Pub Date : 2026-01-01Epub Date: 2026-03-09DOI: 10.1002/arj.70041
Jonathan T Super, Luke V Tollefson, Iain R Murray, Christopher M LaPrade, Robert F LaPrade
Medial meniscus posterior root tears, which may account for up to one fifth of meniscal tears, often go undiagnosed or mistreated, contributing to substantial morbidity. They can be detected on magnetic resonance imaging by the classic "ghost sign" on sagittal sequences-the absence of an identifiable dark meniscus or presence of high signal in place of the normal dark appearance of the meniscus. These tears result in a dramatic impairment in hoop stress force transmission and have been shown to have a similar effect as a subtotal medial meniscectomy, resulting in rapid joint degeneration and an increased risk of early joint replacement. While medial meniscus root repair affords the opportunity to restore meniscus function, failure rates remain high, which shows the need to further refine patient selection, surgical techniques, and rehabilitation strategies to improve outcomes.
{"title":"Editorial Commentary: Root Cause of Failure: Surgeons and Patients Must Take Medial Meniscus Root Repair Seriously.","authors":"Jonathan T Super, Luke V Tollefson, Iain R Murray, Christopher M LaPrade, Robert F LaPrade","doi":"10.1002/arj.70041","DOIUrl":"10.1002/arj.70041","url":null,"abstract":"<p><p>Medial meniscus posterior root tears, which may account for up to one fifth of meniscal tears, often go undiagnosed or mistreated, contributing to substantial morbidity. They can be detected on magnetic resonance imaging by the classic \"ghost sign\" on sagittal sequences-the absence of an identifiable dark meniscus or presence of high signal in place of the normal dark appearance of the meniscus. These tears result in a dramatic impairment in hoop stress force transmission and have been shown to have a similar effect as a subtotal medial meniscectomy, resulting in rapid joint degeneration and an increased risk of early joint replacement. While medial meniscus root repair affords the opportunity to restore meniscus function, failure rates remain high, which shows the need to further refine patient selection, surgical techniques, and rehabilitation strategies to improve outcomes.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"244-246"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-03-08DOI: 10.1002/arj.70035
Vehniah K Tjong
Strategies to minimize damage to the iliofemoral ligament in hip arthroscopy for the treatment of femoroacetabular impingement syndrome have spawned increased curiosity among sports surgeons. Gone are the days when a large T-type capsulotomy or even capsulectomy is performed without some closure. Consensus to repair interportal capsulotomies seems strong. Under scrutiny now is whether the same rules apply to smaller periportal capsulotomies. If we continue to abide by our principles to respect anatomy and restore biomechanical properties, then capsular preservation should be upheld, especially in patients who need it the most.
{"title":"Editorial Commentary: Periportal Capsulotomies Create Significant Axial Distraction in Hip Arthroscopy and Should be Repaired in Certain Hip Phenotypes.","authors":"Vehniah K Tjong","doi":"10.1002/arj.70035","DOIUrl":"10.1002/arj.70035","url":null,"abstract":"<p><p>Strategies to minimize damage to the iliofemoral ligament in hip arthroscopy for the treatment of femoroacetabular impingement syndrome have spawned increased curiosity among sports surgeons. Gone are the days when a large T-type capsulotomy or even capsulectomy is performed without some closure. Consensus to repair interportal capsulotomies seems strong. Under scrutiny now is whether the same rules apply to smaller periportal capsulotomies. If we continue to abide by our principles to respect anatomy and restore biomechanical properties, then capsular preservation should be upheld, especially in patients who need it the most.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"151-152"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-02-26DOI: 10.1002/arj.70051
Francesco Pegreffi, Maria Tiziana di Leo, Gianluca Giuseppe Costa, Sara Bravaccini, Emilia Lo Giudice, Raoul Saggini, Arcangelo Russo
{"title":"Reframing Obesity in Knee Osteoarthritis: A Call for a Transdisciplinary Approach Beyond Biomechanics.","authors":"Francesco Pegreffi, Maria Tiziana di Leo, Gianluca Giuseppe Costa, Sara Bravaccini, Emilia Lo Giudice, Raoul Saggini, Arcangelo Russo","doi":"10.1002/arj.70051","DOIUrl":"10.1002/arj.70051","url":null,"abstract":"","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"14-15"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-02-18DOI: 10.1002/arj.70003
Scott Fong, Jacob Kodra, Kevin Girardi, Michael S Lee, James Macleod, Peter Monahan, Stephen M Gillinov, Jay Moran, Ronak J Mahatme, Akhil Mandavalli, Andrew E Jimenez
Purpose: To compare adverse events, secondary surgery rates, opioid prescriptions, and medical resource utilization between patients undergoing hip arthroscopy with fibromyalgia and a propensity-matched control group without fibromyalgia.
Methods: A retrospective review of the TriNetX national database identified patients who underwent hip arthroscopy between October 2015 and July 2023 with a preoperative fibromyalgia diagnosis. Propensity 1:1 matching was performed with controls who underwent hip arthroscopy without fibromyalgia. Postoperative adverse events, medical service utilization, opioid prescriptions, and secondary surgery rates were compared within 90 days, 1 year, and/or 2 years using Mann-Whitney U and χ2 tests.
Results: A total of 755 patients with fibromyalgia were matched to 755 controls. Mean age was similar (41.5 ± 10.7 vs 41.4 ± 11.6 years, P = .813), with comparable female representation (78.7% vs 78.4%, P = .900). No significant differences were found in revision arthroscopy (odds ratio [OR] 0.91, 95% confidence interval [CI]: 0.68-1.21, P = .502) or conversion to total hip arthroplasty (OR 1.07, 95% CI: 0.65-1.76, P = .798) within 2 years. Patients with fibromyalgia had higher odds of opioid prescription within 90 days (OR 1.56, 95% CI: 1.27-1.91, P < .001) and 1 year (OR 1.41, 95% CI: 1.15-1.74, P < .001) postoperatively. Rates of adverse medical events, mean prescriptions per patient (among those prescribed), secondary surgeries, and medical service utilization did not differ.
