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The Role of Metal Nanoparticles in Promoting Photocatalysis by TiO2 金属纳米颗粒在促进TiO2光催化中的作用
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-03 DOI: 10.1007/s41061-022-00373-x
Michael Bowker, Christopher O’Rourke, Andrew Mills

In this review, we highlight the role played by metal nanoparticles (NPs) in photocatalytic oxidation with titania as a support. This is presented in two parts, namely, partial photo-oxidation in which an organic sacrificial agent is oxidised in anaerobic conditions to produce hydrogen (photo-reforming), and photo-oxidative mineralisation of organics in aerobic conditions. We present some rules for such reactions that dictate which organic molecules can react readily, and which metals are likely to be useful for such reactions. Generally, the presence of metal NPs enhances enormously the ability of titania to yield hydrogen from photo-reforming, and a wide range of molecules can be used, including biomass. The metal NPs most used are those that are easily reduced, that is, the precious metals. The large enhancement in rate seen with metal for hydrogen production is not so extreme for the oxidation reactions, but is still significant. An important factor in all of this catalysis is the nature of the interaction between the metal NPs, which can play a multiplicity of chemical and electronic roles, and the photoactive support. A sharp dependency of rate on loading of metal is found, with maximum rates at ~0.5–2 wt% loading, depending on the metal used. The source of this dependency is the bifunctional nature of the system, in which the intimacy of both materials is crucial to performance. This rate variation is linked to the interface between the two, which is then linked to the size of the metal NPs. In fact, the rate is proportional to an area adjacent to the metal particles that we call the expanding photocatalytic area and overlap (EPAO) kinetic model. This model describes the dependence well. Rising rates with increasing coverage of particles is associated with increase in this total area but, at the maximum, these areas overlap and at higher loadings the available active area diminishes, reproducing the observed behaviour well.

在这篇综述中,我们重点介绍了金属纳米颗粒(NPs)在二氧化钛作为载体的光催化氧化中的作用。这分为两部分,即部分光氧化,其中有机牺牲剂在厌氧条件下氧化产生氢气(光重整),以及在有氧条件下有机物的光氧化矿化。我们提出了这类反应的一些规则,这些规则规定了哪些有机分子容易反应,哪些金属可能对这类反应有用。一般来说,金属NPs的存在极大地增强了二氧化钛光重整产氢的能力,并且可以使用广泛的分子,包括生物质。最常用的金属NPs是那些容易被还原的,即贵金属。在氧化反应中,金属产氢速率的大幅提高并不是那么极端,但仍然很重要。在所有这些催化中,一个重要的因素是金属NPs与光活性载体之间相互作用的性质,NPs可以发挥多种化学和电子作用。速率与金属的载荷有很大的关系,根据所用金属的不同,最大速率为~0.5 - 2% wt%的载荷。这种依赖的来源是系统的双功能性质,其中两种材料的亲密性对性能至关重要。这种速率变化与两者之间的界面有关,而界面又与金属NPs的大小有关。事实上,速率与金属颗粒附近的面积成正比,我们称之为扩展光催化区域和重叠(EPAO)动力学模型。该模型很好地描述了依赖性。随着颗粒覆盖率的增加,速率的增加与总面积的增加有关,但是,在最大值时,这些区域重叠,在更高的负载下,可用的活动面积减少,很好地再现了所观察到的行为。
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引用次数: 10
Total RNA Synthesis and its Covalent Labeling Innovation 总RNA合成及其共价标记创新
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-02-26 DOI: 10.1007/s41061-022-00371-z
Hongling Zhou, Yuanyuan Li, Youfang Gan, Rui Wang

