Neuroimage-Clinical最新文献

{"title":"Additive value of early-phase β-Amyloid-PET for the differential diagnosis of non-Alzheimer’s disease dementia","authors":"Sebastian Eckenweber ,&nbsp;Friederike Völter ,&nbsp;Nicolai Franzmeier ,&nbsp;Carla Palleis ,&nbsp;Olivia Wagemann ,&nbsp;Endy Weidinger ,&nbsp;Sabrina Katzdobler ,&nbsp;Elisabeth Wlasich ,&nbsp;Katja Sandkühler ,&nbsp;Guido Böning ,&nbsp;Johannes Gnörich ,&nbsp;Maximilian Scheifele ,&nbsp;Florian Eckenweber ,&nbsp;Daniel Janowitz ,&nbsp;Carolin Kurz ,&nbsp;Robert Perneczky ,&nbsp;Katharina Bürger ,&nbsp;Adrian Danek ,&nbsp;Günter Höglinger ,&nbsp;Johannes Levin ,&nbsp;Sonja Schönecker","doi":"10.1016/j.nicl.2026.103963","DOIUrl":"10.1016/j.nicl.2026.103963","url":null,"abstract":"<div><h3>Purpose</h3><div>Recent studies demonstrated strong agreement between early-phase β-amyloid-PET perfusion imaging and glucose hypometabolism assessed by [¹⁸F]FDG-PET, indicating the potential of early-phase β-amyloid-PET as a surrogate biomarker of neuronal injury. We therefore aimed to investigate the additive value of early-phase β-amyloid-PET for the differential diagnosis of non-Alzheimer’s disease dementia syndromes in clinical routine.</div></div><div><h3>Materials and methods</h3><div>[¹⁸F]florbetaben- and [¹⁸F]flutemetamol-PET scans (n = 379) performed between July 2013 and July 2021 were analyzed for their amyloid status and the presence of a neurodegenerative hypoperfusion pattern using visual assessment and z-score maps. In patients visually rated as amyloid-negative/neurodegeneration-positive (A-N+), the most likely diagnosis based on perfusion patterns was compared to the final clinical diagnosis, i.e. frontotemporal dementia or psychiatric disorders, suspected 4R-tauopathy, and suspected non-Alzheimer pathophysiology. Logistic regression models based on a data-driven selection of cerebral regions of hypoperfusion by principal component analysis were used to predict neurodegenerative disease and clinical diagnoses. Diagnostic accuracy was compared between visual assessment and the regression models.</div></div><div><h3>Results</h3><div>Neurodegeneration status was correctly identified in 78.8% (119/151) of amyloid-negative patients through visual rating, compared to 67.5% (102/151) using logistic regression. Visual assessment assigned 75.3% (67/89) of A-N+ patients to the correct diagnostic category. In contrast, the regression model classified 69.7% (62/89) of patients.</div></div><div><h3>Conclusions</h3><div>The current study demonstrates an additive value of early-phase β-amyloid-PET for the differential diagnosis of dementia syndromes. While visual assessment of early-phase β-amyloid-PET already provides substantial diagnostic accuracy, a data-driven analysis approach could aid in cases of uncertainty.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103963"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural network topology and cognitive control in very preterm born young adults","authors":"Merle J. Marek ,&nbsp;Dieter Wolke ,&nbsp;Christian Sorg ,&nbsp;Jil Wendt ,&nbsp;Aurore Menegaux ,&nbsp;Dennis Hedderich ,&nbsp;Peter Bartmann ,&nbsp;Micha Burkhardt ,&nbsp;Andrea Hildebrandt ,&nbsp;Axel Heep","doi":"10.1016/j.nicl.2026.103952","DOIUrl":"10.1016/j.nicl.2026.103952","url":null,"abstract":"<div><div>This study investigates the long-term effects of very preterm (VPT) birth (&lt;32 weeks of gestation) on cognitive control and structural brain network topology. Data were obtained from 61 very VPT and 79 full term (FT) individuals aged 26 years, who participated in the prospective Bavarian Longitudinal Study since birth (BLS, <span><span>https://www.bayerische-entwicklungsstudie.de</span><svg><path></path></svg></span>). Cognitive control ability was estimated through a multi-group confirmatory factor analysis, while the structural topology of the cognitive control brain network was analysed through diffusion-weighted magnetic resonance imaging, tractography, and graph-theoretic analysis. Brain-behaviour associations were further examined using structural equation modelling. Consistent with expectations, we observed significant group differences in cognitive control, especially in a latent <em>speed of cognitive control</em> factor, with FT individuals scoring 0.742 standard deviations higher than the VPT group (<em>p</em> = 0.001). This was statistically confirmed by a model comparison in the multi-group framework. Additionally, the VPT group exhibited lower structural network integration, as indicated by reduced global efficiency and average degree of the cognitive control brain network. Contrary to our hypothesis, we found no group differences in network segregation (average clustering coefficient), and structural network characteristics were not significantly associated with latent cognitive control. These findings indicate cognitive control deficits and reduced structural brain network integration in adulthood for VPT individuals and underscores the need for ongoing support and intervention to mitigate the lasting neurodevelopmental impacts of preterm birth.