Journal of Hospital Infection最新文献_第10页

Enhancing central-line-associated bloodstream infection prevention: evaluating enhanced strategies in an academic medical centre in Singapore 加强CLABSI预防：评估新加坡学术医疗中心的加强战略。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.jhin.2025.11.043

X. Ji , P. Jin , Z. Zhang , M.O. Aung , S.J.M. Ong , H.X. Toh , L.C. Lee , K.Y. Tan , M.K.B. How , J.H. Seah , B.S. Ismail , I. Venkatachalam , D.C.M. Lai , M.L. Ling

Background

Whilst insertion and maintenance bundles serve as essential preventive measures for central line-associated bloodstream infections (CLABSIs), the efficacy of enhanced strategies such as chlorhexidine-impregnated dressings and alcohol-impregnated port protectors remains relatively unexplored on a hospital-wide scale. This study evaluates the impact of implementing 2% chlorhexidine gluconate-impregnated (CHG) dressings and 70% isopropyl alcohol-impregnated (IPA) port protectors in reducing CLABSI risks across a 1900-bed academic medical centre in Singapore.

Methods

Singapore General Hospital introduced CHG dressings in July 2020 and expanded their use hospital wide in January 2021. Additionally, IPA port protectors were implemented hospital wide in September 2021. The incidence rates of CLABSI per 1000 central line (CL)-days were monitored to evaluate outcomes.

Results

From November 2017 to January 2020 (baseline period), the CLABSI incidence rate was 0.81 per 1000 CL-days. For the period February 2021 to September 2021, prior to the implementation of IPA port protectors, the rate decreased to 0.53 per 1000 CL-days (incidence rate ratio (IRR) 0.61 (95% confidence interval (CI) 0.37–0.98); P=0.073). The rate further declined to 0.45 per 1000 CL-days from October 2021 to December 2024 (post-implementation of both strategies), representing a statistically significant reduction (IRR 0.53 (95% CI 0.40–0.71); P<0.001). The combined strategy of CHG dressings and IPA port protectors potentially reduced the risk of CLABSIs by 47%.

Conclusion

Our experience demonstrated a statistically significant reduction in CLABSI rates following the 3-year implementation of CHG dressings and IPA port protectors as part of routine hospital-wide preventive measures against CLABSI.

背景：虽然插入和维持捆绑是中心静脉相关血流感染（CLABSIs）的基本预防措施，但在医院范围内，诸如氯己定浸渍敷料和酒精浸渍端口保护器等增强策略的有效性仍未得到广泛的探索。本研究评估了实施2%葡萄糖酸氯己定浸渍（CHG）敷料和70%异丙醇浸渍（IPA）端口保护剂在降低CLABSI风险方面的影响，该研究覆盖了新加坡一个拥有1900个床位的学术医疗中心。方法：新加坡总医院于2020年7月引进CHG敷料，并于2021年1月在全院推广使用。此外，IPA端口保护器于2021年9月在医院范围内实施。监测每1000中心线（CL）天CLABSI的发生率以评估结果。结果：2017年11月至2020年1月（基线期），CLABSI发病率为0.81 / 1000 cl -d。在2021年2月至2021年9月期间，在实施IPA端口保护器之前，该比率降至0.53 / 1,000 CL-days [IRR 0.61 (95% CI 0.37-0.98)；P = 0.073]。从2021年10月至2024年12月（两种策略实施后），死亡率进一步下降至0.45 / 1000 CL-days，统计学上显著降低[IRR 0.53 (95% CI 0.40-0.71)；P < 0.001]。CHG敷料和IPA端口保护剂的联合策略可能将clabsi的风险降低47%。结论：我们的经验表明，在将CHG敷料和IPA端口保护器作为医院常规预防CLABSI措施的一部分实施三年之后，CLABSI发生率有统计学上的显著降低。

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引用次数: 0

In-hospital environmental surface and air contamination by monkeypox virus clade Ib in Germany 德国乙型猴痘病毒对医院环境表面和空气的污染。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-01 DOI: 10.1016/j.jhin.2025.11.022

A.F. Wendel , F. Mattner , D. Peter , M. Krakau , H. Gruell , A. Nitsche , J. Michel

Background

Mpox, caused by monkeypox virus (MPXV), is an acute global public health concern, driven by human-to-human transmissions. Only sporadic cases caused by the emerging MPXV clade Ib have been reported in Europe to date.

