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Recent Advances in the Engineering of Single-Atom Catalysts Through Metal–Organic Frameworks 金属-有机骨架单原子催化剂工程研究进展
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2021-02-05 DOI: 10.1007/s41061-021-00324-y
Qi Xue, Zixuan Zhang, Bryan K. Y. Ng, Pu Zhao, Benedict T. W. Lo

This mini-review highlights some recent progress in the engineering of single-atom catalysts (SACs) through metal–organic frameworks (MOFs) and derivatives. The inherent molecular and chemical specificities within the MOFs and derivatives can offer stabilisation of the SACs with high atomic isolation and dispersion. As MOFs are often considered an infinite array of self-assembled molecular catalysts, specifically designed structures can provide further functionalities to suit the needs of different catalytic applications. In brief, we can divide the preparation approaches into three main categories: (1) fabrication onto functional groups of the ligands, (2) fabrication onto Lewis acid sites of nodal centres, and (3) synthesis via a pyrolysis-mediated technique. Through these approaches, strong metal–support interactions can be established to aid the fine-tuning of the catalytic properties. We also discuss how recent progress in the development of state-of-the-art microscopic, spectroscopic, and crystallographic techniques has enabled scientists to elucidate the structure–activity relationship.

本文综述了近年来利用金属-有机骨架及其衍生物制备单原子催化剂的研究进展。mof及其衍生物固有的分子和化学特性可以为sac提供高原子隔离和分散的稳定性。由于mof通常被认为是一种自组装分子催化剂的无限阵列,专门设计的结构可以提供进一步的功能,以满足不同催化应用的需要。简而言之,我们可以将制备方法分为三大类:(1)在配体官能团上制备,(2)在节点中心的路易斯酸位点上制备,(3)通过热解介导技术合成。通过这些方法,可以建立强金属支撑相互作用,以帮助微调催化性能。我们还讨论了最新的显微镜、光谱学和晶体学技术的发展如何使科学家能够阐明结构-活性关系。
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引用次数: 8
Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19 治疗新型冠状病毒肺炎的小分子生物活性、临床试验及合成进展综述
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2021-01-11 DOI: 10.1007/s41061-020-00318-2
Dingzhong Li, Jianbing Hu, Dian Li, Weijun Yang, Shuang-Feng Yin, Renhua Qiu

COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, Mpro inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress.

COVID-19在全球几乎所有国家迅速爆发,并已发展成为一场大流行。自COVID-19开始传播以来,许多科学家合作研究了大量的旧药物和新的临床试验药物,发现了具有抗COVID-19活性的强效药物,包括抗病毒药物、抗疟药、免疫抑制剂、中药、Mpro抑制剂、JAK抑制剂等。最常用的药物是抗病毒化合物、抗疟疾药物和JAK抑制剂。本文主要综述了抗疟药物氯喹和羟氯喹,抗病毒药物法匹拉韦和瑞德西韦,以及JAK抑制剂鲁索利替尼的生物活性、临床试验和合成进展。
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引用次数: 14
Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges 烷基酸盐作为过渡金属催化下多种杂环快速组装的多功能和强大的化学工具:最新进展和挑战
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2021-01-05 DOI: 10.1007/s41061-020-00316-4
Imtiaz Khan, Aliya Ibrar, Sumera Zaib
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引用次数: 4
Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices 酶法葡萄糖基生物电池:下一代设备的生物能源燃料
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-10-30 DOI: 10.1007/s41061-020-00312-8
Mireia Buaki-Sogó, Laura García-Carmona, Mayte Gil-Agustí, Leire Zubizarreta, Marta García-Pellicer, Alfredo Quijano-López

This article consists of a review of the main concepts and paradigms established in the field of biological fuel cells or biofuel cells. The aim is to provide an overview of the current panorama, basic concepts, and methodologies used in the field of enzymatic biofuel cells, as well as the applications of these bio-systems in flexible electronics and implantable or portable devices. Finally, the challenges needing to be addressed in the development of biofuel cells capable of supplying power to small size devices with applications in areas related to health and well-being or next-generation portable devices are analyzed. The aim of this study is to contribute to biofuel cell technology development; this is a multidisciplinary topic about which review articles related to different scientific areas, from Materials Science to technology applications, can be found. With this article, the authors intend to reach a wide readership in order to spread biofuel cell technology for different scientific profiles and boost new contributions and developments to overcome future challenges.

