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An Ethics Framework for Medical Assistance in Dying: Supporting Ethical Decision-Making in the Practice of MAiD. 死亡医疗援助的伦理框架:支持MAiD实践中的伦理决策。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-10-22 DOI: 10.1111/bioe.70037
Andrea N Frolic, Tim Holland

This paper presents an Ethics Framework for MAiD (Medical Assistance in Dying) to support the integration of evidence-informed, values-based, inclusive and transparent ethical decision-making into everyday MAiD practice. As with other areas of clinical practice, ethical decision-making is an intrinsic part of MAiD. While clinicians connected to academic medical centers or large hospitals may have access to the expertise of an ethicist, those working independently, or in community-based, rural or remote settings may wrestle with ethical issues alone. Without a process to guide ethical reflection and analysis, clinicians navigating complex MAiD cases risk moral distress and uncertainty, and may inadvertently make decisions that are biased, narrow or ill-informed. The proposed Ethics Framework for MAiD includes a description of core values and principles relevant to the delivery of MAiD and a process guide to support the application of values and principles to cases. Use of the framework is illustrated through a simplified complex MAiD case. This Ethics Framework for MAiD is applicable to both clinical patient cases and organizational ethics issues, and adaptable to any jurisdiction and any legal or practice context. It may also be used by ethicists when conducting formal ethics case consultations involving MAiD. The goal of the paper is to empower MAiD assessors, providers, health professionals, program managers and ethicists to address ethical issues arising in everyday practice through the introduction of a pragmatic ethics framework specifically tailored to assisted dying.

本文提出了一个MAiD(死亡医疗援助)的道德框架,以支持将循证、基于价值观、包容和透明的道德决策纳入日常MAiD实践。与临床实践的其他领域一样,道德决策是MAiD的内在组成部分。虽然与学术医疗中心或大医院有联系的临床医生可能有机会获得伦理学家的专业知识,但那些独立工作的人,或在社区、农村或偏远地区工作的人,可能要独自解决伦理问题。如果没有一个指导伦理反思和分析的过程,临床医生在处理复杂的MAiD病例时就会面临道德困扰和不确定性的风险,并可能在无意中做出有偏见、狭隘或不知情的决定。拟议的MAiD道德框架包括对与提供MAiD相关的核心价值观和原则的描述,以及支持将价值观和原则应用于案件的流程指南。通过一个简化的复杂MAiD案例说明了该框架的使用。本MAiD道德框架适用于临床患者案例和组织道德问题,并适用于任何司法管辖区和任何法律或实践背景。伦理学家在进行涉及MAiD的正式伦理案件磋商时也可以使用它。本文的目标是授权MAiD评估人员、提供者、卫生专业人员、项目经理和伦理学家通过引入专门为辅助死亡量身定制的实用伦理框架来解决日常实践中出现的伦理问题。
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引用次数: 0
Israel's Post-War Healthcare Obligations. 以色列战后医疗保健义务。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-10-22 DOI: 10.1111/bioe.70041
Daniel J Hurst, Christopher A Bobier

Since the beginning of the Israel-Hamas war in 2023, the healthcare infrastructure within Gaza has been dismantled. While international humanitarian law mandates distinction between lawful targets (combatants and military objectives) and non-lawful targets (civilians and civilian objects), and acknowledging the inherent complexities of applying this principle in conflicts involving non-state actors like Hamas operating within civilian areas, numerous reports indicate that Israel's actions have resulted in significant and foreseeable consequences for the Gazan civilian population. Due to these substantial and foreseeable harms, which have led to a long-term humanitarian crisis, we argue that the Israeli government bears a moral responsibility to help mitigate the long-term humanitarian crisis, which, at a minimum, requires helping to rebuild the healthcare infrastructure to its status quo ante bellum.