Aim

To assess the potential for environmental contamination and indirect or airborne transmission, we conducted longitudinal environmental sampling during the hospitalization of the first German imported mpox clade Ib case in an airborne infection isolation room.

Methods

Over a period of eight days, six standardized sampling series were carried out in the anteroom, patient's room, and bathroom ≥6 h after cleaning. Swab samples from high- and low-touch areas and air samples (Coriolis μ impinger) were taken. Additionally, the exhaust HEPA filters and mobile air purifier filters were analysed. MPXV contamination was determined by polymerase chain reaction (PCR) and subsequently virus culture was performed.

Findings

Surface and air contamination with MPXV DNA was detected in high- and low-touch areas, as well as near and far from the patient (PCR positivity: 92 out of 100 surface samples and 11 of 12 air samples). Moreover, the analysed air-filters and adhered dust tested positive for MPXV DNA. However, replication-competent virus was identified only on the toilet seat surface on the first sampling day.

Conclusion

Our data show a high degree of MPXV DNA contamination in the patient's environment and suggest potentially infectious fomites. While the relation between widespread DNA contamination and actual transmission risk remains difficult to assess and needs further investigation, our findings underscore the importance of environmental cleaning and disinfection.

背景：猴痘由猴痘病毒（MPXV）引起，是一个严重的全球公共卫生问题，由人际传播驱动。迄今为止，欧洲仅报告了由新出现的MPXV分支Ib引起的散发病例。目的：为了评估环境污染和间接或空气传播的可能性，我们在空气传播隔离室对第一位德国输入mpox分支Ib病例进行了纵向环境采样。方法：在8天的时间内，在接待室、病房和浴室进行6次标准化取样，每次取样时间至少为清洁后6小时。采集高接触区和低接触区拭子样本和空气样本（科里奥利μ冲击）。此外，还对尾气高效微粒微粒过滤器和移动式空气净化器过滤器进行了分析。用聚合酶链反应测定MPXV污染，随后进行病毒培养。结果：在高接触区和低接触区以及离患者近和远的地方检测到MPXV DNA的表面和空气污染（pcr阳性：100个表面样本中有92个阳性，12个空气样本中有11个阳性）。此外，分析的空气过滤器和粘附灰尘检测出MPXV DNA呈阳性。然而，在第一天的采样中，仅在马桶座圈表面发现了具有复制能力的病毒。结论：我们的数据显示患者环境中存在高度的MPXV DNA污染，并提示存在潜在的传染性污染物。虽然广泛的DNA污染与实际传播风险之间的关系仍然难以评估，需要进一步调查，但我们的研究结果强调了环境清洁和消毒的重要性。

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引用次数: 0

222 nm far-UVC to inactivate airborne bacteria in an occupied dental clinic 222纳米远紫外线灭活空气中的细菌在一个被占用的牙科诊所。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jhin.2025.11.015

D. Welch , M. Buonanno , Z. Tang , I. Shuryak , R. Hashmi , V. Belenky , C. Petersen , S. Erde , D.J. Brenner

Background

Methods for cleaning the air can play an important role in decreasing the airborne transmission of diseases. The implementation of far-ultraviolet C (UVC) fixtures emitting at 222 nm is a promising engineering control to directly inactivate airborne microbes within an occupied space.

Aim

To examine the efficacy of a far-UVC installation in a large dental clinic containing 24 treatment chairs.

Methods

Air samples were collected using two different methods and the number of culturable bacteria was determined for conditions with the lamps on and lamps off.

Findings

The estimated reduction using results pooled from both air sampling methods was 39.5% (95% confidence interval: 19%, 60%). Given the 10 air changes per hour from the ventilation system, the operation of far-UVC lighting provided 6.5 additional air changes per hour for the dental clinic.

