Auris Nasus Larynx最新文献

{"title":"Trial for developing a reference extract for future standardization of Japanese cypress pollen extracts","authors":"Kengo Kanai ,&nbsp;Aiko Oka ,&nbsp;Hideaki Kouzaki ,&nbsp;Kento Kawakita ,&nbsp;Takuya Murao ,&nbsp;Takeshi Shimizu ,&nbsp;Takaya Higaki ,&nbsp;Aya Murai ,&nbsp;Mizuo Ando ,&nbsp;Kojiro Hirano ,&nbsp;Isao Suzaki ,&nbsp;Hitome Kobayashi ,&nbsp;Minoru Gotoh ,&nbsp;Kimihiro Okubo ,&nbsp;Mitsuhiro Okano","doi":"10.1016/j.anl.2025.10.001","DOIUrl":"10.1016/j.anl.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Japanese cedar pollinosis (JCP) is the most prevalent seasonal allergic rhinitis in Japan. Many JCP patients are also sensitized to Japanese cypress pollen (JCyP), and their symptoms become exacerbated and prolonged during the JCyP dispersal period after JCP. To date, there have been no reports on the development of JCyP-specific allergen immunotherapy. For the future development of a JCyP-specific skin test and immunotherapy, we sought to develop a reference extract for future standardization of JCyP extract determined by the average threshold dilution eliciting a positive response in the intradermal skin test.</div></div><div><h3>Methods</h3><div>A 1:20 antigen extract (Lot AA) was prepared from JCyP grains by the glycerin extraction method. The protein and allergen concentrations in the extract were determined. After confirming its safety, 3-fold serially diluted solutions of JCyP extract were prepared from Lot AA. The average threshold dilution eliciting a positive response in the intradermal skin test was determined among Japanese subjects with serum JCyP-specific IgE class of 2 or higher according to ImmunoCAP IgE assays or View39 IgE assays.</div></div><div><h3>Results</h3><div>The protein concentration in Lot AA was 4.7 mg/mL, and the allergen concentration was 18.8 μg/mL for Cha o 1 and 1.1 μg/mL for Cha o 3. In total, 85 individuals were registered for this study and finally, 55 subjects were left for the analysis. The threshold dilution for an intradermal reaction was 3⁶ in 32 individuals (58.2 %), 3⁷ in 8 individuals (14.6 %), 3⁸ in 4 individuals (7.3 %), and 3⁹ in 1 individual (1.8 %); no reaction was seen in 10 individuals (18.2 %). The average threshold dilution was 3^6.4, which is equivalent to a 1131-fold dilution. No serious adverse events were observed at any of the tested dilutions.</div></div><div><h3>Conclusion</h3><div>The results showed that Lot AA of JCyP extract exhibited <em>in vivo</em> allergic potency and was safe. Thus, it may be useful as a future standardized antigen of JCyP or a reference antigen for standardizing other JCyP extracts for the diagnosis and treatment of JCyP pollinosis.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 805-810"},"PeriodicalIF":1.5,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Impact of hearing impairment in unilateral hearing loss: A multicenter study of standardized sound localization tests in Japan.” [Auris Nasus Larynx, Volume 52, Issue 6, December 2025, Pages 690-703]","authors":"Takashi Ishino ,&nbsp;Tadao Yoshida ,&nbsp;Satoshi Iwasaki ,&nbsp;Naoki Oishi ,&nbsp;Yusuke Matsuda ,&nbsp;Tetsuya Tono ,&nbsp;Kazuma Sugahara ,&nbsp;Hiroshi Yamazaki ,&nbsp;Sumito Jitsukawa ,&nbsp;Hiroshi Nakanishi ,&nbsp;Ryosuke Kitoh ,&nbsp;Takashi Sato ,&nbsp;Kazuki Nishida ,&nbsp;Takashi Oda ,&nbsp;Rikuto Fujita ,&nbsp;Tomohiro Kawasumi ,&nbsp;Chie Ishikawa ,&nbsp;Manabu Nishida ,&nbsp;Nobuyuki Chikuie ,&nbsp;Yuichiro Horibe ,&nbsp;Sachio Takeno","doi":"10.1016/j.anl.2025.10.012","DOIUrl":"10.1016/j.anl.2025.10.012","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 803-804"},"PeriodicalIF":1.5,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage surgery following boron neutron capture therapy in a case of recurrent hypopharyngeal cancer after radiotherapy: Surgical and pathological insights","authors":"Akihisa Tanaka ,&nbsp;Kohtaro Eguchi ,&nbsp;Mitsuhiko Katoh ,&nbsp;Tatsuya Ito ,&nbsp;Azusa Sakai ,&nbsp;Toshihiko Sakai ,&nbsp;Chihiro Fushimi ,&nbsp;Go Omura ,&nbsp;Taisuke Mori ,&nbsp;Seiichi Yoshimoto","doi":"10.1016/j.anl.2025.10.013","DOIUrl":"10.1016/j.anl.2025.10.013","url":null,"abstract":"<div><div>Radiotherapy (RT) is a cornerstone management strategy for head and neck cancer (HNC); however, local recurrence often requires salvage surgery, which is associated with an elevated risk