Pub Date : 2025-04-23DOI: 10.1016/j.csda.2025.108196
Daniel Gaigall , Philipp Wübbolding
A new goodness-of-fit test for the composite null hypothesis that data originate from a geometric Brownian motion is studied in the functional data setting. This is equivalent to testing if the data are from a scaled Brownian motion with linear drift. Critical values for the test are obtained, ensuring that the specified significance level is achieved in finite samples. The asymptotic behavior of the test statistic under the null distribution and alternatives is studied, and it is also demonstrated that the test is consistent. Furthermore, the proposed approach offers advantages in terms of fast and simple implementation. A comprehensive simulation study shows that the power of the new test compares favorably to that of existing methods. A key application is the assessment of financial time series for the suitability of the Black-Scholes model. Examples relating to various stock and interest rate time series are presented in order to illustrate the proposed test.
{"title":"A goodness-of-fit test for geometric Brownian motion","authors":"Daniel Gaigall , Philipp Wübbolding","doi":"10.1016/j.csda.2025.108196","DOIUrl":"10.1016/j.csda.2025.108196","url":null,"abstract":"<div><div>A new goodness-of-fit test for the composite null hypothesis that data originate from a geometric Brownian motion is studied in the functional data setting. This is equivalent to testing if the data are from a scaled Brownian motion with linear drift. Critical values for the test are obtained, ensuring that the specified significance level is achieved in finite samples. The asymptotic behavior of the test statistic under the null distribution and alternatives is studied, and it is also demonstrated that the test is consistent. Furthermore, the proposed approach offers advantages in terms of fast and simple implementation. A comprehensive simulation study shows that the power of the new test compares favorably to that of existing methods. A key application is the assessment of financial time series for the suitability of the Black-Scholes model. Examples relating to various stock and interest rate time series are presented in order to illustrate the proposed test.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"210 ","pages":"Article 108196"},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-23DOI: 10.1016/j.csda.2025.108197
David Swanson
A method is demonstrated for localizing where two spline terms, or smooths, differ using a true discovery proportion (TDP)-based interpretation. The procedure yields a statement on the proportion of some region where true differences exist between two smooths. The methodology avoids ad hoc approaches to making such statements, like subsetting the data and performing hypothesis tests on the truncated spline terms. TDP estimates are 1-α confidence-bounded simultaneously, which means that a region's TDP estimate is a lower bound on the proportion of actual differences, or true discoveries, in that region, with high confidence regardless of the number of estimates made. The procedure is based on closed-testing using Simes local test. This local test requires that the multivariate test statistics of generalized Wishart type underlying the method be positive regression dependent on subsets (PRDS), a result for which evidence is presented suggesting that the condition holds. Consistency of the procedure is demonstrated for generalized additive models with the tuning parameter chosen by REML or GCV, and the achievement of confidence-bounded TDP is shown in simulation as is an analysis of walking gait.
