Pub Date : 2021-02-05DOI: 10.1007/s41061-021-00324-y
Qi Xue, Zixuan Zhang, Bryan K. Y. Ng, Pu Zhao, Benedict T. W. Lo
This mini-review highlights some recent progress in the engineering of single-atom catalysts (SACs) through metal–organic frameworks (MOFs) and derivatives. The inherent molecular and chemical specificities within the MOFs and derivatives can offer stabilisation of the SACs with high atomic isolation and dispersion. As MOFs are often considered an infinite array of self-assembled molecular catalysts, specifically designed structures can provide further functionalities to suit the needs of different catalytic applications. In brief, we can divide the preparation approaches into three main categories: (1) fabrication onto functional groups of the ligands, (2) fabrication onto Lewis acid sites of nodal centres, and (3) synthesis via a pyrolysis-mediated technique. Through these approaches, strong metal–support interactions can be established to aid the fine-tuning of the catalytic properties. We also discuss how recent progress in the development of state-of-the-art microscopic, spectroscopic, and crystallographic techniques has enabled scientists to elucidate the structure–activity relationship.
{"title":"Recent Advances in the Engineering of Single-Atom Catalysts Through Metal–Organic Frameworks","authors":"Qi Xue, Zixuan Zhang, Bryan K. Y. Ng, Pu Zhao, Benedict T. W. Lo","doi":"10.1007/s41061-021-00324-y","DOIUrl":"https://doi.org/10.1007/s41061-021-00324-y","url":null,"abstract":"<p>This mini-review highlights some recent progress in the engineering of single-atom catalysts (SACs) through metal–organic frameworks (MOFs) and derivatives. The inherent molecular and chemical specificities within the MOFs and derivatives can offer stabilisation of the SACs with high atomic isolation and dispersion. As MOFs are often considered an infinite array of self-assembled molecular catalysts, specifically designed structures can provide further functionalities to suit the needs of different catalytic applications. In brief, we can divide the preparation approaches into three main categories: (1) fabrication onto functional groups of the ligands, (2) fabrication onto Lewis acid sites of nodal centres, and (3) synthesis via a pyrolysis-mediated technique. Through these approaches, strong metal–support interactions can be established to aid the fine-tuning of the catalytic properties. We also discuss how recent progress in the development of state-of-the-art microscopic, spectroscopic, and crystallographic techniques has enabled scientists to elucidate the structure–activity relationship.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00324-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4540902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, Mpro inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress.
{"title":"Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19","authors":"Dingzhong Li, Jianbing Hu, Dian Li, Weijun Yang, Shuang-Feng Yin, Renhua Qiu","doi":"10.1007/s41061-020-00318-2","DOIUrl":"https://doi.org/10.1007/s41061-020-00318-2","url":null,"abstract":"<p>COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, M<sup>pro</sup> inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00318-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4458976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-05DOI: 10.1007/s41061-020-00316-4
Imtiaz Khan, Aliya Ibrar, Sumera Zaib
{"title":"Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges","authors":"Imtiaz Khan, Aliya Ibrar, Sumera Zaib","doi":"10.1007/s41061-020-00316-4","DOIUrl":"https://doi.org/10.1007/s41061-020-00316-4","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00316-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4211557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.1007/s41061-020-00312-8
Mireia Buaki-Sogó, Laura García-Carmona, Mayte Gil-Agustí, Leire Zubizarreta, Marta García-Pellicer, Alfredo Quijano-López
This article consists of a review of the main concepts and paradigms established in the field of biological fuel cells or biofuel cells. The aim is to provide an overview of the current panorama, basic concepts, and methodologies used in the field of enzymatic biofuel cells, as well as the applications of these bio-systems in flexible electronics and implantable or portable devices. Finally, the challenges needing to be addressed in the development of biofuel cells capable of supplying power to small size devices with applications in areas related to health and well-being or next-generation portable devices are analyzed. The aim of this study is to contribute to biofuel cell technology development; this is a multidisciplinary topic about which review articles related to different scientific areas, from Materials Science to technology applications, can be found. With this article, the authors intend to reach a wide readership in order to spread biofuel cell technology for different scientific profiles and boost new contributions and developments to overcome future challenges.