RNA plays critical roles in a wide range of physiological processes. For example, it is well known that RNA plays an important role in regulating gene expression, cell proliferation, and differentiation, and many other chemical and biological processes. However, the research community still suffers from limited approaches that can be applied to readily visualize a specific RNA-of-interest (ROI). Several methods can be used to track RNAs; these rely mainly on biological properties, namely, hybridization, aptamer, reporter protein, and protein binding. With respect to covalent approaches, very few cases have been reported. Happily, several new methods for efficient labeling studies of ROIs have been demonstrated successfully in recent years. Additionally, methods employed for the detection of ROIs by RNA modifying enzymes have also proved feasible. Several approaches, namely, phosphoramidite chemistry, in vitro transcription reactions, co-transcription reactions, chemical post-modification, RNA modifying enzymes, ligation, and other methods targeted at RNA labeling have been revealed in the past decades. To illustrate the most recent achievements, this review aims to summarize the most recent research in the field of synthesis of RNAs-of-interest bearing a variety of unnatural nucleosides, the subsequent RNA labeling research via biocompatible ligation, and beyond.

RNA在广泛的生理过程中起着关键作用。例如,众所周知,RNA在调节基因表达、细胞增殖和分化以及许多其他化学和生物过程中起着重要作用。然而,研究界仍然受到有限的方法的困扰,这些方法可以很容易地用于可视化特定的感兴趣rna (ROI)。有几种方法可以用来跟踪rna;这些主要依赖于生物学特性,即杂交、适体、报告蛋白和蛋白质结合。至于共价方法,报告的病例很少。令人高兴的是,近年来已经成功地证明了几种有效标记roi研究的新方法。此外,利用RNA修饰酶检测roi的方法也被证明是可行的。在过去的几十年里,已经发现了几种方法,即磷酸酰胺化学、体外转录反应、共转录反应、化学后修饰、RNA修饰酶、连接以及其他针对RNA标记的方法。为了说明最新的研究成果,本综述的目的是总结最新的研究领域的RNA的合成具有各种非天然核苷,随后的RNA标记研究通过生物相容性连接,以及其他。
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引用次数: 3
NAST: Nonadiabatic Statistical Theory Package for Predicting Kinetics of Spin-Dependent Processes 用于预测自旋相关过程动力学的非绝热统计理论包
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-02-24 DOI: 10.1007/s41061-022-00366-w
Vsevolod D. Dergachev, Mitra Rooein, Ilya D. Dergachev, Aleksandr O. Lykhin, Robert C. Mauban, Sergey A. Varganov

We present a nonadiabatic statistical theory (NAST) package for predicting kinetics of spin-dependent processes, such as intersystem crossings, spin-forbidden unimolecular reactions, and spin crossovers. The NAST package can calculate the probabilities and rates of transitions between the electronic states of different spin multiplicities. Both the microcanonical (energy-dependent) and canonical (temperature-dependent) rate constants can be obtained. Quantum effects, including tunneling, zero-point vibrational energy, and reaction path interference, can be accounted for. In the limit of an adiabatic unimolecular reaction proceeding on a single electronic state, NAST reduces to the traditional transition state theory. Because NAST requires molecular properties at only a few points on potential energy surfaces, it can be applied to large molecular systems, used with accurate high-level electronic structure methods, and employed to study slow nonadiabatic processes. The essential NAST input data include the nuclear Hessian at the reactant minimum, as well as the nuclear Hessians, energy gradients, and spin–orbit coupling at the minimum energy crossing point (MECP) between two states. The additional computational tools included in the NAST package can be used to extract the required input data from the output files of electronic structure packages, calculate the effective Hessian at the MECP, and fit the reaction coordinate for more advanced NAST calculations. We describe the theory, its implementation, and three examples of application to different molecular systems.

