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Multiple Myeloma in the Global Burden of Disease Study: Statistical Analysis and Trend Forecast From 1990 to 2021. 全球疾病负担研究中的多发性骨髓瘤:1990年至2021年的统计分析和趋势预测。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70068
Piaorong Zeng, Liucui Chen, Liu Zhen, Bangpeng, Yujie Yang, Shengting Chen

Introduction: This study investigates the impact of multiple myeloma (MM) on global health using data from the Global Burden of Disease Study (1990-2021). We aimed to analyze the incidence, prevalence, and mortality rates, and disability-adjusted life years (DALYs) associated with MM across various demographics and regions.

Method: Advanced statistical techniques, including ARIMA and Bayesian models, age-period-cohort analysis, frontier analysis, decomposition analysis, and joinpoint regression analysis, were conducted to explore these trends.

Results: The primary study findings indicated a significant rise in incidence and prevalence rates of MM, particularly in older populations, along with notable regional disparities.

Conclusions: Our study results underscore the urgent need for targeted interventions and resource allocation to mitigate the growing burden of MM, offering policymakers and healthcare providers valuable insights into the potential trends in disease management and prevention strategies.

本研究使用全球疾病负担研究(1990-2021)的数据调查多发性骨髓瘤(MM)对全球健康的影响。我们的目的是分析不同人口统计和地区与MM相关的发病率、患病率、死亡率和残疾调整生命年(DALYs)。方法:采用ARIMA模型、贝叶斯模型、年龄-时期-队列分析、前沿分析、分解分析、结合点回归分析等先进的统计方法对这些趋势进行探讨。结果:主要研究结果表明MM的发病率和流行率显著上升,特别是在老年人群中,并存在显著的地区差异。结论:我们的研究结果强调,迫切需要有针对性的干预和资源分配,以减轻MM日益增长的负担,为政策制定者和医疗保健提供者提供疾病管理和预防策略的潜在趋势的宝贵见解。
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引用次数: 0
A Culturally Tailored Educational Program for Breast Cancer Risk Reduction in Korean Immigrant Women: A Community-Based Pilot Study. 为降低韩国移民妇女乳腺癌风险量身定制的文化教育计划:一项基于社区的试点研究。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70109
Jin Young Seo, So-Hyun Park, Sungeun Choi, Angelica Sanchez, Minkyung Lee, Shiela M Strauss

Objective: This study evaluated the effectiveness of a culturally tailored educational program, the Korean Breast Cancer Risk Reduction Program (KBCRRP), to reduce breast cancer (BC) risk factors and increase screening among Korean American (KA) women.

Methods: Guided by the PRECEDE-PROCEED and Health Belief Models, the KBCRRP targeted healthy weight, physical activity, diet, and BC screening. A quasi-experimental design involved KA women (age ≥ 40 years, BMI ≥ 23 kg/m2) from a community organization in New York City. The intervention group (IG, n = 14) attended eight in person weekly sessions and received 16 weeks of smartphone follow-up. The control group (CG, n = 14) received written cancer prevention materials. Anthropometric measurements and self-reported questionnaires were collected in weeks 1, 8, and 24. Changes in BMI, physical activity, diet, and BC screening were analyzed using descriptive statistics, paired t-tests, and McNemar tests.

Results: Participants (N = 28; IG = 14, CG = 14) had an average age of 58.07 years (SD = 6.78). At eight weeks, IG participants demonstrated a significant reduction in BMI (p = 0.001) and decreased calorie intake at both eight weeks (p = 0.046) and 24 weeks (p = 0.042). CG participants showed an increase in waist-hip ratio at both time points (p < 0.01). Mammography uptake improved in both groups, with no significant group difference.

Conclusion: Despite a small sample size, the KBCRRP showed a significant reduction in key BC risk factors among KA women.

