Auris Nasus Larynx最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 107-110"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147046941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 2","pages":"Pages 252-256"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147260830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 2","pages":"Pages 239-244"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147260833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of Bahasa Malaysia eating assessment tool (mEAT-10): A good screening tool for safe swallowing","authors":"Jia Ji Ng ,&nbsp;Hui Yan Ong ,&nbsp;Ziyad Al Harrasi ,&nbsp;Nik Fariza Husna Nik Hassan ,&nbsp;Sherin Sokmun ,&nbsp;Farah Liana Lokman ,&nbsp;Nadhirah Mohd Shakri ,&nbsp;Mawaddah Azman ,&nbsp;Mohd Razif Mohamad Yunus ,&nbsp;Marina Mat Baki","doi":"10.1016/j.anl.2025.12.002","DOIUrl":"10.1016/j.anl.2025.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the validity and reliability of the Bahasa Malaysia version of the Eating Assessment Tool-10 (mEAT-10) and determine the cutoff point for abnormal swallowing.</div></div><div><h3>Methods</h3><div>This prospective convenience sampling study was conducted at a tertiary center between December 2019 and May 2022. The mEAT-10 was produced following rigorous forward and backward translations. One hundred and thirty-eight participants, including 70 healthy volunteers and 68 patients with dysphagia, were recruited to complete the test–retest mEAT-10 assessment and the 3-ounce water test. The mEAT-10 was repeated within four weeks via telephone interviews or clinic visits. Patients in the dysphagia group underwent flexible endoscopic evaluation of swallowing (FEES). The FEES results were evaluated independently by four different raters to determine the reliability of the penetration-aspiration score (PAS) scoring, which categorizes them into safe and unsafe swallowing for data analysis. Internal consistency and test–retest agreement were assessed using Cronbach alpha and intraclass correlation coefficient (ICC). The mEAT-10 comparison between the normal and dysphagia groups was performed using the Mann–Whitney U test. The association between PAS and mEAT-10, gag reflex,3-ounce water test and the other risk factors were evaluated using chi-square and Fisher exact test, with univariable and multivariable logistic regression.</div></div><div><h3>Results</h3><div>The mEAT-10 test–retest showed a Cronbach alpha of &gt;0.90 and an ICC of &gt;0.85. The mEAT-10 cutoff score indicating abnormal swallowing is seven, with sensitivity and specificity of 0.82 and 0.54, respectively. In univariable analysis, higher mEAT-10 scores (≥7), absence of gag reflex, and failure of the 3-ounce water test were all significantly associated with unsafe swallowing (PAS ≥3). In multivariable logistic regression, however, failure of the 3-ounce water test was the only independent predictor of unsafe swallowing (PAS ≥3; adjusted odds ratio 4.24, 95% confidence interval 1.53–11.77; p=0.006).</div></div><div><h3>Conclusion</h3><div>mEAT-10 is a reliable tool for screening and assessing patients with dysphagia. A cutoff score of 7 or more indicates abnormal swallowing and maybe associated with unsafe swallowing (PAS ≥3).</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 91-98"},"PeriodicalIF":1.5,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost and clinical outcomes of transoral robotic surgery versus radiation therapy for T1–2N0–1M0 pharyngeal and laryngeal cancers","authors":"Susumu Kunisawa ,&nbsp;Ichiro Tateya ,&nbsp;Hisayuki Kato ,&nbsp;Koichi Omori ,&nbsp;Kiyohide Fushimi ,&nbsp;Yuichi Imanaka","doi":"10.1016/j.anl.2025.12.012","DOIUrl":"10.1016/j.anl.2025.12.012","url":null,"abstract":"<div><h3>Objectives</h3><div>Since 2022, transoral robotic surgery (TORS) for pharyngeal and laryngeal cancers has been covered under Japan’s national health insurance system. Despite its technical advantages, such as improved access and functional preservation, its adoption remains limited. One of the barriers may be that TORS is reimbursed at the same level as conventional endoscopic surgery, despite requiring substantial initial investment and operational costs. This raises concerns about the underutilization of a potentially valuable technology. Therefore, an economic evaluation of TORS is warranted to inform reimbursement policy.</div></div><div><h3>Methods</h3><div>We used data from Japan’s national Diagnosis Procedure Combination (DPC) database to identify patients with T1–2N0–1M0 pharyngeal or laryngeal cancers who received either TORS or intensity-modulated radiation therapy (IMRT) in 2022. Total medical costs during the treatment period were compared.</div></div><div><h3>Results</h3><div>Among 447 patients identified, 40 received TORS and 407 underwent IMRT. The TORS group had significantly shorter hospital stays (mean 16.3 vs. 55.5 days) and lower mean costs (1.26 vs. 3.45 million yen; <em>P</em> &lt; 0.01) than those who underwent IMRT. Using a generalised linear model with a gamma distribution and log link, and adjusting for sex, age, tumour site, tumour size and nodal status, TORS was associated with significantly lower costs than IMRT (adjusted cost ratio 0.39; 95 % confidence interval 0.35–0.43; <em>P</em> &lt; 0.01). A similar result was observed even when the analysis was limited to patients with oropharyngeal cancer and N0.