Auris Nasus Larynx最新文献

{"title":"Impact of gross extranodal extension into major neck structures on the prognosis of papillary thyroid carcinoma","authors":"Sueyoshi Moritani,&nbsp;Masao Takenobu,&nbsp;Masakazu Yasunaga,&nbsp;Katsuyuki Kawamoto,&nbsp;Taihei Fujii,&nbsp;Hiroya Kitano","doi":"10.1016/j.anl.2024.12.012","DOIUrl":"10.1016/j.anl.2024.12.012","url":null,"abstract":"<div><h3>Objective</h3><div>The AJCC-8 staging system for papillary thyroid carcinoma (PTC) excludes certain lymph node characteristics from stage determinants due to insufficient evidence of their prognostic impact. This study aimed to examine the influence of gross extranodal extension (N-Ex) on survival and recurrence by comparing outcomes of extrathyroidal extension (T-Ex) and N-Ex cases.</div></div><div><h3>Methods</h3><div>Patients with PTC who underwent initial surgical treatment and had T-Ex or N-Ex were selected. Their survival and recurrence rates were compared, focusing on age and stage classification. Patients younger than 55 years without distant metastasis (DM) are classified as Stage I, regardless of T-Ex or N-Ex. Patients aged 55 years or older without DM are classified as Stage II if they have N-Ex without T-Ex and Stage III or IVA if they have T-Ex. The prognoses of the T-Ex and N-Ex groups stratified by age were compared. Using the T-classification by organ involvement, older patients with N-Ex were subgrouped, and their prognoses were compared with those of the T-Ex group.</div></div><div><h3>Results</h3><div>The study included 183 T-Ex and 50 N-Ex without T-Ex cases. The disease-specific survival (DSS) and disease-free survival (DFS) of the two groups did not differ for the younger patients without distant metastases (Stage I in both groups). For the older patients without distant metastasis, the 10-year DSS was 80.6% and 48.5% for Stages III and IVA (with T4bAnyNM0; T-Ex group) and 74.7% for Stage II (with T1-3N-ExM0; N-Ex group). The 10-year DFS were 68.2%, 0%, and 64.5% for Stages III, IVA (T-Ex group), and II (N-Ex group), respectively. The DSS and DFS did not differ for Stages III and IVA (T-Ex group) and II (N-Ex group). The prognoses of the N-Ex subgroups and the older T-Ex group did not also differ.</div></div><div><h3>Conclusions</h3><div>The patients aged 55 years or older without DM had comparable prognoses, although cases with N-Ex without T-Ex were classified as Stage II, and those with T-Ex were classified as Stage III or IVA. The recurrence rates for the N-Ex and T-Ex stages were also comparable. These suggest that N-Ex is an important prognostic factor.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 127-131"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular nerve neurectomy: Functional and histopathological outcomes in the cochlea of guinea pigs","authors":"Omar Mostafa Youssef Yassin ,&nbsp;Ashraf Abdelzaher Mabrok ,&nbsp;Ayman Mohammed El-kahky ,&nbsp;Hesham Mohamed Othman Taha ,&nbsp;Walaa Adel Abdelmoez ,&nbsp;Amr Adel Mohammed Saad","doi":"10.1016/j.anl.2025.01.010","DOIUrl":"10.1016/j.anl.2025.01.010","url":null,"abstract":"<div><h3>Objectives</h3><div>Experimentally test the effect of vestibular nerve neurectomy on the function and histopathology of the cochlea.</div></div><div><h3>Methods</h3><div>The study was conducted on 20 normal male adult pigmented guinea pigs (Cavia porcellus). First, each animal was tested with Distortion Product Otoacoustic Emissions (DPOAEs) preoperatively then vestibular neurectomy (V.N) was performed on the right side through suboccipital modified retrosigmoid approach. We tested the DPOAEs postoperatively; After 8 weeks, Guinea pigs were euthanized the cochlea of guinea pig was processed for light microscope and transmission electron microscope examination to observe the outer hair cell count, and spiral ganglion cell density in the operated ear compared to contralateral non operated cochlea of the same guinea pig.</div></div><div><h3>Results</h3><div>There was a significant decrease in spiral ganglion cell density in the operated side compared to the non-operated side. However, there was no significant difference in outer hair cell count or DPOAEs between the two sides, except for a significant increase in DPOAEs at 2 KHz in the operated side.</div></div><div><h3>Conclusion</h3><div>The results suggest that vestibular neurectomy may affect spiral ganglion cell density but not necessarily outer hair cell count or DPOAEs, and the relationship between these variables is complex and could be frequency-dependent.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 107-115"},"PeriodicalIF":1.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative course of Eustachian tube plug surgery with Kobayashi plug","authors":"Tomoo Shibasaki ,&nbsp;Naoto Koike ,&nbsp;Hidefumi Shindo ,&nbsp;Ryoji Hirai ,&nbsp;Takeshi Oshima","doi":"10.1016/j.anl.2024.12.006","DOIUrl":"10.1016/j.anl.