Conclusions: Contrary to the initial hypothesis, fibromyalgia was not associated with increased risk of postoperative adverse events, medical service utilization, revision surgery, or conversion to total hip arthroplasty after hip arthroscopy compared to the matched control. However, patients with fibromyalgia had significantly higher odds of receiving opioid prescriptions within both 90 days and 1 year postoperatively. Among those prescribed opioids, the mean number of prescriptions per patient did not differ significantly between cohorts.
Level of evidence: Level III, retrospective comparative case series.
目的:比较纤维肌痛髋关节镜患者和无纤维肌痛倾向匹配对照组的不良事件、二次手术率、阿片类药物处方和医疗资源利用情况。方法:对TriNetX国家数据库进行回顾性分析,确定了2015年10月至2023年7月期间术前诊断为纤维肌痛的髋关节镜检查患者。倾向1:1匹配与对照组进行髋关节镜检查,无纤维肌痛。采用Mann-Whitney U检验和χ2检验比较术后90天、1年和/或2年内的不良事件、医疗服务利用率、阿片类药物处方和二次手术率。结果:共有755名纤维肌痛患者与755名对照组相匹配。平均年龄相似(41.5±10.7岁vs 41.4±11.6岁,P =。813),女性代表比例相当(78.7% vs 78.4%, P = 0.900)。翻修关节镜检查无显著差异(优势比[OR] 0.91, 95%可信区间[CI]: 0.68-1.21, P =。502)或全髋关节置换术(or 1.07, 95% CI: 0.65-1.76, P =。798)在两年内。纤维肌痛患者在90天内获得阿片类药物处方的几率更高(OR 1.56, 95% CI: 1.27-1.91, P)。结论:与最初的假设相反,与匹配的对照组相比,纤维肌痛与术后不良事件、医疗服务利用、翻修手术或髋关节镜术后转全髋关节置换术的风险增加无关。然而,纤维肌痛患者在术后90天和1年内接受阿片类药物处方的几率明显更高。在处方阿片类药物的患者中,每位患者的平均处方数量在队列之间没有显着差异。证据级别:III级,回顾性比较病例系列。
{"title":"Patients With Preoperative Fibromyalgia Undergoing Hip Arthroscopy Demonstrated Increased Odds of Postoperative Opioid Prescriptions Within 90 Days and 1 Year but Similar 2-Year Reoperation Rates Compared to Matched Controls.","authors":"Scott Fong, Jacob Kodra, Kevin Girardi, Michael S Lee, James Macleod, Peter Monahan, Stephen M Gillinov, Jay Moran, Ronak J Mahatme, Akhil Mandavalli, Andrew E Jimenez","doi":"10.1002/arj.70003","DOIUrl":"10.1002/arj.70003","url":null,"abstract":"<p><strong>Purpose: </strong>To compare adverse events, secondary surgery rates, opioid prescriptions, and medical resource utilization between patients undergoing hip arthroscopy with fibromyalgia and a propensity-matched control group without fibromyalgia.</p><p><strong>Methods: </strong>A retrospective review of the TriNetX national database identified patients who underwent hip arthroscopy between October 2015 and July 2023 with a preoperative fibromyalgia diagnosis. Propensity 1:1 matching was performed with controls who underwent hip arthroscopy without fibromyalgia. Postoperative adverse events, medical service utilization, opioid prescriptions, and secondary surgery rates were compared within 90 days, 1 year, and/or 2 years using Mann-Whitney U and χ<sup>2</sup> tests.</p><p><strong>Results: </strong>A total of 755 patients with fibromyalgia were matched to 755 controls. Mean age was similar (41.5 ± 10.7 vs 41.4 ± 11.6 years, P = .813), with comparable female representation (78.7% vs 78.4%, P = .900). No significant differences were found in revision arthroscopy (odds ratio [OR] 0.91, 95% confidence interval [CI]: 0.68-1.21, P = .502) or conversion to total hip arthroplasty (OR 1.07, 95% CI: 0.65-1.76, P = .798) within 2 years. Patients with fibromyalgia had higher odds of opioid prescription within 90 days (OR 1.56, 95% CI: 1.27-1.91, P < .001) and 1 year (OR 1.41, 95% CI: 1.15-1.74, P < .001) postoperatively. Rates of adverse medical events, mean prescriptions per patient (among those prescribed), secondary surgeries, and medical service utilization did not differ.</p><p><strong>Conclusions: </strong>Contrary to the initial hypothesis, fibromyalgia was not associated with increased risk of postoperative adverse events, medical service utilization, revision surgery, or conversion to total hip arthroplasty after hip arthroscopy compared to the matched control. However, patients with fibromyalgia had significantly higher odds of receiving opioid prescriptions within both 90 days and 1 year postoperatively. Among those prescribed opioids, the mean number of prescriptions per patient did not differ significantly between cohorts.</p><p><strong>Level of evidence: </strong>Level III, retrospective comparative case series.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"161-171"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-02-27DOI: 10.1002/arj.70013
Raffy Mirzayan, Tal S David, Justin W Griffin, Misty Suri, L Pearce McCarty, Richard J Harrison, Gregory J Gilot, Erik S Stark, Kevin F Bonner
Purpose: To present outcomes of patients who underwent arthroscopic biologic tuberoplasty (ABT) and evaluate differences in outcomes based on sex, Hamada grade, concomitant procedures, and length of follow-up with a minimum of 1-year follow-up.
