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Couple-Level Manifestations of Posttraumatic Stress and Maternal and Paternal Postpartum Relationship Functioning 夫妻层面的创伤后应激表现与母子产后关系功能
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-28 DOI: 10.1155/2024/6140465
Jordan L. Thomas, Jennifer A. Somers, Christine Dunkel Schetter, Jennifer A. Sumner

Objective. Posttraumatic stress disorder (PTSD) is linked with impaired intimate relationships in postpartum women, yet less is known about couple-level manifestations of posttraumatic psychopathology and potential associations with relationship functioning for mothers and fathers during this critical time. Method. In a predominately low-to-middle income sample of 867 mother-father couple dyads assessed six months following the birth of a child, two analytic methods—a data-driven dyadic latent profile analysis and hypothesis-driven a priori categorization approach—evaluated whether discrete subgroups of couples could be identified based on both partners’ PTSD symptoms. Structural equation models then tested associations between identified subgroups with (1) self-reported relationship quality and (2) interviewer-rated relationship stress. Results. Three couple-level PTSD symptom groupings were common to both methods: both low, mother low-father high, and mother high-father low. Dyad-level PTSD symptom patterns were differentially related to relationship dysfunction for mothers and fathers, although mixed findings emerged across methods regarding the relevance of which partner had elevated symptoms for relationship functioning in PTSD symptom-discordant couples. Individuals in dyads characterized by at least one partner with elevated PTSD symptoms consistently exhibited greater relationship dysfunction—indexed both subjectively and objectively—compared to dyads where both partners had low symptoms. Conclusions. Couple-level typologies of PTSD symptoms can be identified using data- and hypothesis-driven approaches, with generally concordant results. Dyadic patterns of PTSD symptoms are relevant to relationship functioning for both mothers and fathers during the postpartum period and may help to inform more targeted intervention efforts to support couples who are parenting.

目的:创伤后应激障碍(PTSD)与产后妇女亲密关系受损有关。创伤后应激障碍(PTSD)与产后妇女亲密关系受损有关,但在这一关键时期,人们对创伤后精神病理学在夫妻层面的表现以及与母亲和父亲关系功能的潜在关联却知之甚少。研究方法在一个主要由中低收入者组成的样本中,对 867 对母亲-父亲夫妇在孩子出生六个月后的情况进行了评估,采用了两种分析方法--数据驱动的夫妇潜特征分析法和假设驱动的先验分类法--评估是否能根据夫妇双方的创伤后应激障碍症状识别出离散的夫妇亚群。然后,结构方程模型检验了所确定的亚组与 (1) 自我报告的关系质量和 (2) 受访者评价的关系压力之间的关联。结果两种方法都有三种夫妻层面的创伤后应激障碍症状分组:双方都低,母亲低父亲高,母亲高父亲低。虽然在创伤后应激障碍症状不一致的夫妻中,哪一方的症状加重与夫妻关系功能的相关性在不同的方法中出现了不同的结果,但夫妻层面的创伤后应激障碍症状模式与母亲和父亲的关系功能障碍的相关性是不同的。在至少有一方创伤后应激障碍症状升高的夫妻关系中,与双方症状都较轻的夫妻关系相比,夫妻关系功能障碍的主观和客观指数都更高。结论以数据和假设为导向的方法可以确定创伤后应激障碍症状的夫妻层面类型,其结果基本一致。创伤后应激障碍症状的组合模式与母亲和父亲在产后期间的关系功能有关,可能有助于为更有针对性的干预工作提供信息,以支持为人父母的夫妇。
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引用次数: 0
Network Analysis of Internet Addiction, Online Social Anxiety, Fear of Missing Out, and Interpersonal Sensitivity among Chinese University Students 中国大学生网络成瘾、网络社交焦虑、害怕错过和人际关系敏感性的网络分析
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-27 DOI: 10.1155/2024/5447802
Xinyi Zhu, Wen Lian, Lu Fan