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate its effectiveness and safety and clarify the postoperative course of Kobayashi plug surgery for refractory patulous Eustachian tubes.</div></div><div><h3>Methods</h3><div>This retrospective study included 83 patients diagnosed with a patulous Eustachian tube who received Kobayashi plug surgery at our hospital.</div></div><div><h3>Results</h3><div>At 1 month postoperatively, the success rate was 74.0 %; at 3 months, it was 67.1 %; at 6 months, it was 65.0 %; and at 12 months it was 65.2 %. At 6 months, otitis media with effusion (OME) was observed in 12.5 % of cases, and residual tympanic membrane perforation was observed in 5.0 %. Ventilation tube placement was performed in 10 cases, and eight cases required revision surgery. During the course, plugs were removed in four cases.</div><div>Median values of patulous Eustachian Tube Handicap Inventory-10 (PHI-10) at 1, 3, 6, and 12 months postoperatively were 14, 16, 16, and 20, respectively. PHI-10 significantly improved at all the time points after surgery than before surgery (median 33).</div></div><div><h3>Conclusion</h3><div>The Kobayashi plug surgery is safe and effective for refractory patulous Eustachian tubes over the long term. At 6 months postoperatively, there were few cases of OME, and the symptoms also stabilized.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 116-121"},"PeriodicalIF":1.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acute ethanol intoxication on swallowing function in mice","authors":"Takuma Hisaoka ,&nbsp;Jun Suzuki ,&nbsp;Ryoukichi Ikeda ,&nbsp;Jun Ohta ,&nbsp;Hiyori Takahashi ,&nbsp;Yukio Katori","doi":"10.1016/j.anl.2025.01.004","DOIUrl":"10.1016/j.anl.2025.01.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Ethanol consumption may lead to various symptoms depending on its concentration in the blood. Acute ethanol intoxication is a major risk factor for bolus -aspiration; however, studies on the effects of acute ethanol intoxication on swallowing are lacking. Therefore, we investigated the effect of acute ethanol intoxication on mice using the videofluoroscopic swallowing study (VFSS) methodology.</div></div><div><h3>Methods</h3><div>Male C57BL/6 J mice were randomly allocated into three groups: saline injection, 2 g/kg ethanol injection, and 4 g/kg ethanol injection. The VFSS technique was used to analyze the inter-swallow interval, lick-swallow rate, lick rate, bolus area, pharyngeal transit time, bolus speed, and bolus area 3 d before injection (control), 2 h after injection, and 8 h after injection.</div></div><div><h3>Results</h3><div>In the 4 g/kg ethanol injection group, the inter-swallow interval and lick-swallow rate increased after 2 h However, these changes were reversed 8 h after ethanol administration. Additionally, the pharyngeal transit time, bolus speed, and bolus area did not change significantly after ethanol administration.</div></div><div><h3>Conclusions</h3><div>The present study reveals that ethanol administration delays bolus transport in the mouth but does not affect pharyngeal swallowing reflexes and reflex thresholds. Acute ethanol intoxication specifically impairs the oral function as assessed by the VFSS.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 101-106"},"PeriodicalIF":1.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brainwave entrainment using binaural beats stimulation: Exploring the treatment efficacy in individuals with tinnitus having normal hearing sensitivity","authors":"Praveen Prakash,&nbsp;Sreeraj Konadath","doi":"10.1016/j.anl.2024.11.001","DOIUrl":"10.1016/j.anl.2024.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to compare the efficacy of brainwave entrainment in the treatment of individuals with tinnitus having normal hearing sensitivity. The effect of binaural beats (BB) stimulation in reducing negative emotions and tinnitus handicap post-three months is explored in this longitudinal study.</div></div><div><h3>Method</h3><div>The study comprised sixty individuals (four groups) with tinnitus having normal hearing. The outcome measures of BB with beat frequencies falling under delta (4 Hz), theta (6 Hz), and alpha (10 Hz) and a standard tinnitus masker (white noise) were compared with the pre-treatment baseline scores for tinnitus handicap, depression, and stress levels, and quality of life parameters.</div></div><div><h3>Results</h3><div>All four groups showed an improvement in tinnitus symptoms and negative emotions. However, the groups that received BB stimulation (I, II, III) showed a remarkable reduction in scores for the tinnitus handicap, depression, and stress levels and an increase in quality-of-life scores for the domains that assessed physical and psychological health when compared to the group IV who received standard tinnitus masker.