{"title":"A simultaneous confidence-bounded true discovery proportion perspective on localizing differences in smooth terms in regression models","authors":"David Swanson","doi":"10.1016/j.csda.2025.108197","DOIUrl":"10.1016/j.csda.2025.108197","url":null,"abstract":"<div><div>A method is demonstrated for localizing where two spline terms, or smooths, differ using a true discovery proportion (TDP)-based interpretation. The procedure yields a statement on the proportion of some region where true differences exist between two smooths. The methodology avoids ad hoc approaches to making such statements, like subsetting the data and performing hypothesis tests on the truncated spline terms. TDP estimates are 1-<em>α</em> confidence-bounded simultaneously, which means that a region's TDP estimate is a lower bound on the proportion of actual differences, or true discoveries, in that region, with high confidence regardless of the number of estimates made. The procedure is based on closed-testing using Simes local test. This local test requires that the multivariate <span><math><msup><mrow><mi>χ</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span> test statistics of generalized Wishart type underlying the method be positive regression dependent on subsets (PRDS), a result for which evidence is presented suggesting that the condition holds. Consistency of the procedure is demonstrated for generalized additive models with the tuning parameter chosen by REML or GCV, and the achievement of confidence-bounded TDP is shown in simulation as is an analysis of walking gait.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"211 ","pages":"Article 108197"},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-10DOI: 10.1016/j.csda.2025.108188
Joshua Tobin , Michaela Black , James Ng , Debbie Rankin , Jonathan Wallace , Catherine Hughes , Leane Hoey , Adrian Moore , Jinling Wang , Geraldine Horigan , Paul Carlin , Helene McNulty , Anne M. Molloy , Mimi Zhang
The Latent Block Model (LBM) is a prominent model-based co-clustering method, returning parametric representations of each block-cluster and allowing the use of well-grounded model selection methods. Although the LBM has been adapted to accommodate various feature types, it cannot be applied to datasets consisting of multiple distinct sets of features, termed views, for a common set of observations. The multi-view LBM is introduced herein, extending the LBM method to multi-view data, where each view marginally follows an LBM. For any pair of two views, the dependence between them is captured by a row-cluster membership matrix. A likelihood-based approach is formulated for parameter estimation, harnessing a stochastic EM algorithm merged with a Gibbs sampler, while an ICL criterion is formulated to determine the number of row- and column-clusters in each view. To justify the application of the multi-view approach, hypothesis tests are formulated to evaluate the independence of row-clusters across views, with the testing procedure seamlessly integrated into the estimation framework. A penalty scheme is also introduced to induce sparsity in row-clusterings. The algorithm's performance is validated using synthetic and real-world datasets, accompanied by recommendations for optimal parameter selection. Finally, the multi-view co-clustering method is applied to a complex genomics dataset, and is shown to provide new insights for high-dimension multi-view problems.
{"title":"Co-clustering multi-view data using the Latent Block Model","authors":"Joshua Tobin , Michaela Black , James Ng , Debbie Rankin , Jonathan Wallace , Catherine Hughes , Leane Hoey , Adrian Moore , Jinling Wang , Geraldine Horigan , Paul Carlin , Helene McNulty , Anne M. Molloy , Mimi Zhang","doi":"10.1016/j.csda.2025.108188","DOIUrl":"10.1016/j.csda.2025.108188","url":null,"abstract":"<div><div>The Latent Block Model (LBM) is a prominent model-based co-clustering method, returning parametric representations of each block-cluster and allowing the use of well-grounded model selection methods. Although the LBM has been adapted to accommodate various feature types, it cannot be applied to datasets consisting of multiple distinct sets of features, termed views, for a common set of observations. The multi-view LBM is introduced herein, extending the LBM method to multi-view data, where each view marginally follows an LBM. For any pair of two views, the dependence between them is captured by a row-cluster membership matrix. A likelihood-based approach is formulated for parameter estimation, harnessing a stochastic EM algorithm merged with a Gibbs sampler, while an ICL criterion is formulated to determine the number of row- and column-clusters in each view. To justify the application of the multi-view approach, hypothesis tests are formulated to evaluate the independence of row-clusters across views, with the testing procedure seamlessly integrated into the estimation framework. A penalty scheme is also introduced to induce sparsity in row-clusterings. The algorithm's performance is validated using synthetic and real-world datasets, accompanied by recommendations for optimal parameter selection. Finally, the multi-view co-clustering method is applied to a complex genomics dataset, and is shown to provide new insights for high-dimension multi-view problems.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"210 ","pages":"Article 108188"},"PeriodicalIF":1.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-10DOI: 10.1016/j.csda.2025.108189
Angelika Silbernagel , Christian H. Weiß , Alexander Schnurr
Analyzing the cross-dependence within sequentially observed pairs of random variables is an interesting mathematical problem that also has several practical applications. Most of the time, classical dependence measures like Pearson's correlation are used to this end. This quantity, however, only measures linear dependence and has other drawbacks as well. Different concepts for measuring cross-dependence in sequentially observed random vectors, which are based on so-called ordinal patterns or multivariate generalizations of them, are described. In all cases, limiting distributions of the corresponding test statistics are derived. In a simulation study, the performance of these statistics is compared with three competitors, namely, classical Pearson's and Spearman's correlation as well as the rank-based Chatterjee's correlation coefficient. The applicability of the test statistics is illustrated by using them on two real-world data examples.