Methods: Patients who underwent ABT between 2015 and 2022, with a minimum 1-year follow-up, were identified. Inclusion criteria were: (1) massive, irreparable rotator cuff tears, (2) active forward elevation >900, (3) intact or reparable upper border subscapularis tear, and (4) Hamada 1 to 3. ABT was performed with a 3- mm-thick dermal allograft. American Shoulder and Elbow Surgeons (ASES), Single Assessment Numeric Evaluation (SANE), and Visual Analog Scale for pain were recorded.
Results: Fifty patients (68% males) met the inclusion criteria. Mean follow-up was 22.9 ± 15.7 months (range: 12-109 months). The mean age was 64.8 ± 8.1 years (range: 46-79 years). There was a significant improvement in ASES (37.4 ± 14.1-85.8 ± 10.5, P < .0001), SANE (36.3 ± 16.7-83.5 ± 10.1, P < .0001), and Visual Analog Scale for pain (7.2 ± 1.8-1.4 ± 1.9, P < .0001). There was no significant difference in mean postoperative ASES based on sex (P = .6623), Hamada grade (P = .1098), and isolated ABT versus those with concomitant procedures (P = .1087). In addition, there was no difference in postoperative ASES between patients who had 1-year follow-up, those with 1 to 2 years follow-up, and those with >2 years follow-up (P = .3887). Minimal clinically important difference, substantial clinical benefit, and patient acceptable symptomatic state for ASES were 100%, 96%, and 80%, respectively, for SANE were 96%, 78%, and 46%, respectively, and for Visual Analog Scale were 98%, 84%, 92%, respectively. The maximal outcome improvement for ASES was 77.4 and for SANE was 74.1.
Conclusions: Excellent clinical outcomes can be achieved in patients undergoing ABT with significant functional improvement and pain reduction in patients with massive, irreparable rotator cuff tears. These outcomes can be equally achieved in males and females, and in shoulders that are Hamada 1 to 3. Outcomes of patients with >2 years follow-up were similar to those with 1-year follow-up and 1 to 2 years follow-up.
Level of evidence: Level IV, retrospective case series.
{"title":"Arthroscopic Biologic Tuberoplasty With a Dermal Allograft Leads to Significant Improvement in Functional Outcomes in Patients With Massive, Irreparable Rotator Cuff Tears.","authors":"Raffy Mirzayan, Tal S David, Justin W Griffin, Misty Suri, L Pearce McCarty, Richard J Harrison, Gregory J Gilot, Erik S Stark, Kevin F Bonner","doi":"10.1002/arj.70013","DOIUrl":"10.1002/arj.70013","url":null,"abstract":"<p><strong>Purpose: </strong>To present outcomes of patients who underwent arthroscopic biologic tuberoplasty (ABT) and evaluate differences in outcomes based on sex, Hamada grade, concomitant procedures, and length of follow-up with a minimum of 1-year follow-up.</p><p><strong>Methods: </strong>Patients who underwent ABT between 2015 and 2022, with a minimum 1-year follow-up, were identified. Inclusion criteria were: (1) massive, irreparable rotator cuff tears, (2) active forward elevation >90<sup>0</sup>, (3) intact or reparable upper border subscapularis tear, and (4) Hamada 1 to 3. ABT was performed with a 3- mm-thick dermal allograft. American Shoulder and Elbow Surgeons (ASES), Single Assessment Numeric Evaluation (SANE), and Visual Analog Scale for pain were recorded.</p><p><strong>Results: </strong>Fifty patients (68% males) met the inclusion criteria. Mean follow-up was 22.9 ± 15.7 months (range: 12-109 months). The mean age was 64.8 ± 8.1 years (range: 46-79 years). There was a significant improvement in ASES (37.4 ± 14.1-85.8 ± 10.5, P < .0001), SANE (36.3 ± 16.7-83.5 ± 10.1, P < .0001), and Visual Analog Scale for pain (7.2 ± 1.8-1.4 ± 1.9, P < .0001). There was no significant difference in mean postoperative ASES based on sex (P = .6623), Hamada grade (P = .1098), and isolated ABT versus those with concomitant procedures (P = .1087). In addition, there was no difference in postoperative ASES between patients who had 1-year follow-up, those with 1 to 2 years follow-up, and those with >2 years follow-up (P = .3887). Minimal clinically important difference, substantial clinical benefit, and patient acceptable symptomatic state for ASES were 100%, 96%, and 80%, respectively, for SANE were 96%, 78%, and 46%, respectively, and for Visual Analog Scale were 98%, 84%, 92%, respectively. The maximal outcome improvement for ASES was 77.4 and for SANE was 74.1.</p><p><strong>Conclusions: </strong>Excellent clinical outcomes can be achieved in patients undergoing ABT with significant functional improvement and pain reduction in patients with massive, irreparable rotator cuff tears. These outcomes can be equally achieved in males and females, and in shoulders that are Hamada 1 to 3. Outcomes of patients with >2 years follow-up were similar to those with 1-year follow-up and 1 to 2 years follow-up.</p><p><strong>Level of evidence: </strong>Level IV, retrospective case series.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"108-122"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-02-22DOI: 10.1002/arj.70006
Richard N Puzzitiello, Benjamin T Johnson, Ameen Z Khalil, Allan K Metz, Joseph Featherall, Alan L Zhang, Stephen K Aoki
Purpose: To evaluate the in vivo biomechanical effects of periportal capsulotomies, single (modified anterior portal [MAP]) portal repair, and complete (MAP + anterolateral portal [ALP]) repair on altering the resistance to axial distraction compared to the native state (i.e., precapsulotomy).