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103952"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of transcranial random noise stimulation on excitation/inhibition balance in ADHD","authors":"Ornella Dakwar-Kawar ,&nbsp;Amal Jude Ashwin Francis ,&nbsp;Renu Arya ,&nbsp;Noam Mairon ,&nbsp;Jyoti Mishra ,&nbsp;Itai Berger ,&nbsp;Roi Cohen Kadosh ,&nbsp;Pragathi Priyadharsini Balasubramani ,&nbsp;Mor Nahum","doi":"10.1016/j.nicl.2025.103923","DOIUrl":"10.1016/j.nicl.2025.103923","url":null,"abstract":"<div><h3>Background</h3><div>Children with attention-deficit/hyperactivity disorder (ADHD) often show aberrant neural activity, including excitation/inhibition (E/I) imbalances, atypical event-related potentials (ERPs), and neural network dysfunction. Transcranial Random Noise Stimulation (tRNS) has shown promise in modulating neural activity in ADHD.</div></div><div><h3>Methods</h3><div>The current study examined differences in behavioral and EEG signals recorded during an inhibitory control task in children with (N = 23) and without (N = 33) ADHD. Changes in these signals were further assessed following a combined tRNS and cognitive training intervention targeting the right inferior frontal gyrus and left dorsolateral prefrontal cortex in a sham-controlled randomized trial within the ADHD group only (n = 11 and 12 for intervention and sham groups, respectively).</div></div><div><h3>Results</h3><div>At baseline, children with ADHD showed slower reaction times, and higher commission error rates compared to healthy controls. Neurally, they exhibited elevated EEG aperiodic exponents, indicating lower E/I balance. Following intervention, we found slower task speed but fewer omission errors in the active compared to the sham group. Regression model showed reduced aperiodic exponents (β = –1.13, t(21) = –2.45, p = 0.023), decreased late ERP-P3b amplitude, and diminished theta and alpha band activity at the cortical level. There was a weaker but still significant reduction in aperiodic exponent values at follow-up compared to immediately post-treatment (β = 0.485, t(63) = 2.182, p = 0.033).</div></div><div><h3>Conclusion</h3><div>Aperiodic exponent may serve as a useful indicator of treatment-related neural modulation and may provide complementary information to traditional ERP and event-related spectral perturbation <em>(</em>ERSP) measures, warranting further investigation in larger samples.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103923"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive adaptations for memory deficits in MCI and AD patients: A meta-analysis of EEG microstates","authors":"Timothy Piton ,&nbsp;Una Smailovic ,&nbsp;Vesna Jelic ,&nbsp;Thomas Koenig ,&nbsp;Paul G. Unschuld ,&nbsp;Lucie Bréchet","doi":"10.1016/j.nicl.2025.103929","DOIUrl":"10.1016/j.nicl.2025.103929","url":null,"abstract":"<div><h3>Aim</h3><div>EEG microstate analysis enables the exploration of the brain’s neuronal network activity associated with distinct mental states and cognitive functions in neurodegenerative conditions, such as Alzheimer’s disease (AD). Some studies indicated that AD and patients with mild cognitive impairments (MCI) show a reduced presence of microstate C, which is related to self-related memory functions and mind-wandering and involves brain areas of the default mode network (DMN). However, other studies reported an increased presence of microstate A, which is associated with auditory/language functions. Here, we aimed to systematically investigate alterations in the four canonical EEG microstates (A, B, C, and D) in MCI and AD patients compared to healthy older adults.</div></div><div><h3>Methods</h3><div>We performed a meta-analysis that compared microstate temporal parameters − mean duration, occurrence rate, and time coverage − among MCI and AD patients and healthy older adults. We included 12 experimental studies that examined resting-state, eyes-closed EEG microstate parameters in 1347 participants (448 MCI patients, 514 AD patients, and 385 healthy controls).</div></div><div><h3>Results</h3><div>We found that<!--> <!