我们提出了一个非绝热统计理论(NAST)包来预测自旋相关过程的动力学,如系统间交叉、禁止自旋的单分子反应和自旋交叉。NAST包可以计算不同自旋多重度的电子态之间跃迁的概率和速率。微规范(能量相关)和规范(温度相关)速率常数都可以得到。量子效应,包括隧道效应、零点振动能和反应路径干涉,都可以被解释。在单电子态绝热单分子反应的极限下,NAST简化为传统的过渡态理论。由于NAST只需要势能表面上几个点的分子性质,因此它可以应用于大分子系统,与精确的高级电子结构方法一起使用,并用于研究缓慢的非绝热过程。基本的NAST输入数据包括反应物最小值处的核Hessian,以及两态之间最小能量交叉点(MECP)处的核Hessian、能量梯度和自旋轨道耦合。NAST包中包含的附加计算工具可用于从电子结构包的输出文件中提取所需的输入数据,计算MECP上的有效Hessian,并拟合反应坐标以进行更高级的NAST计算。我们描述了理论,它的实现,以及三个应用于不同分子系统的例子。
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引用次数: 5
Sonochemical Protocols for Heterocyclic Synthesis: A Representative Review 杂环合成的声化学方法:一个有代表性的综述
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-02-12 DOI: 10.1007/s41061-022-00369-7
Meena Devi, Rahul Singh, Jayant Sindhu, Ashwani Kumar, Sohan Lal, Ramesh Kumar, Khalid Hussain, Megha Sachdeva, Devender Singh, Parvin Kumar

In the present era of the industrial revolution, we all are familiar with ever-increasing environmental pollution released from various chemical processes. Chemical production has had a severe impact on the environment and human health. For the betterment of our environment, the chemical community has turned their interest to developing green, harmless and sustainable synthetic processes. To accomplish these goals of green chemistry, the extraordinary properties of sonication play an important role. It is well known that sonochemistry can make decisive contributions to creating high pressures of almost 1000 atm and very high temperatures in the range of 4500–5000 °C. The implementation of ultrasound in chemical transformations somehow fulfils the measures of green chemistry, as it reduces energy consumption, enhances product selectivity, and uses lesser amounts of hazardous chemicals and solvents. Furthermore, heterocyclic synthesis under ultrasonication offers several environmental and process-related advantages compared with conventional methods. The remarkable contribution of ultrasonics to the development of green and sustainable synthetic routes inspired us to write this article. Herein, we have discussed only some of the various synthetic methodologies developed for the construction of heterocyclic cores under ultrasonic irradiation, accompanied by mechanistic insights. In some cases, a comparison between sonochemical conditions and conventional conditions has also been investigated. We emphasized principally ‘up to date’ developments on various sono-accelerated chemical transformations comprising aza-Michael, aldol reactions, C–C couplings, oxidation, cycloadditions, multi-component reactions, etc. for the synthesis of heterocycles.

在工业革命的今天,我们都熟悉各种化学过程所产生的日益严重的环境污染。化学品生产对环境和人类健康产生了严重影响。为了改善我们的环境,化工界已经把他们的兴趣转向开发绿色、无害和可持续的合成工艺。为了实现绿色化学的这些目标,声学的非凡特性发挥了重要作用。众所周知,声化学可以在创造近1000 atm的高压和4500-5000°C的高温方面做出决定性的贡献。超声波在化学转化中的应用在某种程度上满足了绿色化学的要求,因为它减少了能源消耗,提高了产品的选择性,并且使用了较少的有害化学品和溶剂。此外,与传统方法相比,超声合成杂环具有许多环境和工艺方面的优势。超声波对绿色可持续合成路线发展的卓越贡献激发了我们写这篇文章。在这里,我们只讨论了一些不同的合成方法开发的建设杂环芯在超声照射下,伴随着机理的见解。在某些情况下,还研究了声化学条件与常规条件之间的比较。我们主要强调了各种声加速化学转化的“最新”进展,包括杂环合成的aza-Michael反应、醛醇反应、C-C偶联、氧化、环加成、多组分反应等。
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引用次数: 3
Bioactive Chitosan-Based Organometallic Scaffolds for Tissue Engineering and Regeneration 生物活性壳聚糖基有机金属支架用于组织工程和再生
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-02-12 DOI: 10.1007/s41061-022-00364-y
Solmaz Zakhireh, Jaleh Barar, Khosro Adibkia, Younes Beygi-Khosrowshahi, Marziyeh Fathi, Hossein Omidain, Yadollah Omidi