Methods: Consecutive patients undergoing primary hip arthroscopy with periportal capsulotomies received intraoperative axial distraction testing at 0, 50, and 100 pounds of force (lbf). Patients were excluded if they did not break their suction seal with 100 lbf. Distraction testing was performed prior to capsulotomy (native), postcapsulotomy, after repair of just the MAP (partial repair), and after repair of both the MAP and ALP (complete repair). Distraction distances were calculated in millimeters (mm) as the difference in joint space between 0 and 50 or 100 lbf on intraoperative fluoroscopy from the lateral sourcil edge of the acetabulum to the femoral head. Repeated measures analysis of variance and Bonferroni-corrected P values were used for comparison.
Results: Eighty-six patients were included (58% female; mean age, 33.6 ± 11.7 years). There was a significant increase in distraction distance in the unreparied capsulotomy state compared to the native state at 100 lbf (1.14 [0.33-1.96] mm, P = .03). After partial and complete repair, the distraction distance was significantly decreased compared to the native state at 100 pounds of traction by 1.09 mm (0.28-1.90, P < .001) and 2.84 mm (2.09-3.59, P < .001), respectively. In a subgroup analysis, males also had a substantial decrease in distraction distance with MAP closure alone compared to the native state at 100 lbf (1.33 [0.32-2.35] mm, P = .04), whereas females did not (0.92 [0.09-1.75] mm, P = .19).
Conclusions: The periportal capsulotomy causes a significant increase in hip distractibility compared to the native state, and both partial and complete capsular repair restore distraction resistance to levels at or greater than the native state.
Level of evidence: Level IV, retrospective case series.
目的:评价门周囊切开术、单一(改良前门静脉[MAP])门静脉修复术和完全(MAP +前门静脉[ALP])门静脉修复术与原生状态(即囊前切开术)相比对轴向牵拉阻力的体内生物力学影响。方法:连续接受初级髋关节镜和门周囊切开术的患者在术中分别接受0、50和100磅力(lbf)的轴向牵张试验。如果患者在100lbf的压力下没有打破吸封,则排除。在囊膜切开(原生)前、囊膜切开后、MAP修复(部分修复)后、MAP和ALP修复(完全修复)后分别进行牵张测试。牵张距离以毫米(mm)为单位计算,即术中透视从髋臼外侧源缘到股骨头的关节间隙在0和50或100 lbf之间的差异。采用重复测量方差分析和bonferroni校正P值进行比较。结果:共纳入86例患者(女性58%,平均年龄33.6±11.7岁)。在100 lbf时,未修复的囊膜切开状态下牵张距离较原始状态明显增加(1.14 [0.33-1.96]mm, P = .03)。部分和完全修复后,牵张距离较100磅牵引时的原位状态明显减少1.09 mm (0.28-1.90, P)。结论:门周囊切开术使髋关节牵张阻力较原位状态显著增加,部分和完全囊修复均使牵张阻力恢复到或大于原位状态。证据级别:四级,回顾性病例系列。
{"title":"Biomechanical Stability of the Hip Is Impacted by Choice of Partial or Complete Closure of the Capsule Following a Periportal Capsulotomy: An In Vivo Time-Zero Comparison.","authors":"Richard N Puzzitiello, Benjamin T Johnson, Ameen Z Khalil, Allan K Metz, Joseph Featherall, Alan L Zhang, Stephen K Aoki","doi":"10.1002/arj.70006","DOIUrl":"10.1002/arj.70006","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the in vivo biomechanical effects of periportal capsulotomies, single (modified anterior portal [MAP]) portal repair, and complete (MAP + anterolateral portal [ALP]) repair on altering the resistance to axial distraction compared to the native state (i.e., precapsulotomy).</p><p><strong>Methods: </strong>Consecutive patients undergoing primary hip arthroscopy with periportal capsulotomies received intraoperative axial distraction testing at 0, 50, and 100 pounds of force (lbf). Patients were excluded if they did not break their suction seal with 100 lbf. Distraction testing was performed prior to capsulotomy (native), postcapsulotomy, after repair of just the MAP (partial repair), and after repair of both the MAP and ALP (complete repair). Distraction distances were calculated in millimeters (mm) as the difference in joint space between 0 and 50 or 100 lbf on intraoperative fluoroscopy from the lateral sourcil edge of the acetabulum to the femoral head. Repeated measures analysis of variance and Bonferroni-corrected P values were used for comparison.</p><p><strong>Results: </strong>Eighty-six patients were included (58% female; mean age, 33.6 ± 11.7 years). There was a significant increase in distraction distance in the unreparied capsulotomy state compared to the native state at 100 lbf (1.14 [0.33-1.96] mm, P = .03). After partial and complete repair, the distraction distance was significantly decreased compared to the native state at 100 pounds of traction by 1.09 mm (0.28-1.90, P < .001) and 2.84 mm (2.09-3.59, P < .001), respectively. In a subgroup analysis, males also had a substantial decrease in distraction distance with MAP closure alone compared to the native state at 100 lbf (1.33 [0.32-2.35] mm, P = .04), whereas females did not (0.92 [0.09-1.75] mm, P = .19).</p><p><strong>Conclusions: </strong>The periportal capsulotomy causes a significant increase in hip distractibility compared to the native state, and both partial and complete capsular repair restore distraction resistance to levels at or greater than the native state.</p><p><strong>Level of evidence: </strong>Level IV, retrospective case series.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"140-150"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-03-12DOI: 10.1002/arj.70002
Roger Quesada-Jimenez, Matthew J Strok, Andrew R Schab, Ady H Kahana-Rojkind, Benjamin G Domb
Purpose: To evaluate outcomes of endoscopic isolated gluteus medius (GM) repairs at minimum 5-year follow-up with a secondary comparison between short- and mid-term functional outcomes.