目的:本研究评估了韩国乳腺癌风险降低计划(KBCRRP)的文化定制教育计划的有效性,该计划旨在减少韩裔美国人(KA)女性患乳腺癌(BC)的危险因素并增加筛查。方法:在pre - proceed和健康信念模型的指导下,KBCRRP以健康体重、身体活动、饮食和BC筛查为目标。准实验设计涉及来自纽约市某社区组织的KA女性(年龄≥40岁,BMI≥23 kg/m2)。干预组(IG, n = 14)每周亲自参加8次会议,并接受16周的智能手机随访。对照组(CG, n = 14)给予书面防癌材料。在第1、8和24周收集人体测量数据和自我报告的问卷。使用描述性统计、配对t检验和McNemar检验分析BMI、体力活动、饮食和BC筛查的变化。结果:参与者(N = 28, IG = 14, CG = 14)平均年龄58.07岁(SD = 6.78)。在8周时,IG参与者表现出BMI (p = 0.001)的显著降低,并且在8周(p = 0.046)和24周(p = 0.042)时卡路里摄入量都有所减少。CG组患者腰臀比在两个时间点均增加(p < 0.01)。两组的乳腺x线照相术摄取均有改善,组间无显著差异。结论:尽管样本量小,但KBCRRP显示KA妇女中关键的BC危险因素显著降低。
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引用次数: 0
Development of a Position Paper on Faculty Qualifications for Community and Public Health Nursing. 关于社区和公共卫生护理教师资格的立场文件的发展。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70094
Priscella Correa, Kim A Decker, Shawna Hebert, Conni DeBlieck, Florence M Weierbach, Mark Siemon, Lynn P Blanchette

This brief report describes the work of the Association of Community Health Nursing Educators (ACHNE) to update the Position Paper Faculty Qualifications for Community/Public Health Nursing (C/PHN) and recommend qualifications for C/PHN faculty and clinical preceptors in undergraduate and graduate programs. Work group members conducted a literature review and a survey of public health faculty, practicing public health nurses, and other nurse educators in 2023. The revised position paper highlights the need for faculty who are academically and experientially prepared to teach community, public, and population health nursing courses. It stresses the importance of well-qualified instructors in both undergraduate and graduate nursing programs. The American Association of Colleges of Nursing added Population Health as a new domain to The Essentials: Core Competencies for Professional Nursing Education. In an effort to meet the new domains it is essential to consider faculty that have the academic and experiential qualifications to be hired or selected to teach C/PHN courses in nursing programs.

这份简短的报告描述了社区卫生护理教育者协会(ACHNE)更新社区/公共卫生护理教师资格(C/PHN)的立场文件的工作,并推荐了C/PHN教师和本科和研究生课程的临床导师的资格。工作组成员在2023年对公共卫生教师、执业公共卫生护士和其他护士教育工作者进行了文献综述和调查。修订后的立场文件强调需要教师谁是学术和经验准备教社区,公众和人口健康护理课程。它强调了在本科和研究生护理课程中高素质教师的重要性。美国护理学院协会将人口健康作为一个新领域添加到“要点:专业护理教育的核心能力”中。为了适应新的领域,必须考虑聘请或选择具有学术和经验资格的教师来教授护理项目中的C/PHN课程。
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引用次数: 0
Temporal Trends and Epidemiological Profile of Disasters in Oceania: 2000-2023. 大洋洲灾害的时间趋势和流行病学特征:2000-2023。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70097
Andrea Fernández García, José Antonio Cernuda Martínez, Pedro Arcos González

Aim: To analyse the epidemiological profile of disasters in Oceania in terms of their temporal trends, as well as their profile of mortality and morbidity.

Design: A retrospective observational study of disasters in Oceania between 2000 and 2023 was conducted using the United Nations definition of disaster, as well as the Centre for Research on the Epidemiology of Disasters inclusion criteria.

Measurements: The absolute and relative frequencies, rates per million inhabitants of deaths, injuries, and affected people, as well as time trends, were calculated.

Results: A total of 398 disasters were recorded between the years 2000 and 2023. Of these, 373 (93.72%) were associated with disasters related to natural hazards, and 25 (6.28%) were attributed to technological disasters. Among disasters related to natural hazards, 153 (38.44%) were meteorological, 111 (27.89%) hydrological, 45 (11.31%) geophysical, 41 (10.30%) climatological, and 23 (5.78%) biological. Of the 20 technological disasters, 5.03% were transport accidents, 0.75% were miscellaneous accidents, and 0.50% were industrial accidents.

