Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis","authors":"Andrew R. Gerlach ,&nbsp;Helmet T. Karim ,&nbsp;Kevin Kahru ,&nbsp;Dana L. Tudorascu ,&nbsp;James J. Gross ,&nbsp;Meryl A. Butters ,&nbsp;Carmen Andreescu","doi":"10.1016/j.bpsc.2025.04.010","DOIUrl":"10.1016/j.bpsc.2025.04.010","url":null,"abstract":"<div><h3>Background</h3><div>Severe worry is a core component of anxiety and depressive disorders and is independently associated with significant morbidity and mortality. However, the neural basis of worry is poorly understood. We investigated effective connectivity (EC) using functional magnetic resonance imaging of a naturalistic worry induction and reappraisal task in late life.</div></div><div><h3>Methods</h3><div>A total of 112 participants age &gt;50 years with varying worry severity completed a personalized, in-scanner worry induction and reappraisal task. We calculated voxelwise EC in neutral, worry, and reappraisal conditions with generalized psychophysiological interactions using seeds in the subgenual anterior cingulate cortex (ACC), dorsal ACC, and left and right amygdalae and used paired <em>t</em> tests to compare conditions. We assessed clusters for association with in-scanner worry severity using linear regression.</div></div><div><h3>Results</h3><div>During the worry condition, EC increased between the subgenual ACC and the default mode network (DMN) and major hubs of the executive control and salience networks. Left amygdala EC to the posterior cingulate also increased during worry, and dorsal ACC connectivity to primary sensory and motor regions decreased. Reappraisal reduced subgenual and dorsal ACC EC observed during worry and the EC between the left amygdala and regions of the dorsal attention network. Broadly, left amygdala EC was robustly associated with in-scanner worry severity.</div></div><div><h3>Conclusions</h3><div>Worry induction robustly engaged the DMN and increased connectivity with other high-order associative networks, potentially subsuming cortical resources. Reappraisal reduced these connectivities and disengaged the amygdala from areas associated with top-down attention. These findings could inform targets for neuromodulatory treatment of severe worry in older adults.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1143-1154"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00317-9","DOIUrl":"10.1016/S2451-9022(25)00317-9","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages A5-A10"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults","authors":"Yu Chen ,&nbsp;Huey-Ting Li ,&nbsp;Xingguang Luo ,&nbsp;Guangfei Li ,&nbsp;Jaime S. Ide ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.bpsc.2025.05.008","DOIUrl":"10.1016/j.bpsc.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>Extensive research has shown aberrant reward and punishment processing in people with depression. Genetic risks contribute to depression, but whether or how these risks of depression may affect behavioral and neural responses to reward and punishment remains unclear.</div></div><div><h3>Methods</h3><div>We curated the data of 879 young adults performing a gambling task during brain imaging from the Human Connectome Project. Depression severity was assessed with the Achenbach Adult Self Report. Polygenic risk scores (PRSs) for depression were computed for all participants. With published routines and at a corrected threshold, we evaluated how brain responses to reward and punishment were associated with depression scores and PRSs in a linear regression in all, male, and female participants, with age, sex (for all), race, and drinking severity as covariates.</div></div><div><h3>Results</h3><div>The results showed broad frontal, parietal, and occipital cortical activation in negative correlation with PRSs during both reward and punishment processing. Notably, posterior cingulate cortical activation was specifically associated with PRS-related punishment processing. In addition, men and women displayed both shared and distinct neural responses to PRS-related reward and punishment processing.</div></div><div><h3>Conclusions</h3><div>These findings highlight the influence of genetic risks for depression on neural responses to reward and punishment and provide insights into genetically informed markers of depression.