3><div>We replicated previous findings of reduced PAF in patients with SCZ compared with healthy control participants. In contrast, PAF in patients with BD did not differ significantly from that in healthy control participants. Furthermore, PAF was significantly correlated with performance on the perceptual and cognitive measures in SCZ but not BD. PAF was also correlated with visual perception in the healthy control group and showed a trend-level correlation with cognition.</div></div><div><h3>Conclusions</h3><div>Together, these results suggest that PAF deficits characterize SCZ, but not BD, and that individual differences in PAF are related to abnormalities in visual information processing and cognition in SCZ.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1132-1140"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guide for Authors 作者指南

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/S2451-9022(24)00290-8

引用次数: 0

Peak Alpha Frequency, Visual Perception, and Cognition in Schizophrenia 精神分裂症患者的阿尔法峰值频率、视觉感知和认知能力

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.09.007

Victor J. Pokorny

引用次数: 0

Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents 大流行相关压力与高危青少年 COVID-19 期间内化症状之间关系的大脑形态宏观结构调节器。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.002

McKinley Pawlak , Jennifer Kemp , Signe Bray , Sneha Chenji , Melanie Noel , Kathryn A. Birnie , Frank P. MacMaster , Jillian Vinall Miller , Daniel C. Kopala-Sibley

Background

According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.

Methods

Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.

Results

Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.

Conclusions

Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.

背景：根据 "因人因环境 "模型，个体特质的差异可能会缓和压力因素与心理病理学发展之间的关联；然而，文献中的研究结果并不一致，很少有文献研究青少年的大脑结构是压力对青少年内化症状影响的调节因素。COVID-19 大流行为研究压力、大脑结构和心理病理学之间的关联提供了一个独特的机会。考虑到大脑皮层形态与青少年抑郁和焦虑之间的联系，本研究调查了大脑皮层形态是否会调节 COVID-19 大流行所带来的压力与家族性高危青少年内化症状发展之间的关系：在 COVID-19 大流行之前，72 名青少年（27 岁）完成了抑郁和焦虑症状的测量，并接受了磁共振成像检查。采集 T1 加权图像以评估皮质厚度和表面积。在COVID-19被宣布为全球性流行病约6-8个月后，青少年报告了他们的抑郁和焦虑症状以及与流行病有关的压力：结果：在对大流行前的抑郁症状、焦虑症状和压力进行调整后，大流行相关压力的增加与抑郁症状的增加有关，但与焦虑症状无关。这种关系受前扣带回皮质厚度和表面积以及内侧眶额皮质厚度的调节，因此只有在这些区域皮质表面积较低而皮质厚度较高的青少年中，压力增加才与抑郁和焦虑症状的增加有关：研究结果进一步加深了我们对压力与内化症状之间的神经脆弱性的理解，尤其是在COVID-19大流行期间。

{"title":"Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents","authors":"McKinley Pawlak , Jennifer Kemp , Signe Bray , Sneha Chenji , Melanie Noel , Kathryn A. Birnie , Frank P. MacMaster , Jillian Vinall Miller , Daniel C. Kopala-Sibley","doi":"10.1016/j.bpsc.2024.07.002","DOIUrl":"10.1016/j.bpsc.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.</div></div><div><h3>Methods</h3><div>Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.</div></div><div><h3>Results</h3><div>Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.</div></div><div><h3>Conclusions</h3><div>Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1141-1177"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Correlates of Metacognition Impairment in Opioid Addiction 阿片类药物成瘾中元认知受损的神经相关性。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.014

Scott J. Moeller , Sameera Abeykoon , Pari Dhayagude , Benjamin Varnas , Jodi J. Weinstein , Greg Perlman , Roberto Gil , Stephen M. Fleming , Anissa Abi-Dargham

Background

Individuals with substance use disorder show impaired self-awareness of ongoing behavior. This deficit suggests problems with metacognition, which has been operationalized in the cognitive neuroscience literature as the ability to monitor and evaluate the success of one’s own cognition and behavior. However, the neural mechanisms of metacognition have not been characterized in a population with drug addiction.

Methods

Community samples of participants with opioid use disorder (OUD) (n = 27) and healthy control participants (n = 29) performed a previously validated functional magnetic resonance imaging metacognition task (perceptual decision-making task along with confidence ratings of performance). Measures of recent drug use and addiction severity were also acquired.