Conclusions: The most frequent disasters in Oceania were disasters related to natural hazards, with meteorological disasters being the most frequent subtype. Although technological disasters were less frequent than natural disasters, they had a higher average mortality rate.

目的:分析大洋洲灾害的流行病学特征及其时间趋势,以及死亡率和发病率特征。设计:利用联合国对灾害的定义以及灾害流行病学研究中心的纳入标准,对2000年至2023年间大洋洲的灾害进行了回顾性观察研究。测量方法:计算了绝对频率和相对频率、每百万居民死亡、受伤和受影响人数的比率以及时间趋势。结果:2000 - 2023年共记录灾害398起。其中,373起(93.72%)与自然灾害有关,25起(6.28%)与技术灾害有关。与自然灾害相关的灾害中,气象灾害153起(38.44%)、水文灾害111起(27.89%)、地球物理灾害45起(11.31%)、气候灾害41起(10.30%)、生物灾害23起(5.78%)。在20起技术灾害中,交通事故占5.03%,杂项事故占0.75%,工业事故占0.50%。结论:大洋洲最常见的灾害类型是自然灾害,气象灾害是最常见的亚型。虽然技术灾害的发生频率低于自然灾害,但它们的平均死亡率更高。
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引用次数: 0
Latent Class-Specific Psychosocial and Behavioral Determinants of Preventive Behavioral Intentions for Emerging Infectious Diseases Among Korean Adults: A Mixture Regression Model Approach. 韩国成人新发传染病的预防行为意向的潜在阶层特异性社会心理和行为决定因素:混合回归模型方法。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70105
Yong-Hyun Moon, Jihea Choi

Objective: This study aimed to identify latent psychosocial-behavioral subgroups among Korean adults and examine how emerging infectious disease (EID) awareness, social responsibility, self-efficacy, vaccination behavior, and mask-wearing behavior can predict preventive behavioral intentions.

Design and sample: A cross-sectional survey was conducted with 149 Korean adults aged ≥19 years and recruited through convenience sampling from two metropolitan areas.

Measurements: Participants completed structured questionnaires assessing psychosocial (EID awareness, social responsibility, and self-efficacy) and behavioral (vaccination and mask-wearing behavior) variables.

Results: Overall, conventional regression analysis showed that social responsibility and vaccination behavior significantly predicted preventive behavioral intentions for EIDs. Mixture regression analysis revealed two latent classes. In Class 1, preventive intentions were influenced by awareness, social responsibility, vaccination, mask-wearing, age, and COVID-19 history. In Class 2, self-efficacy, social responsibility, and vaccination behavior were significant predictors, with COVID-19 history negatively associated. These class-specific patterns in awareness and behavior underscore the importance of subgroup analysis.

Conclusions: Psychosocial and behavioral predictors of preventive behavioral intentions differ across subgroups. These findings emphasize the need for targeted public health strategies that account for population heterogeneity. Moreover, tailored nursing interventions can enhance the effectiveness of EID prevention efforts in diverse communities.

目的:本研究旨在确定韩国成年人潜在的心理社会行为亚群,并研究新发传染病(EID)意识、社会责任、自我效能感、疫苗接种行为和戴口罩行为如何预测预防行为意向。设计与样本:采用横断面调查方法,从两个大都市地区抽取149名年龄≥19岁的韩国成年人。测量方法:参与者完成结构化问卷,评估社会心理(EID意识、社会责任和自我效能)和行为(接种疫苗和戴口罩行为)变量。结果:总体而言,常规回归分析显示,社会责任和疫苗接种行为显著预测了eid的预防行为意愿。混合回归分析显示两个潜在类别。在第一类中,预防意向受意识、社会责任、接种疫苗、佩戴口罩、年龄和COVID-19病史的影响。在第2类中,自我效能感、社会责任和疫苗接种行为是显著的预测因子,与COVID-19病史呈负相关。这些在意识和行为上的类特定模式强调了子群体分析的重要性。结论:预防行为意向的社会心理和行为预测因素在不同亚组之间存在差异。这些发现强调需要有针对性的公共卫生战略来解释人口异质性。此外,量身定制的护理干预措施可以提高不同社区预防EID工作的有效性。
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引用次数: 0
The Influence of Communication Abilities on the Family Disease Burden of Chronic Older Adults in China: An Examination of a Moderated Mediation Model. 沟通能力对中国慢性老年人家庭疾病负担的影响:一个有调节的中介模型检验
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-25 DOI: 10.1111/phn.70102
Tingting Lin, Luyi Xu, Zheng Wang, Siyi Su, Jufang Li, Ping Li

Objectives: This study aimed to investigate the effect of family function on communication abilities and family disease burden in older Chinese adults with chronic diseases, considering the socioeconomic status (SES) as a moderator.