</div></div><div><h3>Conclusion</h3><div>It was observed that all three broadband (BB) stimuli were equally effective in treating tinnitus handicap symptoms. However, the results cannot be definitively attributed to brainwave entrainment, as they may also reflect the effects of sound therapy. Additionally, the lack of significant differences among the BB frequencies suggests that the benefits may not arise specifically from brainwave entrainment, especially without a comparison to beta frequency BB. This technique should be adopted into clinical practice with generalizability after further research on a randomized sample.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 1-11"},"PeriodicalIF":1.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying predictors of persistent post-earthquake dizziness among adolescents after the 2023 earthquakes in Türkiye: A cross-sectional, multicenter study","authors":"Seda Bozduman Çelebi ,&nbsp;Berhan Akdağ ,&nbsp;Nazmiye İnce ,&nbsp;Burak Kamış ,&nbsp;Hilal Yazıcı Kopuz ,&nbsp;Kübra Gıran ,&nbsp;Fethiye Kılıçaslan ,&nbsp;Semiha Cömertoğlu Arslan ,&nbsp;Hatice Altun ,&nbsp;Asiye Arıcı Gürbüz ,&nbsp;Çisel Yazan Songür ,&nbsp;Hülya Binokay","doi":"10.1016/j.anl.2024.10.013","DOIUrl":"10.1016/j.anl.2024.10.013","url":null,"abstract":"<div><h3>Objective</h3><div>The impacts of earthquakes on the mental health of individuals have been well-documented. Additionally, individuals frequently report experiencing dizziness akin to seasickness or carsickness. This phenomenon, termed “post-earthquake dizziness syndrome” (PEDS), has garnered increasing attention due to its unclear etiology. This study investigates the prevalence and predictors of ongoing PEDS within an adolescent population more than one year after the 2023 Kahramanmaraş earthquakes.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted between April 2024 and June 2024 across five cities officially designated as an “earthquake zone” by relevant authorities. The sample comprised 551 adolescents aged 11 to 18 years who were recruited from child psychiatry outpatient clinics within these cities.</div></div><div><h3>Results</h3><div>402 participants (73.0 %) reported experiencing PEDS following the earthquake, while 105 (19.1 %) reported ongoing PEDS. Multivariate logistic regression analysis revealed that higher trait anxiety and post-traumatic stress disorder (PTSD) symptoms, as well as being located on a higher floor during the earthquake, were positively correlated with the persistence of PEDS symptoms.</div></div><div><h3>Conclusions</h3><div>The findings underscore the potential association between PEDS and psychiatric disorders, such as anxiety and PTSD. However, the underlying mechanisms of PEDS remain elusive, requiring further research to elucidate the links between PEDS and psychiatric conditions for more effective treatment strategies.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 6","pages":"Pages 1081-1084"},"PeriodicalIF":1.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of microbial diversity and eosinophilic otitis media biomarkers using next-generation sequencing","authors":"Rieko Ii ,&nbsp;Emiko Noguchi ,&nbsp;Naoto Adachi ,&nbsp;Masanori Kidoguchi ,&nbsp;Takako Nakamura ,&nbsp;Hidetaka Miyamoto ,&nbsp;Yukiko Nishihama ,&nbsp;Ayami Nomura ,&nbsp;Junko Takahata ,&nbsp;Yukihiro Kimura ,&nbsp;Masayuki Okamoto ,&nbsp;Yuki Hirose ,&nbsp;Shuho Tanaka ,&nbsp;Shigeharu Fujieda ,&nbsp;Atsushi Matsubara ,&nbsp;Keiji Tabuchi","doi":"10.1016/j.anl.2024.10.012","DOIUrl":"10.1016/j.anl.2024.10.012","url":null,"abstract":"<div><h3>Objective</h3><div>Eosinophilic otitis media (EOM) is a chronic eosinophilic inflammatory disease linked to bronchial asthma and nasal polyps. EOM is often accompanied by tympanic membrane perforation. Although the primary treatment, steroid therapy, is generally effective, its efficacy may be limited in advanced cases, particularly those involving significant thickening of the middle ear mucosa. Despite its clinical importance, details regarding the pathogenesis of EOM have not been elucidated. Our study aimed to characterize the microbiome associated with EOM and explore changes with and without tympanic membrane perforation.</div></div><div><h3>Methods</h3><div>We enrolled 27 patients clinically diagnosed with EOM, 25 controls without middle ear infections, and 10 patients with chronic suppurative otitis media (CSOM) [1] [2]. Specimens were collected by swabbing the middle ear, nasopharynx, and external auditory canal (EAC) of subjects in the EOM and control groups, whereas CSOM specimens were collected only from the middle ear. The V3-V4 regions of the 16S ribosomal RNA genes were amplified and subjected to high-throughput sequencing. We evaluated alpha and beta diversity indices between the EOM and control subjects, followed by Linear discriminant analysis Effect Size (LEfSe) analysis to identify potential biomarkers. Additionally, co-occurrence patterns were analyzed to explore the associated microbial interactions. To assess whether similar biomarkers were identified between the EOM and CSOM subjects, LEfSe analysis was conducted for these two groups.