Methods: Prospectively collected data were retrospectively analyzed for all patients who underwent endoscopic GM repairs between May 2009 and December 2018. Included patients had completed preoperative and minimum 5-year questionnaires for at least one patient-reported outcome (PRO) measure: the modified Harris Hip Score (mHHS), Non-Arthritic Hip Score (NAHS), International Hip Outcome Tool (iHOT-12), Visual Analogue Scale (VAS), and patient satisfaction. Patients who were deceased or had revision surgeries were also included. The minimal clinically important difference (MCID) was calculated using a distribution-based method for all PROs and included in the analysis. A durability comparison between the mentioned PRO scores between 2- and 5-year postoperative was performed. Complications and secondary surgery were reported.
Results: Of 31 eligible hips, 26 hips (83.87%) were included in this study and demonstrated significant mean improvements in all evaluated PROs (mHHS from 54.67 to 80.75, NAHS from 58.88 to 84.38, iHOT-12 from 32.96 to 72.16, and VAS from 5.85 to 2.93, P < .01), with high patient satisfaction reported. Moreover, a high percentage of patients had delta values that met MCID for mHHS (82.35%), NAHS (82.35%), and iHOT-12 (80.00%). Score improvements were sustained from 2 to 5 years across all PROs, with continued improvement in mHHS seen at the 5-year timepoint. Three hips (11.54%) underwent secondary surgery, all of which had full-thickness or high-grade partial-thickness (>50%) GM tear at the time of the primary endoscopic GM repair.
Conclusions: Endoscopic GM repairs yield significant improvement in functional PROs at 5-year minimum follow-up with a high percentage of patients meeting clinically relevant thresholds. Moreover, patients showed continued improvement over time, with score enhancements observed from 2 to 5 years postsurgery. An 88.46% revision-free survival rate was observed, with all revision endoscopies being females who had high-grade to full-thickness GM tears.
Level of evidence: Level IV, retrospective case series.
{"title":"Five-Year Outcomes of Endoscopic Gluteus Medius Repair Show Sustained Functional Improvement and High Clinically Relevant Threshold Achievement.","authors":"Roger Quesada-Jimenez, Matthew J Strok, Andrew R Schab, Ady H Kahana-Rojkind, Benjamin G Domb","doi":"10.1002/arj.70002","DOIUrl":"10.1002/arj.70002","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate outcomes of endoscopic isolated gluteus medius (GM) repairs at minimum 5-year follow-up with a secondary comparison between short- and mid-term functional outcomes.</p><p><strong>Methods: </strong>Prospectively collected data were retrospectively analyzed for all patients who underwent endoscopic GM repairs between May 2009 and December 2018. Included patients had completed preoperative and minimum 5-year questionnaires for at least one patient-reported outcome (PRO) measure: the modified Harris Hip Score (mHHS), Non-Arthritic Hip Score (NAHS), International Hip Outcome Tool (iHOT-12), Visual Analogue Scale (VAS), and patient satisfaction. Patients who were deceased or had revision surgeries were also included. The minimal clinically important difference (MCID) was calculated using a distribution-based method for all PROs and included in the analysis. A durability comparison between the mentioned PRO scores between 2- and 5-year postoperative was performed. Complications and secondary surgery were reported.</p><p><strong>Results: </strong>Of 31 eligible hips, 26 hips (83.87%) were included in this study and demonstrated significant mean improvements in all evaluated PROs (mHHS from 54.67 to 80.75, NAHS from 58.88 to 84.38, iHOT-12 from 32.96 to 72.16, and VAS from 5.85 to 2.93, P < .01), with high patient satisfaction reported. Moreover, a high percentage of patients had delta values that met MCID for mHHS (82.35%), NAHS (82.35%), and iHOT-12 (80.00%). Score improvements were sustained from 2 to 5 years across all PROs, with continued improvement in mHHS seen at the 5-year timepoint. Three hips (11.54%) underwent secondary surgery, all of which had full-thickness or high-grade partial-thickness (>50%) GM tear at the time of the primary endoscopic GM repair.</p><p><strong>Conclusions: </strong>Endoscopic GM repairs yield significant improvement in functional PROs at 5-year minimum follow-up with a high percentage of patients meeting clinically relevant thresholds. Moreover, patients showed continued improvement over time, with score enhancements observed from 2 to 5 years postsurgery. An 88.46% revision-free survival rate was observed, with all revision endoscopies being females who had high-grade to full-thickness GM tears.</p><p><strong>Level of evidence: </strong>Level IV, retrospective case series.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"153-160"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-03-11DOI: 10.1002/arj.70011
Maximilian Hinz, Justin F M Hollenbeck, Bradley M Kruckeberg, Jason Sidrak, Natalie Cortes, Wyatt H Buchalter, Capt Matthew T Provencher, Peter J Millett
Purpose: To evaluate the isolated and combined biomechanical effect of suture retensioning and the addition of a posteroinferior (PI) anchor during Bankart repair.
Methods: Ten fresh-frozen cadaveric shoulders (age, 61.3 ± 5.1 years; sex, 90.0% males) were tested in the present study. After preconditioning, Bankart lesions were created, and each shoulder underwent 4 different repair states using knotless soft body anchors: (1) 3-anchor Bankart repair (5:30, 4:30, and 3:30 o'clock), (2) 4-anchor Bankart repair with a PI anchor (6:30 o'clock), (3) 3-anchor Bankart repair with suture retensioning, and (4) 4-anchor Bankart repair with a PI anchor and suture retensioning. Repair sutures were passed through 1 cm of capsulolabral tissue and tensioned to 50 N. Retensioning of each suture was performed to 50 N twice. Stiffness and elongation were evaluated before and after 100 cycles of cyclic loading to 25 N.