{"title":"Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices","authors":"Mireia Buaki-Sogó, Laura García-Carmona, Mayte Gil-Agustí, Leire Zubizarreta, Marta García-Pellicer, Alfredo Quijano-López","doi":"10.1007/s41061-020-00312-8","DOIUrl":"https://doi.org/10.1007/s41061-020-00312-8","url":null,"abstract":"<p>This article consists of a review of the main concepts and paradigms established in the field of biological fuel cells or biofuel cells. The aim is to provide an overview of the current panorama, basic concepts, and methodologies used in the field of enzymatic biofuel cells, as well as the applications of these bio-systems in flexible electronics and implantable or portable devices. Finally, the challenges needing to be addressed in the development of biofuel cells capable of supplying power to small size devices with applications in areas related to health and well-being or next-generation portable devices are analyzed. The aim of this study is to contribute to biofuel cell technology development; this is a multidisciplinary topic about which review articles related to different scientific areas, from Materials Science to technology applications, can be found. With this article, the authors intend to reach a wide readership in order to spread biofuel cell technology for different scientific profiles and boost new contributions and developments to overcome future challenges.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00312-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5167162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-02DOI: 10.1007/s41061-020-00308-4
Sina Matavos-Aramyan, Sadaf Soukhakian, Mohammad Hossein Jazebizadeh
{"title":"Retraction Note to: Mononuclear Cu Complexes Based on Nitrogen Heterocyclic Carbene: A Comprehensive Review","authors":"Sina Matavos-Aramyan, Sadaf Soukhakian, Mohammad Hossein Jazebizadeh","doi":"10.1007/s41061-020-00308-4","DOIUrl":"https://doi.org/10.1007/s41061-020-00308-4","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00308-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4104310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-10DOI: 10.1007/s41061-020-00307-5
Nusrat Sahiba, Shikha Agarwal
{"title":"Recent Advances in the Synthesis of Perimidines and their Applications","authors":"Nusrat Sahiba, Shikha Agarwal","doi":"10.1007/s41061-020-00307-5","DOIUrl":"https://doi.org/10.1007/s41061-020-00307-5","url":null,"abstract":"","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00307-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4410078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-19DOI: 10.1007/s41061-020-00306-6
Daily Rodriguez-Padron, Md Ariful Ahsan, Mohamed Fathi Sanad, Rafael Luque, Alain R. Puente Santiago
In recent years, the incorporation of molecular enzymes into nanostructured frameworks to create efficient energy conversion biomaterials has gained increasing interest as a promising strategy owing to both the dynamic behavior of proteins for their electrocatalytic function and the unique properties of the synergistic interactions between proteins and nanosized materials. Herein, we review the impact of proteins on energy conversion fields and the contribution of proteins to the improved activity of the resulting nanocomposites. We address different strategies to fabricate protein-based nanocatalysts as well as current knowledge on the structure–function relationships of enzymes during the catalytic processes. Additionally, a comprehensive review of state-of-the-art bioelectrocatalytic materials for water-splitting reactions such as hydrogen evolution reaction (HER) and oxygen evolution reactions (OER) is afforded. Finally, we briefly envision opportunities to develop a new generation of electrocatalysts towards the electrochemical reduction of N2 to NH3 using theoretical tools to built nature-inspired nitrogen reduction reaction catalysts.
