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IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

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IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01

引用次数: 0

Simulating tDCS-induced electric fields in stroke patients: Realistic-lesion head models are needed 模拟脑卒中患者tdcs诱导的电场：需要真实病变头部模型。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103931

Ikko Kimura , Marcus Meinzer , Daria Antonenko , Robert Darkow , Agnes Flöel , Axel Thielscher

Introduction

Transcranial direct current stimulation (tDCS) is tested as tool for post-stroke rehabilitation in aphasia, and individualized simulations of tDCS-induced electric fields (E-fields) can guide its application. However, the accuracy of simulations is challenged by complex and variable tissue properties of stroke lesions. Here, we assessed the impact of stroke lesions on tDCS-induced E-fields realistically in terms of lesion size, shape, and conductivity.

Methods

Structural and diffusion MRI datasets of stroke patients with aphasia (n = 13, six females, age = 38–70 years) and age-matched healthy controls (n = 13, eight females, age = 24–76 years) from a previous study were analyzed. Simulated E-fields were first compared between healthy head models with and without artificial lesions homogenously filled with cerebrospinal fluid. Then, the effects of lesion heterogeneity were tested by comparing E-fields for models of stroke patients with homogenous versus inhomogeneous (realistic) lesion conductivity informed by diffusion-to-conductivity mapping.

Results

Adding artificial lesions to healthy head models altered the E-field strengths (|E|) near the target region-of-interest (ROI) by up to 47%. Diffusion-to-conductivity mapping revealed substantial variability in lesion conductivities within and across patients. Modifying homogenous to realistic lesion models showed mostly small to moderate |E| differences within the ROI depending on montage type, lesion size, and lesion-to-target distance.

Conclusion

Stroke lesions affect tDCS-induced E-fields with substantial variability across montages and individuals. These findings support the use of head models that include realistic representations of the shape, size and conductivity of the lesions to improve the accuracy of individualized tDCS simulations and guide personalized stimulation protocols in stroke rehabilitation.

前言：经颅直流电刺激（Transcranial direct current stimulation, tDCS）作为脑卒中后失语症康复的工具进行了试验，tDCS诱导电场（E-fields）的个体化模拟可以指导其应用。然而，模拟的准确性受到脑卒中病变复杂多变的组织特性的挑战。在这里，我们评估了脑卒中病变对tdcs诱导的电场的影响，包括病变的大小、形状和电导率。方法：对既往研究的脑卒中失语患者（n = 13, 6例女性，年龄38 ~ 70岁）和年龄匹配的健康对照（n = 13, 8例女性，年龄24 ~ 76岁）的结构和扩散MRI数据集进行分析。首先比较有和没有均匀填充脑脊液的人工病变的健康头部模型的模拟电场。然后，通过比较具有均匀和不均匀（真实）病变电导率的脑卒中患者模型的电场，通过弥散-电导率映射来测试病变异质性的影响。结果：在健康头部模型上添加人工病变，可使目标感兴趣区域（ROI）附近的电场强度（|E|）提高47%。弥散-电导率成像显示了患者内部和患者之间病变电导率的显著差异。根据蒙太奇类型、病变大小和病变到目标的距离，将同质病变模型修改为真实病变模型，在ROI内显示小到中等的|E|差异。结论：脑卒中损害影响tdcs诱导的电场，在蒙太奇和个体之间存在显著差异。这些发现支持使用包括病变形状、大小和电导率的真实表征的头部模型来提高个体化tDCS模拟的准确性，并指导中风康复中的个性化刺激方案。

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引用次数: 0

Association of acute blood biomarkers with diffusion tensor imaging and outcome in patients with traumatic brain injury presenting with GCS of 13–15 急性血液生物标志物与弥散张量成像与外伤性脑损伤GCS患者预后的关系

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103934

Malla Mononen , Mehrbod Mohammadian , Iftakher Hossain , Timo Roine , Olli Tenovuo , Kaj Blennow , Jessica Gill , Mark van Gils , Peter Hutchinson , Teemu M. Luoto , Henna-Riikka Maanpää , David K. Menon , Virginia F.J. Newcombe , Rahul Raj , Jean-Charles Sanchez , Riikka S.K. Takala , Jussi Tallus , Henrik Zetterberg , Jussi P. Posti

The aim of the study was to assess the association between blood-based biomarkers of different cellular origins and later white matter integrity, measured using post-acute diffusion tensor metrics, and their relation to outcome in patients presenting with Glasgow Coma Scale of 13–15 after traumatic brain injury (TBI).

Admission plasma samples for glial fibrillary acidic protein (GFAP), interleukin 10 (IL-10), heart fatty-acid binding protein (H-FABP), S100 calcium-binding protein B (S100B), total tau (T-tau), and amyloid beta 40 and 42 (Aβ40 and Aβ42) were taken for 92 patients. Diffusion-weighted magnetic resonance imaging (DW-MRI) and outcome evaluation was done ≥ 90 days post-injury. Outcome was assessed using Glasgow Outcome Scale-Extended (GOSE) and dichotomized as complete (GOSE 8) and incomplete (GOSE < 8) recovery. Mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from the skeletonized white matter tracts of the whole brain.