自2023年以色列-哈马斯战争开始以来,加沙境内的医疗保健基础设施已被拆除。虽然国际人道主义法要求区分合法目标(战斗人员和军事目标)和非合法目标(平民和民用物体),并承认在涉及哈马斯等非国家行为体在平民区活动的冲突中应用这一原则的内在复杂性,但许多报告表明,以色列的行动对加沙平民造成了重大和可预见的后果。由于这些重大和可预见的危害,导致了长期的人道主义危机,我们认为以色列政府承担着帮助缓解长期人道主义危机的道德责任,这至少需要帮助重建医疗基础设施,使其恢复到战前的状态。
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引用次数: 0
Three Roles for Clinical Ethicists to Provide Clarity and Guidance on Physician-Assisted Suicide/Euthanasia. 临床伦理学家在医生协助自杀/安乐死方面的三个角色
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-10-15 DOI: 10.1111/bioe.70038
Katherine Drabiak

A minority of countries around the world have taken steps to legalize the practice of physician-assisted suicide and/or euthanasia (PAS/E). Proponents frame PAS/E as a means to enhance patient autonomy, reduce suffering, alleviate the burden of illness, and respect patient dignity. Critics of PAS/E, on the other hand, assert that it reflects a distortion of autonomy, mistakes the source of patient suffering, and dangerously affirms to people that their dignity and worth are contingent on not requiring burdensome caregiving. This has the potential to create uncertainty for how clinicians and institutions should provide ethical guidance to patients on morally controversial matters such as PAS/E. Although ethicists have a duty to explain the range of ethical arguments, they also have an obligation to reinforce ethical boundaries and provide decisive guidance when an intervention is irreconcilable with the practice of medicine. In their clinical role, ethicists can explain why PAS/E is not a healing act and why it violates the principles of beneficence and nonmaleficence. This article outlines three roles for clinical ethicists to provide education, consultation, and develop policies designed to respond to patient suffering in a manner that preserves the integrity of medicine.