Conclusion

These results show the efficacy of far-UVC lighting for the inactivation of airborne bacteria. Far-UVC lighting is a promising intervention technology for preventing disease transmission in a clinic.

背景：净化空气的方法对减少疾病的空气传播具有重要作用。在222nm发射远紫外线装置的实施是一个有前途的工程控制，直接灭活空气中的微生物在占用的空间。方法：本研究考察了远紫外线装置在大型牙科诊所24治疗椅的功效。用两种不同的方法收集空气样本，并在开灯和关灯的情况下测定可培养细菌的数量。结果：使用两种空气采样方法汇总的结果估计减少了39.5%（95%置信区间：19%，60%）。考虑到通风系统每小时换气10次，远紫外线照明的运行每小时为牙科诊所额外提供6.5次换气。结论：远紫外线照明对空气中细菌具有灭活作用。远紫外线照明是临床上预防疾病传播的一种很有前途的干预技术。

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引用次数: 0

Implementation of a novel aseptic insertion device for peripheral venous catheters: safety, performance, and nurse satisfaction 一种新型无菌外周静脉导管插入装置的实施：安全性、性能和护士满意度。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI: 10.1016/j.jhin.2025.11.027

T. Ruiz-Merlo , A.I. Sánchez Morgado , P. Brañas , R. Hontoria-Alcoceba , I. Rodríguez-Goncer , M. Fernández-Ruiz , J.M. Aguado , F. López-Medrano

Background

Peripheral venous catheters (PVCs) are widely used invasive devices in hospitalised patients, but their insertion carries risks such as phlebitis, extravasation, and catheter-related bloodstream infections (CRBSIs). Current World Health Organization (WHO) guidelines recommend non-sterile gloves during PVC insertion, which conflicts with aseptic technique principles.

Aim

To evaluate a patented device that was developed to prevent direct contact between non-sterile gloves and the catheter hub.

Methods

We conducted a single-centre, non-comparative proof-of-concept study to assess the safety and feasibility of the device in routine clinical practice within an inpatient unit with an established PVC care bundle. Eighty-eight adult patients requiring PVCs for >48 h were included prospectively. Trained nurses inserted 116 PVCs using the device, with daily monitoring of complications and aseptic culture of catheter tips. Nurse satisfaction was surveyed.

Findings

Most catheters (78.4%) were successfully inserted at the first attempt. Complication rates were as follows: phlebitis (1.7 episodes/100 catheter-days), extravasation (2.6/100 catheter-days) and pericatheter leakage (3.2/100 catheter-days). Of 73 cultured PVC tips, 95.9% were sterile and three showed skin flora growth without clinical phlebitis. No CRBSI cases were documented. Nurse satisfaction averaged 3.57/5, with 62.3% expressing satisfaction.

Conclusion

The use of this innovative device, in conjunction with an established evidence-based care bundle, was associated with low complication and contamination rates and no cases of CRBSIs. These findings support the device’s potential utility in promoting aseptic technique during PVC insertion without disrupting routine clinical workflows. Nurse satisfaction was moderate, as expected with the introduction of a new tool that modifies long-standing clinical routines.

背景：外周静脉导管（PVCs）是住院患者广泛使用的侵入性装置，但其插入存在静脉炎、外渗和导管相关性血流感染（crbsi）等风险。目前世卫组织指南建议在插入PVC时使用非无菌手套，这与无菌技术原则相冲突。为了解决这个问题，一种专利装置被开发出来，以防止非无菌手套和导管中心之间的直接接触。方法：我们进行了一项单中心、非比较性的概念验证研究，以评估该装置在常规临床实践中的安全性和可行性，并在住院病房中建立了PVC护理包。88例需要室性心动过速的成年患者在bbb48小时内被纳入前瞻性研究。训练有素的护士使用该装置插入116颗室早，每日监测并发症和导管尖端无菌培养。调查护士满意度。结果：首次置管成功率为78.4%。并发症发生率为：静脉炎（1.7次/100导管-天）、外渗（2.6次/100导管-天）和导管周渗漏（3.2次/100导管-天）。73例培养的PVC针尖中，95.9%无菌，3例皮肤菌群生长，无临床静脉炎。无CRBSI病例记录。护士满意度平均为3.57/5，满意度为62.3%。结论：使用这种创新的设备，结合已建立的循证护理包，与低并发症和污染率相关，并且没有crbsi病例。这些发现支持该设备在PVC插入过程中促进无菌技术的潜在效用，而不会干扰常规临床工作流程。护士满意度中等，正如预期的那样，引入了一种新的工具，修改了长期的临床惯例。