Captivating achievements in developing advanced hybrid biostructures through integrating natural biopolymers with inorganic materials (e.g., metals and metalloids) have paved the way towards the application of bioactive organometallic scaffolds (OMSs) in tissue engineering and regenerative medicine (TERM). Of various biopolymers, chitosan (CS) has been used widely for the development of bioactive OMSs, in large part due to its unique characteristics (e.g., biocompatibility, biodegradability, surface chemistry, and functionalization potential). In integration with inorganic elements, CS has been used to engineer advanced biomimetic matrices to accommodate both embedded cells and drug molecules and serve as scaffolds in TERM. The use of the CS-based OMSs is envisioned to provide a new pragmatic potential in TERM and even in precision medicine. In this review, we aim to elaborate on recent achievements in a variety of CS/metal, CS/metalloid hybrid scaffolds, and discuss their applications in TERM. We also provide comprehensive insights into the formulation, surface modification, characterization, biocompatibility, and cytotoxicity of different types of CS-based OMSs.

通过将天然生物聚合物与无机材料(如金属和类金属)相结合,在开发先进的杂交生物结构方面取得了令人瞩目的成就,这为生物活性有机金属支架(OMSs)在组织工程和再生医学(TERM)中的应用铺平了道路。在各种生物聚合物中,壳聚糖(CS)由于其独特的特性(如生物相容性、生物可降解性、表面化学和功能化潜力)被广泛用于开发生物活性的oms。在与无机元素的整合中,CS已被用于设计先进的仿生基质,以容纳嵌入的细胞和药物分子,并作为TERM的支架。基于cs的oms的使用有望在TERM甚至精准医学中提供新的实用潜力。本文综述了近年来CS/metal、CS/metalloid复合支架的研究进展,并对其在TERM中的应用进行了讨论。我们还提供了对不同类型的基于cs的oms的配方,表面改性,表征,生物相容性和细胞毒性的全面见解。
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引用次数: 6
Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold 1,2,4-三唑[3,4-b][1,3,4]噻二嗪支架的合成及药用研究进展
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-02-05 DOI: 10.1007/s41061-022-00365-x
Ranjana Aggarwal, Mona Hooda, Prince Kumar, Garima Sumran

The present review article strives to compile the latest synthetic approaches for the synthesis of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities, viz. anticancer, antimicrobial, analgesic and anti-inflammatory, antioxidant, antiviral, enzyme inhibitors (carbonic anhydrase inhibitors, cholinesterase inhibitors, alkaline phosphatase inhibitors, anti-lipase activity, and aromatase inhibitors) and antitubercular agents. The review focuses particularly on the structure–activity relationship of biologically important 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines, which have profound importance in drug design, discovery and development. In silico pharmacokinetic and molecular modeling studies have also been summarized. It is hoped that this review article will be of help to researchers engaged in the development of new biologically active entities for the rational design and development of new target-oriented 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine-based drugs for the treatment of multifunctional diseases.

Graphical Abstract

本文综述了三唑噻二嗪及其衍生物的最新合成方法,以及它们在抗癌、抗菌、镇痛、抗炎、抗氧化、抗病毒、酶抑制剂(碳酸酐酶抑制剂、胆碱酯酶抑制剂、碱性磷酸酶抑制剂、抗脂肪酶活性、芳香化酶抑制剂)和抗结核药物等方面的药理活性。综述了具有重要生物学意义的1,2,4-三唑[3,4-b][1,3,4]噻二嗪类化合物的构效关系,这些化合物在药物设计、发现和开发中具有重要意义。本文还对药物动力学和分子模型的研究进行了综述。希望本文综述能对从事新型生物活性物质开发的研究人员合理设计和开发以1,2,4-三唑[3,4-b][1,3,4]噻二嗪为基础的靶向治疗多功能疾病的新药物有所帮助。图形抽象
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引用次数: 6
Coupled- and Independent-Trajectory Approaches Based on the Exact Factorization Using the PyUNIxMD Package 基于PyUNIxMD包的精确分解的耦合和独立轨迹方法
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-01-27 DOI: 10.1007/s41061-021-00361-7
Tae In Kim, Jong-Kwon Ha, Seung Kyu Min

We present mixed quantum-classical approaches based on the exact factorization framework. The electron–nuclear correlation term in the exact factorization enables us to deal with quantum coherences by accounting for electronic and nuclear nonadiabatic couplings effectively within classical nuclei approximation. We compare coupled- and independent-trajectory approximations with each other to understand algorithms in description of the bifurcation of nuclear wave packets and the correct spatial distribution of electronic wave functions along with nuclear trajectories. Finally, we show numerical results for comparisons of coupled- and independent-trajectory approaches for the photoisomerization of a protonated Schiff base from excited state molecular dynamics (ESMD) simulations with the recently developed Python-based ESMD code, namely, the PyUNIxMD program.