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1155-1165"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketosis Elevates Antioxidants and Markers of Energy Metabolism: A Proton Magnetic Resonance Spectroscopy Study","authors":"Helena van Nieuwenhuizen ,&nbsp;Botond B. Antal ,&nbsp;Antoine Hone-Blanchet ,&nbsp;Andrew Lithen ,&nbsp;Liam McMahon ,&nbsp;Sofia Nikolaidou ,&nbsp;Zeming Kuang ,&nbsp;Kieran Clarke ,&nbsp;Bruce G. Jenkins ,&nbsp;Douglas L. Rothman ,&nbsp;Lilianne R. Mujica-Parodi ,&nbsp;Eva-Maria Ratai","doi":"10.1016/j.bpsc.2025.06.009","DOIUrl":"10.1016/j.bpsc.2025.06.009","url":null,"abstract":"<div><h3>Background</h3><div>Ketosis is known to alter the balance of neuroactive amino acids and enhance neural function compared with a glycolytic condition. However, its influence on other metabolites, such as antioxidants and neural energy markers, and the mechanisms by which ketosis improves neural function remain unclear.</div></div><div><h3>Methods</h3><div>Here, we measured the neurochemical effects of acute ketosis on key brain metabolites (neurotransmitters, antioxidants, and energy markers) in the human brain using ultra-high-field proton magnetic resonance spectroscopy (¹H-MRS) and investigated the subsequent impact on neural function, measured via dynamic functional connectivity, using resting-state functional magnetic resonance imaging (rs-fMRI). In a within-subjects design, 63 healthy adults (30 female) from across the lifespan underwent ¹H-MRS and rs-fMRI scans before and after consuming individually weight-dosed and calorically matched ketone monoester or glucose drinks.</div></div><div><h3>Results</h3><div>Ketone monoester administration, but not glucose, significantly elevated cerebral antioxidants and energy markers while decreasing GABA (gamma-aminobutyric acid), glutamate, and glutamine levels in the posterior cingulate cortex. Notably, increased energy markers, specifically an increase in total creatine, correlated with greater improvements in neural function measured using rs-fMRI.</div></div><div><h3>Conclusions</h3><div>Our results integrate metabolic and functional neuroimaging findings, offering a comprehensive understanding of ketosis-induced changes in brain chemistry and functional network dynamics. These insights clarify potential mechanisms by which ketosis imparts its neural benefits and provide valuable information to assist the development of novel treatment strategies for a variety of psychiatric and neurodegenerative disorders.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 11","pages":"Pages 1186-1196"},"PeriodicalIF":4.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Brain Differences in the Alzheimer’s Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium","authors":"Tavia E. Evans ,&nbsp;Natalia Vilor-Tejedor ,&nbsp;Gregory Operto ,&nbsp;Carles Falcon ,&nbsp;Albert Hofman ,&nbsp;Agustin Ibáñez ,&nbsp;Sudha Seshadari ,&nbsp;Louis C.S. Tan ,&nbsp;Michael Weiner ,&nbsp;Suverna Alladi ,&nbsp;Udunna Anazodo ,&nbsp;Juan Domingo Gispert ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative,&nbsp;Australian Imaging Biomarkers and Lifestyle flagship study of ageing,&nbsp;Hieab H.H. Adams","doi":"10.1016/j.bpsc.2024.07.019","DOIUrl":"10.1016/j.bpsc.2024.07.019","url":null,"abstract":"<div><h3>Background</h3><div>Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer’s disease (AD) and how relationships vary across sources of heterogeneity.</div></div><div><h3>Methods</h3><div>Using 6 international datasets (<em>N</em> &gt; 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis. We investigated whether associations varied across elements of magnetic resonance imaging acquisition, study design, and populations.</div></div><div><h3>Results</h3><div>Modest differences in associations were found depending on how data were acquired; however, patterns were similar. Preliminary results suggested that neuroimaging marker–AD relationships differ across ethnic groups.</div></div><div><h3>Conclusions</h3><div>Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the data and quantify its contribution to research findings at the meta-analytical stage.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Pages 1025-1036"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Surface: Deep Transcranial Magnetic Stimulation Efficacy in Reducing Craving in Addictive Disorders: A Systematic Review and Meta-Analysis","authors":"Lilia Del Mauro ,&nbsp;Alessandra Vergallito ,&nbsp;Francantonio Devoto ,&nbsp;Gaia Locatelli ,&nbsp;Gabriel Hassan ,&nbsp;Leonor Josefina Romero Lauro","doi":"10.1016/j.bpsc.2025.03.012","DOIUrl":"10.1016/j.bpsc.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a promising neuromodulation technique capable of reaching deep and bilateral brain regions. However, no definite recommendation for its use in addiction treatment exists. In this study, we systematically reviewed and quantitatively analyzed dTMS effects in SUDs and GD.