SLAS Technology最新文献

英文中文

Application of 3D printing imaging technology in the treatment of bronchopleural fistula with individual customized bronchial occluder 3D打印成像技术在个性化支气管封堵器治疗支气管胸膜瘘中的应用

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-27 DOI: 10.1016/j.slast.2025.100344

Zelin Xiao , Jianqi Gao , Hui Zhang , Linyao Wang

Background

Bronchopleural fistula (BPF) is a common and severe complication in thoracic surgery, characterized by its complex nature and high mortality rate. Bronchial occluder is one of the effective methods for the interventional treatment of BPF under bronchoscopy.

Objective

This work was to evaluate the adoption and efficacy of individualized bronchial occluder designed with the assistance of 3D printing technology in the treatment of BPF.

Material and Methods

This single-center, retrospective study included 60 patients (35 males and 25 females, aged 40–78 years, without severe dysfunction of major organs or history of mental disorders) diagnosed with BPF between January 2020 and December 2023, who received different treatment and were divided into the Control Group (CG, receiving thoracotomy treatment), Therapy group-I (TG-I, receiving septal occluder treatment), and Therapy group-II (TG-II, receiving treatment with 3D-printed individualized bronchial occluder). Serum levels of high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) were measured by enzyme-linked immunosorbent assay preoperatively and at 1, 4, and 12 weeks postoperatively. Daytime cough scores were assessed according to guidelines, pain scores were evaluated using a visual analog scale, clinical efficacy was determined based on consensus criteria, and complications were recorded. Quantitative variables were compared using one-way ANOVA with Bonferroni correction, while categorical variables were analyzed by chi-square or Fisher’s exact test.

Results

the overall clinical efficacy was higher in TG-I and TG-II versus CG, with TG-II showing a greatly higher efficacy after twelve weeks of treatment (P < 0.05). Relative to CG, both TG-I and TG-II demonstrated lower serum levels of hs-CRP and PCT, markedly reduced cough and pain symptom scores, and markedly lower complication rates (P < 0.05). Additionally, TG-II resulted in notably lower serum inflammatory markers, cough and pain symptom scores, and complication rates versus TG-I (P < 0.05).

Conclusion

The 3D-printed personalized occluder (TG-II) significantly reduced postoperative inflammatory responses and alleviated cough-associated pain, demonstrating superior short-term efficacy and safety compared to conventional treatment (CG) and commercially available occluders (TG-I). This approach offers distinct advantages for the personalized precision treatment of BPF. However, further clinical studies are required to validate its potential as an alternative to surgical repair.

背景：支气管胸膜瘘（BPF）是胸外科手术中常见且严重的并发症，其性质复杂，死亡率高。支气管闭塞术是支气管镜下介入治疗BPF的有效方法之一。目的：评价3D打印技术辅助设计的个体化支气管封堵器在BPF治疗中的应用及疗效。材料和方法：本单中心回顾性研究纳入2020年1月至2023年12月诊断为BPF的患者60例（男35例，女25例，年龄40-78岁，无严重主要器官功能障碍或精神障碍史），接受不同治疗，分为对照组（CG，接受开胸治疗）、治疗组i （TG-I，接受间隔闭塞治疗）和治疗组ii (TG-II，接受3d打印个性化支气管封堵器治疗)。术前、术后1、4、12周采用酶联免疫吸附法测定血清高敏c反应蛋白（hs-CRP）和降钙素原（PCT）水平。根据指南评估日间咳嗽评分，使用视觉模拟量表评估疼痛评分，根据共识标准确定临床疗效，并记录并发症。定量变量比较采用Bonferroni校正的单因素方差分析，分类变量分析采用卡方或Fisher精确检验。结果：与CG相比，TG-I和TG-II的总体临床疗效更高，其中TG-II在治疗12周后的疗效明显更高(p结论：3d打印个性化封口器（TG-II）显著降低了术后炎症反应，缓解了咳嗽相关疼痛，与常规治疗（CG）和市售封口器（TG-I）相比，具有更优越的短期疗效和安全性。这种方法为BPF的个性化精确治疗提供了明显的优势。然而，需要进一步的临床研究来验证其作为手术修复替代方案的潜力。

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引用次数: 0

Bio-inspired computing and Machine learning analytics for future-oriented mental well-being 面向未来的心理健康的生物启发计算和机器学习分析。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-14 DOI: 10.1016/j.slast.2025.100343

Chinmay Chakraborty , Bhuvan Unhelkar , Saïd Mahmoudi

引用次数: 0

Life sciences and artificial intelligence 生命科学与人工智能。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-11 DOI: 10.1016/j.slast.2025.100342