of complications, particularly in previously irradiated fields. Boron neutron capture therapy (BNCT) has broadened treatment options; however, the safety and feasibility of salvage surgery after BNCT remain unclear owing to the limited case number. Herein, we describe a rare case of hypopharyngeal squamous cell carcinoma initially treated with RT, followed by BNCT for local recurrence, and ultimately with successful salvage surgery. The patient experienced no significant intraoperative or postoperative complications, and has remained recurrence-free for three years while maintaining adequate activities of daily living. Histopathological examination revealed no abnormal fibrosis exceeding that typically observed following standard RT alone throughout the resected specimen. Instead, edematous changes predominated over fibrotic alterations exclusively within the tumor region, presumed to be most affected by BNCT, accompanied by strong expression of L-type amino acid transporter 1, a potential surrogate marker of BNCT indication, suggesting the tumor-specific therapeutic effect of BNCT. This is the first report of salvage surgery for an organ previously treated with RT and BNCT, which provides valuable clinical and histopathological insights into this condition.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 785-789"},"PeriodicalIF":1.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck stiffness and its correlation with dysphagia after radiotherapy in head and neck cancer","authors":"Junki Ono ,&nbsp;Hideaki Nishi ,&nbsp;Sumie Takashima ,&nbsp;Shuntaro Soejima ,&nbsp;Ryo Toya ,&nbsp;Yoshihiko Kumai","doi":"10.1016/j.anl.2025.10.011","DOIUrl":"10.1016/j.anl.2025.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>Dysphagia is one of the most significant adverse effects after radiotherapy (RT) for advanced head and neck cancer (HNC). We hypothesized that neck stiffness may impair laryngeal elevation (LE) in HNC patients and contribute to post-RT dysphagia. We evaluated the association between cervical stiffness and swallowing dysfunction after RT for HNC.</div></div><div><h3>Methods</h3><div>Ultrasound and swallowing function tests were conducted before and 6 months after RT for HNC. Stiffness of the sternocleidomastoid muscle (SM) was measured via shear wave elastography (SWE). To assess swallowing function comprehensively, videofluoroscopic swallowing studies were performed; based on these data, we calculated the Penetration–Aspiration Scale (PAS) score and quantified hyoid bone displacement and LE delay time.</div></div><div><h3>Results</h3><div>Of 29 patients, 8 showed post-RT dysphagia. Compared to prophylactic irradiation, a significant increase in neck stiffness was observed in the radical irradiation group (<em>p</em> = 0.018). Multivariable logistic regression analysis indicated that greater reductions in laryngeal elevation distance (LED) were significantly associated with post-RT dysphagia (OR: 0.67, 95 % CI: 0.47–1.10, <em>p</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>SWE demonstrated a significant increase in neck stiffness following radiotherapy. Moreover, a greater reduction in LED was significantly associated with post-RT dysphagia, suggesting that impaired LE function may contribute to its development.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 796-802"},"PeriodicalIF":1.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete and successful resection of antrochoanal polyps using endoscopic modified medial maxillectomy","authors":"Kotaro Kano ,&nbsp;Satoshi Yamada ,&nbsp;Arika Matsushita ,&nbsp;Taiki Mori ,&nbsp;Mamoru Masuda ,&nbsp;Yusei Makoshi ,&nbsp;Shigeru Matsuda ,&nbsp;Kotaro Ishida ,&nbsp;Kazutaka Takeuchi ,&nbsp;Yuki Nakamura ,&nbsp;Kosuke Sugawara ,&nbsp;Sosuke Sahara ,&nbsp;Natsuki Sugiyama ,&nbsp;Junya Kita ,&nbsp;Kotaro Morita ,&nbsp;Hiroshi Nakanishi ,&nbsp;Atsushi Imai ,&nbsp;Jun Okamura ,&nbsp;Yoshinori Takizawa ,&nbsp;Yuki Misawa ,&nbsp;Kiyoshi Misawa","doi":"10.1016/j.anl.2025.10.014","DOIUrl":"10.1016/j.anl.2025.10.014","url":null,"abstract":"<div><h3>Objective</h3><div>Antrochoanal polyps (ACPs) are benign lesions of the maxillary sinus mucosa that are often treated with endoscopic sinus surgery using middle meatal antrostomy (MMA). However, MMA alone may not provide sufficient access to the mucosal attachment site of polyp, particularly at the anterior or inferior wall of the maxillary sinus, and additional procedures may be required to achieve complete resection. Although many reports have described ACP resection with MMA in combination with supplementary procedures, no study has evaluated whether ACPs can be effectively removed using a single approach without MMA. Endoscopic modified medial maxillectomy (EMMM) provides wide access to the maxillary sinus without additional procedures. This study aimed to evaluate the efficacy of EMMM alone, without MMA, in achieving complete resection of ACPs.