Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"The Influence of Maternal and Paternal Parenting on Adolescent Brain Structure","authors":"Qingwen Ding ,&nbsp;Xinying Li ,&nbsp;Divyangana Rakesh ,&nbsp;Siya Peng ,&nbsp;Jiahua Xu ,&nbsp;Jie Chen ,&nbsp;Nengzhi Jiang ,&nbsp;Yu Luo ,&nbsp;Xuebing Li ,&nbsp;Shaozheng Qin ,&nbsp;Sarah Whittle","doi":"10.1016/j.bpsc.2024.06.013","DOIUrl":"10.1016/j.bpsc.2024.06.013","url":null,"abstract":"<div><h3>Background</h3><div><span>Adolescents raised in families with different maternal and paternal parenting combinations exhibit variations in neurocognition and psychopathology; however, whether neural differences exist remains unexplored. This study used a longitudinal twin sample to delineate how different parenting combinations influence adolescent brain structure and to elucidate the </span>genetic contribution.</div></div><div><h3>Methods</h3><div>A cohort of 216 twins participated in parenting assessments during early adolescence and underwent magnetic resonance imaging scanning during middle adolescence. We utilized latent profile analysis<span><span> to distinguish between various maternal and paternal parenting profiles and subsequently investigated their influences on brain anatomy. </span>Biometric analysis was applied to assess genetic influences on brain structure, and associations with internalizing symptoms were explored.</span></div></div><div><h3>Results</h3><div><span>In early adolescence, 4 parenting profiles emerged, which were characterized by levels of harshness and hostility in one or both parents. Compared with adolescents in “catparent” families (low harshness/hostility in both parents), those raised in “tigermom” families (harsh/hostile mother only) exhibited a smaller nucleus accumbens<span> volume and larger temporal cortex<span> surface area; those in “tigerdad” families demonstrated larger </span></span></span>thalamus<span> volumes; and those in “tigerparent” families displayed smaller volumes in the midanterior corpus callosum<span>. Genetic risk factors contributed significantly to the observed brain structural heterogeneity and internalizing symptoms. However, the influences of parenting profiles and brain structure on internalizing symptoms were not significant.</span></span></div></div><div><h3>Conclusions</h3><div>The findings underscore distinct brain structural features linked to maternal and paternal parenting combinations, particularly in terms of subcortical volume and cortical surface area. This study suggests an interdependent role of maternal and paternal parenting in shaping adolescent neurodevelopment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1249-1257"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies","authors":"Ioana Varvari ,&nbsp;Lara Bolte ,&nbsp;Chiara Colli ,&nbsp;Valentina Mancini ,&nbsp;Matthew M. Nour ,&nbsp;Philip McGuire ,&nbsp;Robert A. McCutcheon","doi":"10.1016/j.bpsc.2025.07.004","DOIUrl":"10.1016/j.bpsc.2025.07.004","url":null,"abstract":"<div><div>Aberrant dopamine and glutamate signaling are implicated in the pathophysiology of schizophrenia. Existing treatments primarily target dopamine pathways underlying positive symptoms but have relatively little effect on cognitive and negative symptoms. Glutamatergic modulators may treat the latter symptom domains, and neuroimaging studies have the potential to identify therapeutic mechanisms. We conducted a systematic review to examine functional neuroimaging studies of glutamatergic modulators in psychosis and determine whether these agents alter brain activity, chemistry, or functional connectivity and whether such changes map onto clinical outcomes. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO: <span><span>CRD42024549120</span><svg><path></path></svg></span>), MEDLINE, Embase, and PsycInfo were searched from inception to June 2024 for studies administering pharmacologic glutamate modulators to individuals with psychosis, using functional neuroimaging (proton magnetic resonance spectroscopy [¹H-MRS], functional magnetic resonance imaging [fMRI], arterial spin labeling, positron emission tomography, electroencephalography [EEG], or magnetoencephalography). Twenty-seven articles met inclusion criteria, encompassing 841 participants. Evidence from ¹H-MRS suggests that sarcosine, <em>N</em>-acetylcysteine, and riluzole reduce glutamate concentrations in frontal and hippocampal regions, but clinical outcomes have not been investigated. Resting-state and task-based fMRI studies suggest that NMDA receptor modulators may normalize measures of functional dysconnectivity, although effects were often short-lived and did not always correspond to sustained symptom improvements. Similarly, EEG studies consistently identified normalization of mismatch negativity and gamma oscillations, but correlations with symptom or cognitive outcomes were inconsistent. While glutamatergic modulators show measurable effects on brain chemistry and electrophysiology, the relationship to robust, durable clinical benefits remains elusive. Future work should use larger, longer-duration, and multimodal imaging studies to clarify the precise mechanisms, optimal dosing, and the patient subgroups most likely to benefit from glutamatergic interventions in psychosis.