{"title":"Non-parametric tests for cross-dependence based on multivariate extensions of ordinal patterns","authors":"Angelika Silbernagel , Christian H. Weiß , Alexander Schnurr","doi":"10.1016/j.csda.2025.108189","DOIUrl":"10.1016/j.csda.2025.108189","url":null,"abstract":"<div><div>Analyzing the cross-dependence within sequentially observed pairs of random variables is an interesting mathematical problem that also has several practical applications. Most of the time, classical dependence measures like Pearson's correlation are used to this end. This quantity, however, only measures linear dependence and has other drawbacks as well. Different concepts for measuring cross-dependence in sequentially observed random vectors, which are based on so-called ordinal patterns or multivariate generalizations of them, are described. In all cases, limiting distributions of the corresponding test statistics are derived. In a simulation study, the performance of these statistics is compared with three competitors, namely, classical Pearson's and Spearman's correlation as well as the rank-based Chatterjee's correlation coefficient. The applicability of the test statistics is illustrated by using them on two real-world data examples.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"210 ","pages":"Article 108189"},"PeriodicalIF":1.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-04DOI: 10.1016/j.csda.2025.108181
Alice Giampino, Roberto Ascari, Sonia Migliorati
Understanding how the human gut microbiome affects host health is challenging due to the wide interindividual variability, sparsity, and high dimensionality of microbiome data. Mixed-membership models have been previously applied to these data to detect latent communities of bacterial taxa that are expected to co-occur. The most widely used mixed-membership model is latent Dirichlet allocation (LDA). However, LDA is limited by the rigidity of the Dirichlet distribution imposed on the community proportions, which hinders its ability to model dependencies and account for overdispersion. To address this limitation, a generalization of LDA is proposed that introduces greater flexibility into the covariance matrix by incorporating the flexible Dirichlet (FD), a specific identifiable mixture with Dirichlet components. In addition to identifying communities, the new model enables the detection of enterotypes, i.e., clusters of samples with similar microbe composition. For inferential purposes, a computationally efficient collapsed Gibbs sampler that exploits the conjugacy of the FD distribution with respect to the multinomial model is proposed. A simulation study demonstrates the model's ability to accurately recover true parameter values by minimizing appropriate compositional discrepancy measures between the true and estimated values. Additionally, the model correctly identifies the number of communities, as evidenced by perplexity scores. Moreover, an application to the COMBO dataset highlights its effectiveness in detecting biologically significant and coherent communities and enterotypes, revealing a broader range of correlations between community abundances. These results underscore the new model as a definite improvement over LDA.
{"title":"A flexible mixed-membership model for community and enterotype detection for microbiome data","authors":"Alice Giampino, Roberto Ascari, Sonia Migliorati","doi":"10.1016/j.csda.2025.108181","DOIUrl":"10.1016/j.csda.2025.108181","url":null,"abstract":"<div><div>Understanding how the human gut microbiome affects host health is challenging due to the wide interindividual variability, sparsity, and high dimensionality of microbiome data. Mixed-membership models have been previously applied to these data to detect latent communities of bacterial taxa that are expected to co-occur. The most widely used mixed-membership model is latent Dirichlet allocation (LDA). However, LDA is limited by the rigidity of the Dirichlet distribution imposed on the community proportions, which hinders its ability to model dependencies and account for overdispersion. To address this limitation, a generalization of LDA is proposed that introduces greater flexibility into the covariance matrix by incorporating the flexible Dirichlet (FD), a specific identifiable mixture with Dirichlet components. In addition to identifying communities, the new model enables the detection of enterotypes, i.e., clusters of samples with similar microbe composition. For inferential purposes, a computationally efficient collapsed Gibbs sampler that exploits the conjugacy of the FD distribution with respect to the multinomial model is proposed. A simulation study demonstrates the model's ability to accurately recover true parameter values by minimizing appropriate compositional discrepancy measures between the true and estimated values. Additionally, the model correctly identifies the number of communities, as evidenced by perplexity scores. Moreover, an application to the COMBO dataset highlights its effectiveness in detecting biologically significant and coherent communities and enterotypes, revealing a broader range of correlations between community abundances. These results underscore the new model as a definite improvement over LDA.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"210 ","pages":"Article 108181"},"PeriodicalIF":1.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.csda.2025.108175