Methods: This investigation employed a cross-sectional methodology to examine older adults, along with their caregivers, within both urban and rural settings in Zhejiang Province. Data were collected using the general demographic questionnaire, the family evaluation scale, and the family burden scale of illness. Data analysis included principal component analysis (PCA), the Spearman correlation analysis, and the bootstrapping methods.

Results: Mediation analysis revealed a significant total effect of communication abilities on family disease burden (B = -1.782, p <0.001). Communication abilities positively correlated with family function (B = 0.907, p <0.001) and negatively with disease burden (B = 0.651, p <0.001). The regulatory mediation model demonstrated that the interaction between communication abilities and SES index significantly predicted family function (B = 0.281, p <0.05).

Conclusion: More than half of China's elderly with chronic illnesses burden their families. Family functions mediate between communication abilities and disease burden, with SES moderating this. A "government-community-family" support system is needed. Government should enhance social security, for example, through long-term care insurance and tiered reimbursement, to ease economic burdens and improve communication. Communities should use health records to identify elderly with communication barriers and provide training. Families should adopt communication techniques; interventions for dysfunctional families, like empathy building and behavior control, can improve functions and relieve burdens.

目的:本研究旨在探讨家庭功能对中国老年慢性病患者沟通能力和家庭疾病负担的影响,并考虑社会经济地位(SES)的调节作用。方法:本研究采用横断面方法对浙江省城市和农村地区的老年人及其照顾者进行调查。采用普通人口调查问卷、家庭评价量表和家庭疾病负担量表收集数据。数据分析包括主成分分析(PCA)、Spearman相关分析和bootstrapping方法。结果:中介分析显示,沟通能力对家庭疾病负担的总影响显著(B = -1.782, p)。结论:中国一半以上的老年慢性病患者给家庭造成负担。家庭功能在沟通能力和疾病负担之间起中介作用,其中社会经济地位起调节作用。需要一个“政府-社区-家庭”的支持系统。政府应加强社会保障,例如通过长期护理保险和分级报销,以减轻经济负担并改善沟通。社区应利用健康记录识别有沟通障碍的老年人,并提供培训。家庭应采用沟通技巧;对功能失调家庭的干预,如移情建设和行为控制,可以改善功能,减轻负担。
{"title":"The Influence of Communication Abilities on the Family Disease Burden of Chronic Older Adults in China: An Examination of a Moderated Mediation Model.","authors":"Tingting Lin, Luyi Xu, Zheng Wang, Siyi Su, Jufang Li, Ping Li","doi":"10.1111/phn.70102","DOIUrl":"https://doi.org/10.1111/phn.70102","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effect of family function on communication abilities and family disease burden in older Chinese adults with chronic diseases, considering the socioeconomic status (SES) as a moderator.</p><p><strong>Methods: </strong>This investigation employed a cross-sectional methodology to examine older adults, along with their caregivers, within both urban and rural settings in Zhejiang Province. Data were collected using the general demographic questionnaire, the family evaluation scale, and the family burden scale of illness. Data analysis included principal component analysis (PCA), the Spearman correlation analysis, and the bootstrapping methods.</p><p><strong>Results: </strong>Mediation analysis revealed a significant total effect of communication abilities on family disease burden (B = -1.782, p <0.001). Communication abilities positively correlated with family function (B = 0.907, p <0.001) and negatively with disease burden (B = 0.651, p <0.001). The regulatory mediation model demonstrated that the interaction between communication abilities and SES index significantly predicted family function (B = 0.281, p <0.05).</p><p><strong>Conclusion: </strong>More than half of China's elderly with chronic illnesses burden their families. Family functions mediate between communication abilities and disease burden, with SES moderating this. A \"government-community-family\" support system is needed. Government should enhance social security, for example, through long-term care insurance and tiered reimbursement, to ease economic burdens and improve communication. Communities should use health records to identify elderly with communication barriers and provide training. Families should adopt communication techniques; interventions for dysfunctional families, like empathy building and behavior control, can improve functions and relieve burdens.</p>","PeriodicalId":54533,"journal":{"name":"Public Health Nursing","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying the Public Health Nursing Intervention Wheel to a Paternal Perinatal Mental Health Case Study. 公共卫生护理干预轮在父亲围产期心理健康案例研究中的应用
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-24 DOI: 10.1111/phn.70099
Lloyd Frank Philpott, Helen Mulcahy