Results: Stiffness after cyclic loading was highest in the 4-anchor Bankart repair with suture retensioning and was significantly stiffer than the 3-anchor and the 4-anchor Bankart repair (P = .013 and .040, respectively). It was not significantly stiffer than the 3-anchor Bankart repair with suture retensioning (P > .127). Elongation after cyclic loading was lowest in the 4-anchor Bankart repair with suture retensioning and was significantly lower than the 3-anchor and 4-anchor Bankart repair (P = .042 and .020, respectively). It was not significantly different than the 3-anchor Bankart repair with suture retensioning (P > .232).
Conclusions: The addition of suture retensioning and a PI anchor to the Bankart repair showed a modest increase in stiffness and a reduction in elongation after cyclic loading.
Clinical relevance: Adding both suture retensioning and a PI anchor to the Bankart repair may decrease the risk for instability recurrence.
{"title":"Suture Retensioning and an Additional Posteroinferior Anchor Increases Stiffness and Decreases Elongation on Cyclic Bankart Repair Biomechanics in a Human Cadaveric Model.","authors":"Maximilian Hinz, Justin F M Hollenbeck, Bradley M Kruckeberg, Jason Sidrak, Natalie Cortes, Wyatt H Buchalter, Capt Matthew T Provencher, Peter J Millett","doi":"10.1002/arj.70011","DOIUrl":"10.1002/arj.70011","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the isolated and combined biomechanical effect of suture retensioning and the addition of a posteroinferior (PI) anchor during Bankart repair.</p><p><strong>Methods: </strong>Ten fresh-frozen cadaveric shoulders (age, 61.3 ± 5.1 years; sex, 90.0% males) were tested in the present study. After preconditioning, Bankart lesions were created, and each shoulder underwent 4 different repair states using knotless soft body anchors: (1) 3-anchor Bankart repair (5:30, 4:30, and 3:30 o'clock), (2) 4-anchor Bankart repair with a PI anchor (6:30 o'clock), (3) 3-anchor Bankart repair with suture retensioning, and (4) 4-anchor Bankart repair with a PI anchor and suture retensioning. Repair sutures were passed through 1 cm of capsulolabral tissue and tensioned to 50 N. Retensioning of each suture was performed to 50 N twice. Stiffness and elongation were evaluated before and after 100 cycles of cyclic loading to 25 N.</p><p><strong>Results: </strong>Stiffness after cyclic loading was highest in the 4-anchor Bankart repair with suture retensioning and was significantly stiffer than the 3-anchor and the 4-anchor Bankart repair (P = .013 and .040, respectively). It was not significantly stiffer than the 3-anchor Bankart repair with suture retensioning (P > .127). Elongation after cyclic loading was lowest in the 4-anchor Bankart repair with suture retensioning and was significantly lower than the 3-anchor and 4-anchor Bankart repair (P = .042 and .020, respectively). It was not significantly different than the 3-anchor Bankart repair with suture retensioning (P > .232).</p><p><strong>Conclusions: </strong>The addition of suture retensioning and a PI anchor to the Bankart repair showed a modest increase in stiffness and a reduction in elongation after cyclic loading.</p><p><strong>Clinical relevance: </strong>Adding both suture retensioning and a PI anchor to the Bankart repair may decrease the risk for instability recurrence.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"24-32"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-03-11DOI: 10.1002/arj.70008
Mustafa S Rashid, Georgios Mamarelis, Kristie More, Deanne Meredyk, Justin LeBlanc, Martin Bouliane, Ian K Y Lo
Purpose: To report the 2-year clinical and radiological outcomes of arthroscopic distal tibial allograft (DTA) reconstruction with labral repair, with or without remplissage for restoring glenoid bone loss in traumatic anterior shoulder instability.
Methods: Between March 2019 and February 2022, patients undergoing arthroscopic DTA reconstruction, performed by 3 fellowship-trained surgeons across 3 centers, were recruited to participate in this study. All patients had some degree of glenoid bone loss and recurrent traumatic anterior shoulder instability. Clinical and radiological outcomes included Western Ontario Stability Index, American Shoulder and Elbow Surgeons, and range of motion preoperatively and at 3, 6, 12, and 24 months postoperatively. Patients underwent computed tomography scanning at 6 months to determine graft union and position.
Results: Thirty-two patients were enrolled into the study (24 males, 8 females). Mean preoperative glenoid bone loss was 19.5% (standard deviation [SD] 6.3%, range 10%-34%). Seven of thirty-two patients underwent a remplissage procedure in addition to the labral repair and distal tibia allograft reconstruction. Compared to baseline, outcome scores improved to 2 years postoperatively (mean Western Ontario Stability Index 37.4% [SD 14.9] to 81.7% [SD 14.1]; mean American Shoulder and Elbow Surgeons score 60 [SD 19] to 92.3 [SD 7.6]). Mean forward elevation returned to normal by 2 years. The mean deficit in external rotation at 2 years was 7° (SD 13°) compared to the contralateral side. Thirty-one patients had computed tomography scans at 6 months to confirm healing and graft position. Partial or full graft healing at 6 months was 94%. In the axial plane, grafts were a mean 12.9° (SD 13.0°) to the native glenoid face and translated a mean 0.8 mm (SD 2.4) medial to the anterior glenoid rim. In the sagittal plane, the graft was positioned 1.6 mm (SD 2.1) superior to the midpoint of the native glenoid defect. One patient experienced an subluxation event postoperatively without further instability. Another required revision to Latarjet procedure. There were no perioperative complications.