Shanshan Luo , Yechi Zhang , Wei Li , Zhi Geng
Unmeasured confounding presents a common challenge in observational studies, potentially making standard causal parameters unidentifiable without additional assumptions. Given the increasing availability of diverse data sources, exploiting data linkage offers a potential solution to mitigate unmeasured confounding within a primary study of interest. However, this approach often introduces selection bias, as data linkage is feasible only for a subset of the study population. To address such a concern, this paper explores three nonparametric identification strategies assuming that a unit's inclusion in the linked cohort is determined solely by the observed confounders, while acknowledging that the ignorability assumption may depend on some partially unobserved covariates. The existence of multiple identification strategies motivates the development of estimators that effectively capture distinct components of the observed data distribution. Appropriately combining these estimators yields triply robust estimators for the average treatment effect. These estimators remain consistent if at least one of the three distinct parts of the observed data law is correct. Moreover, they are locally efficient if all the models are correctly specified. The proposed estimators are evaluated using simulation studies and real data analysis.
{"title":"Multiply robust estimation of causal effects using linked data","authors":"Shanshan Luo , Yechi Zhang , Wei Li , Zhi Geng","doi":"10.1016/j.csda.2025.108175","DOIUrl":"10.1016/j.csda.2025.108175","url":null,"abstract":"<div><div>Unmeasured confounding presents a common challenge in observational studies, potentially making standard causal parameters unidentifiable without additional assumptions. Given the increasing availability of diverse data sources, exploiting data linkage offers a potential solution to mitigate unmeasured confounding within a primary study of interest. However, this approach often introduces selection bias, as data linkage is feasible only for a subset of the study population. To address such a concern, this paper explores three nonparametric identification strategies assuming that a unit's inclusion in the linked cohort is determined solely by the observed confounders, while acknowledging that the ignorability assumption may depend on some partially unobserved covariates. The existence of multiple identification strategies motivates the development of estimators that effectively capture distinct components of the observed data distribution. Appropriately combining these estimators yields triply robust estimators for the average treatment effect. These estimators remain consistent if at least one of the three distinct parts of the observed data law is correct. Moreover, they are locally efficient if all the models are correctly specified. The proposed estimators are evaluated using simulation studies and real data analysis.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"209 ","pages":"Article 108175"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the Bayesian framework power prior distributions are increasingly adopted in clinical trials and similar studies to incorporate external and past information, typically to inform the parameter associated with a treatment effect. Their use is particularly effective in scenarios with small sample sizes and where robust prior information is available. A crucial component of this methodology is represented by its weight parameter, which controls the volume of historical information incorporated into the current analysis. Although this parameter can be modeled as either fixed or random, eliciting its prior distribution via a full Bayesian approach remains challenging. In general, this parameter should be carefully selected to accurately reflect the available historical information without dominating the posterior inferential conclusions. A novel simulation-based calibrated Bayes factor procedure is proposed to elicit the prior distribution of the weight parameter, allowing it to be updated according to the strength of the evidence in the data. The goal is to facilitate the integration of historical data when there is agreement with current information and to limit it when discrepancies arise in terms, for instance, of prior-data conflicts. The performance of the proposed method is tested through simulation studies and applied to real data from clinical trials.