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1221-1238"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(25)00340-4","DOIUrl":"10.1016/S2451-9022(25)00340-4","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Page A2"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profiles of Impulsivity and Emotion Regulation in Children With Externalizing Disorders Are Associated With Alterations in Striatocortical Connectivity","authors":"Joseph Aloi ,&nbsp;Tahlia E. Korin ,&nbsp;Olivia K. Murray ,&nbsp;Kathleen I. Crum ,&nbsp;Katherine LeFevre ,&nbsp;Mario Dzemidzic ,&nbsp;Leslie A. Hulvershorn","doi":"10.1016/j.bpsc.2025.02.013","DOIUrl":"10.1016/j.bpsc.2025.02.013","url":null,"abstract":"<div><h3>Background</h3><div>Children with externalizing disorders often have difficulties with impulsivity (IMP) and emotion regulation (ER). These constructs have been associated with dysfunction in the recruitment of reward-processing circuits and striatal connectivity with cortical networks. However, it is unclear to what extent co-presentations of IMP and ER are associated with differences in striatocortical connectivity.</div></div><div><h3>Methods</h3><div>In study 1, a latent profile analysis (LPA) was conducted in a sample of 198 youths with externalizing disorders (oppositional defiant disorder and/or conduct disorder) to investigate co-presentation of IMP and ER symptoms. Participants completed the UPPS Impulsivity Scale (UPPS) and the Emotion Regulation Checklist (ERC). LPA was applied to the subscales of the UPPS and ERC. In study 2, we examined 169 participants who completed a resting-state functional magnetic resonance imaging scan to examine differences in striatocortical connectivity between profiles.</div></div><div><h3>Results</h3><div><span><span>The LPA identified 3 profiles: moderate IMP/moderate ER, high IMP/low ER, and high IMP/moderate ER. The 2 high IMP profiles were associated with greater connectivity between the posterior caudate nucleus and </span>parietal cortex. The high IMP/low ER profile was associated with increased connectivity between the anterior caudate and anterior </span>insula.</div></div><div><h3>Conclusions</h3><div><span>The current data indicate that the profiles associated with high IMP are associated with greater caudate–parietal cortex connectivity, while the profile associated with high IMP and impaired ER showed increased anterior caudate–anterior insular cortex connectivity. The current work contributes to the literature by examining the relationship between heterogeneity of externalizing symptoms and </span>functional connectivity.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1258-1267"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder","authors":"Drew E. Winters,&nbsp;Joseph P. Schacht","doi":"10.1016/j.bpsc.2025.06.003","DOIUrl":"10.1016/j.bpsc.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Dysregulation of inhibitory control is a core feature of alcohol use disorder (AUD) and is mediated, in part, by catechol-<em>O</em>-methyltransferase (COMT) regulation of cortical dopaminergic neurotransmission. Tolcapone, a brain-penetrant COMT inhibitor, potentiates evoked dopamine release and may improve inhibitory control in AUD.</div></div><div><h3>Methods</h3><div>Non–treatment-seeking participants with AUD (<em>N</em> = 64) were randomized to tolcapone (titrated to 200 mg three times a day) or placebo for 8 days and completed a functional magnetic resonance imaging stop signal task on study days 1 (prior to medication ingestion) and 7. Brain areas in which activation for the contrast of successful versus unsuccessful stop trials (stop success [SS]&gt;stop error [SE]) differed between medication groups on day 7 relative to day 1 were identified. Activation of these areas and their functional connectivity with other areas were tested for association with changes in drinking during the medication period and with changes in stop signal reaction time, a behavioral index of inhibitory control.</div></div><div><h3>Results</h3><div>The tolcapone group demonstrated greater SS&gt;SE activation in the right dorsolateral prefrontal cortex and inferior frontal gyrus (iFG). In the tolcapone group, greater activation of both areas was associated with improved inhibitory control, and greater iFG activation was associated with reduced drinking. Increased connectivity between the iFG and right anterior insula was associated with reduced drinking, and increased connectivity between the iFG and anterior cingulate cortex was associated with improved inhibitory control.</div></div><div><h3>Conclusions</h3><div>Tolcapone increased activation of cortical areas implicated in inhibitory control. The associations between increased iFG activation and connectivity, improved inhibitory control, and reduced drinking suggest that pharmacological interventions that increase cortical dopamine may rescue dysregulated inhibitory control among people with AUD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1302-1312"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1016/j.bpsc.2025.10.015","DOIUrl":"10.1016/j.bpsc.2025.10.015","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1313-1316"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala-Centered Emotional Processing in Prolonged Grief Disorder: Relationship With Clinical Symptomatology","authors":"Gyujoon Hwang ,&nbsp;Nutta-on P. Blair ,&nbsp;B. Douglas Ward ,&nbsp;Timothy L. McAuliffe ,&nbsp;Stacy A. Claesges ,&nbsp;Abigail R. Webber ,&nbsp;Keri R. Hainsworth ,&nbsp;Yang Wang ,&nbsp;Charles F. Reynolds ,&nbsp;Elliot A. Stein ,&nbsp;Joseph S. Goveas","doi":"10.1016/j.bpsc.2024.12.008","DOIUrl":"10.1016/j.bpsc.