-->AD patients showed increased duration and time coverage of microstate A and increased duration of microstate B, while the occurrence of microstates C and D was reduced. MCI patients also exhibited increased duration, occurrence, and time coverage of microstate A, while all three parameters of microstate D were reduced compared to healthy controls.</div></div><div><h3>Conclusion</h3><div>These results suggest that MCI and AD patients suffer from disruption in their cognitive control, memory, and self-referential processes. They may compensate for these deficits by verbalizing and visualizing their inner thoughts to maintain cognitive engagement.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103929"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural progression of glioma enhances functional connection with the cerebral cortex through synaptogenesis","authors":"Jiacheng Lai ,&nbsp;Yan Bai ,&nbsp;Hongbo Bao ,&nbsp;Shuai Wu ,&nbsp;Xinyu Wang ,&nbsp;Xia Liang ,&nbsp;Peng Liang","doi":"10.1016/j.nicl.2026.103942","DOIUrl":"10.1016/j.nicl.2026.103942","url":null,"abstract":"<div><h3>Objectives</h3><div>Understanding the progression mechanisms of glioma holds significant implications for improving clinical management. However, the natural progression patterns of glioma remain poorly understood due to the lack of longitudinal clinical samples from untreated patients.</div></div><div><h3>Materials and methods</h3><div>In this study, we systematically explored the natural progression trajectory of glioma by combining functional magnetic resonance imaging (fMRI) analysis of 24 rare multifocal glioma patients with bioinformatic analysis of single-cell RNA sequencing (scRNA-seq) data obtained from tumor samples of glioma mouse with early, mid, and endpoint lesions.</div></div><div><h3>Results</h3><div>We discovered that larger tumors in multifocal gliomas exhibit stronger functional connectivity with the cerebral cortex and higher degree centrality within brain networks. ScRNA-seq of longitudinal mouse glioma samples revealed progressive activation of synaptic organization and associated regulatory pathways during the natural progression of glioma.</div></div><div><h3>Conclusion</h3><div>Our multimodal, cross-scale study demonstrates that the natural progression pattern of glioma macroscopically manifests as functional hyperconnectivity with the cerebral cortex, which is supported by microscale molecular programs driving synaptogenesis. These findings elucidate the characteristics and mechanisms underlying glioma natural progression.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103942"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis","authors":"Ava J. White ,&nbsp;Jennifer L. Robinson ,&nbsp;Alan E. Wilson ,&nbsp;Meredith A. Reid","doi":"10.1016/j.nicl.2026.103959","DOIUrl":"10.1016/j.nicl.2026.103959","url":null,"abstract":"<div><div>Major Depressive Disorder (MDD) diagnoses have drastically increased in the United States from 6.5% to 21–30% since 2019, burdening individuals and society alike. Despite considerable efforts to understand the pathogenesis of MDD, the heterogeneity of the disorder has made it difficult to delineate its underpinnings, highlighting the need for biomarker identification. This study assessed the concentrations of key neurometabolites in the anterior cingulate cortex (ACC) in people with MDD (average n = 496) compared to healthy controls (average n = 404). We conducted a systematic review that ultimately led to the inclusion of n = 43 proton magnetic resonance spectroscopy (¹H-MRS) studies for <em>meta</em>-analysis. Average concentrations of eight neurometabolites were compared using a random effects model. We found that subjects with MDD had significantly decreased N-acetylaspartate (NAA; Hedges’ <em>g</em> = -0.16, 95% CI −0.299 to −0.030, p = 0.017), and gamma-aminobutyric acid (GABA; Hedges’ <em>g</em> = -0.26, 95% CI −0.434 to −0.082, p = 0.004), and increased levels of glutamine (Gln; Hedges’ <em>g</em> = 0.21, 95% CI 0.105 to 0.311, p &lt; 0.001) in the ACC. Subgroup analyses suggested significantly increased NAA detected by magnets stronger than 1.5 Tesla only, glutamate (Glu) in the dorsal ACC only and significantly increased myo-inositol (mI) and choline (Cho) in exclusively unmedicated subjects. This study provides a summative picture of the neurometabolic profile of the ACC in people with MDD and provides a foundation for the development of biomarker-based diagnostic criteria and novel pharmacological treatments.