Results

Individuals with OUD had lower metacognitive sensitivity (i.e., disconnection between task performance and task-related confidence) than control individuals. Trial-by-trial analyses showed that this overall group difference was driven by (suboptimally) low confidence in participants with OUD during correct trials. In functional magnetic resonance imaging analyses, the task engaged an expected network of brain regions (e.g., rostrolateral prefrontal cortex and dorsal anterior cingulate/supplementary motor area, both previously linked to metacognition); group differences emerged in a large ventral anterior cluster that included the medial and lateral orbitofrontal cortex and striatum (higher activation in OUD). Trial-by-trial functional magnetic resonance imaging analyses showed group differences in rostrolateral prefrontal cortex activation, which further correlated with metacognitive behavior across all participants. Exploratory analyses suggested that the behavioral and neural group differences were exacerbated by recent illicit opioid use and unexplained by general cognition.

Conclusions

With confirmation and extension of these findings, metacognition and its associated neural circuits could become new, promising therapeutic targets in addiction.

背景：药物滥用障碍患者对当前行为的自我意识存在缺陷。元认知在认知神经科学文献中被定义为监控和评估自身认知和行为成功与否的能力。然而，元认知的神经机制尚未在吸毒人群中得到描述：方法：社区样本中的阿片类药物使用障碍（OUD）患者（27 人）和健康对照组（29 人）执行了一项先前经过验证的 fMRI 元认知任务（感知决策任务以及对表现的信心评级）。此外，还对近期吸毒情况和成瘾严重程度进行了测量：结果：与对照组相比，OUD 患者的元认知敏感性较低（即任务表现与任务相关的自信心脱节）。逐次试验分析表明，这一总体组别差异是由正确试验期间对 OUD 的（次优）低信心造成的。在 fMRI 分析中，这项任务涉及到一个预期的大脑区域网络（例如，喙外侧前额叶皮层和背侧前扣带回/辅助运动区，这两个区域以前都与元认知有关）；群体差异出现在一个大型的腹侧前部集群中，该集群包括内侧和外侧眶额皮层和纹状体（在 OUD 中激活程度较高）。逐次试验的 fMRI 分析显示了喙外侧前额叶皮层激活的组间差异，这与所有参与者的元认知行为进一步相关。探索性分析表明，近期非法使用阿片类药物加剧了行为和神经的群体差异，而一般认知则无法解释这种差异：随着这些发现的确认和扩展，元认知及其相关神经回路可能成为治疗成瘾的新的、有前途的目标。

{"title":"Neural Correlates of Metacognition Impairment in Opioid Addiction","authors":"Scott J. Moeller , Sameera Abeykoon , Pari Dhayagude , Benjamin Varnas , Jodi J. Weinstein , Greg Perlman , Roberto Gil , Stephen M. Fleming , Anissa Abi-Dargham","doi":"10.1016/j.bpsc.2024.07.014","DOIUrl":"10.1016/j.bpsc.2024.07.014","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with substance use disorder show impaired self-awareness of ongoing behavior. This deficit suggests problems with metacognition, which has been operationalized in the cognitive neuroscience literature as the ability to monitor and evaluate the success of one’s own cognition and behavior. However, the neural mechanisms of metacognition have not been characterized in a population with drug addiction.</div></div><div><h3>Methods</h3><div>Community samples of participants with opioid use disorder (OUD) (<em>n</em> = 27) and healthy control participants (<em>n</em> = 29) performed a previously validated functional magnetic resonance imaging metacognition task (perceptual decision-making task along with confidence ratings of performance). Measures of recent drug use and addiction severity were also acquired.</div></div><div><h3>Results</h3><div>Individuals with OUD had lower metacognitive sensitivity (i.e., disconnection between task performance and task-related confidence) than control individuals. Trial-by-trial analyses showed that this overall group difference was driven by (suboptimally) low confidence in participants with OUD during correct trials. In functional magnetic resonance imaging analyses, the task engaged an expected network of brain regions (e.g., rostrolateral prefrontal cortex and dorsal anterior cingulate/supplementary motor area, both previously linked to metacognition); group differences emerged in a large ventral anterior cluster that included the medial and lateral orbitofrontal cortex and striatum (higher activation in OUD). Trial-by-trial functional magnetic resonance imaging analyses showed group differences in rostrolateral prefrontal cortex activation, which further correlated with metacognitive behavior across all participants. Exploratory analyses suggested that the behavioral and neural group differences were exacerbated by recent illicit opioid use and unexplained by general cognition.</div></div><div><h3>Conclusions</h3><div>With confirmation and extension of these findings, metacognition and its associated neural circuits could become new, promising therapeutic targets in addiction.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1211-1221"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keeping an Eye Out for Change: Anxiety Disrupts Adaptive Resolution of Policy Uncertainty 关注变化：焦虑扰乱了对政策不确定性的适应性解决。

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.07.015

Amrita Lamba , Michael J. Frank , Oriel FeldmanHall

Background

Human learning unfolds under uncertainty. Uncertainty is heterogeneous with different forms exerting distinct influences on learning. While one can be uncertain about what to do to maximize rewarding outcomes, known as policy uncertainty, one can also be uncertain about general world knowledge, known as epistemic uncertainty (EU). In complex and naturalistic environments such as the social world, adaptive learning may hinge on striking a balance between attending to and resolving each type of uncertainty. Prior work illustrates that people with anxiety—those with increased threat and uncertainty sensitivity—learn less from aversive outcomes, particularly as outcomes become more uncertain. How does a learner adaptively trade-off between attending to these distinct sources of uncertainty to successfully learn about their social environment?