Background. Despite the growing prevalence of internet usage among young people, the relationships between internet addiction, online social anxiety, fear of missing out (FoMO), and interpersonal sensitivity remain uncertain, intricate, and multifaceted. To gain insight into the underlying psychological mechanisms, we employed network analysis to explore the interconnections between them. This endeavor may provide fresh opportunities for intervention and treatment. Methods. In this study, 470 participants were assessed at age from 18 to 22 (M = 20.18 years, SD = 1.861) years. Network analysis was used to examine the connections between symptoms, and statistical measures were applied to assess the stability of the network model. Results. Online social anxiety and interpersonal sensitivity had the strongest associations with other symptoms in the network, with “Evaluation anxiety” having the highest expected influence centrality, followed by “Privacy concern anxiety,” “Need for approval,” “Suspicion,” and “vulnerability.” The FoMO symptom, “Fear of missing information,” had the strongest direct relation to internet addiction. “Evaluation anxiety” and “Fear of missing information” played a key role in bridging internet addiction and interpersonal sensitivity. Additionally, the structure distribution of edge weights had a significant difference between gender. Conclusions. Our findings indicated that FoMO, interpersonal sensitivity, and online social anxiety likely play a significant role in the development and continuation of internet addiction. Interpersonal sensitivity seems to contribute to increased online social anxiety, FoMO, and the development of internet addiction, indicating that targeting these symptoms may help reduce negative online behavior and psychological burden.

背景。尽管互联网在青少年中的使用越来越普遍,但网络成瘾、网络社交焦虑、害怕错过(FoMO)和人际关系敏感度之间的关系仍然是不确定的、错综复杂的和多方面的。为了深入了解其背后的心理机制,我们采用了网络分析的方法来探索它们之间的相互联系。这项工作可能会为干预和治疗提供新的机会。研究方法在这项研究中,我们对 470 名年龄在 18-22 岁(M=20.18 岁,SD=1.861)的参与者进行了评估。研究人员使用网络分析来检查症状之间的联系,并使用统计方法来评估网络模型的稳定性。结果显示网络社交焦虑和人际关系敏感与网络中其他症状的关联性最强,其中 "评价焦虑 "的预期影响中心度最高,其次是 "隐私担忧焦虑"、"需要认可"、"怀疑 "和 "脆弱性"。FoMO 症状 "害怕遗失信息 "与网络成瘾的直接关系最强。"评价焦虑 "和 "对信息缺失的恐惧 "在连接网络成瘾和人际关系敏感性方面发挥了关键作用。此外,边缘权重的结构分布在性别间存在显著差异。结论我们的研究结果表明,FoMO、人际关系敏感性和网络社交焦虑可能在网络成瘾的发展和持续中起着重要作用。人际敏感性似乎会导致网络社交焦虑、FoMO 和网络成瘾的发展,这表明针对这些症状可能有助于减少负面网络行为和心理负担。
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引用次数: 0
Person-Centered Associations between High- and Low-Risk Personality Profiles and Psychological Adjustment in University Students 大学生高风险和低风险人格特征与心理适应之间以人为本的关联
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-26 DOI: 10.1155/2024/8810153
Rocco Servidio, Maria Giuseppina Bartolo, Flaviana Tenuta, Anna Lisa Palermiti, Francesca Candreva, Carmela Ciccarelli, Angela Costabile, Linda S. Pagani, Francesco Craig

Personality traits are considered potential risk or protective factors for learning and psychological adjustment. This is a concern in higher education settings, which comprise mostly youth in emerging adulthood. The purpose of this study is to apply a person-centered approach to identify personality profiles of university students based on their character traits and then evaluate whether some clusters predict differences in emotional distress and coping strategies. We conducted a cross-sectional web-based survey with 467 southern Italian undergraduate university students (M = 21.8, SD = 3.69). Students completed an anonymous online survey and self-report questionnaires measuring sociodemographic characteristics, personality traits (Personality Inventory for DSM-5), emotional distress (General Anxiety Disorders-7, Patient Health Questionnaire-9), and coping strategies (Brief-COPE). Two distinct clusters were identified, differing in relation to maladaptive personality traits. One was characterized by high maladaptive personality traits, comprising 45.6% of the sample population. This high-risk profile evidenced higher levels of negative affect, detachment, psychoticism, antagonism, and disinhibition. A second cluster, with low maladaptive personality traits, represented the remainder of the sample. Participants featuring high maladaptive personality traits reported lower functioning in terms of avoidant coping strategies in comparison to the second low-risk cluster. Generating profiles of latent traits, such as in cluster analysis, can enhance a more profound theoretical understanding of underlying patterns within personality traits. This can enable higher education settings to meet variations in student needs by adapting their support services and interventions. Students can be trained to use coping strategies more effectively and efficiently.