世界上少数国家已经采取措施使医生协助自杀和/或安乐死(PAS/E)的做法合法化。支持者认为PAS/E是一种增强患者自主性、减少痛苦、减轻疾病负担和尊重患者尊严的手段。另一方面,PAS/E的批评者断言,它反映了对自主权的扭曲,错误地理解了病人痛苦的根源,并危险地向人们肯定,他们的尊严和价值取决于不需要负担沉重的照顾。这可能会给临床医生和机构如何在PAS/E等有道德争议的问题上向患者提供伦理指导带来不确定性。尽管伦理学家有责任解释伦理争论的范围,但他们也有义务加强伦理界限,并在干预与医学实践不可调和时提供决定性的指导。在他们的临床角色中,伦理学家可以解释为什么PAS/E不是一种治疗行为,为什么它违反了仁慈和无害的原则。本文概述了临床伦理学家的三个角色,即提供教育、咨询和制定旨在以保持医学完整性的方式应对患者痛苦的政策。
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引用次数: 0
Little Things Mean A Lot 小事情意味着很多。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-10-05 DOI: 10.1111/bioe.70036
Ruth Chadwick
<p>For various reasons I have been doing a lot of hospital visiting lately and it has offered an opportunity to observe the care that is provided by obviously overworked health care professionals, who are routinely faced with challenging situations in conditions that inevitably involve scarcity of resources.</p><p>One incident that I witnessed concerned an apparently frail elderly person whose dentures had been lost in the hospital. The person's daughter was understandably annoyed by this and was offered an opportunity to claim for monetary compensation. While this may be the best that could be offered under the circumstances, it does not address the immediate needs of the patient, as obtaining new dentures may be difficult in this case. At the very least, it would take some time.</p><p>Thinking about this from a bioethical point of view, some might invoke a principle of dignity and argue that to leave a patient without his dentures infringes such a principle, although this obviously was not done deliberately. There are other ways of looking at it, however. With frail elderly patients, considerable focus is naturally placed on capacity to make decisions, and there is a surrounding legal framework to establish what counts as such capacity or the lack of it. There is another, natural, sense of capacity, however, concerning ability to function physically. Without one's dentures the capacity to take in nutrition is clearly compromised.</p><p>This thought leads to consideration of the class of ‘add-ons’ that might have similar importance. Artificial body parts and mobility aids should be considered. Spectacles and hearing aids are obvious examples that spring to mind. Another possible candidate is a watch. While younger generations might rely on their mobile phones for telling the time, for their seniors this might not be the case, and when eyesight is failing, seeing a clock on the wall might be challenging. Knowing what the time is, however, may be important to a patient in maintaining a sense of normality.</p><p>Hospitals cannot be expected to take responsibility for the possessions of their patients. The suggestion being put forward here, however, is that there should be some systems in place to safeguard those patient possessions that are key to their physical functioning. Obviously there are challenges to be faced, for example when patients have to move between beds or wards to facilitate the best care for themselves or for other patients. It is easy to see how possessions might get lost in the transfer. But some of those possessions, such as those mentioned above, are much more important than others (e.g., books and magazines), in so far as they support physical capacity. Where they do not already exist, there should therefore be a system of specific checks in place for these, just as there are mechanisms for checking that the proper medication has been administered. This is because they are in an important sense an extension of the patient's p
由于各种原因,我最近去了很多医院,这给我提供了一个机会,去观察那些显然超负荷工作的医疗保健专业人员所提供的护理,他们在不可避免地涉及资源短缺的情况下,经常面临着挑战。我亲眼目睹的一件事是关于一个看起来很虚弱的老人,他的假牙在医院里丢了。可以理解,这个人的女儿对此很恼火,并得到了一个要求金钱赔偿的机会。虽然这可能是在这种情况下可以提供的最好的,但它并不能解决患者的直接需求,因为在这种情况下获得新的假牙可能很困难。至少,这需要一些时间。从生物伦理学的角度来考虑这个问题,有些人可能会援引尊严原则,认为让病人不戴假牙违反了这一原则,尽管这显然不是故意的。然而,还有其他的方式来看待它。对于体弱的老年患者,相当大的焦点自然放在决策能力上,并且有一个周围的法律框架来确定什么是这种能力或缺乏这种能力。然而,还有另一种自然的能力感,与身体机能有关。没有假牙,人吸收营养的能力显然会受到损害。这种想法导致了对可能具有类似重要性的“附加组件”类别的考虑。应该考虑使用人工身体部件和辅助行动设备。眼镜和助听器是显而易见的例子。另一个可能的选择是手表。年轻一代可能会依靠手机来看时间,但对于老年人来说,情况可能并非如此。当视力下降时,看到墙上的时钟可能会很有挑战性。然而,知道时间对病人保持正常的感觉可能很重要。不能指望医院对病人的财产负责。然而,这里提出的建议是,应该有一些系统来保护这些病人的财产,这些财产对他们的身体功能至关重要。显然,需要面对一些挑战,例如,患者必须在病床或病房之间移动,以便为自己或其他患者提供最好的护理。很容易看出财产可能会在转移中丢失。但其中一些财产,比如上面提到的那些,比其他财产(比如书籍和杂志)重要得多,因为它们支持身体能力。因此,在还不存在这些问题的地方,应该有一个专门检查这些问题的系统,就像有检查是否使用了适当药物的机制一样。这是因为它们在一个重要的意义上是病人身体的延伸。将这项检查与其他检查一起纳入日常程序(希望如此),对于已经在压力下工作的员工来说,可能不会要求太高。
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引用次数: 0
Can Global Bioethics Benefit From Islamic Jurisprudential Principles? 全球生命伦理能否受益于伊斯兰法学原则?
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-27 DOI: 10.1111/bioe.70035
Sayyed Mohamed Muhsin, Abdurezak Abdulahi Hashi, Nageeb Gounjaria, Mohammed H. Alashaikh, Alexis Heng Boon Chin