{"title":"Eliciting prior information from clinical trials via calibrated Bayes factor","authors":"Roberto Macrì Demartino , Leonardo Egidi , Nicola Torelli , Ioannis Ntzoufras","doi":"10.1016/j.csda.2025.108180","DOIUrl":"10.1016/j.csda.2025.108180","url":null,"abstract":"<div><div>In the Bayesian framework power prior distributions are increasingly adopted in clinical trials and similar studies to incorporate external and past information, typically to inform the parameter associated with a treatment effect. Their use is particularly effective in scenarios with small sample sizes and where robust prior information is available. A crucial component of this methodology is represented by its weight parameter, which controls the volume of historical information incorporated into the current analysis. Although this parameter can be modeled as either fixed or random, eliciting its prior distribution via a full Bayesian approach remains challenging. In general, this parameter should be carefully selected to accurately reflect the available historical information without dominating the posterior inferential conclusions. A novel simulation-based calibrated Bayes factor procedure is proposed to elicit the prior distribution of the weight parameter, allowing it to be updated according to the strength of the evidence in the data. The goal is to facilitate the integration of historical data when there is agreement with current information and to limit it when discrepancies arise in terms, for instance, of prior-data conflicts. The performance of the proposed method is tested through simulation studies and applied to real data from clinical trials.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"209 ","pages":"Article 108180"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-27DOI: 10.1016/j.csda.2025.108174
Youngmin Ahn , Woongjoon Park , Gunwoong Park
As the importance of data privacy continues to grow, data masking has emerged as a crucial method. Notably, data masking techniques aim to protect individual privacy, while enabling data analysts to derive meaningful statistical results, such as the identification of directional or causal relationships between variables. Hence, this study demonstrates the advantages of a quantile-based discretization for protecting privacy and uncovering the relationships between variables in Gaussian directed acyclic graphical (DAG) models. Specifically, it introduces quantile-discretized Gaussian DAG models where each node variable is discretized based on the quantiles. Additionally, it proposes the bi-partition process, which aids in recovering the covariance matrix; hence, the models can be identifiable. Furthermore, a consistent algorithm is developed for learning the underlying structure using the quantile-based discretized data. Finally, through numerical experiments and the application of DAG learning algorithms to discretized MLB data, the proposed algorithm is demonstrated to significantly outperform the state-of-the-art DAG model learning algorithms.
{"title":"Discretization: Privacy-preserving data publishing for causal discovery","authors":"Youngmin Ahn , Woongjoon Park , Gunwoong Park","doi":"10.1016/j.csda.2025.108174","DOIUrl":"10.1016/j.csda.2025.108174","url":null,"abstract":"<div><div>As the importance of data privacy continues to grow, data masking has emerged as a crucial method. Notably, data masking techniques aim to protect individual privacy, while enabling data analysts to derive meaningful statistical results, such as the identification of directional or causal relationships between variables. Hence, this study demonstrates the advantages of a quantile-based discretization for protecting privacy and uncovering the relationships between variables in Gaussian directed acyclic graphical (DAG) models. Specifically, it introduces quantile-discretized Gaussian DAG models where each node variable is discretized based on the quantiles. Additionally, it proposes the bi-partition process, which aids in recovering the covariance matrix; hence, the models can be identifiable. Furthermore, a consistent algorithm is developed for learning the underlying structure using the quantile-based discretized data. Finally, through numerical experiments and the application of DAG learning algorithms to discretized MLB data, the proposed algorithm is demonstrated to significantly outperform the state-of-the-art DAG model learning algorithms.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"209 ","pages":"Article 108174"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-27DOI: 10.1016/j.csda.2025.108178
Huimin Lu , Yilong Wang , Heming Bing , Shuying Wang , Niya Li
Variable selection is discussed in many cases in survival analysis. In particular, the analysis of using proportional hazards (PH) models to deal with censored survival data has established a large amount of literature. Based on interval-censored data, this paper discusses the situation of complex network structures existing in covariates. To address the issue, a more flexible and versatile PH model has been developed by combining probabilistic graphical models with PH models, to describe the correlation between covariates. Based on the block coordinate descent method, a penalized estimation method is proposed, which can simultaneously perform variable selection and parameter estimation. The effectiveness of the proposed model and its parameter estimation method are evaluated through simulation studies and the analysis of clinical trial data related to Alzheimer's disease, confirming the reliability and accuracy of the proposed model and method.