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged grief disorder (PGD) is a multidimensional condition with adverse health consequences. We hypothesized that enhanced negative emotional bias characterizes this disorder and underlies its key clinical symptoms.</div></div><div><h3>Methods</h3><div>In a cross-sectional design, chronically grieving older adults (age 61.5 ± 8.9 years) experiencing probable PGD (<em>n</em> = 33) were compared with demographic- and time since loss–equated integrated (adaptive) grief participants (<em>n</em> = 38). To probe generalized negative affective reactivity, participants performed an emotional face-matching task during functional magnetic resonance imaging scanning and completed demographic and clinical assessments. Contrast maps (fearful + angry faces [−] shapes) were generated to determine group differences in brain activity within hypothesized affective and regulatory processing regions (amygdala, anterior insula, dorsal anterior cingulate, dorsolateral prefrontal cortex) and in exploratory whole-brain regression analyses.</div></div><div><h3>Results</h3><div><span>The PGD group showed higher right amygdala activation to negative emotional stimuli than the integrated grief group (</span><em>p</em>_corrected<span><span><span> &lt; .05), which positively correlated with intrusive thoughts. Generalized psychophysiological interaction analysis revealed lower task-dependent </span>functional connectivity (FC) between the right amygdala and </span>posterior cingulate cortex/precuneus in PGD (</span><em>p</em>_corrected<span> &lt; .05), which negatively correlated with avoidance of loss reminders. Resting-state FC between the identified right amygdala and thalamus was higher in PGD (</span><em>p</em>_corrected &lt; .05), which negatively correlated with loneliness.</div></div><div><h3>Conclusions</h3><div>Dysregulated amygdala-centric neural activity and FC during processing of negative affective stimuli and at rest appear to differentiate prolonged from integrated grief in older adults. Future investigations that use interventions to target amygdala-centric neural circuit abnormalities may provide new insights into the role of enhanced negative bias and related mechanisms that underlie PGD and support treatment efficacy.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1284-1293"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00339-8","DOIUrl":"10.1016/S2451-9022(25)00339-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Page A1"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring Cortical Control: Dopaminergic Modulation of Inhibitory Networks in Alcohol Use Disorder","authors":"Meredith E. Halcomb","doi":"10.1016/j.bpsc.2025.10.009","DOIUrl":"10.1016/j.bpsc.2025.10.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1218-1220"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliable Multimodal Brain Signatures Predict Mental Health Outcomes in Children","authors":"Kathryn Y. Manning ,&nbsp;Alberto Llera ,&nbsp;Catherine Lebel","doi":"10.1016/j.bpsc.2025.03.003","DOIUrl":"10.1016/j.bpsc.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Interindividual brain differences likely precede the emergence of mood and anxiety disorders; however, the specific brain alterations remain unclear. While many studies focus on a single imaging modality in isolation, recent advances in multimodal image analysis allow for a more comprehensive understanding of the complex neurobiology that underlies mental health.</div></div><div><h3>Methods</h3><div>In a large population-based cohort of children from the ABCD (Adolescent Brain Cognitive Development) Study (<em>N</em> &gt; 10,000), we applied data-driven linked independent component analysis to identify linked variations in cortical structure and white matter microstructure that together predict longitudinal behavioral and mental health symptoms. Brain differences were examined in a subsample of twins depending on the presence of at-risk behaviors.</div></div><div><h3>Results</h3><div>Two multimodal brain signatures at ages 9 to 10 years predicted longitudinal mental health symptoms from 9 to 12 years, with small effect sizes. Cortical variations in association, limbic, and default mode regions linked with peripheral white matter microstructure together predicted higher depression and anxiety symptoms across 2 independent split-halves. The brain signature differed between depression and anxiety symptom trajectories and related to emotion regulation network functional connectivity. Linked variations of subcortical structures and projection tract microstructure variably predicted behavioral inhibition, sensation seeking, and psychosis symptom severity over time in male participants. These brain patterns were significantly different between pairs of twins discordant for self-injurious behavior.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate reliable, multimodal brain patterns in childhood, before mood and anxiety disorders tend to emerge, that lay the foundation for long-term mental health outcomes and offer targets for early identification of children at risk.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1197-1209"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}