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引用次数: 0

Scabies outbreak in paediatric malignancy patients: clinical and healthcare burden 小儿恶性肿瘤患者疥疮爆发：临床和医疗负担。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI: 10.1016/j.jhin.2025.11.035

A. Uygun, C. Albayrak, Ü. Özgen, İ. Kartal, O.S. Dinçer, H. Kangal Şimşek, M.E. Öğretici Çolak

Introduction

Scabies is a highly contagious parasitic skin infestation with increased severity in immunocompromised individuals. Paediatric oncology patients represent a uniquely vulnerable population, where delayed diagnosis and atypical presentations can complicate management. This study aimed to evaluate the clinical outcomes and institutional burden of a scabies outbreak in a paediatric haematology-oncology unit.

Methods

This retrospective study included paediatric malignancy patients diagnosed with scabies between January 2020 and January 2024 in a tertiary paediatric oncology centre. Diagnosis was based on clinical evaluation by dermatologists. Data collected included demographics, underlying malignancy, treatment modalities, duration of infection, complications and impact on healthcare services. Statistical analyses included t-tests, Chi-squared tests and univariable regression.

Results

Among 1483 unique inpatients over 4 years, 23 (1.55%) were diagnosed with scabies, with 78% of cases occurring within a 6-month period. The mean ± standard deviation (SD) age was 12.7 ± 5.95 years; 82.6% were male. The mean ± SD duration from symptom onset to resolution was 3.26 ± 2.47 months. Complications occurred in 43.5% of patients, including secondary bacterial infections, chemotherapy delays and one catheter-related event. A prolonged infection duration was significantly associated with complications (P = 0.008). All caregivers were affected, and 11 healthcare workers developed symptoms, leading to workforce shortages and single-room isolation that halved bed capacity.

Discussion

This outbreak underscores the diagnostic and therapeutic challenges of scabies in immunosuppressed paediatric patients. The involvement of caregivers and healthcare staff, coupled with operational disruptions, highlights the need for early recognition, standardised treatment protocols and proactive infection control strategies in high-risk hospital settings.

简介：疥疮是一种高度传染性的皮肤寄生虫感染，在免疫功能低下的个体中严重程度增加。儿科肿瘤患者是一个独特的弱势群体，其延迟诊断和非典型表现可能使管理复杂化。本研究旨在评估小儿血液科肿瘤科疥疮爆发的临床结果和机构负担。方法：本回顾性研究纳入了2020年1月至2024年1月在三级儿科肿瘤中心诊断为疥疮的儿科恶性肿瘤患者。诊断基于皮肤科医生的临床评估。收集的数据包括人口统计、潜在的恶性肿瘤、治疗方式、感染持续时间、并发症以及对医疗保健服务的影响。统计分析包括t检验、卡方检验和单变量回归。结果：在1483例四年以上的独特住院患者中，23例（1.55%）被诊断为疥疮，其中78%的病例发生在六个月内。平均年龄12.7±5.95岁；82.6%为男性。从症状出现到缓解的平均时间为3.26±2.47个月。43.5%的患者出现并发症，包括继发性细菌感染、化疗延迟和1例导管相关事件。感染时间延长与并发症显著相关（p = 0.008）。所有护理人员都受到影响，11名医护人员出现症状，导致劳动力短缺和单间隔离，使床位减少了一半。讨论：这次暴发强调了免疫抑制儿童患者疥疮的诊断和治疗挑战。护理人员和卫生保健人员的参与，加上业务中断，突出表明需要在高风险医院环境中进行早期识别、标准化治疗方案和主动感染控制战略。