人格特征被认为是学习和心理适应的潜在风险或保护因素。这在高等教育环境中是一个值得关注的问题,因为高等教育中的学生大多是刚步入成年的青年。本研究的目的是采用以人为本的方法,根据大学生的性格特征识别他们的性格特征,然后评估某些群组是否能预测情绪困扰和应对策略的差异。我们对 467 名意大利南部本科大学生(M=21.8,SD=3.69)进行了横断面网络调查。学生们完成了匿名在线调查和自我报告问卷,调查内容包括社会人口学特征、人格特质(DSM-5 人格问卷)、情绪困扰(一般焦虑症-7、患者健康问卷-9)和应对策略(Brief-COPE)。根据适应不良人格特质的不同,确定了两个不同的群组。其中一个群组的特点是具有高度适应不良的人格特质,占样本人群的 45.6%。这种高风险特征表现为较高程度的消极情绪、疏离、精神错乱、对抗和抑制。第二组是低适应不良人格特质者,占样本的其余部分。与第二个低风险群组相比,具有高适应不良人格特质的参与者在回避应对策略方面的功能较低。通过聚类分析等方法生成潜在特质的轮廓,可以从理论上加深对人格特质内在模式的理解。这可以使高等教育机构通过调整其支持服务和干预措施来满足学生的不同需求。可以培训学生更有效、更高效地使用应对策略。
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引用次数: 0
Serum Ghrelin and Leptin Concentrations in Patients with Major Depressive Disorder before and after Supplementation with Vitamin D3 补充维生素 D3 前后重度抑郁症患者的血清胃泌素和瘦素浓度
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-25 DOI: 10.1155/2024/2057881
Shareefa AlGhamdi, Nabilah Alsulami, Sawsan Khoja, Hadeil Alsufiani, Haythum O. Tayeb, Huda Alshaibi, Frank I. Tarazi

Aim. To determine serum concentrations of leptin and ghrelin in patients with major depressive disorder (MDD) before and after vitamin D3 supplementation. Methods. A total of 72 participants were recruited in this study (40 MDD patients and 32 healthy controls). MDD was diagnosed by using Beck’s Depression Inventory (BDI) scale. Blood samples were collected from all participants at the beginning of the study to determine baseline serum 25(OH)D3, leptin, and ghrelin concentrations. Patients were then treated weekly with vitamin D3 (50,000 IU) for 3 months, and blood samples were collected again by the end of the study. Results. At baseline, serum leptin concentrations were significantly higher in MDD patients than in healthy controls. In contrast, serum ghrelin concentrations were significantly lower compared to those in healthy controls. After supplementation with vitamin D3 for three months, MDD patients showed improvements characterized by a decrease in their BDI’s scores and an increase in their serum vitamin D and ghrelin concentrations. No effects of vitamin D3 supplementation were seen on serum leptin concentration. Conclusions. The antidepressant effects of vitamin D3 supplementation could be mediated by ghrelin but not leptin.

目的测定重度抑郁障碍(MDD)患者在补充维生素 D3 前后血清中瘦素和胃泌素的浓度。研究方法本研究共招募了 72 名参与者(40 名重度抑郁症患者和 32 名健康对照组)。MDD通过贝克抑郁量表(BDI)进行诊断。研究开始时采集所有参与者的血样,以确定血清 25(OH)D3、瘦素和胃泌素的基线浓度。然后,患者每周接受一次维生素 D3(50,000 IU)治疗,为期 3 个月,研究结束时再次采集血液样本。研究结果基线时,多发性硬化症患者的血清瘦素浓度明显高于健康对照组。相比之下,血清胃泌素浓度明显低于健康对照组。在补充维生素 D3 三个月后,多发性硬化症患者的病情有所改善,BDI 评分下降,血清维生素 D 和胃泌素浓度上升。补充维生素 D3 对血清瘦素浓度没有影响。结论补充维生素D3的抗抑郁作用可能是由胃泌素而非瘦素介导的。
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引用次数: 0
Performance of Working Memory Updating in Socially Anxious Individuals 社交焦虑者工作记忆更新的表现
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-20 DOI: 10.1155/2024/1799948
Jing Yuan, Xiran Sun, Qin Zhang, Lixia Cui