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted using data of 13 patients with ACPs treated surgically (EMMM, n = 8; MMA with or without additional procedures, n = 5) between October 2019 and May 2023. Surgical outcomes, including operative time, blood loss, mucosal healing, complications, and recurrence, were compared between the two groups.</div></div><div><h3>Results</h3><div>Intraoperative blood loss was significantly reduced and mucosal healing was significantly rapid in the patients in the EMMM group (p &lt; 0.05). No complications occurred in both groups. Recurrence occurred in the MMA group only (n = 1). Postoperatively, the patients in the EMMM group had improved preservation of sinonasal structures and wound healing since the procedure avoided middle meatus manipulation.</div></div><div><h3>Conclusions</h3><div>In the present study, EMMM could be a safe and effective technique for complete ACP resection. It might minimizes tissue trauma, promote rapid healing, reduce the risk of recurrence, and have the potential to become a standard procedure for ACP removal, especially when preservation of nasal structures is prioritized.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 790-795"},"PeriodicalIF":1.5,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and safety of transaxillary robotic thyroidectomy in Japan – Comparison with video-assisted neck surgery in initial cases","authors":"Yosuke Tanabe,&nbsp;Tomoki Kuki,&nbsp;Kohei Yamahara,&nbsp;Hisayuki Kato,&nbsp;Ichiro Tateya","doi":"10.1016/j.anl.2025.10.006","DOIUrl":"10.1016/j.anl.2025.10.006","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> To evaluate the safety and feasibility of transaxillary robotic thyroidectomy (TART) in Japan by comparing early cases with video-assisted neck surgery (VANS).</div></div><div><h3>Methods</h3><div><strong>:</strong> Single-center retrospective review of 31 consecutive thyroid lobectomies: 16 VANS (Nov 2020–Feb 2025) and 15 TART (Mar 2022–Feb 2025). TART used da Vinci Surgical system (da Vinci) Xi for early cases and predominantly da Vinci SP thereafter. Indications included differentiated cancer ≤4 cm, cN0, unilateral disease without extrathyroidal invasion, or follicular tumors 3–5 cm. Operative time, blood loss, hospital stay, complications, and cosmetic outcomes were evaluated and compared with statistical analysis.</div></div><div><h3>Results</h3><div><strong>:</strong> All procedures were completed without conversion to open surgery. Blood loss (16.5 g vs 25.8 g) and length of stay (6.3 vs 6.1 days) were comparable. Complications included two transient recurrent laryngeal nerve palsies after VANS and, after TART, one axillary bleed controlled under local anesthesia and one lymphatic leak; overall rates were similar. High cosmetic satisfaction was reported in both cohorts.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> Early experience shows TART is feasible and safe in Japan, achieving perioperative outcomes comparable to VANS with excellent cosmetic results.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 769-775"},"PeriodicalIF":1.5,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transoral robotic approaches for benign and malignant parapharyngeal space tumors: comparative analysis and systematic review","authors":"Francesco Chiari ,&nbsp;Daria Maria Filippini ,&nbsp;Edoardo Serafini ,&nbsp;Matteo Fermi ,&nbsp;Livio Presutti ,&nbsp;Antonino Maniaci ,&nbsp;Claudio Donadio Caporale ,&nbsp;Pierre Guarino","doi":"10.1016/j.anl.2025.10.008","DOIUrl":"10.1016/j.anl.2025.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this systematic review was to provide a comprehensive overview of the clinical characteristics of patients with parapharyngeal space (PPS) tumors treated with transoral robotic surgery (TORS). Additionally, comparative analyses were conducted to evaluate differences based on tumor histology, tumor location, and the type of transoral robotic approach used.