{"title":"Scabies outbreak in paediatric malignancy patients: clinical and healthcare burden","authors":"A. Uygun, C. Albayrak, Ü. Özgen, İ. Kartal, O.S. Dinçer, H. Kangal Şimşek, M.E. Öğretici Çolak","doi":"10.1016/j.jhin.2025.11.035","DOIUrl":"10.1016/j.jhin.2025.11.035","url":null,"abstract":"<div><h3>Introduction</h3><div>Scabies is a highly contagious parasitic skin infestation with increased severity in immunocompromised individuals. Paediatric oncology patients represent a uniquely vulnerable population, where delayed diagnosis and atypical presentations can complicate management. This study aimed to evaluate the clinical outcomes and institutional burden of a scabies outbreak in a paediatric haematology-oncology unit.</div></div><div><h3>Methods</h3><div>This retrospective study included paediatric malignancy patients diagnosed with scabies between January 2020 and January 2024 in a tertiary paediatric oncology centre. Diagnosis was based on clinical evaluation by dermatologists. Data collected included demographics, underlying malignancy, treatment modalities, duration of infection, complications and impact on healthcare services. Statistical analyses included <em>t</em>-tests, Chi-squared tests and univariable regression.</div></div><div><h3>Results</h3><div>Among 1483 unique inpatients over 4 years, 23 (1.55%) were diagnosed with scabies, with 78% of cases occurring within a 6-month period. The mean ± standard deviation (SD) age was 12.7 ± 5.95 years; 82.6% were male. The mean ± SD duration from symptom onset to resolution was 3.26 ± 2.47 months. Complications occurred in 43.5% of patients, including secondary bacterial infections, chemotherapy delays and one catheter-related event. A prolonged infection duration was significantly associated with complications (<em>P</em> = 0.008). All caregivers were affected, and 11 healthcare workers developed symptoms, leading to workforce shortages and single-room isolation that halved bed capacity.</div></div><div><h3>Discussion</h3><div>This outbreak underscores the diagnostic and therapeutic challenges of scabies in immunosuppressed paediatric patients. The involvement of caregivers and healthcare staff, coupled with operational disruptions, highlights the need for early recognition, standardised treatment protocols and proactive infection control strategies in high-risk hospital settings.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"168 ","pages":"Pages 58-63"},"PeriodicalIF":3.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbapenemase-producing Enterobacterales within the West Midlands: who, what, where and why? 西米德兰兹郡产碳青霉烯酶肠杆菌：谁，什么，在哪里，为什么？

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.jhin.2025.11.034

S. Drazich-Taylor , A. Hussain

引用次数: 0

Manual reprocessing of endovaginal and transrectal ultrasonography probes: evaluation of a wipe procedure in comparison with an immersion procedure 阴道内和经直肠超声探头的手工再处理：与浸泡程序相比，擦拭程序的评估。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jhin.2025.11.023

M. Rausch , M. Eggers , B. Hornei , C. Ilschner , S. Engelhart , K.-M. Roesch , N.T. Mutters , J. Gebel

Objective

The objective of this study was to evaluate the cleaning performance and disinfection efficacy of a validated manual wipe-based reprocessing procedure for endocavitary ultrasound probes under realistic worst-case conditions.

Methods

Used transvaginal and transrectal ultrasound probes were artificially contaminated with interfering substances (ultrasound gel, mucin and protein soil) and test organisms (Enterococcus hirae, Staphylococcus aureus, Candida albicans and Simian Virus 40 [SV40] as a surrogate for human papillomavirus [HPV]). Effectiveness of the cleaning procedure with ready-to-use wipes was evaluated using protein quantification and total organic carbon (TOC) analysis. For disinfection testing, the full two-step protocol (cleaning followed by disinfection) was applied and microbial reduction was measured on defined probe test fields.

Results

After the cleaning process, protein and TOC levels were within the required limits of <100 μg/instrument test field and <6.0 μg/cm², respectively. The combined cleaning and disinfection procedure achieved reproducible microbial reductions above the log reductions required according to the European Standard EN 14485 for all tested organisms, including complete inactivation of SV40 as an HPV surrogate, confirming bactericidal, yeasticidal and virucidal efficacy. The method proved reproducible across multiple individual users and all test runs.