Kerstin Thurow

引用次数: 0

Life sciences and society – an alphabetical journey 生命科学与社会——按字母顺序排列的旅程。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-10 DOI: 10.1016/j.slast.2025.100341

Kerstin Thurow

引用次数: 0

Self-supervised disc and cup segmentation via non-local deformable convolution and adaptive transformer 基于非局部可变形卷积和自适应变压器的自监督圆盘杯分割。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-09 DOI: 10.1016/j.slast.2025.100338

Wenbo Zhao , Yu Wang

Optic disc and cup segmentation is a crucial subfield of computer vision, playing a pivotal role in automated pathological image analysis. It enables precise, efficient, and automated diagnosis of ocular conditions, significantly aiding clinicians in real-world medical applications. However, due to the scarcity of medical segmentation data and the insufficient integration of global contextual information, the segmentation accuracy remains suboptimal. This issue becomes particularly pronounced in optic disc and cup cases with complex anatomical structures and ambiguous boundaries. In order to address these limitations, this paper introduces a self-supervised training strategy integrated with a newly designed network architecture to improve segmentation accuracy. Specifically,we initially propose a non-local dual deformable convolutional block,which aims to capture the irregular image patterns(

i . e .

boundary). Secondly,we modify the traditional vision transformer and design an adaptive K-Nearest Neighbors(KNN) transformation block to extract the global semantic context from images. Finally,an initialization strategy based on self-supervised training is proposed to reduce the burden on the network on labeled data. Comprehensive experimental evaluations demonstrate the effectiveness of our proposed method, which outperforms previous networks and achieves state-of-the-art performance,with IOU scores of 0.9577 for the optic disc and 0.8399 for the optic cup on the REFUGE dataset.

视盘杯分割是计算机视觉的一个重要分支，在病理图像自动分析中起着举足轻重的作用。它能够精确、高效和自动地诊断眼部疾病，极大地帮助临床医生在现实世界的医疗应用。然而，由于医学分割数据的缺乏和对全局上下文信息的整合不足，分割精度仍然不理想。这个问题变得特别明显视盘和杯病例复杂的解剖结构和模糊的边界。为了解决这些限制，本文引入了一种与新设计的网络架构相结合的自监督训练策略，以提高分割精度。具体来说，我们最初提出了一种非局部对偶可变形卷积块，其目的是捕获不规则的图像模式(即。边界)。其次，对传统的视觉变换进行改进，设计自适应k近邻变换块，从图像中提取全局语义上下文；最后，提出了一种基于自监督训练的初始化策略，以减轻网络对标记数据的负担。综合实验评估证明了我们提出的方法的有效性，该方法优于以前的网络，并达到了最先进的性能，在REFUGE数据集上视盘的IOU得分为0.9577，光学杯的IOU得分为0.8399。

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引用次数: 0

Life sciences discovery and technology highlights 生命科学发现和技术亮点。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-06 DOI: 10.1016/j.slast.2025.100340

Tal Murthy , Jamien Lim

引用次数: 0

Nanosilver Gel, as a novel therapeutic approach, ameliorates wound healing in hand injury patients. 纳米银凝胶作为一种新的治疗方法，改善了手部损伤患者的伤口愈合。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-01 DOI: 10.1016/j.slast.2025.100339

Qingyu Wang, Wenyao Zhong, Xingmiao Feng

Background: In recent years, nanosilver gel has gained attention due to its excellent antimicrobial properties and wound healing effects. Meanwhile, the comprehensive care model has improved the rehabilitation environment for patients with its holistic and individualized care approach. This study aimed to investigate the promoting effects of nanosilver gel on wound healing in hand injury patients and the intervention effects of the comprehensive care model.

Methods: This study adopted a randomized controlled trial (RCT) design. A total of 120 hand injury patients admitted to the Hand Surgery Department of Beijing Jishuitan Hospital between January 2020 and January 2023 were enrolled and randomly allocated into three groups (n=40 each). The control group (C group) received standard care, experimental group A (Exp A) underwent a comprehensive nursing intervention, and experimental group B (Exp B) received additional nanosilver gel dressing treatment based on the comprehensive nursing protocol. Primary outcome measures included wound healing time, pain intensity (visual analogue scale (VAS) score), functional recovery (grip strength, hand dexterity, and range of motion), and wound healing rate.

Results: Exp group B had notably better outcomes in terms of wound healing time, pain intensity, functional recovery, and wound healing rate versus C group and Exp group A.

Conclusion: This study demonstrates that the combination of nanosilver gel and the comprehensive care model significantly improves wound healing outcomes in hand injury patients, providing a new and effective possibility for the treatment of hand injuries.