本文综述了生物燃料电池或生物燃料电池领域的主要概念和模式。目的是提供当前全景,基本概念和方法的概述,用于酶生物燃料电池领域,以及这些生物系统在柔性电子和植入式或便携式设备中的应用。最后,分析了在开发能够为小型设备供电的生物燃料电池中需要解决的挑战,这些设备应用于与健康和福祉有关的领域或下一代便携式设备。本研究旨在促进生物燃料电池技术的发展;这是一个多学科的主题,涉及不同科学领域的评论文章,从材料科学到技术应用,都可以找到。通过这篇文章,作者希望获得广泛的读者,以便将生物燃料电池技术推广到不同的科学领域,并促进新的贡献和发展,以克服未来的挑战。
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引用次数: 10
Retraction Note to: Mononuclear Cu Complexes Based on Nitrogen Heterocyclic Carbene: A Comprehensive Review 基于氮杂环卡宾的单核铜配合物:综述
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-09-02 DOI: 10.1007/s41061-020-00308-4
Sina Matavos-Aramyan, Sadaf Soukhakian, Mohammad Hossein Jazebizadeh
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引用次数: 2
Recent Advances in the Synthesis of Perimidines and their Applications 邻嘧啶类化合物的合成及其应用研究进展
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-08-10 DOI: 10.1007/s41061-020-00307-5
Nusrat Sahiba, Shikha Agarwal
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引用次数: 16
Proteins-Based Nanocatalysts for Energy Conversion Reactions 基于蛋白质的能量转化反应纳米催化剂
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-06-19 DOI: 10.1007/s41061-020-00306-6
Daily Rodriguez-Padron, Md Ariful Ahsan, Mohamed Fathi Sanad, Rafael Luque, Alain R. Puente Santiago

In recent years, the incorporation of molecular enzymes into nanostructured frameworks to create efficient energy conversion biomaterials has gained increasing interest as a promising strategy owing to both the dynamic behavior of proteins for their electrocatalytic function and the unique properties of the synergistic interactions between proteins and nanosized materials. Herein, we review the impact of proteins on energy conversion fields and the contribution of proteins to the improved activity of the resulting nanocomposites. We address different strategies to fabricate protein-based nanocatalysts as well as current knowledge on the structure–function relationships of enzymes during the catalytic processes. Additionally, a comprehensive review of state-of-the-art bioelectrocatalytic materials for water-splitting reactions such as hydrogen evolution reaction (HER) and oxygen evolution reactions (OER) is afforded. Finally, we briefly envision opportunities to develop a new generation of electrocatalysts towards the electrochemical reduction of N2 to NH3 using theoretical tools to built nature-inspired nitrogen reduction reaction catalysts.

近年来,由于蛋白质电催化功能的动态行为以及蛋白质与纳米材料之间协同作用的独特性质,将分子酶结合到纳米结构框架中以创造高效的能量转换生物材料作为一种有前途的策略受到越来越多的关注。在此,我们回顾了蛋白质对能量转换场的影响以及蛋白质对所得纳米复合材料活性提高的贡献。我们提出了不同的策略来制造基于蛋白质的纳米催化剂,以及在催化过程中酶的结构-功能关系的当前知识。此外,全面回顾了最先进的生物电催化材料的水分解反应,如析氢反应(HER)和析氧反应(OER)。最后,我们简要地展望了利用理论工具构建自然氮还原反应催化剂,开发新一代电化学还原N2到NH3的电催化剂的机会。
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引用次数: 4
Remote C–H Functionalization of 8-Aminoquinoline Ring 8-氨基喹啉环的远端碳氢功能化
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-06-10 DOI: 10.1007/s41061-020-00303-9
Zhihui Xu, Xiaogang Yang, Shuang-Feng Yin, Renhua Qiu

8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C–H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2–C7 on the 8-aminoquinoline ring, which involves the formation of C–C and C–Z (Z?=?heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.