Working memory updating plays a critical role in executive function. Few studies explored the working memory updating in socially anxious individuals. In this study, we wanted to explore the working memory updating in socially anxious individuals. We studied this issue by instructing participants to perform an emotional 2-back task, and recording their response time and accuracy. We found that high socially anxious individuals showed significant longer response time in positive word condition than that of negative and neutral words. But there was no significant difference in word type in low socially anxious group. In accuracy, we did not observe any significant difference in group, word type, and their interaction. These results indicate that socially anxious individuals have deficits in positive content updating, which have an important implication for developing method to reduce social anxiety.

工作记忆更新在执行功能中起着至关重要的作用。很少有研究探讨社交焦虑者的工作记忆更新。在本研究中,我们希望探索社交焦虑者的工作记忆更新。我们通过指导受试者执行情绪2-back任务,并记录他们的反应时间和准确性来研究这一问题。我们发现,高社交焦虑者在积极词语条件下的反应时间明显长于消极和中性词语条件下的反应时间。但低社交焦虑组在词语类型上没有明显差异。在准确性方面,我们没有观察到组别、词语类型以及它们之间的交互作用有任何显著差异。这些结果表明,社交焦虑者在积极内容更新方面存在缺陷,这对开发减少社交焦虑的方法具有重要意义。
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引用次数: 0
Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders 探索线粒体 DNA 与生活方式因素在精神疾病发病机制中的相互作用
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-20 DOI: 10.1155/2024/4914777
Wenming Wei, Bolun Cheng, Yijing Zhao, Dan He, Xiaoge Chu, Xiaoyue Qin, Na Zhang, Sirong Shi, Qingqing Cai, Jingni Hui, Yan Wen, Huan Liu, Yumeng Jia, Feng Zhang

The objectives of this study were to investigate the interaction of mitochondrial DNA (mtDNA) and lifestyle factors in the development of psychiatric disorders and to gain greater insight into their pathogenesis and comorbidity. We analyzed data from approximately 150,000 individuals from the UK Biobank. Mitochondrial gene-by-environment interaction studies (mtGEIS) were performed to assess the relationships between mtDNA and psychiatric disorders, such as anxiety, depression, and self-harm. These disorders were defined using diagnostic and severity indicators derived from the General Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9). Smoking and drinking behaviors were characterized based on UK Biobank criteria. For the mtGEIS, logistic and linear regression models from PLINK 2.0 were employed, accounting for covariates like age, sex, PC1-10, Townsend Deprivation Index (TDI), and educational attainment. We also conducted sex-stratified analyses to detect any gender-specific effects. Our findings highlighted significant associations between mtDNA and three psychiatric disorders. Moreover, the interplay between mtDNA and lifestyle factors showed significant associations with psychiatric disorders (all P values < 0.05). Specifically, two mutant loci, T5004C (BAnx_self = −0.0026, BDep_self = −0.0024, BSelf−harm = −0.0018) and G9123A (BAnx_self = −0.0030, BDep_self = −0.0024, BSelf−harm = −0.0017), were found to reduce the risk of three disorders after interacting with alcohol. Sex-specific differences were also observed. In summary, the expression of mitochondrial genes could be modulated by lifestyle factors like smoking and drinking, potentially affecting psychiatric disorders. These habits might influence mitochondrial respiratory chain activity and the replication and transcriptional regulation of mitochondrial genes, culminating in changes in mitochondrial functionality and subsequently psychiatric disorders.