Conclusions: Arthroscopic DTA bone block glenoid reconstruction using 2 pairs of suture buttons to treat recurrent traumatic anterior instability with significant bone loss yields improved clinical and acceptable radiological outcomes.
Level of evidence: Level IV, retrospective case series.
目的:报道关节镜下胫骨远端同种异体移植物(DTA)重建与唇部修复,有或没有复发的2年临床和影像学结果恢复外伤性肩关节前不稳定的盂骨丢失。方法:在2019年3月至2022年2月期间,招募了3个中心的3名接受过奖学金培训的外科医生进行关节镜DTA重建的患者参与本研究。所有患者均有一定程度的盂骨丢失和复发性外伤性前肩不稳。临床和影像学结果包括术前、术后3、6、12和24个月的西部安大略稳定指数、美国肩关节外科医生和活动范围。患者在6个月时进行计算机断层扫描以确定移植物愈合和位置。结果:32例患者入组,其中男性24例,女性8例。术前平均盂骨丢失19.5%(标准差[SD] 6.3%,范围10%-34%)。32例患者中有7例除唇部修复和胫骨远端异体移植物重建外,还接受了复诊手术。与基线相比,术后2年的预后评分有所提高(Western Ontario Stability Index平均为37.4% [SD 14.9]至81.7% [SD 14.1]; American Shoulder and肘部外科医生平均评分为60 [SD 19]至92.3 [SD 7.6])。平均前高程在2年后恢复正常。与对侧相比,2年时外旋的平均缺损为7°(SD 13°)。31例患者在6个月时进行了计算机断层扫描,以确认愈合和移植物位置。6个月时移植物部分或全部愈合为94%。在轴向面,移植物距原关节面平均12.9°(SD 13.0°),距前关节缘内侧平均0.8 mm (SD 2.4)。在矢状面,移植物位于原生关节盂缺损中点上方1.6 mm (SD 2.1)。1例患者术后出现半脱位,无进一步不稳定。另一个需要修改Latarjet程序。无围手术期并发症。结论:关节镜下采用2对缝合扣进行DTA骨块盂骨重建治疗复发性外伤性前路失稳伴明显骨质丢失,临床疗效和影像学结果均得到改善。证据级别:四级,回顾性病例系列。
{"title":"Arthroscopic Distal Tibial Allograft Reconstruction With Suture Button Fixation and Capsulolabral Repair for Traumatic Anterior Shoulder Instability Yields High Rates of Graft Union and Improves Clinical Outcomes at 2 Years.","authors":"Mustafa S Rashid, Georgios Mamarelis, Kristie More, Deanne Meredyk, Justin LeBlanc, Martin Bouliane, Ian K Y Lo","doi":"10.1002/arj.70008","DOIUrl":"10.1002/arj.70008","url":null,"abstract":"<p><strong>Purpose: </strong>To report the 2-year clinical and radiological outcomes of arthroscopic distal tibial allograft (DTA) reconstruction with labral repair, with or without remplissage for restoring glenoid bone loss in traumatic anterior shoulder instability.</p><p><strong>Methods: </strong>Between March 2019 and February 2022, patients undergoing arthroscopic DTA reconstruction, performed by 3 fellowship-trained surgeons across 3 centers, were recruited to participate in this study. All patients had some degree of glenoid bone loss and recurrent traumatic anterior shoulder instability. Clinical and radiological outcomes included Western Ontario Stability Index, American Shoulder and Elbow Surgeons, and range of motion preoperatively and at 3, 6, 12, and 24 months postoperatively. Patients underwent computed tomography scanning at 6 months to determine graft union and position.</p><p><strong>Results: </strong>Thirty-two patients were enrolled into the study (24 males, 8 females). Mean preoperative glenoid bone loss was 19.5% (standard deviation [SD] 6.3%, range 10%-34%). Seven of thirty-two patients underwent a remplissage procedure in addition to the labral repair and distal tibia allograft reconstruction. Compared to baseline, outcome scores improved to 2 years postoperatively (mean Western Ontario Stability Index 37.4% [SD 14.9] to 81.7% [SD 14.1]; mean American Shoulder and Elbow Surgeons score 60 [SD 19] to 92.3 [SD 7.6]). Mean forward elevation returned to normal by 2 years. The mean deficit in external rotation at 2 years was 7° (SD 13°) compared to the contralateral side. Thirty-one patients had computed tomography scans at 6 months to confirm healing and graft position. Partial or full graft healing at 6 months was 94%. In the axial plane, grafts were a mean 12.9° (SD 13.0°) to the native glenoid face and translated a mean 0.8 mm (SD 2.4) medial to the anterior glenoid rim. In the sagittal plane, the graft was positioned 1.6 mm (SD 2.1) superior to the midpoint of the native glenoid defect. One patient experienced an subluxation event postoperatively without further instability. Another required revision to Latarjet procedure. There were no perioperative complications.</p><p><strong>Conclusions: </strong>Arthroscopic DTA bone block glenoid reconstruction using 2 pairs of suture buttons to treat recurrent traumatic anterior instability with significant bone loss yields improved clinical and acceptable radiological outcomes.</p><p><strong>Level of evidence: </strong>Level IV, retrospective case series.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"87-95"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-03-11DOI: 10.1002/arj.70021
Charles P Hannon, Navya Dandu, Hailey P Huddleston, Divesh Sachdev, Neal B Naveen, David Frisbie, Wayne McIlwraith, Arnavaz Hakimiyan, Brian J Cole, Susanna Chubinskaya, Adam B Yanke
Purpose: To evaluate the anti-inflammatory and disease-modifying potential of bone marrow aspirate concentrate (BMAC) and amniotic suspension allograft (ASA) in a chondrocyte and synovium coculture model of osteoarthritis.