</div></div><div><h3>Methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we screened 4 electronic databases up to February 2024 and selected relevant original English-language research articles. Seventeen articles were included in the systematic review and 12 in the meta-analysis. Because only a minority of studies used a sham-controlled design, we ran a main analysis computing the standardized mean change (SMCC) from pre to post real stimulation as the effect size, with self-reported craving scores as the outcome measure.</div></div><div><h3>Results</h3><div>The results showed a significant and large effect of real dTMS in reducing craving scores (SMCC = −1.26; 95% CI, −1.67 to −0.86; <em>p</em> &lt; .001). High heterogeneity across studies was found at both quantitative and qualitative levels.</div></div><div><h3>Conclusions</h3><div>Results provide preliminary evidence supporting the effectiveness of dTMS for the treatment of SUDs. Current limitations and future directions are critically discussed, highlighting the need for further rigorous research to refine the therapeutic potential and develop consensus-based guidelines for dTMS clinical application.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Pages 1005-1014"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00270-8","DOIUrl":"10.1016/S2451-9022(25)00270-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Page A1"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings","authors":"Hanna Seelemeyer ,&nbsp;Caroline Gurr ,&nbsp;Johanna Leyhausen ,&nbsp;Lisa M. Berg ,&nbsp;Charlotte M. Pretzsch ,&nbsp;Tim Schäfer ,&nbsp;Bassem Hermila ,&nbsp;Christine M. Freitag ,&nbsp;Eva Loth ,&nbsp;Bethany Oakley ,&nbsp;Luke Mason ,&nbsp;Jan K. Buitelaar ,&nbsp;Christian F. Beckmann ,&nbsp;Dorothea L. Floris ,&nbsp;Tony Charman ,&nbsp;Tobias Banaschewski ,&nbsp;Emily Jones ,&nbsp;Thomas Bourgeron","doi":"10.1016/j.bpsc.2024.12.003","DOIUrl":"10.1016/j.bpsc.2024.12.003","url":null,"abstract":"<div><h3>Background</h3><div>Autism is accompanied by highly individualized patterns of neurodevelopmental differences in brain anatomy. This variability makes the neuroanatomy of autism inherently difficult to describe at the group level. Here, we examined interindividual neuroanatomical differences using a dimensional approach that decomposed the domains of social communication and interaction (SCI), restricted and repetitive behaviors (RRBs), and atypical sensory processing (ASP) within a neurodiverse study population. Moreover, we aimed to link the resulting neuroanatomical patterns to specific molecular underpinnings.</div></div><div><h3>Methods</h3><div>Neurodevelopmental differences in cortical thickness (CT) and surface area (SA) were correlated with SCI, RRB, and ASP domain scores by regression of a general linear model in a large neurodiverse sample of 288 autistic individuals and 140 nonautistic individuals, ages 6 to 30 years, recruited within the European Autism Interventions Longitudinal European Autism Project (EU-AIMS LEAP). The domain-specific patterns of neuroanatomical variability were subsequently correlated with cortical gene expression profiles via the Allen Human Brain Atlas.</div></div><div><h3>Results</h3><div>Across groups, behavioral variations in SCI, RRBs, and ASP were associated with interindividual differences in CT and SA in partially non-overlapping frontoparietal, temporal, and occipital networks. These domain-specific imaging patterns were enriched for genes that 1) are differentially expressed in autism, 2) mediate typical brain development, and 3) are associated with specific cortical cell types. Many of these genes were implicated in pathways governing synaptic structure and function.</div></div><div><h3>Conclusions</h3><div>Our study corroborates the close relationship between neuroanatomical variation and interindividual differences in autism-related symptoms and traits within the general framework of neurodiversity and links domain-specific patterns of neuroanatomical differences to putative molecular underpinnings.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Pages 1067-1077"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Neural Circuits and Gene Expression in Attention-Deficit/Hyperactivity Disorder: Insights From a Multimodal Approach","authors":"Renata Basso Cupertino","doi":"10.1016/j.bpsc.2025.08.003","DOIUrl":"10.1016/j.bpsc.2025.08.003","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Pages 1003-1004"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00274-5","DOIUrl":"10.1016/S2451-9022(25)00274-5","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 10","pages":"Pages A6-A11"},"PeriodicalIF":4.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}