8-氨基喹啉是许多天然产物、功能材料和有用药物中常见的含氮杂环骨架。近年来,它作为一种强有力的双齿导向基团或配体助剂在碳-氢键激活/功能化领域得到了发展。在此背景下,取代8-氨基喹啉的合成具有重要意义。本文综述了8-氨基喹啉环上C2-C7位的官能化,包括在过渡金属催化剂、光催化剂或无金属条件下形成C-C和C-Z (Z =?杂原子)键。在大多数情况下,单电子转移(SET)途径被认为是可行的。
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引用次数: 7
Engineering Functional DNA–Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications 用于生物传感、生物医学和纳米组装的工程功能dna -蛋白质偶联物
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-05-24 DOI: 10.1007/s41061-020-00305-7
Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing

DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson–Crick hybridization properties. The DNA–protein conjugate with combined properties enables a broad range of applications, such as sensitive and selective bioassays, therapeutic agents, and building blocks for programmable nanoassemblies. In this review, we survey the conjugates from the aspects of conjugation chemistries as well as applications in biomedical and nanotechnology fields. We highlight the functions of both biological moieties of a conjugate for target binding and signal transduction in bioassays. We also review the use of DNA–protein conjugates for the construction of a variety of functional and dynamic nanostructures, from isolated hybrid cages to three-dimensional (3D) protein crystalline lattices. Moreover, these conjugates have been used as carriers to deliver enzymes or functional nucleic acids for disease treatments and gene editing.

DNA和蛋白质是构成生命基础的最重要的两类生物大分子。使用交联化学将两者结合,可以实现分子识别、酶催化和沃森-克里克杂交特性的结合。具有组合特性的dna -蛋白质偶联物具有广泛的应用,例如敏感和选择性生物测定,治疗剂和可编程纳米组件的构建块。本文从缀合化学的角度对缀合物及其在生物医学和纳米技术领域的应用进行了综述。我们强调了在生物测定中结合靶标和信号转导的共轭物的两个生物部分的功能。我们还回顾了dna -蛋白质偶联物在构建各种功能和动态纳米结构中的应用,从分离的杂交笼到三维(3D)蛋白质晶体晶格。此外,这些缀合物已被用作递送酶或功能性核酸的载体,用于疾病治疗和基因编辑。
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引用次数: 21
Magnetic Nanoparticles as MRI Contrast Agents 磁性纳米颗粒作为MRI造影剂
IF 8.6 2区 化学 Q1 Chemistry Pub Date : 2020-05-07 DOI: 10.1007/s41061-020-00302-w
Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín

Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular?MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.

氧化铁纳米颗粒(IONPs)已成为磁共振成像(MRI)中传统造影剂(CAs)的有前途的替代品。由于具有较高的生物相容性和优异的磁性,它们作为CAs被广泛研究。此外,它们的表面易于与不同类型的配体(抗体,肽,糖等)功能化,从而开辟了进行分子MRI的可能性。因此,与上皮生长因子受体抗体、短肽(如RGD)或适体等一起功能化的IONPs已被提出用于诊断各种类型的癌症,包括乳腺癌、胃癌、结肠癌、肾癌、肝癌或脑癌。除了癌症诊断,不同类型的离子迁移蛋白已经被开发用于其他应用,如检测脑部炎症或血栓形成的早期诊断。本文综述了IONPs用于MRI应用的发展的关键方面,即无机核心的合成,使IONPs具有生物相容性的功能化过程,并将其靶向于特定的组织或细胞,最后是动物模型的体内研究,特别强调肿瘤模型。
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引用次数: 88
期刊
Topics in Current Chemistry
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