Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Latent Profiles of Impulsivity and Emotion Regulation in Children With Externalizing Disorders Are Associated With Alterations in Striatocortical Connectivity","authors":"Joseph Aloi ,&nbsp;Tahlia E. Korin ,&nbsp;Olivia K. Murray ,&nbsp;Kathleen I. Crum ,&nbsp;Katherine LeFevre ,&nbsp;Mario Dzemidzic ,&nbsp;Leslie A. Hulvershorn","doi":"10.1016/j.bpsc.2025.02.013","DOIUrl":"10.1016/j.bpsc.2025.02.013","url":null,"abstract":"<div><h3>Background</h3><div>Children with externalizing disorders often have difficulties with impulsivity (IMP) and emotion regulation (ER). These constructs have been associated with dysfunction in the recruitment of reward-processing circuits and striatal connectivity with cortical networks. However, it is unclear to what extent co-presentations of IMP and ER are associated with differences in striatocortical connectivity.</div></div><div><h3>Methods</h3><div>In study 1, a latent profile analysis (LPA) was conducted in a sample of 198 youths with externalizing disorders (oppositional defiant disorder and/or conduct disorder) to investigate co-presentation of IMP and ER symptoms. Participants completed the UPPS Impulsivity Scale (UPPS) and the Emotion Regulation Checklist (ERC). LPA was applied to the subscales of the UPPS and ERC. In study 2, we examined 169 participants who completed a resting-state functional magnetic resonance imaging scan to examine differences in striatocortical connectivity between profiles.</div></div><div><h3>Results</h3><div><span><span>The LPA identified 3 profiles: moderate IMP/moderate ER, high IMP/low ER, and high IMP/moderate ER. The 2 high IMP profiles were associated with greater connectivity between the posterior caudate nucleus and </span>parietal cortex. The high IMP/low ER profile was associated with increased connectivity between the anterior caudate and anterior </span>insula.</div></div><div><h3>Conclusions</h3><div><span>The current data indicate that the profiles associated with high IMP are associated with greater caudate–parietal cortex connectivity, while the profile associated with high IMP and impaired ER showed increased anterior caudate–anterior insular cortex connectivity. The current work contributes to the literature by examining the relationship between heterogeneity of externalizing symptoms and </span>functional connectivity.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1258-1267"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1016/j.bpsc.2025.10.015","DOIUrl":"10.1016/j.bpsc.2025.10.015","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1313-1316"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00339-8","DOIUrl":"10.1016/S2451-9022(25)00339-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Page A1"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala-Centered Emotional Processing in Prolonged Grief Disorder: Relationship With Clinical Symptomatology","authors":"Gyujoon Hwang ,&nbsp;Nutta-on P. Blair ,&nbsp;B. Douglas Ward ,&nbsp;Timothy L. McAuliffe ,&nbsp;Stacy A. Claesges ,&nbsp;Abigail R. Webber ,&nbsp;Keri R. Hainsworth ,&nbsp;Yang Wang ,&nbsp;Charles F. Reynolds ,&nbsp;Elliot A. Stein ,&nbsp;Joseph S. Goveas","doi":"10.1016/j.bpsc.2024.12.008","DOIUrl":"10.1016/j.bpsc.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged grief disorder (PGD) is a multidimensional condition with adverse health consequences. We hypothesized that enhanced negative emotional bias characterizes this disorder and underlies its key clinical symptoms.</div></div><div><h3>Methods</h3><div>In a cross-sectional design, chronically grieving older adults (age 61.5 ± 8.9 years) experiencing probable PGD (<em>n</em> = 33) were compared with demographic- and time since loss–equated integrated (adaptive) grief participants (<em>n</em> = 38). To probe generalized negative affective reactivity, participants performed an emotional face-matching task during functional magnetic resonance imaging scanning and completed demographic and clinical assessments. Contrast maps (fearful + angry faces [−] shapes) were generated to determine group differences in brain activity within hypothesized affective and regulatory processing regions (amygdala, anterior insula, dorsal anterior cingulate, dorsolateral prefrontal cortex) and in exploratory whole-brain regression analyses.