IL-10 and T-tau showed significant weak-moderate negative correlations with FA, and significant positive correlations with MD and RD in incompletely recovered patients. GFAP showed significant weak positive correlations with MD and RD, while its correlation with FA was slightly below significance threshold after correction for multiple comparison in incompletely recovered patients. Similar trends were observed in the whole cohort and in the CT-positive cohort, although these did not reach statistical significance.

Higher acute levels of GFAP, IL-10 and T-tau may be associated with the development of axonal injury. If validated in future studies, these biomarkers may help identify patients who require closer follow-up and DW-MRI.

该研究的目的是评估不同细胞来源的血液生物标志物与后来白质完整性之间的关系，使用急性后弥散张量测量，以及它们与创伤性脑损伤（TBI）后格拉斯哥昏迷评分为13-15的患者预后的关系。92例患者取入院血浆中胶质原纤维酸性蛋白（GFAP）、白细胞介素10 （IL-10）、心脏脂肪酸结合蛋白（H-FABP）、S100钙结合蛋白B （S100B）、总tau蛋白（T-tau）、淀粉样蛋白β40和β42 （Aβ40和Aβ42）。损伤后≥90天进行弥散加权磁共振成像（DW-MRI）和预后评估。使用格拉斯哥结局量表扩展（GOSE）评估结果，并将其分为完整（GOSE 8）和不完整（GOSE）

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引用次数: 0

Bridging the self to the world: resting-state functional connectivity of the temporoparietal junction in post-traumatic stress disorder and its dissociative subtype 连接自我与世界：创伤后应激障碍及其分离亚型中颞顶连接的静息状态功能连接。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103920

Sandhya Narikuzhy , Sherain Harricharan , Daniela Rabellino , Maria Densmore , Jean Théberge , Jonathan Lieberman , Margaret C. McKinnon , Andrew A. Nicholson , Ruth A. Lanius

Background

The temporoparietal junction (TPJ) is a cross-network hub involved in social cognition and attention, processes which are directly impacted by symptoms observed in clinical profiles of post-traumatic stress disorder (PTSD) and its dissociative subtype (PTSD + DS).

Methods

Using SPM12 and CONN, seed-based TPJ resting-state functional connectivity patterns were analyzed in individuals with PTSD (n = 81), PTSD + DS (n = 49), and healthy controls (n = 54) using four seeds [right anterior TPJ (raTPJ), left anterior TPJ (laTPJ), right posterior TPJ (rpTPJ), left posterior TPJ (lpTPJ)]. Post-hoc graph theoretical analyses were performed for raTPJ connectivity in PTSD + DS and healthy controls.

Results

As compared to healthy controls, PTSD + DS showed decreased raTPJ functional connectivity with critical anterior frontal lobe nodes involved in the ventral attention and social cognition networks (i.e., left ventrolateral and dorsomedial prefrontal cortices). PTSD showed decreased lpTPJ functional connectivity with the left superior parietal lobule as compared to healthy controls. When comparing PTSD to PTSD + DS, we observed increased bilateral TPJ functional connectivity with the cerebellum. Lastly, compared to healthy controls, both PTSD and PTSD + DS displayed decreased bilateral TPJ functional connectivity with the occipital lobe. Graph theoretical analyses revealed that PTSD + DS showed limited raTPJ involvement and instead more efficient neural communication between occipital lobe and frontal lobe structures as compared to healthy controls, suggesting a possible compensatory neural network in PTSD + DS.

Conclusions

These findings reveal disruptions in TPJ neural circuitry in PTSD and PTSD + DS, which may carry cascading effects on intersecting neural networks involving the TPJ. Implications for psychotherapeutic treatments targeting disembodiment and social cognition are discussed.

背景：颞顶交界处（TPJ）是一个参与社会认知和注意的跨网络枢纽，其过程直接受到创伤后应激障碍（PTSD）及其分离亚型（PTSD + DS）临床症状的影响。方法：采用SPM12和CONN，对PTSD（81例）、PTSD + DS（49例）和健康对照组（54例）的TPJ静息状态功能连接模式进行分析，采用4种种子[右TPJ前路（raTPJ）、左TPJ前路（laTPJ）、右TPJ后路（rpTPJ）、左TPJ后路（lpTPJ）]。对PTSD + DS和健康对照的raTPJ连通性进行事后图理论分析。结果：与健康对照组相比，PTSD + DS表现出与腹侧注意和社会认知网络（即左腹外侧和背内侧前额皮质）相关的关键额叶节点的raTPJ功能连连性下降。与健康对照组相比，PTSD显示lpTPJ与左侧顶叶上小叶的功能连通性下降。当比较PTSD与PTSD + DS时，我们观察到双侧TPJ与小脑的功能连接增加。最后，与健康对照组相比，PTSD和PTSD + DS均表现出双侧TPJ与枕叶的功能连通性下降。图理论分析显示，与健康对照组相比，PTSD + DS的raTPJ受感有限，枕叶和额叶结构之间的神经交流更有效，这表明PTSD + DS可能存在代偿性神经网络。结论：这些发现揭示了PTSD和PTSD + DS中TPJ神经回路的破坏，这可能对涉及TPJ的交叉神经网络产生级联效应。讨论了针对分离和社会认知的心理治疗治疗的意义。

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