Background: Adverse paternal perinatal mental health is recognized as a serious public health concern due to the negative implications for fathers, their families, and wider society. However, in the Irish healthcare system there is no evidence that the assessment and management of paternal perinatal mental health is part of current public health nursing practice.

Case presentation: The authors designed a hypothetical case study and used it with the public health nursing intervention wheel to analyze and illustrate how public health nursing practice is more likely to focus on maternal and infant health outcomes.

Findings: The case illustrated that there are opportunities to integrate applicable interventions such as assessment, screening, consultation, counseling, health teaching, referral, and follow-up at paternal and family level, as well as outreach, advocacy, and social marketing at community level. Evidence from the research-based literature is used to discuss how these interventions can result in beneficial outcomes for fathers, families and population health.

Conclusion: Furthermore, it illustrates how case studies can enhance teaching in relation to public health nursing education.

背景:由于对父亲、其家庭和更广泛的社会产生负面影响,不良的父亲围产期心理健康被认为是一个严重的公共卫生问题。然而,在爱尔兰的医疗保健系统中,没有证据表明对父亲围产期心理健康的评估和管理是当前公共卫生护理实践的一部分。案例介绍:作者设计了一个假设的案例研究,并将其与公共卫生护理干预轮一起使用,以分析和说明公共卫生护理实践如何更有可能关注孕产妇和婴儿健康结果。研究结果:该病例表明,有机会在父亲和家庭层面整合适用的干预措施,如评估、筛查、咨询、咨询、健康教学、转诊和随访,以及在社区层面的外展、宣传和社会营销。来自研究文献的证据被用来讨论这些干预措施如何为父亲、家庭和人口健康带来有益的结果。结论:进一步说明个案研究对公共卫生护理教育教学的促进作用。
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引用次数: 0
Development and Validation of Self-Management Infographics for Patients With Type 2 Diabetes Mellitus in Rural Kenya. 肯尼亚农村2型糖尿病患者自我管理信息图表的开发与验证
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-23 DOI: 10.1111/phn.70087
Pauline Muthoni Maina, Melanie Pienaar

Objective: The objective of the study was to develop and validate a set of infographics tailored for self-management by patients with Type 2 diabetes mellitus (T2DM) in rural Kenya, to prevent chronic kidney disease.

Design: In collaboration with two graphic designers and through an iterative participatory process, the authors developed self-management infographics tailored for patients with T2DM. The authors followed the following steps in the development process: goal identification, target audience identification, definition of the intended message, identification of relevant symbols or graphics and infographic compilation.

Sample: The images were validated by using participatory groups with patients with T2DM (n = 13) and healthcare workers (n = 7) caring for patients with T2DM. The International Organization for Standardization (ISO) 9186 testing guided the comprehension level of images.

Results: In total, 28 infographics received a score greater than 66%. The following characteristics significantly affected the comprehensibility of the infographics: whether written text was included, prior knowledge, viewers' frames, image characteristics, whether images were familiar/commonly encountered, the positioning of images, and colors and measurements that could be interpreted intuitively.

Conclusions: The authors conclude that an iterative approach is viable for developing tailored infographics for specific populations.