</div></div><div><h3>Results</h3><div>Compared with controls, EOM patients were significantly enriched in <em>Nocardioides</em> in the middle ear, nasopharynx, and EAC, highlighting a distinct microbiological feature. Both alpha and beta diversity were significantly reduced in EOM patients with tympanic membrane perforation. When comparing the EOM and CSOM groups, <em>Nocardioides</em> was consistently identified as a significant biomarker for EOM, confirming its distinct association with EOM. In co-occurrence analysis, <em>Nocardioides</em> showed notable positive co-occurrence with several other genera.</div></div><div><h3>Conclusion</h3><div>This study reports the first detailed exploration of the EOM microbiome and identified <em>Nocardioides</em> as a new biomarker. The significant shift in microbial co-occurrence associated with tympanic membrane perforation may contribute to the disease's refractory nature, suggesting new avenues for understanding and managing EOM.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 6","pages":"Pages 1073-1080"},"PeriodicalIF":1.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonography of the cricoarytenoid joint and its movements","authors":"Chikako Kunieda ,&nbsp;Tomohiro Mori ,&nbsp;Ujimoto Konomi ,&nbsp;Koji Matsushima ,&nbsp;Daigo Komazawa ,&nbsp;Takeharu Kanazawa","doi":"10.1016/j.anl.2024.10.001","DOIUrl":"10.1016/j.anl.2024.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Ultrasound provides real-time anatomical information and motion. We used ultrasound to image the cricoarytenoid joint and its rotating, rocking, and gliding movements.</div></div><div><h3>Methods</h3><div>Between March and October 2023, 20 patients (10 males and 10 females) who visited our hospital underwent laryngeal ultrasonography. The joint cavity was delineated in four patients (20 %, two males and two females). Conversely, the other patients did not detect it because of acoustic shadows on ultrasonography. We also performed ultrasonography on five volunteers (three males and two females), but only two of them (two females) showed imaging of the joint cavity. Herein, we report the case of a female volunteer in her 30 s who had the best delineation of joint movements.</div></div><div><h3>Results</h3><div>Joint movements were three-dimensional, whereas ultrasound images were two-dimensional. However, combined with scanning techniques, characteristic joint movements were successfully imaged using ultrasound. Initially, we performed a trans-thyroid cartilage transversal procedure to visualize the muscular process of the arytenoid cartilage and rotational movement. Subsequently, the probe was rotated to an oblique position, and the articular cavity of the cricoarytenoid joint was visualized. We then observed the rocking and gliding movements. In Addition, we demonstrated a seamless transition from gliding to rocking. Finally, we observed that the arytenoid cartilage was pulled toward the posterior cricoarytenoid muscle (PCA) during sniffing. The PCA is the only muscle opening the vocal cords, so the arytenoid cartilage shifts toward the PCA and tilts outward from the larynx.</div></div><div><h3>Conclusion</h3><div>The presented probe scanning techniques and specific joint movements may help identify notable conditions such as arthritis or joint dislocation.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 6","pages":"Pages 1068-1072"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 1.5% levofloxacin otic solution in treating acute otitis externa: A post hoc analysis of ENT103-3001, a multicenter randomized double-blind parallel-group placebo-controlled phase III study in otitis media with persistent otorrhea","authors":"Han Matsuda ,&nbsp;Masafumi Sawada ,&nbsp;Kayo Suzuki ,&nbsp;Haruo Takahashi ,&nbsp;Tetsuo Ikezono","doi":"10.1016/j.anl.2024.10.015","DOIUrl":"10.1016/j.anl.2024.10.015","url":null,"abstract":"<div><h3>Objective</h3><div>In this post hoc analysis, we aimed to evaluate the efficacy of 1.5% levofloxacin (LVFX) otic solution for the treatment of acute otitis externa (AOE) in patients with nonintact tympanic membrane (NTM) accompanied by chronic suppurative and acute otitis media.