本研究的目的是调查线粒体 DNA(mtDNA)和生活方式因素在精神疾病发展过程中的相互作用,并进一步了解精神疾病的发病机制和合并症。我们分析了英国生物库中约 15 万人的数据。我们进行了线粒体基因与环境相互作用研究(mtGEIS),以评估 mtDNA 与焦虑、抑郁和自残等精神疾病之间的关系。这些疾病的定义采用了从一般焦虑症(GAD-7)和患者健康问卷(PHQ-9)中得出的诊断指标和严重程度指标。吸烟和饮酒行为的特征则根据英国生物库标准确定。对于 mtGEIS,我们采用了 PLINK 2.0 的逻辑和线性回归模型,并考虑了年龄、性别、PC1-10、汤森贫困指数(TDI)和教育程度等协变量。我们还进行了性别分层分析,以检测性别特异性效应。我们的研究结果突显了 mtDNA 与三种精神疾病之间的重要关联。此外,mtDNA 与生活方式因素之间的相互作用也显示出与精神疾病的显著关联(所有 P 值均小于 0.05)。具体来说,两个突变位点T5004C(BAnx_self=-0.0026,BDep_self=-0.0024,BSelf-harm=-0.0018)和G9123A(BAnx_self=-0.0030,BDep_self=-0.0024,BSelf-harm=-0.0017)与酒精相互作用后,可降低三种疾病的风险。此外,还观察到了性别差异。总之,线粒体基因的表达可能会受到吸烟和饮酒等生活方式因素的影响,从而对精神疾病产生潜在影响。这些习惯可能会影响线粒体呼吸链的活性以及线粒体基因的复制和转录调控,最终导致线粒体功能的改变,进而引发精神疾病。
{"title":"Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders","authors":"Wenming Wei,&nbsp;Bolun Cheng,&nbsp;Yijing Zhao,&nbsp;Dan He,&nbsp;Xiaoge Chu,&nbsp;Xiaoyue Qin,&nbsp;Na Zhang,&nbsp;Sirong Shi,&nbsp;Qingqing Cai,&nbsp;Jingni Hui,&nbsp;Yan Wen,&nbsp;Huan Liu,&nbsp;Yumeng Jia,&nbsp;Feng Zhang","doi":"10.1155/2024/4914777","DOIUrl":"10.1155/2024/4914777","url":null,"abstract":"<p>The objectives of this study were to investigate the interaction of mitochondrial DNA (mtDNA) and lifestyle factors in the development of psychiatric disorders and to gain greater insight into their pathogenesis and comorbidity. We analyzed data from approximately 150,000 individuals from the UK Biobank. Mitochondrial gene-by-environment interaction studies (mtGEIS) were performed to assess the relationships between mtDNA and psychiatric disorders, such as anxiety, depression, and self-harm. These disorders were defined using diagnostic and severity indicators derived from the General Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9). Smoking and drinking behaviors were characterized based on UK Biobank criteria. For the mtGEIS, logistic and linear regression models from PLINK 2.0 were employed, accounting for covariates like age, sex, PC1-10, Townsend Deprivation Index (TDI), and educational attainment. We also conducted sex-stratified analyses to detect any gender-specific effects. Our findings highlighted significant associations between mtDNA and three psychiatric disorders. Moreover, the interplay between mtDNA and lifestyle factors showed significant associations with psychiatric disorders (all <i>P</i> values &lt; 0.05). Specifically, two mutant loci, T5004C (<i>B</i><sub>Anx_self</sub> = −0.0026, <i>B</i><sub>Dep_self</sub> = −0.0024, <i>B</i><sub>Self−harm</sub> = −0.0018) and G9123A (<i>B</i><sub>Anx_self</sub> = −0.0030, <i>B</i><sub>Dep_self</sub> = −0.0024, <i>B</i><sub>Self−harm</sub> = −0.0017), were found to reduce the risk of three disorders after interacting with alcohol. Sex-specific differences were also observed. In summary, the expression of mitochondrial genes could be modulated by lifestyle factors like smoking and drinking, potentially affecting psychiatric disorders. These habits might influence mitochondrial respiratory chain activity and the replication and transcriptional regulation of mitochondrial genes, culminating in changes in mitochondrial functionality and subsequently psychiatric disorders.</p>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comorbid Anxiety and Depression among Pregnant and Postpartum Women: A Longitudinal Population-Based Study 孕妇和产后妇女的焦虑和抑郁并发症:基于人群的纵向研究
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-15 DOI: 10.1155/2024/7802142
Quan Shen, Meili Xiao, Binglu Wang, Tan He, Jinxing Zhao, Jun Lei