我们提出了基于精确分解框架的混合量子经典方法。精确分解中的电子-核相关项使我们能够在经典核近似中有效地考虑电子和核的非绝热耦合来处理量子相干。我们将耦合轨迹近似和独立轨迹近似相互比较,以了解描述核波包分岔的算法以及电子波函数随核轨迹的正确空间分布。最后,我们展示了激发态分子动力学(ESMD)模拟中质子化希夫碱光异构化的耦合和独立轨迹方法与最近开发的基于python的ESMD代码(即PyUNIxMD程序)的比较数值结果。
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引用次数: 3
Review on Amphiphilic Ionic Liquids as New Surfactants: From Fundamentals to Applications 两亲性离子液体作为新型表面活性剂的研究进展:从基础到应用
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-11-29 DOI: 10.1007/s41061-021-00362-6
Mona Kharazi, Javad Saien, Simin Asadabadi

The demand for lowering interfacial tension (IFT) in different processes has persuaded researchers to use stable and resistant surfactants with low environmental impact. For this purpose, surface-active ionic liquids (SAILs) have attracted much attention owing to their good amphiphilic nature and prominent properties like recyclability and high performance under harsh conditions. This review initially explains how the IFT and critical micelle concentration of different systems vary in the presence of different SAILs with a variety of alkyl chain lengths, head groups, and counter anions. Towards this aim, some physicochemical properties of SAILs as well as the corresponding theoretical aspects of adsorption are considered. Then, recent advances in utilizing SAILs for reducing IFT of different chemical systems are surveyed. Relevantly, the role of important operating parameters of temperature, pH, presence of electrolytes, and the chemical nature of involved phases are adequately discussed. Further, an overview of different SAILs applications in stabilization, separation, and in petroleum industries is scrutinized. To allow better judgment, precise comparisons between different types of SAILs and conventional surfactants are provided. Finally, challenges and possible directions of future research on SAILs are highlighted.

降低不同工艺界面张力(IFT)的需求促使研究人员使用稳定、耐腐蚀、对环境影响小的表面活性剂。因此,表面活性离子液体(SAILs)因其良好的两亲性、可回收性和恶劣条件下的高性能等突出特性而备受关注。这篇综述首先解释了不同体系的IFT和临界胶束浓度在不同的烷基链长、头基和反阴离子存在下是如何变化的。为此,考虑了风帆的一些物理化学性质以及相应的吸附理论方面。然后,综述了利用风帆降低不同化学体系IFT的最新进展。相应的,对温度、pH值、电解质的存在以及所涉及相的化学性质等重要操作参数的作用进行了充分的讨论。此外,还详细介绍了风帆在稳定、分离和石油工业中的不同应用。为了做出更好的判断,提供了不同类型的风帆和常规表面活性剂之间的精确比较。最后,指出了未来研究面临的挑战和可能的方向。
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引用次数: 21
Ensemble Density Functional Theory of Neutral and Charged Excitations 中性和带电激励的系综密度泛函理论
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-11-26 DOI: 10.1007/s41061-021-00359-1
Filip Cernatic, Bruno Senjean, Vincent Robert, Emmanuel Fromager