</div></div><div><h3>Methods</h3><div>Digital endoscopic images of the tympanic membrane and cavity were evaluated. In addition, the full analysis set from the original ENT103-3001 study was analyzed to determine the efficacy of the 1.5% LVFX otic solution in treating patients with otitis media with persistent otorrhea. AOE was diagnosed by a study-specific blinded independent review committee (BIRC) in the present study, which reviewed the presence of inflammatory findings, such as edema, erosion, and/or erythema (redness), in the external ear canal on the digital endoscopic images acquired at screening. The improvement in the inflammatory findings in each diseased ear was evaluated by examining the digital endoscopic images acquired at the end of treatment (EOT; including study discontinuation) and follow-up (F/U) visits. Data regarding residual purulent otorrhea at EOT and F/U visits were assessed by the BIRC of the ENT103-3001 study. Similarly, otological symptoms at EOT were recorded in the patients’ diaries, and the bacterial eradication rates were used from the ENT103-3001 study. Improvement was defined as the resolution of the inflammatory findings and purulent otorrhea.</div></div><div><h3>Results</h3><div>Among the 201 patients with otitis media, 161 patients had AOE (LVFX group, 82; placebo group, 79). The difference (95% confidence interval) between the groups at EOT was 27.3% (12.7, 40.3), and the proportion of patients showing improvement in all inflammatory findings in the external ear canal in the LVFX group (47.6%, 39/82) was significantly higher than that in the placebo group (20.3%, 16/79; Fisher's exact test, <em>p</em> &lt; 0.001). Similarly, the bacterial eradication rate in the LVFX group (94.3%, 66/70) was also significantly higher than that in the placebo group (10.3%, 7/68; Fisher's exact test, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The use of 1.5% LVFX otic solution resulted in a significantly higher rate of improvement in inflammatory findings in the external ear canal and bacterial eradication rate, indicating its efficacy. Thus, 1.5% LVFX otic solution may be an effective treatment for chronic suppurative otitis media and acute otitis media, as well as AOE with NTM.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 6","pages":"Pages 1060-1067"},"PeriodicalIF":1.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of basic and clinical studies for vocal fold regeneration therapies","authors":"Cathrine Miura ,&nbsp;Rumi Ueha ,&nbsp;Maria Angela Dealino ,&nbsp;Naoyuki Matsumoto ,&nbsp;Taku Sato ,&nbsp;Takao Goto ,&nbsp;Kenji Kondo","doi":"10.1016/j.anl.2024.10.011","DOIUrl":"10.1016/j.anl.2024.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>To review the various basic research and treatments available to regenerate the vocal folds and to discuss the direction for future treatments.</div></div><div><h3>Methods</h3><div>A comprehensive review was performed in PubMed database and Google Scholar utilizing search terms including combinations and variations of the following concepts: vocal fold anatomy, vocal fold disorders, and regenerative therapies. No particular inclusion or exclusion criteria were set due to the nature of this narrative review article.</div></div><div><h3>Results/Discussion</h3><div>The regenerative treatments available for each vocal fold layer are the following: 1) epidermal growth factor and transforming growth factor-β1 for the epithelial layer, 2) autologous fibroblasts, autologous bone-marrow derived mesenchymal stem cells (MSCs), autologous adipose tissue-derived stromal vascular fraction (ADSVF), basic fibroblast growth factor (bFGF), collagen-hyaluronic acid nanofiber, pirfenidone, hepatocyte growth factor (HGF), pulsed dye laser (PDL), diode laser, and platelet-rich plasma (PRP) for the lamina propria, 3) bFGF and controlled-release bFGF with autologous fascia, HGF, c-Met agonistic antibody, and PRP for the muscular layer, 4) and bFGF and PRP-loaded nerve guidance conduit for the nerve. Treatments deemed clinically safe with sustained efficacy assessed up to 6 months are HGF and PDL, while bFGF, autologous fibroblasts, autologous bone marrow-derived MSCs, ADSVF, and PRP have been studied up to 12 months.</div></div><div><h3>Conclusion</h3><div>An ideal regenerative treatment is one that restores the injured or lost components of the vocal fold. The layered structure of the vocal fold allows for several mechanisms of action for these regenerative therapies. Further experimental and clinical studies are warranted, and these would dictate the impact of vocal fold regenerative therapies. Regenerative medicine may soon be at the forefront for treating vocal fold disorders. Clinicians should be open to advancements in treatment and consider the potential of novel therapies to treat specific pathologies.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 6","pages":"Pages 1052-1059"},"PeriodicalIF":1.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}