目的:该研究的目的是开发和验证一套专为肯尼亚农村2型糖尿病(T2DM)患者自我管理量身定制的信息图表,以预防慢性肾脏疾病。设计:与两位平面设计师合作,通过反复参与的过程,作者开发了为T2DM患者量身定制的自我管理信息图表。作者在开发过程中遵循了以下步骤:目标识别,目标受众识别,意图信息的定义,相关符号或图形的识别以及信息图表的编制。样本:通过T2DM患者(n = 13)和护理T2DM患者的医护人员(n = 7)参与组对图像进行验证。国际标准化组织(ISO) 9186测试指导图像的理解水平。结果:共有28张信息图得分大于66%。以下特征显著影响信息图表的可理解性:是否包含书面文本、先验知识、观看者的框架、图像特征、图像是否熟悉/经常遇到、图像的定位以及可以直观理解的颜色和测量。结论:作者得出结论,迭代方法是可行的,为特定人群开发量身定制的信息图表。
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引用次数: 0
Adherence to Human Papillomavirus Vaccination in the Province of Oujda-Angad, Morocco. 摩洛哥Oujda-Angad省坚持接种人乳头瘤病毒疫苗。
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-23 DOI: 10.1111/phn.70100
Ouafae El Ajroudi, El Mahdi Razzok, Zaouia Khadija, Housni Safae, Chadmi Hiba

Background: In a global context, where millions of women have died from cervical cancer, hesitancy toward the human papillomavirus (HPV) vaccine remains high, and this reluctance continues to contribute to preventable mortality.

Objective: This study aimed to examine the determinants of human papillomavirus vaccination adherence in the province of Oujda-Angad, eastern Morocco.

Methods: A cross-sectional community-based study was conducted between December 2024 and May 2025 and included 434 participants stratified into two distinct categories (girls aged 11-26 years and parents of minor girls). Participants were recruited from urban and rural areas. Data were collected using a structured questionnaire in Moroccan Arabic dialect covering sociodemographic characteristics, awareness of the HPV infection, cervical cancer, HPV vaccine, and decision-making processes. Associations were tested using chi-square, with p < 0.05 considered statistically significant.

Results: The study findings revealed an overall low vaccination coverage (6.7%) and a low level of knowledge about HPV infection (39.3%). While a high proportion of participants demonstrated awareness of cervical cancer severity (92.3%), fewer correctly identified the link between HPV infection and cervical cancer (25.5%) or were aware of existence of the HPV vaccine (31.7%). Only 16.4% of young adult women reported being solely responsible for the vaccination decision-making. Religious and cultural beliefs were identified as barriers to vaccine acceptance. HPV vaccination status was significantly associated with monthly income (p = 0.049), knowledge of HPV infection (p < 0.0001), knowledge of HPV transmission, and awareness of its link to cervical cancer (p < 0.001). In turn, awareness of HPV vaccination was significantly associated with educational level, occupation, and monthly income (p < 0.001).

Conclusions: Persistent structural and sociocultural barriers were revealed by our study, including distrust in the healthcare system, deficits in communication and information, social circle influences, and religious and moral beliefs. These findings underscore the need to strengthen the role of healthcare professionals and to implement coordinated, targeted educational outreach strategies to improve vaccine perception and increase HPV vaccination coverage in Morocco.

