Brain and Language最新文献

The corpus callosum, the largest white matter inter-hemispheric pathway, is involved in language and communication. In a cohort of 15 children and adolescents (8–15 years) with developmental absence of the corpus callosum (AgCC), this study aimed to describe language and everyday communication functioning, and explored the role of anatomical factors, social risk, and non-verbal IQ in these outcomes. Standardised measures of language and everyday communication functioning, intellectual ability and social risk were used. AgCC classification and anterior commissure volume, a potential alternative pathway, were extracted from T1-weighted images. Participants with AgCC showed reduced receptive and expressive language compared with test norms, and high rates of language and communication impairments. Complete AgCC, higher social risk and lower non-verbal IQ were associated with communication difficulties. Anterior commissure volume was not associated with language and communication. Recognising heterogeneity in language and communication functioning enhances our understanding and suggests specific focuses for potential interventions.

The goal of this study was to investigate sentence-level reading circuits in deaf native signers, a unique group of deaf people who are immersed in a fully accessible linguistic environment from birth, and hearing readers. Task-based fMRI, functional connectivity and lateralization analyses were conducted. Both groups exhibited overlapping brain activity in the left-hemispheric perisylvian regions in response to a semantic sentence task. We found increased activity in left occipitotemporal and right frontal and temporal regions in deaf readers. Lateralization analyses did not confirm more rightward asymmetry in deaf individuals. Deaf readers exhibited weaker functional connectivity between inferior frontal and middle temporal gyri and enhanced coupling between temporal and insular cortex. In conclusion, despite the shared functional activity within the semantic reading network across both groups, our results suggest greater reliance on cognitive control processes for deaf readers, possibly resulting in greater effort required to perform the task in this group.

Developmental Language Disorder (DLD) has been explained as either a deficit deriving from an abstract representational deficit or as emerging from difficulties in acquiring and coordinating multiple interacting cues guiding learning. These competing explanations are often difficult to decide between when tested on European languages. This paper reports an experimental study of relative clause (RC) production in Cantonese-speaking children with and without DLD, which enabled us to test multiple developmental predictions derived from one prominent theory − emergentism. Children with DLD (N = 22; aged 6;6–9;7) were compared with age-matched typically-developing peers (N = 23) and language-matched, typically-developing children (N = 21; aged 4;7–7;6) on a sentence repetition task. Results showed that children’s production across multiple RC types was influenced by structural frequency, general semantic complexity, and the linear order of constituents, with the DLD group performing worse than their age-matched and language-matched peers. The results are consistent with the emergentist explanation of DLD.

A key aspect of linguistic communication involves semantic reference to objects. Presently, we investigate neural responses at objects when reference is disrupted, e.g., “The connoisseur tasted *that wine“… vs. “…*that roof…” Without any previous linguistic context or visual gesture, use of the demonstrative determiner “that” renders interpretation at the noun as incoherent. This incoherence is not based on knowledge of how the world plausibly works but instead is based on grammatical rules of reference. Whereas Event-Related Potential (ERP) responses to sentences such as “The connoisseur tasted the wine …” vs. “the roof” would result in an N400 effect, it is unclear what to expect for doubly incoherent “…*that roof…”. Results revealed an N400 effect, as expected, preceded by a P200 component (instead of predicted P600 effect). These independent ERP components at the doubly violated condition support the notion that semantic interpretation can be partitioned into grammatical vs. contextual constructs.

Considerable work has investigated similarities between the processing of music and language, but it remains unclear whether typical, genuine music can influence speech processing via cross-domain priming. To investigate this, we measured ERPs to musical phrases and to syntactically ambiguous Chinese phrases that could be disambiguated by early or late prosodic boundaries. Musical primes also had either early or late prosodic boundaries and we asked participants to judge whether the prime and target have the same structure. Within musical phrases, prosodic boundaries elicited reduced N1 and enhanced P2 components (relative to the no-boundary condition) and musical phrases with late boundaries exhibited a closure positive shift (CPS) component. More importantly, primed target phrases elicited a smaller CPS compared to non-primed phrases, regardless of the type of ambiguous phrase. These results suggest that prosodic priming can occur across domains, supporting the existence of common neural processes in music and language processing.

The neural correlates of predictive processing in language, critical for efficient sentence comprehension, is well documented in adults. Specifically, adults exhibit alpha power (9–12 Hz) suppression when processing high versus low predictability sentences. This study explores whether young children exhibit similar neural mechanisms. We analyzed EEG data from 29 children aged 3–5 years listening to sentences of varying predictability. Our results revealed significant neural oscillation differences in the 5–12 Hz range between high and low predictability sentences, similar to adult patterns. Crucially, the degree of these differences correlated with children’s language abilities. These findings are the first to demonstrate the neural basis of predictive processing in young children and its association with language development.

Adjectives in English and Mandarin are typically prenominal, but the corresponding grammatical rules vary in subtle ways. Our event-related potential (ERP) study shows that native speakers of both languages rely on similar processing mechanisms when reading sentences with anomalous noun-adjective order (e.g., the vase *white) in their first language, reflected by a biphasic N400-P600 profile. Only Mandarin native speakers showed an additional N400 on grammatical adjectives (e.g., the white vase), potentially due to atypical word-by-word presentation of lexicalized compounds. English native speakers with advanced Mandarin proficiency were tested in both languages. They processed ungrammatical noun-adjective pairs in English like English monolinguals (N400-P600), but only exhibited an N400 in Mandarin. The absent P600 effect corresponded to their (surprisingly) low proficiency with noun-adjective violations in Mandarin, questioning simple rule transfer from English grammar.

Converging evidence suggests that emotions are often dulled in one’s foreign language. Here, we paired fMRI with a naturalistic viewing paradigm (i.e., original vs. dubbed versions of sad, fun and neutral movie clips) to investigate the neural correlates of emotion perception as a function of native (L1) and foreign (L2) language context. Watching emotional clips in L1 (vs. L2) reflected in activations of anterior temporal cortices involved in semantic cognition, arguably indicating a closer association of emotion concepts with the native language. The processing of fun clips in L1 (vs. L2) reflected in enhanced response of the right amygdala, suggesting a deeper emotional experience of positively valenced stimuli in the L1. Of interest, the amygdala response to fun clips positively correlated with participants’ proficiency in the L2, indicating that a higher L2 competence may reduce emotional processing differences across a bilingual’s two languages. Our findings are compatible with the view that language provides a context for the construction of emotions.

In human languages, it is a common phenomenon for a single word to have multiple meanings. This study used fMRI to investigate how the brain processed different types of lexical ambiguity, and how it differentiated the meanings of ambiguous words. We focused on homonyms and polysemy that differed in the relatedness among multiple meanings. Participants (N = 35) performed a prime-target semantic relatedness task, where a specific meaning of an ambiguous word was primed. Results showed that homonyms elicited greater activation in bilateral dorsal prefrontal and posterior parietal cortices than polysemous words, suggesting that these regions may be more engaged in cognitive control when the meanings of ambiguous words are unrelated. Multivariate pattern analysis further revealed that meanings of homonyms with different syntactic categories were represented differently in the frontal and temporal cortices. The findings highlighted the importance of semantic relations and grammatical factors in the brain’s representation of lexical ambiguities.

Geometry has been identified as a cognitive domain where deaf individuals exhibit relative strength, yet the neural mechanisms underlying geometry processing in this population remain poorly understood. This fMRI study aimed to investigate the neural correlates of geometry processing in deaf and hearing individuals. Twenty-two adult deaf signers and 25 hearing non-signers completed a geometry decision task. We found no group differences in performance, while there were some differences in parietal activation. As expected, the posterior superior parietal lobule (SPL) was recruited for both groups. The anterior SPL was significantly more activated in the deaf group, and the inferior parietal lobule was significantly more deactivated in the hearing group. In conclusion, despite similar performance across groups, there were differences in the recruitment of parietal regions. These differences may reflect inherent differences in brain organization due to different early sensory and linguistic experiences.