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103959"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating tDCS-induced electric fields in stroke patients: Realistic-lesion head models are needed","authors":"Ikko Kimura ,&nbsp;Marcus Meinzer ,&nbsp;Daria Antonenko ,&nbsp;Robert Darkow ,&nbsp;Agnes Flöel ,&nbsp;Axel Thielscher","doi":"10.1016/j.nicl.2025.103931","DOIUrl":"10.1016/j.nicl.2025.103931","url":null,"abstract":"<div><h3>Introduction</h3><div>Transcranial direct current stimulation (tDCS) is tested as tool for post-stroke rehabilitation in aphasia, and individualized simulations of tDCS-induced electric fields (E-fields) can guide its application. However, the accuracy of simulations is challenged by complex and variable tissue properties of stroke lesions. Here, we assessed the impact of stroke lesions on tDCS-induced E-fields realistically in terms of lesion size, shape, and conductivity.</div></div><div><h3>Methods</h3><div>Structural and diffusion MRI datasets of stroke patients with aphasia (n = 13, six females, age = 38–70 years) and age-matched healthy controls (n = 13, eight females, age = 24–76 years) from a previous study were analyzed. Simulated E-fields were first compared between healthy head models with and without artificial lesions homogenously filled with cerebrospinal fluid. Then, the effects of lesion heterogeneity were tested by comparing E-fields for models of stroke patients with homogenous versus inhomogeneous (realistic) lesion conductivity informed by diffusion-to-conductivity mapping.</div></div><div><h3>Results</h3><div>Adding artificial lesions to healthy head models altered the E-field strengths (|E|) near the target region-of-interest (ROI) by up to 47%. Diffusion-to-conductivity mapping revealed substantial variability in lesion conductivities within and across patients. Modifying homogenous to realistic lesion models showed mostly small to moderate |E| differences within the ROI depending on montage type, lesion size, and lesion-to-target distance.</div></div><div><h3>Conclusion</h3><div>Stroke lesions affect tDCS-induced E-fields with substantial variability across montages and individuals. These findings support the use of head models that include realistic representations of the shape, size and conductivity of the lesions to improve the accuracy of individualized tDCS simulations and guide personalized stimulation protocols in stroke rehabilitation.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103931"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of acute blood biomarkers with diffusion tensor imaging and outcome in patients with traumatic brain injury presenting with GCS of 13–15","authors":"Malla Mononen ,&nbsp;Mehrbod Mohammadian ,&nbsp;Iftakher Hossain ,&nbsp;Timo Roine ,&nbsp;Olli Tenovuo ,&nbsp;Kaj Blennow ,&nbsp;Jessica Gill ,&nbsp;Mark van Gils ,&nbsp;Peter Hutchinson ,&nbsp;Teemu M. Luoto ,&nbsp;Henna-Riikka Maanpää ,&nbsp;David K. Menon ,&nbsp;Virginia F.J. Newcombe ,&nbsp;Rahul Raj ,&nbsp;Jean-Charles Sanchez ,&nbsp;Riikka S.K. Takala ,&nbsp;Jussi Tallus ,&nbsp;Henrik Zetterberg ,&nbsp;Jussi P. Posti","doi":"10.1016/j.nicl.2025.103934","DOIUrl":"10.1016/j.nicl.2025.103934","url":null,"abstract":"<div><div>The aim of the study was to assess the association between blood-based biomarkers of different cellular origins and later white matter integrity, measured using post-acute diffusion tensor metrics, and their relation to outcome in patients presenting with Glasgow Coma Scale of 13–15 after traumatic brain injury (TBI).</div><div>Admission plasma samples for glial fibrillary acidic protein (GFAP), interleukin 10 (IL-10), heart fatty-acid binding protein (H-FABP), S100 calcium-binding protein B (S100B), total tau (T-tau), and amyloid beta 40 and 42 (Aβ40 and Aβ42) were taken for 92 patients. Diffusion-weighted magnetic resonance imaging (DW-MRI) and outcome evaluation was done ≥ 90 days post-injury. Outcome was assessed using Glasgow Outcome Scale-Extended (GOSE) and dichotomized as complete (GOSE 8) and incomplete (GOSE &lt; 8) recovery. Mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from the skeletonized white matter tracts of the whole brain.</div><div>IL-10 and T-tau showed significant weak-moderate negative correlations with FA, and significant positive correlations with MD and RD in incompletely recovered patients. GFAP showed significant weak positive correlations with MD and RD, while its correlation with FA was slightly below significance threshold after correction for multiple comparison in incompletely recovered patients. Similar trends were observed in the whole cohort and in the CT-positive cohort, although these did not reach statistical significance.</div><div>Higher acute levels of GFAP, IL-10 and T-tau may be associated with the development of axonal injury. If validated in future studies, these biomarkers may help identify patients who require closer follow-up and DW-MRI.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103934"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the self to the world: resting-state functional connectivity of the temporoparietal junction in post-traumatic stress disorder and its dissociative subtype","authors":"Sandhya Narikuzhy ,&nbsp;Sherain Harricharan ,&nbsp;Daniela Rabellino ,&nbsp;Maria Densmore ,&nbsp;Jean Théberge ,&nbsp;Jonathan Lieberman ,&nbsp;Margaret C. McKinnon ,&nbsp;Andrew A. Nicholson ,&nbsp;Ruth A. Lanius","doi":"10.1016/j.nicl.2025.103920","DOIUrl":"10.1016/j.nicl.2025.103920","url":null,"abstract":"<div><h3>Background</h3><div>The temporoparietal junction (TPJ) is a cross-network hub involved in social cognition and attention, processes which are directly impacted by symptoms observed in clinical profiles of post-traumatic stress disorder (PTSD) and its dissociative subtype (PTSD + DS).</div></div><div><h3>Methods</h3><div>Using SPM12 and CONN, seed-based TPJ resting-state functional connectivity patterns were analyzed in individuals with PTSD (<em>n</em> = 81), PTSD + DS (<em>n</em> = 49), and healthy controls (<em>n</em> = 54) using four seeds [right anterior TPJ (raTPJ), left anterior TPJ (laTPJ), right posterior TPJ (rpTPJ), left posterior TPJ (lpTPJ)]. Post-hoc graph theoretical analyses were performed for raTPJ connectivity in PTSD + DS and healthy controls.</div></div><div><h3>Results</h3><div>As compared to healthy controls, PTSD + DS showed decreased raTPJ functional connectivity with critical anterior frontal lobe nodes involved in the ventral attention and social cognition networks (i.e., left ventrolateral and dorsomedial prefrontal cortices). PTSD showed decreased lpTPJ functional connectivity with the left superior parietal lobule as compared to healthy controls. When comparing PTSD to PTSD + DS, we observed increased bilateral TPJ functional connectivity with the cerebellum. Lastly, compared to healthy controls, both PTSD and PTSD + DS displayed decreased bilateral TPJ functional connectivity with the occipital lobe. Graph theoretical analyses revealed that PTSD + DS showed limited raTPJ involvement and instead more efficient neural communication between occipital lobe and frontal lobe structures as compared to healthy controls, suggesting a possible compensatory neural network in PTSD + DS.</div></div><div><h3>Conclusions</h3><div>These findings reveal disruptions in TPJ neural circuitry in PTSD and PTSD + DS, which may carry cascading effects on intersecting neural networks involving the TPJ. Implications for psychotherapeutic treatments targeting disembodiment and social cognition are discussed.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103920"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of perinatal asphyxia on cortical activity in two-year-old children","authors":"Sebastian König ,&nbsp;Anna Tuiskula ,&nbsp;Marjo Metsäranta ,&nbsp;Susanna Stjerna ,&nbsp;Emma Saure ,&nbsp;Leena Haataja ,&nbsp;Sampsa Vanhatalo ,&nbsp;Anton Tokariev","doi":"10.1016/j.nicl.2025.103933","DOIUrl":"10.1016/j.nicl.2025.103933","url":null,"abstract":"<div><div>Perinatal asphyxia can lead to clinical hypoxic-ischemic encephalopathy (HIE) associated with high morbidity and mortality, but less is known about long-lasting effects of perinatal asphyxia alone (PA). Here, we investigate how PA with versus without clinical HIE affects cortical activity networks at two years of age. Electroencephalographic (EEG) recordings were acquired during sleep from three cohorts of children (PA only (n = 10), PA with mild to moderate HIE (n = 8), and healthy controls (n = 37)), and we assessed the group differences in local cortical function and cortico-cortical networks. Compared with the healthy controls, both PA and HIE were linked to reduced frequency-specific amplitudes. In two-year-old children with PA, the amplitude-related networks were stronger at low frequencies and weaker at higher frequencies, however, two-year-olds with HIE showed decreased connectivity at all frequencies. Likewise, phase-related networks in children with PA were stronger at lower frequencies and weaker at higher frequencies. Local phase-amplitude coupling was affected by PA or HIE in only a few cortical regions. Our findings suggest that PA, even without clinical HIE, may be associated with long-lasting changes to both local cortical activity and the large-scale cortical networks, which could potentially affect normal brain functions.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"49 ","pages":"Article 103933"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}