Contemporary bioethical debates in the West are often polarized between secular liberal and conservative Christian perspectives, leaving limited space for cultural viewpoints rooted in non-Western traditions such as those of Hinduism, Confucianism, Islam and various African value systems. Secular liberalism's emphasis on individual autonomy often clashes with the communitarian and family-centred ethics prevalent in many Asian and African societies (i.e., the Global South). Meanwhile, certain conservative Christian positions, such as blanket opposition to embryo-based stem cell research or abortion even in cases of rape, are increasingly being challenged, including within Western contexts, for their perceived inflexibility and impracticality. Historical trends suggest that rigid ideological frameworks may lose relevance over time, underscoring the need for a more inclusive and pragmatic model of global bioethics. This article examines the potential contribution of fiqh, the science of interpreting Islamic revealed texts, and Maqāṣid al-Sharīʿah (the higher objectives of Islamic law) to the discourse of global bioethics. It explores the intersection of Universalism and Realism in Islamic thought and discusses how Sharīʿah conceptualizes human life and the strategies for its protection, particularly through the principle of the Preservation of Life (ḥifẓ al-nafs) as a central objective. Furthermore, it analyses the role of maṣlaḥah (public interest), the function of Islamic legal maxims as a roadmap to achieving ethical goals, and the centrality of family and community in Islamic ethics. These themes are considered in contrast to the individualistic values predominant in Western bioethical frameworks.

当代西方的生命伦理辩论往往在世俗的自由主义和保守的基督教观点之间两极分化,给植根于非西方传统的文化观点留下了有限的空间,比如印度教、儒教、伊斯兰教和各种非洲价值体系。世俗自由主义对个人自治的强调往往与许多亚洲和非洲社会(即全球南方)普遍存在的社区主义和以家庭为中心的伦理冲突。与此同时,某些保守的基督教立场,如全面反对基于胚胎的干细胞研究或甚至在强奸的情况下堕胎,正日益受到挑战,包括在西方背景下,因为他们被认为是不灵活和不切实际的。历史趋势表明,僵化的意识形态框架可能会随着时间的推移而失去相关性,这强调了建立一个更具包容性和实用性的全球生物伦理学模型的必要性。本文考察了fiqh(解释伊斯兰启示文本的科学)和Maqāṣid al- shari 'ah(伊斯兰法律的更高目标)对全球生物伦理学话语的潜在贡献。它探讨了伊斯兰思想中普遍主义和现实主义的交集,并讨论了shari 'ah如何将人类生命概念化以及保护人类生命的策略,特别是通过将生命保存原则(ḥifẓ al-nafs)作为中心目标。此外,它还分析了maṣlaḥah(公共利益)的作用,伊斯兰法律准则作为实现伦理目标的路线图的功能,以及家庭和社区在伊斯兰伦理中的中心地位。这些主题被认为与西方生物伦理框架中占主导地位的个人主义价值观形成对比。
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引用次数: 0
I Feel I Need to Think about It: A Defence of Affective Moral Enhancement 我觉得我需要考虑一下:为情感性道德提升辩护。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-22 DOI: 10.1111/bioe.70033
Pei-hua Huang

Critics of affective moral enhancement generally contend that moral improvement can only be properly achieved through interventions that engage a person's rational faculties. Therefore, they view attempts to achieve moral improvement by targeting emotions as futile at best and detrimental to moral agency at worst. In this paper, I argue that even if we accept the view that genuine moral improvement requires the engagement of rational faculties, we need not reject all forms of affective moral enhancement. My argument premises on the view that certain types of affect are highly informative. Affective moral enhancement that aims to elicit these affective states grants enhancement recipients access to vital moral knowledge they may not be able to attain otherwise. I then introduce the distinction between two types of affect—emotions and moods—and argue that the concerns regarding affective moral enhancement only apply to interventions that aim to achieve moral improvement via direct mood modulation.