背景：近年来，纳米银凝胶因其优异的抗菌性能和伤口愈合效果而受到人们的关注。同时，综合护理模式以其整体和个性化的护理方式改善了患者的康复环境。本研究旨在探讨纳米银凝胶对手部损伤患者创面愈合的促进作用及综合护理模式的干预效果。方法采用随机对照试验（RCT）设计。选取2020年1月至2023年1月北京积水潭医院手外科收治的120例手部损伤患者，随机分为3组，每组40例。对照组（C组）给予标准护理，实验组A （Exp A）给予综合护理干预，实验组B （Exp B）在综合护理方案的基础上给予纳米银凝胶敷料治疗。主要结局指标包括伤口愈合时间、疼痛强度（视觉模拟量表（VAS）评分）、功能恢复（握力、手灵活性和活动范围）和伤口愈合率。结果：Exp B组在创面愈合时间、疼痛强度、功能恢复、创面愈合率等方面均明显优于C组和Exp a组。结论：本研究表明纳米银凝胶联合综合护理模式显著改善了手外伤患者创面愈合效果，为手外伤治疗提供了新的有效可能。

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引用次数: 0

Bio-inspired computing and Machine learning analytics for a future-oriented mental well-being 面向未来的心理健康的生物启发计算和机器学习分析。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-01 DOI: 10.1016/j.slast.2025.100316

Chinmay Chakraborty , Bhuvan Unhelkar , Saïd Mahmoudi

引用次数: 0

Titanium surface functionalization with calcium-doped ZnO nanoparticles for hard tissue implant applications 钙掺杂ZnO纳米颗粒对钛表面功能化的研究

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-01 DOI: 10.1016/j.slast.2025.100337

Komel Tariq, Nosheen Fatima Rana, Sabah Javaid, Muneeba Khadim

Implant-associated infections remain a significant challenge in orthopaedic and dental implants because they frequently result in implant failure, extended hospital stays, reoperations, and increased healthcare costs. Studies have shown that the cost of managing orthopaedic implant infections can range from USD 30,000 to over USD 100,000 per case, depending on severity and required surgical interventions. One of the primary pathogens responsible for these infections is Staphylococcus aureus, known for its potential to make biofilms on the surfaces of implants. To address this problem, this study investigates the formation of calcium phosphate-based biomimetic coatings substituted with calcium-doped ZnO nanoparticles on titanium discs to strengthen the antibacterial properties and enhance tissue integration. The SEM analysis of discs revealed uniform and dense coating layers with negligible surface defects, indicating a strong adhesive coating on titanium discs. The biomimetic-coated titanium implants with Ca-doped ZnO NPs were then evaluated for antibacterial activity using a closed system in an in vitro biofilm model. In case of 14 days treated disc, a significant increase in the antibacterial properties was observed against (Staphylococcus aureus, p < 0.0001). These findings suggest that calcium phosphate-based biomimetic coatings, doped with calcium-doped ZnO NPs show great potential for reducing the risk for implant-associated infections and improving the success rate of implants in clinical settings.

种植体相关感染仍然是骨科和牙科种植体的一个重大挑战，因为它们经常导致种植体失败、延长住院时间、再手术和增加医疗费用。研究表明，根据严重程度和所需的手术干预措施，治疗骨科植入物感染的费用从每例3万美元到10万美元以上不等。造成这些感染的主要病原体之一是金黄色葡萄球菌，它以在植入物表面形成生物膜的潜力而闻名。为了解决这一问题，本研究研究了在钛盘上形成磷酸钙基仿生涂层，取代钙掺杂ZnO纳米颗粒，以增强抗菌性能和增强组织整合。扫描电镜分析表明，钛盘表面涂层均匀致密，表面缺陷可忽略不计，表明钛盘表面具有较强的粘结性涂层。然后在封闭系统的体外生物膜模型中评估了含ca掺杂ZnO NPs的仿生包覆钛植入物的抗菌活性。在治疗椎间盘14天的情况下，观察到对金黄色葡萄球菌的抗菌性能显著增加，p <；0.0001)。这些发现表明，掺钙ZnO纳米粒子的磷酸钙仿生涂层在降低种植体相关感染风险和提高临床种植体成功率方面具有很大的潜力。

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引用次数: 0

Literature highlights column: From the literature life sciences discovery and technology highlights 生命科学发现和技术亮点。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology

Pub Date : 2025-08-01 DOI: 10.1016/j.slast.2025.100311

Jamien Lim , Tal Murthy

引用次数: 0

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