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive electronic search was performed across Embase, PubMed, Scopus, and Cochrane Library to identify studies published between 2007 and 2024.</div></div><div><h3>Results</h3><div>A total of 31 studies met the inclusion criteria, encompassing individual data from 148 patients. The TORS-combined approach was more frequently employed in the management of malignant PPS (<em>p</em> = .010), with a larger size (<em>p</em> = &lt;.001). Furthermore, malignant PPS tumors presented a higher incidence of feeding tube placement, tracheotomy, and prolonged hospitalization when compared to benign neoplasms (<em>p</em> &lt; .001). Post-operative complications were related to retro-styloid tumors (<em>p</em> = .023).</div></div><div><h3>Conclusions</h3><div>The TORS-only approach is appropriate for the treatment of isolated, small, and well-encapsulated tumors. Based on previously published evidence, a TORS-combined approach has been recommended for the management of malignant tumors exceeding 3 cm in diameter. In the current analysis, larger tumor size was associated with the choice of a TORS-combined procedure, but this was not directly correlated with malignant histology</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 776-784"},"PeriodicalIF":1.5,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sialendoscopy for the management of sialolithiasis in Japan","authors":"Miki Takahara","doi":"10.1016/j.anl.2025.10.004","DOIUrl":"10.1016/j.anl.2025.10.004","url":null,"abstract":"<div><div>Sialolithiasis, the formation of calculi in the major salivary glands, is the leading cause of obstructive salivary disease and occurs predominantly in the submandibular gland. Traditional management of hilar or parenchymal stones has often required submandibular gland excision, which carries the risk of visible scarring and potential facial nerve injury. Sialendoscopy has emerged as a minimally invasive alternative for both diagnosis and treatment. Since its introduction in the 1990s and subsequent refinement, it has become standard therapy in Europe and North America, but in Japan, despite national insurance coverage since 2014, adoption remains limited because of technical complexity, high cost of consumables, and limited endoscope durability. A review of the literature and our own 144-case experience demonstrated a 40 % success rate for stone removal using sialendoscopy alone in Japan. Stone mobility was the most important predictor of success, while size greater than about 7.5 mm and parenchymal location markedly reduced success rates. Complications were generally mild and self-limiting: transient glandular swelling and lingual nerve paresis resolved within months, though occasional ranula formation or recurrence required secondary procedures. Similar factors predict outcomes in parotid stones, with reported endoscopic success of about 30–50 %. Fourier transform infrared spectrophotometry of 133 stones showed calcium phosphate and protein as the main components, and a higher calcium phosphate fraction correlated with stronger ductal adhesion and lower success rates. Sialendoscopy is therefore a safe, effective, and cosmetically advantageous alternative to gland excision, and we hope that this review will help lay the groundwork for its broader adoption and continued advancement in Japan.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 764-768"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-salt intake exacerbates endolymphatic hydrops and alters aldosterone regulation in a Ménière’s disease animal model","authors":"Makoto Kinoshita ,&nbsp;Akinobu Kakigi ,&nbsp;Yuki Katsutani ,&nbsp;Teru Kamogashira ,&nbsp;Kento Koda ,&nbsp;Kentaro Ichijo ,&nbsp;Chisato Fujimoto ,&nbsp;Shinji Yamashita ,&nbsp;Kenji Kondo","doi":"10.1016/j.anl.2025.10.010","DOIUrl":"10.1016/j.anl.2025.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>Ménière’s disease (MD) causes episodic vertigo and fluctuating hearing loss and is pathologically characterized by endolymphatic hydrops (EHs), often resulting from impaired endolymph absorption in the endolymphatic sac (ES). Although salt restriction is widely recommended, its mechanistic basis remains unclear. This study aims to examine how ES dysfunction and dietary salt intake interactively affect endolymphatic homeostasis, vestibular function, and aldosterone regulation.