情感道德提升的批评者通常认为,道德提升只能通过参与人的理性能力的干预来适当实现。因此,他们认为,通过针对情感来实现道德提升的尝试往好里说是徒劳的,往坏里说是有害于道德行为的。在本文中,我认为,即使我们接受真正的道德提升需要理性能力参与的观点,我们也不需要拒绝所有形式的情感道德提升。我的论点的前提是,某些类型的影响是高度信息性的。情感性道德强化旨在引发这些情感性状态,使接受者能够获得重要的道德知识,否则他们可能无法获得。然后,我介绍了两种类型的情感——情绪和情绪——之间的区别,并论证了关于情感道德提升的关注只适用于旨在通过直接情绪调节来实现道德提升的干预。
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引用次数: 0
When Is It Safe to Introduce an AI System Into Healthcare? A Practical Decision Algorithm for the Ethical Implementation of Black-Box AI in Medicine 将人工智能系统引入医疗保健行业何时安全?黑箱人工智能在医学中伦理实现的实用决策算法。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-18 DOI: 10.1111/bioe.70032
Jemima Winifred Allen, Dominic Wilkinson, Julian Savulescu

There is mounting global interest in the revolutionary potential of AI tools. However, its use in healthcare carries certain risks. Some argue that opaque (‘black box’) AI systems in particular undermine patients' informed consent. While interpretable models offer an alternative, this approach may be impossible with generative AI and large language models (LLMs). Thus, we propose that AI tools should be evaluated for clinical use based on their implementation risk, rather than interpretability. We introduce a practical decision algorithm for the clinical implementation of black-box AI by evaluating its risk of implementation. Applied to the case of an LLM for surgical informed consent, we assess a system's implementation risk by evaluating: (1) technical robustness, (2) implementation feasibility and (3) analysis of harms and benefits. Accordingly, the system is categorised as minimal-risk (standard use), moderate-risk (innovative use) or high-risk (experimental use). Recommendations for implementation are proportional to risk, requiring more oversight for higher-risk categories. The algorithm also considers the system's cost-effectiveness and patients' informed consent.

全球对人工智能工具的革命性潜力越来越感兴趣。然而,在医疗保健中使用它会带来一定的风险。一些人认为,不透明的(“黑箱”)人工智能系统尤其会破坏患者的知情同意。虽然可解释模型提供了另一种选择,但对于生成式人工智能和大型语言模型(llm)来说,这种方法可能是不可能的。因此,我们建议应该根据人工智能工具的实施风险而不是可解释性来评估其临床应用。通过评估黑箱人工智能的实施风险,提出了一种实用的黑箱人工智能临床实施决策算法。应用于外科手术知情同意法学硕士的案例,我们通过评估:(1)技术稳健性,(2)实施可行性和(3)危害和收益分析来评估系统的实施风险。因此,该系统被分类为最低风险(标准使用),中等风险(创新使用)或高风险(实验使用)。实施建议与风险成正比,需要对高风险类别进行更多监督。该算法还考虑了系统的成本效益和患者的知情同意。
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引用次数: 0
Violence Toward Palestinians in Israeli Prisons During the "Iron Swords" War. 在“铁剑”战争期间,以色列监狱中对巴勒斯坦人的暴力行为。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-15 DOI: 10.1111/bioe.70034
Daniel J N Weishut, Bettina Steiner-Birmanns

This study examines the violence inflicted upon Palestinians in Israeli prisons during the initial phase of the "Iron Swords" war, which commenced following a Hamas attack on Israeli civilians on October 7, 2023. It investigates how wartime circumstances can intensify the use of torture and ill-treatment within prisons, with a particular focus on the impact on detainees who were not implicated in activities connected to the attack. Utilizing the case files of Palestinian security prisoners who lodged complaints of mistreatment with Israeli NGOs, the study uses descriptive analysis to categorize and quantify diverse forms of reported violence that could potentially constitute torture. The study's findings reveal a concerning pattern: all 19 subjects reported experiencing violence from prison staff, with 18 of these cases involving physical violence. Multiple claims referenced more than one instance of violence, and eleven claims additionally reported violence against other detainees. The claims of violence spanned seven different prisons, underscoring the systemic nature of the issue. Reported methods of violence encompassed beatings, forced positioning in painful postures, threats, and humiliation, sometimes with sexual undertones, among other forms of abuse. Seven subjects had visible bruises and wounds, two suffered broken limbs, and one sustained a fractured tooth. These findings suggest a correlation between war, a decline in ethical standards, and the abuse of prisoners. By bringing these issues to light, the study advocates for evaluating prison practices and a commitment to upholding human rights standards, even during violent conflict and war.