Methods: Seventeen patients were enrolled for cartilage, synovium, and bone marrow aspirate tissue donation prior to a total knee arthroplasty. Cartilage and synovium explants were cocultured into four different groups: one baseline group, one control group (96-hour coculture), BMAC group, and ASA group. Interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured at 96 hours in the media with enzyme-linked immunosorbent assay. Collagen type 1 α 1, Collagen type 2 α 2, Collagen type 3 α 1, aggrecan, and Cartilage Oligomeric Matrix Protein were measured in the cartilage and synovium by reverse transcription polymerase chain reaction. Safranin-O staining were performed on all groups and scored by the modified Mankin scoring system.
Results: Samples treated with ASA showed a significantly lower concentration of IL-1β when compared to control samples (11.2 ± 13.9 vs 20.2 ± 39.5 pg/mL, P = .04). Treatment with BMAC was associated with a significantly lower concentrations of IL-6 when compared to control samples (607.32 ± 271.07 vs 767.11 ± 30.84, P = .02). No significant differences were observed in gene expression within chondrocytes and synoviocytes or for Mankin scoring between treatment and control groups.
Conclusions: Osteoarthritic chondrocytes and synovial tissue may respond to BMAC and ASA by a reduction in IL-1β and IL-6 concentrations, but short-term cytokine responses are variable. The mechanism of response remains unknown.
Clinical relevance: This study aims to reveal the mechanism of BMAC and ASA by which these biologics function in a model of an arthritic joint.
目的:评价骨髓浓缩液(BMAC)和羊水悬浮液同种异体移植物(ASA)在骨关节炎软骨细胞-滑膜共培养模型中的抗炎和减病作用。方法:17例患者在全膝关节置换术前接受软骨、滑膜和骨髓抽吸组织捐赠。将软骨和滑膜外植体共培养成4个不同的组:基线组、对照组(共培养96小时)、BMAC组和ASA组。用酶联免疫吸附法测定培养液中白细胞介素-1β (IL-1β)、白细胞介素-6 (IL-6)和肿瘤坏死因子-α (TNF-α)的含量。采用逆转录聚合酶链反应法测定软骨和滑膜中1型胶原α 1、2型胶原α 2、3型胶原α 1、聚集蛋白和软骨寡聚基质蛋白的含量。各组均行红花素- o染色,采用改良的Mankin评分系统进行评分。结果:与对照组相比,ASA处理的样品IL-1β浓度显著降低(11.2±13.9 vs 20.2±39.5 pg/mL, P = 0.04)。与对照组相比,BMAC治疗组IL-6浓度显著降低(607.32±271.07 vs 767.11±30.84,P = 0.02)。在治疗组和对照组之间,软骨细胞和滑膜细胞内的基因表达或Mankin评分均无显著差异。结论:骨关节炎软骨细胞和滑膜组织可能通过降低IL-1β和IL-6浓度对BMAC和ASA产生反应,但短期细胞因子反应是可变的。其反应机制尚不清楚。临床意义:本研究旨在揭示BMAC和ASA在关节炎关节模型中的作用机制。
{"title":"Amniotic Suspension Allograft and Bone Marrow Aspirate Concentrate Results in Highly Variable Proinflammatory Cytokines in a Coculture Model of Osteoarthritis.","authors":"Charles P Hannon, Navya Dandu, Hailey P Huddleston, Divesh Sachdev, Neal B Naveen, David Frisbie, Wayne McIlwraith, Arnavaz Hakimiyan, Brian J Cole, Susanna Chubinskaya, Adam B Yanke","doi":"10.1002/arj.70021","DOIUrl":"10.1002/arj.70021","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the anti-inflammatory and disease-modifying potential of bone marrow aspirate concentrate (BMAC) and amniotic suspension allograft (ASA) in a chondrocyte and synovium coculture model of osteoarthritis.</p><p><strong>Methods: </strong>Seventeen patients were enrolled for cartilage, synovium, and bone marrow aspirate tissue donation prior to a total knee arthroplasty. Cartilage and synovium explants were cocultured into four different groups: one baseline group, one control group (96-hour coculture), BMAC group, and ASA group. Interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured at 96 hours in the media with enzyme-linked immunosorbent assay. Collagen type 1 α 1, Collagen type 2 α 2, Collagen type 3 α 1, aggrecan, and Cartilage Oligomeric Matrix Protein were measured in the cartilage and synovium by reverse transcription polymerase chain reaction. Safranin-O staining were performed on all groups and scored by the modified Mankin scoring system.</p><p><strong>Results: </strong>Samples treated with ASA showed a significantly lower concentration of IL-1β when compared to control samples (11.2 ± 13.9 vs 20.2 ± 39.5 pg/mL, P = .04). Treatment with BMAC was associated with a significantly lower concentrations of IL-6 when compared to control samples (607.32 ± 271.07 vs 767.11 ± 30.84, P = .02). No significant differences were observed in gene expression within chondrocytes and synoviocytes or for Mankin scoring between treatment and control groups.</p><p><strong>Conclusions: </strong>Osteoarthritic chondrocytes and synovial tissue may respond to BMAC and ASA by a reduction in IL-1β and IL-6 concentrations, but short-term cytokine responses are variable. The mechanism of response remains unknown.</p><p><strong>Clinical relevance: </strong>This study aims to reveal the mechanism of BMAC and ASA by which these biologics function in a model of an arthritic joint.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":"263-272"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}