</div></div><div><h3>Results</h3><div><span>The PGD group showed higher right amygdala activation to negative emotional stimuli than the integrated grief group (</span><em>p</em>_corrected<span><span><span> &lt; .05), which positively correlated with intrusive thoughts. Generalized psychophysiological interaction analysis revealed lower task-dependent </span>functional connectivity (FC) between the right amygdala and </span>posterior cingulate cortex/precuneus in PGD (</span><em>p</em>_corrected<span> &lt; .05), which negatively correlated with avoidance of loss reminders. Resting-state FC between the identified right amygdala and thalamus was higher in PGD (</span><em>p</em>_corrected &lt; .05), which negatively correlated with loneliness.</div></div><div><h3>Conclusions</h3><div>Dysregulated amygdala-centric neural activity and FC during processing of negative affective stimuli and at rest appear to differentiate prolonged from integrated grief in older adults. Future investigations that use interventions to target amygdala-centric neural circuit abnormalities may provide new insights into the role of enhanced negative bias and related mechanisms that underlie PGD and support treatment efficacy.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1284-1293"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring Cortical Control: Dopaminergic Modulation of Inhibitory Networks in Alcohol Use Disorder","authors":"Meredith E. Halcomb","doi":"10.1016/j.bpsc.2025.10.009","DOIUrl":"10.1016/j.bpsc.2025.10.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 12","pages":"Pages 1218-1220"},"PeriodicalIF":4.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encoding-Retrieval Similarity Reveals Distinct Neural Reinstatement of Safety Memories Following Counterconditioning in Posttraumatic Stress Disorder","authors":"Elizabeth A. Bauer ,&nbsp;Samuel E. Cooper ,&nbsp;Nicole E. Keller ,&nbsp;Josh M. Cisler ,&nbsp;Joseph E. Dunsmoor","doi":"10.1016/j.bpsc.2025.07.007","DOIUrl":"10.1016/j.bpsc.2025.07.007","url":null,"abstract":"<div><h3>Background</h3><div>Posttraumatic stress disorder (PTSD) is characterized by deficits in the ability to retrieve extinction memories, which likely contribute to symptom relapse over time. Adapting a hybrid Pavlovian conditioning and episodic memory paradigm, we examined whether counterconditioning produces a more stable and persistent long-term neural memory trace of safety compared with standard extinction in the ventromedial prefrontal cortex (vmPFC)—a region associated with the learning and retrieval of safety.</div></div><div><h3>Methods</h3><div>Participants consisted of 32 individuals (27 female) who met diagnostic criteria for PTSD and 21 healthy (13 female) comparison participants. Participants completed a multiday Pavlovian conditioning and episodic memory paradigm with standard extinction/counterconditioning.</div></div><div><h3>Results</h3><div>In healthy adults, we identified overlapping multivariate patterns of functional magnetic resonance imaging activity in the vmPFC associated with the formation and 24-hour retrieval of stimuli that underwent counterconditioning, but neural reinstatement diminished after ∼1 month. This pattern was reversed in PTSD, such that neural reinstatement of counterconditioning was not observed the day after safety learning but did emerge a month later. Interestingly, participants with PTSD showed reinstatement of standard extinction memories in the dorsal anterior cingulate cortex—a region associated with learning and retrieval of threat—both 24 hours and 1 month after safety learning.</div></div><div><h3>Conclusions</h3><div>These results provide the first evidence that counterconditioning may stabilize a long-term safety memory trace in PTSD. These effects seem to emerge over longer time scales, suggesting that counterconditioning could be an effective strategy for sustained treatment gains.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1125-1133"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliable Multimodal Brain Signatures Predict Mental Health Outcomes in Children","authors":"Kathryn Y. Manning ,&nbsp;Alberto Llera ,&nbsp;Catherine Lebel","doi":"10.1016/j.bpsc.2025.03.003","DOIUrl":"10.1016/j.bpsc.