本研究调查了在“铁剑”战争初期,以色列监狱中巴勒斯坦人遭受的暴力行为。“铁剑”战争是在哈马斯于2023年10月7日袭击以色列平民之后开始的。它调查了战时环境如何加剧监狱内使用酷刑和虐待,特别侧重于对与袭击有关的活动没有牵连的被拘留者的影响。该研究利用向以色列非政府组织投诉虐待的巴勒斯坦安全囚犯的案件档案,使用描述性分析对可能构成酷刑的各种形式的暴力行为进行分类和量化。研究结果揭示了一个令人担忧的模式:所有19名受试者都报告遭受监狱工作人员的暴力,其中18起涉及身体暴力。多项索赔提到不止一起暴力事件,11项索赔还报告了对其他被拘留者的暴力行为。有关暴力的指控涉及七个不同的监狱,凸显了这一问题的系统性。报告的暴力手段包括殴打、强迫摆出痛苦的姿势、威胁和羞辱,有时带有性暗示,以及其他形式的虐待。七名受试者有明显的瘀伤和伤口,两人四肢骨折,一人牙齿骨折。这些发现表明,战争、道德标准的下降和虐待囚犯之间存在关联。通过揭露这些问题,该研究倡导对监狱的做法进行评估,并承诺即使在暴力冲突和战争期间也要坚持人权标准。
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引用次数: 0
Thoughtful Accompaniment in Life's Final Stages: Philosophical Practice as a Complement to Ethics Consultation. 人生最后阶段的深思陪伴:哲学实践对伦理咨询的补充。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-12 DOI: 10.1111/bioe.70031
Patrick Schuchter, Sandra Radinger, Stefanie Veronika Rieger, Klaus Wegleitner

This paper argues that philosophical practice can complement existing medical ethics structures by offering a publicly accessible space for discourse and negotiation of basic concepts that are relevant to ethical decision making. The potential of collaboration becomes particularly evident by the example of assisted dying: it raises a wide range of philosophical questions which, however, tend to remain unarticulated where there is urgency for action and focus on ethical dilemma. In this paper, we first provide an analysis of the neglect of profound questions in ethics consultation and why these need to be considered and negotiated within a broader socio-philosophical framework and place. These reflections are grounded in conceptual approaches informed by Immanuel Kant, Charles Taylor, and the tradition of Hellenistic philosophy as interpreted by Pierre Hadot. These frameworks are not presented as final answers, but as productive starting points and historically significant philosophical thought figures for engaging with the complex philosophical dimensions of assisted suicide. Then, we draw upon insights from an ongoing research project on philosophical practice in palliative care and hospice work. Interim results indicate that people experience a need for a kind of dialogue that gives such philosophical considerations a space and a person who is capable of facilitating it. Synthesizing theoretical-philosophical and empirical insights, the paper provides an outlook for fruitful collaboration amongst medical ethics structures and philosophical practice.