Methods

We developed a novel eye-tracking method to capture highly granular estimates of policy uncertainty and EU based on gaze patterns and pupil diameter (a physiological estimate of arousal).

Results

These empirically derived uncertainty measures revealed that humans (N = 94) flexibly switched between resolving policy uncertainty and EU to adaptively learn about which individuals can be trusted and which should be avoided. However, those with increased anxiety (n = 49) did not flexibly switch between resolving policy uncertainty and EU and instead expressed less uncertainty overall.

Conclusions

Combining modeling and eye-tracking techniques, we show that altered learning in people with anxiety emerged from an insensitivity to policy uncertainty and rigid choice policies, leading to maladaptive behaviors with untrustworthy people.

背景介绍人类的学习是在不确定性下展开的。不确定性是多种多样的，不同形式的不确定性会对学习产生不同的影响。一个人可能对如何做才能获得最大回报结果不确定，这被称为政策的不确定性；一个人也可能对一般世界知识不确定，这被称为认识的不确定性。在复杂和自然的环境中，如社会世界，适应性学习可能取决于在关注和解决每种不确定性之间取得平衡。先前的研究表明，焦虑的人--对威胁和不确定性的敏感性增强的人--从厌恶的结果中学到的东西较少，尤其是当结果变得更加不确定时。学习者如何在关注这些不同的不确定性来源之间进行适应性权衡，从而成功地学习他们所处的社会环境？结果：这些根据经验得出的不确定性测量结果显示，人类（N = 94）在解决政策和认识不确定性之间灵活切换，以适应性地了解哪些人可以信任，哪些人应该避免。然而，焦虑增加的人（N = 49）并不能在解决政策和认识不确定性之间灵活切换，相反，他们表达的不确定性总体较低：结合建模和眼动追踪技术，我们发现焦虑症患者对政策不确定性和僵化的选择政策不敏感，从而导致他们对不值得信任的人采取不适应行为，从而改变了他们的学习能力。

{"title":"Keeping an Eye Out for Change: Anxiety Disrupts Adaptive Resolution of Policy Uncertainty","authors":"Amrita Lamba , Michael J. Frank , Oriel FeldmanHall","doi":"10.1016/j.bpsc.2024.07.015","DOIUrl":"10.1016/j.bpsc.2024.07.015","url":null,"abstract":"<div><h3>Background</h3><div>Human learning unfolds under uncertainty. Uncertainty is heterogeneous with different forms exerting distinct influences on learning. While one can be uncertain about what to do to maximize rewarding outcomes, known as policy uncertainty, one can also be uncertain about general world knowledge, known as epistemic uncertainty (EU). In complex and naturalistic environments such as the social world, adaptive learning may hinge on striking a balance between attending to and resolving each type of uncertainty. Prior work illustrates that people with anxiety—those with increased threat and uncertainty sensitivity—learn less from aversive outcomes, particularly as outcomes become more uncertain. How does a learner adaptively trade-off between attending to these distinct sources of uncertainty to successfully learn about their social environment?</div></div><div><h3>Methods</h3><div>We developed a novel eye-tracking method to capture highly granular estimates of policy uncertainty and EU based on gaze patterns and pupil diameter (a physiological estimate of arousal).</div></div><div><h3>Results</h3><div>These empirically derived uncertainty measures revealed that humans (<em>N</em> = 94) flexibly switched between resolving policy uncertainty and EU to adaptively learn about which individuals can be trusted and which should be avoided. However, those with increased anxiety (<em>n</em> = 49) did not flexibly switch between resolving policy uncertainty and EU and instead expressed less uncertainty overall.</div></div><div><h3>Conclusions</h3><div>Combining modeling and eye-tracking techniques, we show that altered learning in people with anxiety emerged from an insensitivity to policy uncertainty and rigid choice policies, leading to maladaptive behaviors with untrustworthy people.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1188-1198"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metacognition and Addiction: A New Look Inside 元认知与成瘾：内部新视角

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsc.2024.09.004

Charles W. Bradberry

引用次数: 0

Editorial Board Page 编辑委员会页面

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Pub Date : 2024-11-01 DOI: 10.1016/S2451-9022(24)00286-6

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