Configurations are gestalt-like conjunctions of stimuli or stimulus features leading to holistic perception. The current study in humans investigated configural threat learning with bimodal visual-auditory conjunctions. The associative learning task involved classical discriminative conditioning with elemental visual (V), elemental auditory (A) and complex bimodal audiovisual (AV) stimuli, some of which were reinforced and some not. We focused on early theta oscillations (4–7 Hz) evoked by stimuli, and we used data-driven approach to magnetoencephalographic data recorded during participants’ performance on the task. We observed a robust increase in theta-band power in response to reinforced configural audiovisual stimuli (AV+), compared either to non-reinforced audiovisual stimuli (AV−) or to reinforced elemental stimuli (A+ or V+). Notably, the effect in response to the configural stimulus exhibited non-additive properties, indicating emergent integrative processing that extends beyond a simple superposition of its elements. Source localization revealed a distributed network of higher-order associative brain regions specifically engaged during configural learning, including the parahippocampal complex and dorsolateral prefrontal cortex – areas traditionally associated with learning and memory. Significant theta power increases were also observed in the inferior parietal cortex and temporoparietal junction, as well as in the lateral and inferior temporal cortices. These regions, known for their roles in multimodal integration and higher-order cognition, are implicated in relational processing, attentional modulation, and object categorization. Together, these findings underscore the role of theta synchronization in binding complex sensory inputs into unified, higher-level representations during configural learning in humans. We interpret these results in terms of hippocampal-cortical communication and concept formation.
扫码关注我们
求助内容:
应助结果提醒方式:
