Biological Psychology最新文献

Eye contact with a human and with a humanoid robot elicits attention- and affect-related psychophysiological responses. However, these responses have mostly been studied in adults, leaving their developmental origin poorly understood. In this study, 114 infants (6–8 months old) viewed direct and averted gaze directions of a live human and an embodied humanoid robot while their heart rate deceleration (attention orienting), skin conductance (affective arousal), and facial muscle activity (affective valence) were measured. In addition, a non-humanoid object (a vase) was used as a control stimulus. Infants’ attention orienting was stronger to averted versus direct gaze of a human and a robot, but indifferent to the averted versus direct orientation of the non-humanoid object. Moreover, infants’ attention orienting was equally intensive toward a human and a robot, but less intensive toward a non-humanoid object. Affective arousal was insensitive to gaze direction and did not differ between the human, the robot, and the non-humanoid object. Facial muscle responses showed sensitivity to the gaze direction of a human and of a robot but not to the orientation of the non-humanoid object. These results suggest that infants recognize the attentional and affective/affiliative significance not only in a human’s gaze but also in a robot’s gaze.

Objective

Elevated pediatric irritability is a transdiagnostic symptom that predicts multiple mental health problems in adolescence and adulthood. Altered top-down regulatory networks, such as inhibitory control networks that suppress an impulse in favor of goal-directed behavior, are thought to contribute to high levels of youth irritability. Nevertheless, little work has examined links between youth irritability and neural processes supporting inhibitory control in large diverse samples, nor have they focused on the key period ramping up to adolescence (i.e., preadolescence).

Method

Functional MRI data from 5380 preadolescents (age M=9.97 years, SD=0.62) in the baseline Adolescent Brain and Cognitive Development (ABCD) Study were analyzed. Parents reported on their preadolescent’s irritability. The stop signal task (SST) was leveraged to probe successful and failed inhibitory control. Activation and functional connectivity with amygdala, ventral striatum, and prefrontal seed regions were calculated during the SST and used in whole brain and region of interest (ROI) group-level analyses evaluating irritability effects.

Results

Preadolescents with higher levels of irritability displayed decreases in functional connectivity among amygdala, ventral striatum, and prefrontal cortex regions during both successful and failed inhibitory control conditions. These results remained after adjusting for co-occurring anxiety, depression, and attention-deficit/hyperactivity symptoms.

Conclusions

Findings suggest neural aberrations in inhibitory control play a role in the pathophysiology of preadolescent irritability and associations are not merely due to co-occurring symptoms. Neural mechanisms of inhibitory control associated with irritability may provide novel intervention targets.

Tobacco smoking is a risk factor for countless diseases, and smoking relapse remains a major public health concern. Subjective reports of stress by smokers are a common theme for relapse, however, the role of objective stress-related biomarkers in predicting tobacco relapse risk has been less studied. The aim of this manuscript was to review existing literature on the connection between biomarkers of stress and smoking relapse. Overall, trends indicate that blunted hypothalamic-pituitary-adrenal (HPA) responses to acute stress, larger reductions in HPA biomarkers during the initial days of abstinence during cessation (compared to pre-cessation levels), and exaggerated autonomic responses to stress predict increased risk of relapse. In addition, successful cessation is followed by changes in stress biomarkers (e.g., reductions in cortisol and heart rate, HR). This review also identifies potential modifiers, such as methodological differences, biological sex, and chronic stress, to account for heterogeneity of findings within and across studies. In addition, we identify gaps in the literature and suggest future research directions focusing on the roles of genetics and gene expression as well as the influence of neurobiological mechanisms on stress and relapse risk. Future clinical implications of this research include identifying reliable indicators of relapse risk and the potential of pharmacotherapeutic treatments to target stress response systems to correct dysregulation and potentially reduce stress-related risk of relapse.

In a rapidly changing and uncertain business environment, individuals with high entrepreneurial intention (HEI) inevitably need to compete or cooperate with others to maximize their gains. However, the effects of competition and cooperation on the risky decision-making and neural mechanisms of individuals with HEI are not clear. By combining the modified Devil Task and electroencephalogram (EEG) technology, the current study showed that a competition context is more likely to motivate optimal decisions and enhance the total decision gains for individuals with HEI than a cooperation context. A positive relationship between the frequency of optimal decisions and the total gains of decision-making for individuals with HEI was also found, and this relationship was mediated by the degree of entrepreneurial intention. The EEG results showed that individuals with HEI made decisions in the competition context with greater P2 amplitude of frontal regions than in the cooperation context, and source localization analyses revealed that this difference in brain activity was manifested in the medial prefrontal cortex. Finally, the results revealed a positive relationship between the P2 amplitude and the degree of entrepreneurial intention of individuals with HEI. Overall, the study suggests that competition is an effective way to motivate individuals with HEI to make optimal decisions and, thus, maximize their profits, providing new perspectives on ways to promote successful entrepreneurship.

Social pain is a painful feeling evoked by social rejection, exclusion, or the loss of other important people. Previous research suggests that physical pain is reduced by increased signals from baroreceptors that monitor blood pressure. This pre-registered study investigated whether social pain is attenuated by increased baroafferent signals, as observed in physical pain. Given that baroafferent signals increase during cardiac systole and decrease during diastole, we hypothesized that feelings of pain induced by social rejection would be lower when exclusion events are presented at the cardiac systole than when they are presented at the diastole. Participants completed the cyberball task, a computerized ball-tossing game involving two other players. In the rejection condition, the ball was rarely thrown to the participant, while the other players kept tossing it to each other. Throws between other players were defined as exclusion events and were presented either at the cardiac systole (a systole condition) or at the diastole (a diastole condition). We found that exclusion events evoked significantly less social pain in the systole condition than in the diastole condition. Furthermore, the effects of cardiac cycle were more pronounced in participants with higher heart rate variability than those with lower heart rate variability. Our results suggest that cardiac afferent signals contribute not only to physical pain but also to social pain.

The cortisol awakening response (CAR) has been hypothesized to prepare the body for anticipated demands of the upcoming day. This pilot study investigates the influence of anticipated stress on the upcoming day on the CAR, using an intensive longitudinal design with ecological momentary assessments. Over a 30-day period, three healthy participants collected saliva samples each morning at three time points after awakening to measure cortisol levels and completed a questionnaire each evening on the anticipated stress for the following day. Additionally, they wore a smart headband to objectively determine the time point of awakening. There was high variability in the CAR magnitude within participants over time. A multi-level model was estimated to investigate the influence of anticipated stress on the CAR. Results indicated that anticipated stress is predictive of the CAR on the following morning, with higher anticipated stress being associated with increased cortisol levels at the post-awakening time points. These findings underscore the role of stress anticipation in modulating the CAR and highlight the importance of considering within-person variation and temporally lagged effects in biopsychological research.

Prior research suggests that cognitive control, indicated by NoGo N2 amplitudes in Go/NoGo tasks, is associated with dispositional anxiety. This negative association tends to be reduced in anxiety-enhancing experimental conditions. However, anxiety-reducing conditions have not yet been investigated systematically. Thus, the present study compares the effect of a relaxation instruction with the conventional speed/accuracy instruction in a Go/NoGo task on the correlation of the NoGo N2 with two subconstructs of dispositional anxiety, namely anxious apprehension and anxious arousal. As the test of differences between correlations needs considerable statistical power, the present study was included into the multi-lab CoScience Project. The hypotheses, manipulation checks, and the main path of pre-processing and statistical analysis were preregistered. Complete data sets of 777 participants were available for data analysis. Preregistered general linear models revealed that the different instructions of the task (speed/accuracy vs. relaxation) had no effect on the association between dispositional anxiety and the NoGo N2 amplitude in general. This result was supported by Cooperative-Forking-Path analysis. In contrast, a preregistered latent growth model with categorical variables revealed that anxious arousal was a negative predictor of the NoGo N2 intercept and a positive predictor of the NoGo N2 slope. Non-preregistered growth models, allowing for correlations of anxious apprehension with anxious arousal, revealed that higher anxious apprehension scores were associated with more negative NoGo N2 amplitudes with increased relaxation. Results are discussed in the context of the compensatory error monitoring hypothesis and the revised Reinforcement Sensitivity Theory.

Choice impulsivity can be measured by offering a sequence of various binary choices between smaller, immediately available rewards and larger, later available rewards. An individual’s delay discount (DD) rate reflects the aggregate decision-making tendency. Given the broad spectrum of disorders associated with a high DD rate, this may be an important transdiagnostic factor. This study aimed to establish whether post-decisional neurophysiological processes reflecting the presence of error monitoring are involved in delay discounting. A large sample (N = 97) was investigated, including 46 females and 51 males. The electroencephalogram (EEG) was recorded during the classic monetary choice questionnaire (MCQ-27). Error-related event-related potentials (ERPs) and event-related oscillations (EROs) following responses were analyzed. A modest relationship between error positivity (Pe) and DD rate was seen centro-parietal, with higher amplitude for low DD individuals after choosing immediate rewards. A robust association was found between DD rate and theta oscillation power increases. This was most prominent in low DD individuals after making an immediate reward choice. Theta power was positively associated with decision (reaction) time, suggesting an association between pre- and post-decisional conflict. No evidence was found for an error-related negativity (ERN) and delta oscillations. This study provides clear evidence for conflict monitoring as a post-decision process in delay discounting. Findings suggest that diminished theta band power bursts and lower Pe amplitude, observed after choosing an immediate reward, reflect the neurophysiological consequence and possibly the cause of steep delay discounting. High DD was characterized by prefrontal hypoactivation and appears to result from affective decision-making.

Highlights

Hoarding disorder (HD) and obsessive-compulsive disorder (OCD) are highly comorbid and genetically related, but their similarities and differences at the neural level are not well characterized. The present study examined the time-frequency information contained in stimulus-related EEG data as participants worked on a visual flanker task. Three groups were included: participants diagnosed with HD (N = 33), OCD (N = 26), and healthy controls (N = 35). Permutation-controlled mass-univariate analyses found no differences between groups in terms of the magnitude of the oscillatory responses. Differences between groups were found selectively for phase-based measures (phase-locking across trials and across sensors) in time ranges well after those consistent with initial visuocortical processes, in the alpha (10 Hz) as well as theta and beta frequency bands, centered around 6 Hz and 15 Hz, respectively. Specifically, HD showed attenuated phase locking in theta and alpha compared to OCD and HC, while OCD showed heightened inter-site phase locking in alpha/beta. Including age as a covariate attenuated, but did not eliminate, the group differences. These findings point to signatures of cortical dynamics and cortical communication task processing that are unique to HD, and which are specifically present during higher-order visual cognition such as stimulus-response mapping, response selection, and action monitoring.