背景:在全球范围内,数百万妇女死于宫颈癌,对人乳头瘤病毒(HPV)疫苗的犹豫态度仍然很高,这种不情愿继续导致可预防的死亡率。目的:本研究旨在研究摩洛哥东部Oujda-Angad省人乳头瘤病毒疫苗接种依从性的决定因素。方法:在2024年12月至2025年5月期间进行了一项以社区为基础的横断面研究,包括434名参与者,分为两类(1126岁的女孩和未成年女孩的父母)。参与者从城市和农村地区招募。使用摩洛哥阿拉伯语方言的结构化问卷收集数据,涵盖社会人口统计学特征、对HPV感染的认识、宫颈癌、HPV疫苗和决策过程。相关性采用卡方检验,p < 0.05认为有统计学意义。结果:研究结果显示,疫苗接种覆盖率总体较低(6.7%),HPV感染知识水平较低(39.3%)。虽然高比例的参与者表现出对宫颈癌严重程度的认识(92.3%),但正确识别HPV感染与宫颈癌之间的联系(25.5%)或知道存在HPV疫苗(31.7%)的人较少。只有16.4%的年轻成年妇女报告独自负责疫苗接种决策。宗教和文化信仰被认为是接受疫苗的障碍。HPV疫苗接种状况与月收入(p = 0.049)、对HPV感染的认识(p < 0.0001)、对HPV传播的认识以及对其与宫颈癌的联系的认识(p < 0.001)显著相关。反过来,HPV疫苗接种意识与教育水平、职业和月收入显著相关(p < 0.001)。结论:我们的研究揭示了持续存在的结构性和社会文化障碍,包括对医疗保健系统的不信任,沟通和信息的缺陷,社交圈的影响以及宗教和道德信仰。这些发现强调需要加强卫生保健专业人员的作用,并实施协调一致的、有针对性的教育外展战略,以改善对疫苗的认识,增加摩洛哥人乳头瘤病毒疫苗接种的覆盖率。
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引用次数: 0
Association Between Blood Heavy Metal Exposure and Lower Urinary Tract Symptoms in Middle-Aged and Elderly Men: Insights From NHANES and Mendelian Randomization Study. 中老年男性血液重金属暴露与下尿路症状的关系:来自NHANES和孟德尔随机化研究的见解
IF 1.3 4区 医学 Q2 NURSING Pub Date : 2026-02-23 DOI: 10.1111/phn.70088
Xuexue Hao, Xiangyu Chen, Song Li, Xiaoqiang Liu

Background: The association between cadmium, lead, and mercury exposure and lower urinary tract symptoms (LUTS) in middle-aged and elderly men remains underexplored. This study aimed to investigate the associations and dose-response relationships between blood levels of these heavy metals and the risk of LUTS, and to further examine potential causal links using Mendelian randomization (MR) analysis.

Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES 2005-2008). Weighted multivariable logistic regression models were used to assess associations between serum heavy metals and LUTS. Restricted cubic spline (RCS) analysis evaluated dose-response patterns, and MR analysis was performed to infer causality.

Results: Serum lead levels in Q2-Q4 were significantly associated with increased LUTS risk (OR = 1.54, 95% CI: 1.00-2.36, P = 0.047; OR = 1.67, 95% CI: 1.10-2.54, P = 0.016; OR = 1.58, 95% CI: 1.02-2.44, P = 0.039). Serum mercury in Q4 was also associated with higher LUTS risk (OR = 1.64, P = 0.009), while no significant association was observed for cadmium. RCS analysis suggested linear associations for cadmium, lead, and mercury, and a significant nonlinear U-shaped association for mixed metal exposure. MR analysis supported a potential causal effect of mercury on benign prostatic hyperplasia (OR = 1.54, P = 0.040).

Conclusions: Elevated blood levels of lead and mercury are associated with increased risk of LUTS in men, with mercury possibly exerting a causal influence.

背景:镉、铅和汞暴露与中老年男性下尿路症状(LUTS)之间的关系仍未得到充分研究。本研究旨在探讨这些重金属血液水平与LUTS风险之间的关联和剂量-反应关系,并利用孟德尔随机化(MR)分析进一步研究潜在的因果关系。方法:我们使用国家健康和营养检查调查(NHANES 2005-2008)的数据进行了横断面研究。采用加权多变量logistic回归模型评估血清重金属与LUTS之间的关系。限制性三次样条(RCS)分析评估剂量-反应模式,MR分析推断因果关系。结果:第二季度至第四季度血清铅水平与LUTS风险增加显著相关(OR = 1.54, 95% CI: 1.00-2.36, P = 0.047; OR = 1.67, 95% CI: 1.10-2.54, P = 0.016; OR = 1.58, 95% CI: 1.02-2.44, P = 0.039)。Q4的血清汞也与较高的LUTS风险相关(OR = 1.64, P = 0.009),而未观察到镉的显著相关性。RCS分析表明,镉、铅和汞呈线性关系,而混合金属暴露呈显著的非线性u形关系。磁共振分析支持汞对良性前列腺增生的潜在因果效应(OR = 1.54, P = 0.040)。结论:血铅和汞水平升高与男性LUTS风险增加有关,汞可能发挥因果影响。
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Public Health Nursing
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