Recent progress in the field of (time-independent) ensemble density-functional theory (DFT) for excited states are reviewed. Both Gross–Oliveira–Kohn (GOK) and N-centered ensemble formalisms, which are mathematically very similar and allow for an in-principle-exact description of neutral and charged electronic excitations, respectively, are discussed. Key exact results, for example, the equivalence between the infamous derivative discontinuity problem and the description of weight dependencies in the ensemble exchange-correlation density functional, are highlighted. The variational evaluation of orbital-dependent ensemble Hartree-exchange (Hx) energies is discussed in detail. We show in passing that state-averaging individual exact Hx energies can lead to severe (although solvable) v-representability issues. Finally, we explore the possibility of using the concept of density-driven correlation, which has been introduced recently and does not exist in regular ground-state DFT, for improving state-of-the-art correlation density-functional approximations for ensembles. The present review reflects the efforts of a growing community to turn ensemble DFT into a rigorous and reliable low-cost computational method for excited states. We hope that, in the near future, this contribution will stimulate new formal and practical developments in the field.

综述了激发态(时间无关)系综密度泛函理论(DFT)领域的最新进展。讨论了Gross-Oliveira-Kohn (GOK)和n中心系综形式,它们在数学上非常相似,并且分别允许对中性和带电电子激发进行原则上精确的描述。重点强调了关键的精确结果,例如臭名昭著的导数不连续问题与集成交换相关密度泛函中权重依赖描述之间的等价性。详细讨论了轨道相关系综Hartree-exchange (Hx)能量的变分计算。我们顺带表明,状态平均的个体精确Hx能量可能导致严重(尽管可解决)的v-可表征性问题。最后,我们探索了使用密度驱动相关概念的可能性,该概念最近被引入,并且不存在于规则基态DFT中,用于改进最先进的相关系综密度泛函近似。目前的综述反映了越来越多的群体将集合DFT转变为一种严格可靠的低成本激发态计算方法的努力。我们希望,在不久的将来,这一贡献将促进该领域新的正式和实际的发展。
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引用次数: 10
Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives 海藻酸盐基智能材料及其应用:最新进展与展望
IF 8.6 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-11-23 DOI: 10.1007/s41061-021-00360-8
Chandan Maity, Nikita Das

Nature produces materials using available molecular building blocks following a bottom-up approach. These materials are formed with great precision and flexibility in a controlled manner. This approach offers the inspiration for manufacturing new artificial materials and devices. Synthetic artificial materials can find many important applications ranging from personalized therapeutics to solutions for environmental problems. Among these materials, responsive synthetic materials are capable of changing their structure and/or properties in response to external stimuli, and hence are termed “smart” materials. Herein, this review focuses on alginate-based smart materials and their stimuli-responsive preparation, fragmentation, and applications in diverse fields from drug delivery and tissue engineering to water purification and environmental remediation. In the first part of this report, we review stimuli-induced preparation of alginate-based materials. Stimuli-triggered decomposition of alginate materials in a controlled fashion is documented in the second part, followed by the application of smart alginate materials in diverse fields. Because of their biocompatibility, easy accessibility, and simple techniques of material formation, alginates can provide solutions for several present and future problems of humankind. However, new research is needed for novel alginate-based materials with new functionalities and well-defined properties for targeted applications.

自然使用可用的分子构建块,遵循自下而上的方法生产材料。这些材料在可控的情况下以极高的精度和灵活性形成。这种方法为制造新的人工材料和设备提供了灵感。合成人工材料可以找到许多重要的应用,从个性化治疗到解决环境问题。在这些材料中,响应性合成材料能够根据外部刺激改变其结构和/或性能,因此被称为“智能”材料。本文综述了海藻酸盐智能材料及其刺激响应制备、碎片化及其在药物输送、组织工程、水净化和环境修复等领域的应用。在本报告的第一部分,我们回顾了海藻酸盐基材料的刺激诱导制备。刺激触发的海藻酸盐材料在受控方式的分解记录在第二部分,其次是智能海藻酸盐材料在不同领域的应用。由于海藻酸盐具有生物相容性、易获得性和简单的材料形成技术,可以为人类当前和未来的一些问题提供解决方案。然而,新的研究需要新的藻酸盐基材料,具有新的功能和明确的性质,为目标应用。
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引用次数: 27
期刊
Topics in Current Chemistry
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