Conclusion

Manual wipe-based reprocessing can achieve reproducible and validatable disinfection of transvaginal and transrectal ultrasound probes for the complete probe surface, including difficult-to-access niches, is effectively cleaned and training and validation requirements are met. The method may serve as a practical alternative in settings where automated or immersion-based reprocessing is not feasible.

目的：评价一种经验证的人工湿巾对腔内超声探头在实际最坏情况下的清洗性能和消毒效果。方法：使用经阴道和经直肠超声探头，人工污染干扰物质（超声凝胶、粘蛋白、蛋白土）和检测生物（霍乱肠球菌、金黄色葡萄球菌、白色念珠菌、HPV替代物SV40）。利用蛋白质定量和总有机碳（TOC）分析评估即用湿巾清洁程序的有效性。对于消毒测试，采用完整的两步方案（清洁后消毒），并在定义的探针测试区域测量微生物减少量。结果：清洗过程后，蛋白质和TOC含量分别在< 100 μg/仪器测试场和< 6.0 μg/cm2的要求范围内。结合清洁和消毒程序实现了可重复的微生物减少，超过了欧洲标准EN 14485对所有被测试生物体要求的lg减少，包括SV40作为HPV替代品的完全失活，确认了杀菌、杀酵母和杀病毒的功效。该方法在多个用户和所有测试运行中证明是可重复的。结论：手工湿巾再处理可实现经阴道和经直肠超声探头的可重复性和可验证性消毒，探头表面包括难以接近的小生境全部得到有效清洁，满足培训和验证要求。在自动化或浸没式后处理不可行的情况下，该方法可作为一种实用的替代方法。

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引用次数: 0

Lessons unlearned: sustaining preparedness and public health resilience beyond COVID-19 未吸取的教训：在2019冠状病毒病之后保持防范和公共卫生韧性。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.jhin.2025.12.003

M.J. Fletcher , J.R. Price

引用次数: 0

Sustainable application of ready-to-use disinfectant wipes in clinical practice: efficacy, handling, and contamination risks 即用型消毒湿巾在临床实践中的可持续应用：功效、处理和污染风险。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.jhin.2025.11.024

M. Rausch , G. Barth , A. Dornaika , B. Hornei , C. Ilschner , K-M. Roesch , J. Gebel , S. Engelhart , N.T. Mutters

Background

Healthcare facilities face the challenge of reducing greenhouse gas emissions. In this context, the use of surface disinfectant wipes as a component of infection control requires special consideration. This study examined options for using disinfectant wipes that ensure a favourable eco-balance without compromising patient or occupational safety. User application routines and laboratory test parameters were considered.

Methods

The study comprised a clinical observational study and complementary laboratory analyses. Laboratory tests evaluated three different alcohol-based wipe types and assessed surface coverage and liquid release on different surfaces. The risk of persistent microbial contamination of the wipe after use and the risk of microbial transfer from wipe to gloved hand was investigated. In the observational study, 69 wipe procedures were recorded across three clinical departments.

Results

The cellulose-based wipe demonstrated superior surface coverage compared with two different wipes, with double-ply application consistently outperforming single-ply use across all wipes and all tested surfaces. The wipes fulfilled efficacy criteria even at the end of their wiping range. Transfer risk evaluation indicated that microorganisms may remain viable within the wipe and can be transferred onto gloves. Clinical observations further revealed substantial variability in folding and wiping techniques.

Conclusion

This study highlights key aspects of surface coverage and handling-related variability, and contamination risks associated with disinfectant wipe use. The findings underscore the importance of proper wipe handling and glove use to support sustainable use of ready-to-use wipes while maintaining infection prevention standards.