本文认为,哲学实践可以为与伦理决策相关的基本概念提供一个公开的话语和谈判空间,从而补充现有的医学伦理结构。合作的潜力在协助死亡的例子中变得尤为明显:它提出了一系列广泛的哲学问题,然而,在行动的紧迫性和对道德困境的关注方面,这些问题往往没有得到明确的阐述。在本文中,我们首先分析了伦理咨询中对深刻问题的忽视,以及为什么这些问题需要在更广泛的社会哲学框架和场所中进行考虑和谈判。这些反思是基于伊曼努尔·康德、查尔斯·泰勒和皮埃尔·哈多所解释的希腊哲学传统的概念方法。这些框架不是作为最终答案呈现的,而是作为富有成效的起点和具有历史意义的哲学思想人物,用于参与协助自杀的复杂哲学维度。然后,我们从一个正在进行的关于姑息治疗和临终关怀工作的哲学实践的研究项目中吸取见解。中期结果表明,人们需要一种对话,为这种哲学思考提供空间,并需要一个能够促进这种对话的人。综合理论哲学和实证见解,本文提供了医学伦理结构和哲学实践之间富有成效的合作前景。
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引用次数: 0
Community Engagement Strategy for Building Trust in Human Challenge Studies Using Participatory and Creative Methods: An Ethical Imperative 使用参与性和创造性方法在人类挑战研究中建立信任的社区参与策略:一种道德要求。
IF 2.1 2区 哲学 Q2 ETHICS Pub Date : 2025-09-12 DOI: 10.1111/bioe.70028
Evelyn Muleba Kunda-Ng'andu, Masuzyo Chirwa, Seke Muzazu, Natasha Laban, Caroline Chisenga, Michelo Simuyandi, Stanley Mwale, Roma Chilengi, Anjali Sharma

Human Infection Challenge studies (HICs) are crucial for advancing global understanding of disease pathogenesis, immune responses, and accelerating vaccine and drug development. Explorations on willingness to participate among medical students revealed the need to ensure full understanding of HIC requirements, for example, for residency, by the broader community. This raised the question of ‘How could we ensure informed and understood consent for the ethical conduct of HIC?’ We employed iterative participatory discovery and creative design methods, including three Zoom meetings and discussions with university students and community leaders. Neighbourhood Health Committee leaders further refined suggested creatives of a future mass-media campaign for building trust in HICs. Deliberative focus group discussions and workshops were conducted on communication strategies on HICs’ requirements, risks, requirements, and benefits. The final creative brief suggested (1) using a pyramid approach utilizing existing community structures, to introduce HIC concepts progressively to larger groups, (2) engaging communities through theatre for development, community dialogue, and engagement meetings, and wide society through social and mass media advertisements, and (3) preference for the term ‘Human Challenge Studies’ over ‘Human Infection Challenge Studies’. We learned that community engagement, if properly conducted, can create systems of ownership of research and build communication strategies to achieve an accurate understanding of HICs and use informed participation that results in trustworthy data. We need further research, including in rural areas, pilot testing of evaluation strategies, and continued engagement with diverse stakeholders to create products that can be adapted by future HIC studies in settings such as Zambia.

人类感染挑战研究(HICs)对于促进全球对疾病发病机制、免疫反应的了解以及加速疫苗和药物开发至关重要。对医学生参与意愿的探索表明,需要确保更广泛的社区充分了解健康保险的要求,例如住院医师的要求。这就提出了一个问题:“我们如何确保对HIC道德行为的知情和理解同意?”我们采用了迭代式的参与式发现和创造性的设计方法,包括三次Zoom会议和与大学生和社区领袖的讨论。社区卫生委员会领导人进一步完善了未来大众媒体运动的创意,以建立对高收入社区的信任。就HICs的要求、风险、要求和利益的沟通策略进行了审议性焦点小组讨论和讲习班。最后的创意简报建议(1)使用金字塔方法利用现有的社区结构,逐步向更大的群体介绍HIC概念,(2)通过发展剧院、社区对话和参与会议吸引社区参与,并通过社会和大众媒体广告广泛的社会参与,以及(3)首选术语“人类挑战研究”而不是“人类感染挑战研究”。我们了解到,如果进行得当,社区参与可以创建研究所有权制度,并制定沟通策略,以实现对高收入国家的准确理解,并利用知情参与产生可靠的数据。我们需要进一步的研究,包括在农村地区进行研究,对评估战略进行试点测试,并继续与不同利益攸关方接触,以创造可在赞比亚等环境中进行未来HIC研究的产品。
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