{"title":"Proteins-Based Nanocatalysts for Energy Conversion Reactions","authors":"Daily Rodriguez-Padron, Md Ariful Ahsan, Mohamed Fathi Sanad, Rafael Luque, Alain R. Puente Santiago","doi":"10.1007/s41061-020-00306-6","DOIUrl":"https://doi.org/10.1007/s41061-020-00306-6","url":null,"abstract":"<p>In recent years, the incorporation of molecular enzymes into nanostructured frameworks to create efficient energy conversion biomaterials has gained increasing interest as a promising strategy owing to both the dynamic behavior of proteins for their electrocatalytic function and the unique properties of the synergistic interactions between proteins and nanosized materials. Herein, we review the impact of proteins on energy conversion fields and the contribution of proteins to the improved activity of the resulting nanocomposites. We address different strategies to fabricate protein-based nanocatalysts as well as current knowledge on the structure–function relationships of enzymes during the catalytic processes. Additionally, a comprehensive review of state-of-the-art bioelectrocatalytic materials for water-splitting reactions such as hydrogen evolution reaction (HER) and oxygen evolution reactions (OER) is afforded. Finally, we briefly envision opportunities to develop a new generation of electrocatalysts towards the electrochemical reduction of N<sub>2</sub> to NH<sub>3</sub> using theoretical tools to built nature-inspired nitrogen reduction reaction catalysts.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00306-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4753737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C–H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2–C7 on the 8-aminoquinoline ring, which involves the formation of C–C and C–Z (Z?=?heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.
8-氨基喹啉是许多天然产物、功能材料和有用药物中常见的含氮杂环骨架。近年来,它作为一种强有力的双齿导向基团或配体助剂在碳-氢键激活/功能化领域得到了发展。在此背景下,取代8-氨基喹啉的合成具有重要意义。本文综述了8-氨基喹啉环上C2-C7位的官能化,包括在过渡金属催化剂、光催化剂或无金属条件下形成C-C和C-Z (Z =?杂原子)键。在大多数情况下,单电子转移(SET)途径被认为是可行的。
{"title":"Remote C–H Functionalization of 8-Aminoquinoline Ring","authors":"Zhihui Xu, Xiaogang Yang, Shuang-Feng Yin, Renhua Qiu","doi":"10.1007/s41061-020-00303-9","DOIUrl":"https://doi.org/10.1007/s41061-020-00303-9","url":null,"abstract":"<p>8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C–H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2–C7 on the 8-aminoquinoline ring, which involves the formation of C–C and C–Z (Z?=?heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00303-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4426659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-24DOI: 10.1007/s41061-020-00305-7
Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing
DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson–Crick hybridization properties. The DNA–protein conjugate with combined properties enables a broad range of applications, such as sensitive and selective bioassays, therapeutic agents, and building blocks for programmable nanoassemblies. In this review, we survey the conjugates from the aspects of conjugation chemistries as well as applications in biomedical and nanotechnology fields. We highlight the functions of both biological moieties of a conjugate for target binding and signal transduction in bioassays. We also review the use of DNA–protein conjugates for the construction of a variety of functional and dynamic nanostructures, from isolated hybrid cages to three-dimensional (3D) protein crystalline lattices. Moreover, these conjugates have been used as carriers to deliver enzymes or functional nucleic acids for disease treatments and gene editing.
{"title":"Engineering Functional DNA–Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications","authors":"Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing","doi":"10.1007/s41061-020-00305-7","DOIUrl":"https://doi.org/10.1007/s41061-020-00305-7","url":null,"abstract":"<p>DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson–Crick hybridization properties. The DNA–protein conjugate with combined properties enables a broad range of applications, such as sensitive and selective bioassays, therapeutic agents, and building blocks for programmable nanoassemblies. In this review, we survey the conjugates from the aspects of conjugation chemistries as well as applications in biomedical and nanotechnology fields. We highlight the functions of both biological moieties of a conjugate for target binding and signal transduction in bioassays. We also review the use of DNA–protein conjugates for the construction of a variety of functional and dynamic nanostructures, from isolated hybrid cages to three-dimensional (3D) protein crystalline lattices. Moreover, these conjugates have been used as carriers to deliver enzymes or functional nucleic acids for disease treatments and gene editing.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00305-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4944034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-07DOI: 10.1007/s41061-020-00302-w
Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular?MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.
{"title":"Magnetic Nanoparticles as MRI Contrast Agents","authors":"Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín","doi":"10.1007/s41061-020-00302-w","DOIUrl":"https://doi.org/10.1007/s41061-020-00302-w","url":null,"abstract":"<p>Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular?MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.</p>","PeriodicalId":54344,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-020-00302-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4315882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}