{"title":"Efficient regularized estimation of graphical proportional hazards model with interval-censored data","authors":"Huimin Lu , Yilong Wang , Heming Bing , Shuying Wang , Niya Li","doi":"10.1016/j.csda.2025.108178","DOIUrl":"10.1016/j.csda.2025.108178","url":null,"abstract":"<div><div>Variable selection is discussed in many cases in survival analysis. In particular, the analysis of using proportional hazards (PH) models to deal with censored survival data has established a large amount of literature. Based on interval-censored data, this paper discusses the situation of complex network structures existing in covariates. To address the issue, a more flexible and versatile PH model has been developed by combining probabilistic graphical models with PH models, to describe the correlation between covariates. Based on the block coordinate descent method, a penalized estimation method is proposed, which can simultaneously perform variable selection and parameter estimation. The effectiveness of the proposed model and its parameter estimation method are evaluated through simulation studies and the analysis of clinical trial data related to Alzheimer's disease, confirming the reliability and accuracy of the proposed model and method.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"209 ","pages":"Article 108178"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-27DOI: 10.1016/j.csda.2025.108176
Kwan-Young Bak , Seongoh Park
This paper presents a study on an -penalized covariance regression method. Conventional approaches in high-dimensional covariance estimation often lack the flexibility to integrate external information. As a remedy, we adopt the regression-based covariance modeling framework and introduce a linear covariance selection model (LCSM) to encompass a broader spectrum of covariance structures when covariate information is available. Unlike existing methods, we do not assume that the true covariance matrix can be exactly represented by a linear combination of known basis matrices. Instead, we adopt additional basis matrices for a portion of the covariance patterns not captured by the given bases. To estimate high-dimensional regression coefficients, we exploit the sparsity-inducing -penalization scheme. Our theoretical analyses are based on the (symmetric) matrix regression model with additive random error matrix, which allows us to establish new non-asymptotic convergence rates of the proposed covariance estimator. The proposed method is implemented with the coordinate descent algorithm. We conduct empirical evaluation on simulated data to complement theoretical findings and underscore the efficacy of our approach. To show a practical applicability of our method, we further apply it to the co-expression analysis of liver gene expression data where the given basis corresponds to the adjacency matrix of the co-expression network.
{"title":"Linear covariance selection model via ℓ1-penalization","authors":"Kwan-Young Bak , Seongoh Park","doi":"10.1016/j.csda.2025.108176","DOIUrl":"10.1016/j.csda.2025.108176","url":null,"abstract":"<div><div>This paper presents a study on an <span><math><msub><mrow><mi>ℓ</mi></mrow><mrow><mn>1</mn></mrow></msub></math></span>-penalized covariance regression method. Conventional approaches in high-dimensional covariance estimation often lack the flexibility to integrate external information. As a remedy, we adopt the regression-based covariance modeling framework and introduce a linear covariance selection model (LCSM) to encompass a broader spectrum of covariance structures when covariate information is available. Unlike existing methods, we do not assume that the true covariance matrix can be exactly represented by a linear combination of known basis matrices. Instead, we adopt additional basis matrices for a portion of the covariance patterns not captured by the given bases. To estimate high-dimensional regression coefficients, we exploit the sparsity-inducing <span><math><msub><mrow><mi>ℓ</mi></mrow><mrow><mn>1</mn></mrow></msub></math></span>-penalization scheme. Our theoretical analyses are based on the (symmetric) matrix regression model with additive random error matrix, which allows us to establish new non-asymptotic convergence rates of the proposed covariance estimator. The proposed method is implemented with the coordinate descent algorithm. We conduct empirical evaluation on simulated data to complement theoretical findings and underscore the efficacy of our approach. To show a practical applicability of our method, we further apply it to the co-expression analysis of liver gene expression data where the given basis corresponds to the adjacency matrix of the co-expression network.</div></div>","PeriodicalId":55225,"journal":{"name":"Computational Statistics & Data Analysis","volume":"209 ","pages":"Article 108176"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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