背景：卫生保健设施面临着减少温室气体排放（GHG）的必要性的挑战。在这种情况下，还必须特别考虑使用表面消毒湿巾作为感染控制的一个组成部分。本研究考察了使用消毒湿巾在不损害患者和职业安全的情况下确保有利的生态平衡的可能性。为此，考虑了用户应用程序以及实验室测试参数。方法：本研究包括临床观察研究和补充实验室分析。实验室测试评估了三种不同的醇基擦拭类型，并评估了不同表面的表面覆盖率和液体释放情况。此外，还调查了擦巾使用后微生物持续污染的风险以及微生物从擦巾转移到戴手套的手上的风险。在观察性研究中，记录了三个临床科室的69例擦拭手术。结果：与两种不同的湿巾相比，纤维素基湿巾的表面覆盖率更高，在所有湿巾和所有测试表面上，双层湿巾的应用始终优于单层湿巾。即使在擦拭范围结束时，湿巾也达到了功效标准。转移风险评估表明，微生物可能在擦布内存活，并可能转移到手套上。临床观察进一步揭示了折叠和擦拭技术的实质性差异。结论：这项研究强调了表面覆盖和处理相关的可变性的关键方面，以及与消毒擦拭使用相关的污染风险。研究结果强调了正确处理湿巾和戴手套的重要性，以支持可持续使用RTU湿巾，同时保持感染预防标准。

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引用次数: 0

Evaluation of a rapid quality control method for endoscope cleaning 内窥镜清洗快速质量控制方法评价。

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.jhin.2025.11.033

S. Bulot, L. Pineau

Background

Over the past 30 years, endoscope processing has improved significantly, guided by various standards and recommendations. None the less, contamination remains an issue, with 21.1% of endoscopes exceeding acceptable thresholds in 2021. Cleaning, including pre-treatment, is identified as critical for successful endoscope processing. ISO 15883–5 and AAMI guidelines provide frameworks for evaluating cleaning efficacy, with ANSI/AAMI ST91 recommending verification of cleanliness for high-risk and complex-design endoscopes after each cycle. This study assesses the EndoCheck protein detection kit (HEALTHMARK) as a rapid test for evaluating cleaning quality in endoscope channels.

Methods

The study was conducted in two phases: (1) performance testing (detection limit, extraction efficiency, and sensitivity), and (2) real-use testing (comparison with a standard flush sampling method).

Results

The EndoCheck kit consistently detected ≥5 μg of bovine serum albumin (BSA) in polytetrafluoroethylene (PTFE) tubes, equivalent to 0.4 μg/cm², and recovered an average of 68 ± 11% of the initial soil. Under real-use conditions, it identified 51% of endoscopes as non-compliant, compared with 14% with the flush method. This discrepancy was more pronounced in bronchoscopes, likely due to the nature of the residual soil.

Conclusion

The EndoCheck kit is a highly sensitive, easy-to-use method for detecting residual protein in biopsy channels. Its greater stringency compared with current flush methods makes it a reliable tool for confirming cleanliness when results are negative. Positive results can serve as early indicators, prompting further investigation.

在过去的30年里，在各种标准和建议的指导下，内窥镜处理有了显著的改进。尽管如此，污染仍然是一个问题，2021年有21.1%的内窥镜超过了可接受的阈值。清洁，包括预处理，被认为是成功的内窥镜处理的关键。ISO 15883-5和AAMI指南提供了评估清洁效果的框架，ANSI/AAMI ST91建议在每个周期后对高风险和复杂设计的内窥镜进行清洁度验证。本研究评估了EndoCheck蛋白检测试剂盒（HEALTHMARK）作为评估内窥镜通道清洁质量的快速测试。研究分两个阶段进行：(1)性能测试（检出限、提取效率和灵敏度）；(2)实际使用测试（与标准冲洗取样方法的比较）。EndoCheck试剂盒在聚四氟乙烯（PTFE）管中连续检测到牛血清白蛋白(BSA)≥5 μg，相当于0.4 μg/cm2，平均回收率为初始土壤的68±11%。在实际使用条件下，该方法识别出51%的内窥镜不合规，而冲洗法识别出14%的内窥镜不合规。这种差异在支气管镜中更为明显，可能是由于残留土壤的性质。总之，EndoCheck试剂盒是一种高度敏感、易于使用的检测活检通道中残留蛋白的方法。与目前的冲洗方法相比，其更严格的要求使其成为确认结果为阴性时清洁度的可靠工具。阳性结果可作为早期指标，促使进一步调查。

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引用次数: 0