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Interindividual brain differences likely precede the emergence of mood and anxiety disorders; however, the specific brain alterations remain unclear. While many studies focus on a single imaging modality in isolation, recent advances in multimodal image analysis allow for a more comprehensive understanding of the complex neurobiology that underlies mental health.</div></div><div><h3>Methods</h3><div>In a large population-based cohort of children from the ABCD (Adolescent Brain Cognitive Development) Study (<em>N</em> &gt; 10,000), we applied data-driven linked independent component analysis to identify linked variations in cortical structure and white matter microstructure that together predict longitudinal behavioral and mental health symptoms. Brain differences were examined in a subsample of twins depending on the presence of at-risk behaviors.</div></div><div><h3>Results</h3><div>Two multimodal brain signatures at ages 9 to 10 years predicted longitudinal mental health symptoms from 9 to 12 years, with small effect sizes. Cortical variations in association, limbic, and default mode regions linked with peripheral white matter microstructure together predicted higher depression and anxiety symptoms across 2 independent split-halves. The brain signature differed between depression and anxiety symptom trajectories and related to emotion regulation network functional connectivity. Linked variations of subcortical structures and projection tract microstructure variably predicted behavioral inhibition, sensation seeking, and psychosis symptom severity over time in male participants. These brain patterns were significantly different between pairs of twins discordant for self-injurious behavior.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate reliable, multimodal brain patterns in childhood, before mood and anxiety disorders tend to emerge, that lay the foundation for long-term mental health outcomes and offer targets for early identification of children at risk.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1197-1209"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(25)00314-3","DOIUrl":"10.1016/S2451-9022(25)00314-3","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Page A2"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trading Fear for Safety","authors":"Kai Zhang,&nbsp;Lihan Cui,&nbsp;Mohammed R. Milad","doi":"10.1016/j.bpsc.2025.09.009","DOIUrl":"10.1016/j.bpsc.2025.09.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1109-1111"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder","authors":"Lachlan Webb ,&nbsp;Luke J. Hearne ,&nbsp;Ye E. Tian ,&nbsp;Andrew Zalesky ,&nbsp;Conor Robinson ,&nbsp;Caitlin V. Hall ,&nbsp;Saurabh Sonkusare ,&nbsp;Bjorn Burgher ,&nbsp;Michael Breakspear ,&nbsp;Garance M. Meyer ,&nbsp;Andreas Horn ,&nbsp;Sebastien Naze ,&nbsp;Philip Mosley ,&nbsp;Luca Cocchi","doi":"10.1016/j.bpsc.2025.07.006","DOIUrl":"10.1016/j.bpsc.2025.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organization of striatal connections.</div></div><div><h3>Methods</h3><div>We calculated spatial striatal gradients linked to whole-brain activity in 52 people with OCD and 45 control participants. Gradients were computed with individuals at rest and when they underwent a threat-safety reversal task. Using a longitudinal dataset of 47 people with OCD, we investigated possible associations between changes in striatal gradient topology and fluctuations in symptom severity.</div></div><div><h3>Results</h3><div>Results showed group differences in the main gradient topology at rest, specifically in striatal regions that overlap with the putamen and caudate. Individuals who showed a reduction in symptoms over time tended to change their gradient topology in favor of the control participants’ average topology. Finally, gradients linked to the appraisal of safety reversal, but not threat reversal, showed a group difference in a region separating the right nucleus accumbens and the putamen.</div></div><div><h3>Conclusions</h3><div>This study advances knowledge of striatal connectivity profiles in OCD, supporting a core role of distinct changes in striatal topology in the expression of symptoms. Collectively, these results encourage studies assessing neural mechanisms that drive the dynamic reorganization of striatal topology and the development of therapies that leverage striatocortical plasticity.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1134-1142"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}