</div></div><div><h3>Methods</h3><div>Guinea pigs underwent ES ablation or sham surgery and were fed either a normal- (0.41 % NaCl) or high-salt (2.0 % NaCl) diet, generating four groups (Sham-Normal, Sham-Na, ES-Normal, ES-Na; <em>n</em> = 4 per group). Vestibular evoked potential (VsEP) thresholds and plasma aldosterone were measured at 4 weeks post-surgery. Animals were then given their assigned diets for 2 weeks, after which both variables were re-evaluated at week 6. Animals were subsequently euthanized, and EHs were quantified using optical coherence tomography (OCT) as the extension ratio of Reissner’s membrane length and increase ratio of scala media area (IR-A).</div></div><div><h3>Results</h3><div>Two-way ANOVA revealed a significant surgery × salt interaction for IR-A, indicating synergistic hydrops when ES damage and high salt co-occurred. VsEP thresholds increased with both factors but showed no interaction, indicating additive vestibular impairment. Aldosterone exhibited a clear interaction: ES ablation elevated aldosterone under normal salt conditions, whereas high salt suppressed aldosterone irrespective of surgical status.</div></div><div><h3>Conclusion</h3><div>Sodium excess is associated with worsening EHs in ES dysfunction, suggesting a relation between sodium intake and EHs formation in MD. These results support further studies, including a low-salt group, to clarify whether and how sodium restriction could improve MD symptoms.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 756-763"},"PeriodicalIF":1.5,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of transoral injection laryngoplasty in the apneic window","authors":"Nurullah Türe ,&nbsp;Serkan Telli ,&nbsp;Onur Kibar","doi":"10.1016/j.anl.2025.10.009","DOIUrl":"10.1016/j.anl.2025.10.009","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was report the feasibility, safety profile, and within-patient voice outcomes of transoral injection laryngoplasty performed during a protocolized apneic window in unilateral vocal fold paralysis (UVFP)<strong>.</strong></div></div><div><h3>Methods</h3><div>This retrospective single-arm cohort study included patients who underwent transoral IL in the apneic window because of UVFP between February 2021 and March 2024. The following parameters were compared before and after the injection: GRBAS, maximum phonation time (MPT,seconds), Turkish Voice Handicap Index-10 (T-VHI-10), Turkish Voice-Related Quality of Life Questionnaire (T-V-RQOL), Turkish Eating Assessment Tool (T-EAT-10), and acoustic analysis parameters (F0, Jitter (%), Shimmer (%), CPPs, AVQI v03.01).</div></div><div><h3>Results</h3><div>Final analysis was made of 27 patients, comprising 19 (70.4 %) females and 8 (29.6 %) males, with a mean age of 58 years (range, 21–75 years). Following the apneic window IL technique, statistically significant decreases were determined in the GRBAS G-score (2.36 vs.0.28, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), MPT (5.68 vs.13.56 secs, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), T-VHI-10 (28 vs. 6, <strong><em>p</em></strong> <strong>&lt;</strong> <strong>0.001</strong>), and T-EAT-10 (14 vs. 4, <strong><em>p</em></strong> <strong>&lt;</strong> <strong>0.001</strong>). In the acoustic voice analysis, statistically significant decreases were observed in Jitter % (0.67 vs. 0.3, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), Shimmer % (5.81 vs.1.6, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>) and AVQI v03.01 (5.9 vs. 2.8, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>).</div></div><div><h3>Conclusion</h3><div>Transoral IL in an apneic window is a feasible and safe tubeless option that yielded significant within-patient improvements across perceptual, aerodynamic, patient-reported, and acoustic domains under a predefined safety workflow. The technique preserves a wide, tube-free operative field and may be considered complementary in selected candidates. Comparative studies versus intubated IL are warranted to establish non-inferiority or superiority.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 750-755"},"PeriodicalIF":1.5,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}