Background. Longitudinal studies investigating the prevalence of comorbid anxiety and depression (CAD) and its risk factors during the perinatal period are limited. The objective of this longitudinal study was to describe the prevalence and risk factors of CAD among pregnant and postpartum women in China. Methods. From the Population Health Data Archive of the National Population Health Data Center, 1,941 Chinese pregnant or postpartum women who were surveyed for both depressive and anxiety symptoms during and after pregnancy were included in the study. This population-based longitudinal study was conducted between March 2017 and March 2022. The self-rating anxiety scale and self-rating depression scale were used to assess anxiety and depression symptoms at four time points throughout the perinatal period. The generalized estimation equation model was used to identify sociodemographic, obstetric, and mental health factors for CAD. Results. The prevalence of CAD was 15.67%, 8.36%, 11.64%, and 13.24% in the first, second, and third trimesters and postpartum, respectively. A higher proportion of women reporting, compared to women with single anxiety or depression, CAD during and after pregnancy were primiparas (OR = 1.32, 95% CI 1.06-1.65), having a smoking history (OR = 1.51, 95% CI 1.05-2.18), and having dissatisfied marital relationship (OR = 1.97, 95% CI 1.28-3.06). Women conceived with assisted reproductive treatment were reported to be less likely to have CAD (OR = 0.69, 95% CI 0.55-0.86). Conclusions. These findings highlight that CAD is relatively common in pregnant and postpartum women and recommend targeted interventions for higher risk women, specifically primiparas with a history of smoking and dissatisfied marital relationships.

背景。有关围产期合并焦虑和抑郁(CAD)的患病率及其风险因素的纵向研究十分有限。本纵向研究旨在描述中国孕妇和产后妇女中焦虑和抑郁(CAD)的患病率及其风险因素。研究方法从国家人口健康数据中心的人口健康数据档案中选取了1941名中国孕妇或产后妇女作为研究对象,这些妇女在怀孕期间和产后均接受了抑郁症状和焦虑症状的调查。这项基于人群的纵向研究在 2017 年 3 月至 2022 年 3 月期间进行。研究采用焦虑自评量表和抑郁自评量表评估围产期四个时间点的焦虑和抑郁症状。采用广义估计方程模型来确定导致腹壁缺损的社会人口、产科和心理健康因素。结果显示在第一、第二、第三和产后三个月中,CAD 的患病率分别为 15.67%、8.36%、11.64% 和 13.24%。与患有单一焦虑症或抑郁症的妇女相比,报告在怀孕期间和产后患有 CAD 的妇女中,初产妇(OR=1.32,95% CI 1.06-1.65)、有吸烟史(OR=1.51,95% CI 1.05-2.18)和婚姻关系不满意(OR=1.97,95% CI 1.28-3.06)的比例较高。据报道,通过辅助生殖治疗受孕的女性患 CAD 的可能性较低(OR=0.69,95% CI 0.55-0.86)。结论。这些研究结果表明,在孕妇和产后妇女中,冠状动脉粥样硬化较为常见,建议对高风险妇女,特别是有吸烟史和婚姻关系不和谐的初产妇,采取有针对性的干预措施。
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引用次数: 0
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory 根据抑郁症状轨迹分类的围产期抑郁症的风险因素、预后、对后代的影响和遗传结构
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-15 DOI: 10.1155/2024/6622666
Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.

本研究旨在揭示围产期抑郁症(PD)的风险因素、预后、对后代的影响以及遗传结构,并根据抑郁症状轨迹进行分类。研究人员招募了无重度抑郁症(MDD)病史的孕妇,并对她们的后代进行了产后1至5年的随访。利用围产期的四份自我报告问卷,将抑郁症分为四种亚型:孕期、产后早期、产后晚期和慢性抑郁症。研究人员比较了四种产后抑郁症亚型的风险因素、产后1至5年的抑郁症状轨迹以及儿童行为问题。对每种亚型进行了全基因组关联研究(GWAS)。研究还考察了肢端麻痹症亚型与多基因风险评分(PRS)之间的关系,多基因风险评分是一种精神疾病,而经前综合征(PMS)是一种荷尔蒙紊乱。在 12,338 名参与者中,1,145 人(9.3%)罹患妊娠抑郁症,856 人(6.9%)罹患产后早期抑郁症,382 人(3.1%)罹患产后晚期抑郁症,1,048 人(8.5%)罹患慢性抑郁症。产后5年内,抑郁症状下降至61.0%-73.3%。根据产后抑郁症亚型的不同,风险因素与产后抑郁症之间的关系也有所不同。此外,慢性帕金森病会使儿童出现行为问题的风险增加2至3倍。全球基因组研究发现,根据帕金森氏症亚型的不同,在不同基因位点上存在五个显著变异,这表明存在亚型特异性遗传结构。MDD的PRS与妊娠、产后早期和慢性PD有关,而PMS的PRS与产后晚期PD有关。研究得出结论,根据抑郁症状的轨迹,产后抑郁症具有异质性。因此,需要制定具体的预防和治疗策略。
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引用次数: 0
The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder–Fine-Grained Meta-Analyses 黑暗阴郁的大脑:重度抑郁障碍的灰质体积变化--细粒度元分析
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-03-02 DOI: 10.1155/2024/6673522
Zaira Romeo, Margherita Biondi, Leif Oltedal, Chiara Spironelli

Background. While the brain correlates of major depressive disorder (MDD) have been extensively studied, there is no consensus conclusion so far. Various meta-analyses tried to determine the most consistent findings, but the results are often discordant for grey matter volume (GMV) atrophy and hypertrophy. Applying rigorous and stringent inclusion criteria and controlling for confounding factors, such as the presence of anxiety comorbidity, we carried out two novel meta-analyses on the existing literature to unveil MDD signatures. Methods. A systematic literature search was performed up to January 2023. Seventy-three studies on MDD patients reporting GMV abnormalities were included in the first meta-analysis, for a total of 6167 patients and 6237 healthy controls (HC). To test the effects of anxiety comorbidity, we conducted a second meta-analysis, by adding to the original pure MDD sample a new cohort of MDD patients with comorbid anxiety disorders (308 patients and 342 HC). An activation likelihood estimation (ALE) analysis and a coordinate-based mapping approach separate for atrophy and hypertrophy were used to identify common brain structural alterations among patients. Results. The pure MDD sample exhibited atrophy in the left insula, as well as hypertrophy in the bilateral amygdala and parahippocampal gyri. When we added patients with comorbid anxiety to the original sample, bilateral insula atrophy emerged, whereas the hypertrophy results were not replicated. Conclusions. Our findings revealed important structural alterations in pure MDD patients, particularly in the insula and amygdala, which play key roles in sensory input integration and in emotional processing, respectively. Additionally, the amygdala and parahippocampal gyrus hypertrophy may be related to MDD functional overactivation to emotional stimuli, rumination, and overactive self-referential thinking. Conversely, the presence of anxiety comorbidity revealed separate effects which were not seen in the pure MDD sample, underscoring the importance of strict inclusion criteria for investigations of disorder-specific effects.

背景。虽然对重度抑郁障碍(MDD)的大脑相关因素进行了广泛的研究,但迄今为止尚未得出一致的结论。各种荟萃分析试图确定最一致的研究结果,但灰质体积(GMV)萎缩和肥大的结果往往不一致。我们采用严格的纳入标准,并控制了焦虑合并症等混杂因素,对现有文献进行了两项新的荟萃分析,以揭示 MDD 的特征。研究方法我们对截至 2023 年 1 月的文献进行了系统检索。第一项荟萃分析纳入了 73 项关于 MDD 患者 GMV 异常的研究,共计 6167 名患者和 6237 名健康对照(HC)。为了检验焦虑症合并症的影响,我们进行了第二次荟萃分析,在原来的纯 MDD 样本中加入了新的合并焦虑症的 MDD 患者队列(308 名患者和 342 名健康对照)。我们采用激活似然估计(ALE)分析和基于坐标的映射方法,分别对萎缩和肥厚进行分析,以确定患者之间共同的大脑结构改变。结果显示单纯 MDD 样本显示左侧岛叶萎缩,双侧杏仁核和海马旁回肥大。当我们在原始样本中加入合并焦虑症的患者时,出现了双侧岛叶萎缩,而肥大的结果却没有被复制。结论。我们的研究结果表明,纯合子多发性硬化症患者的脑岛和杏仁核的结构发生了重要改变,尤其是在感觉输入整合和情绪处理方面分别发挥了关键作用。此外,杏仁核和海马旁回肥大可能与 MDD 对情绪刺激的功能性过度激活、反刍和过度活跃的自我参照思维有关。与此相反,焦虑症合并症显示了单独的效应,这在纯粹的 MDD 样本中是看不到的,这强调了严格的纳入标准对于研究特定障碍效应的重要性。
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引用次数: 0
The Neuroimaging Role of Modified Electroconvulsive Therapy in the Major Depressive Disorder: Effectiveness in First-Episode Antipsychotic-Naive Major Depressive Disorder Patients 改良电休克疗法在重度抑郁症中的神经影像学作用:对首发抗精神病药物无效的重度抑郁障碍患者的疗效
IF 7.4 2区 医学 Q1 Psychology Pub Date : 2024-02-12 DOI: 10.1155/2024/9211145
Yi Zhong, Jianfeng Li, Haitao Li, Mingzhe Li, Yanaohai Lyu, Minghu Cui, Yujun Gao

Objectives. It is a high risk for adolescents with first-episode major depressive disorder (MDD) to commit suicide. However, few studies reported the effect of modified electroconvulsive therapy (MECT) in first-episode antipsychotic-naive MDD adolescents. Methods. The study explores the alternations of regional homogeneity of modified electroconvulsive therapy to treat the first-episode antipsychotic-naive major depressive disorder. 72 first-episode MDD patients were recruited from Tianyou Hospital Affiliated to Wuhan University of Science and Technology from October 2017 to May 2020, and 65 of 72 completed the trial. Results. Before MECT treatment, ReHo values of the bilateral cerebellum and left cuneus were higher, and ReHo value of left postcentral and supramarginal gyrus was lower in MDD patients compared to healthy subjects (HS). After treatment, the MDD patients have higher ReHo values of the right insula and postcentral gyrus, while left fusiform gyrus were lower than the pretreatment. Compared to the HS, the ReHo values of left lingual gyrus, right calcarine cortex, and right mid occipital thalamus were higher in the posttreatment. In the posttreatment, left calcarine cortex and right cerebrum were lower than in healthy subjects. Conclusions. The study confirmed that MECT improves psychotic symptoms in patients with first-episode antipsychotic-naive MDD. These results further contributed to a more tailored treatment approach to MDD from the pathophysiological and neuroimaging views.

目的。首发重度抑郁症(MDD)青少年自杀的风险很高。然而,很少有研究报道改良电休克疗法(MECT)对首发抗精神病药物无效的重度抑郁症青少年的效果。研究方法本研究探讨了改良电休克疗法治疗初发抗精神病药物无效重度抑郁症的区域同质性交替。2017年10月至2020年5月从武汉科技大学附属天佑医院招募72例首发MDD患者,72例中65例完成试验。结果显示MECT治疗前,与健康受试者(HS)相比,MDD患者双侧小脑和左侧楔回的ReHo值较高,左侧中央后回和边际上回的ReHo值较低。治疗后,MDD 患者右侧岛叶和中央后回的 ReHo 值高于治疗前,而左侧纺锤回的 ReHo 值低于治疗前。与 HS 相比,治疗后左舌回、右侧钙皮质和右侧枕中丘脑的 ReHo 值更高。在治疗后,左侧心盏皮质和右侧大脑皮质的 ReHo 值低于健康受试者。结论该研究证实,MECT可改善初发抗精神病药无效的MDD患者的精神病症状。这些结果进一步促进了从病理生理学和神经影像学角度对 MDD 采取更有针对性的治疗方法。
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Depression and Anxiety
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