</div></div><div><h3>Conclusions</h3><div>TORS demonstrated a significant reduction in medical costs for treating patients with T1–2N0–1M0 pharyngeal or laryngeal cancer. However, this result should be interpreted with caution, as the observed cost advantage is probably due to the current Japanese reimbursement pricing. Nevertheless, the shortened treatment period associated with TORS offers meaningful benefits from the patient perspective. Even with moderate adjustments in reimbursement, the cost-effectiveness of TORS is expected to remain robust.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 86-90"},"PeriodicalIF":1.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of cranial nerve disorders in pharyngo-laryngeal herpes zoster: A retrospective study of 34 cases at a single institution","authors":"Kanoko Minoshima ,&nbsp;Hiroko Yanagi ,&nbsp;Hiroki Sato ,&nbsp;Michiya Matsumura ,&nbsp;Yasushi Furuta","doi":"10.1016/j.anl.2025.12.014","DOIUrl":"10.1016/j.anl.2025.12.014","url":null,"abstract":"<div><h3>Objective</h3><div>Pharyngo-laryngeal herpes zoster (HZ) is a rare but clinically important manifestation of varicella-zoster virus (VZV) reactivation. Unlike the well-described Ramsay Hunt syndrome, its neurological spectrum and outcomes remain poorly characterized. This study aimed to clarify patterns of cranial nerve involvement, recovery outcomes, and diagnostic challenges in pharyngo-laryngeal HZ, representing the largest single-center series to date.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 34 patients diagnosed with pharyngo-laryngeal HZ at a tertiary referral hospital in Japan between July 2007 and June 2025. VZV reactivation was confirmed serologically in all cases. Clinical features, affected cranial nerves, treatments, and recovery outcomes were analyzed. Neurological recovery was defined as complete resolution of paralysis, and swallowing recovery as tolerance of the pre-onset diet.</div></div><div><h3>Results</h3><div>The cohort comprised 24 men and 10 women (mean age, 61.7 years). Herpetic lesions were identified in 23 patients, while 11 (32 %) presented without rash and were diagnosed with zoster sine herpete, underscoring the diagnostic value of serology. The glossopharyngeal (IX) and vagus (X) nerves were most frequently affected (59 % each), followed by the facial nerve (24 %). Dysphagia occurred in 22 patients (65 %), with 5 requiring nutritional support and 2 developing aspiration pneumonia. Among 25 patients with cranial nerve paralysis, only 14 (56 %) achieved complete recovery. Laryngeal paralysis resulting from the X nerve impairment demonstrated the poorest prognosis, with a recovery rate of 50 %, although none required surgical intervention. In contrast, all cases of facial paralysis recovered fully, often after delayed onset following IX/X nerve symptoms. Incomplete recovery was more common in older patients and those who did not receive combined antiviral and corticosteroid therapy, though differences were not statistically significant. Overall, dysphagia resolved in 21 of 22 patients (95 %), but recovery was frequently prolonged, with most requiring &gt;2 weeks of swallowing rehabilitation before resuming oral intake.</div></div><div><h3>Conclusions</h3><div>Pharyngo-laryngeal HZ is a distinct clinical entity typically manifesting as cranial polyneuropathy. The IX and X nerves are most often involved, with laryngeal paralysis associated with poorer outcomes. A substantial proportion of patients experience severe or prolonged dysphagia, necessitating nutritional support and rehabilitation. The frequent occurrence of zoster sine herpete highlights the critical role of serological testing in diagnosis. These findings emphasize that pharyngo-laryngeal HZ can cause severe, lasting morbidity, warranting early recognition, aggressive treatment, and preventive strategies, including zoster vaccination.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 80-85"},"PeriodicalIF":1.5,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid cancer with internal jugular vein tumor embolism and skull base invasion causing polyneuropathy","authors":"Hiroki Matsushita ,&nbsp;Gaku Omura ,&nbsp;Sumiyo Saburi ,&nbsp;Takahiro Tsujikawa ,&nbsp;Shigeru Hirano","doi":"10.1016/j.anl.2025.12.009","DOIUrl":"10.1016/j.anl.2025.12.009","url":null,"abstract":"<div><div>We report a rare case of thyroid cancer with tumor embolism of the internal jugular vein (IJV) that progressed cranially into the skull base and caused multiple cranial neuropathies. An 80-year-old woman presented with a progressively enlarging right cervical mass, which had been neglected for 10 years. Ultrasonography and magnetic resonance imaging revealed a cystic cervical lesion with a tumor embolism within the IJV extending to the jugular foramen and hypoglossal and facial canals. Fine-needle aspiration cytology yielded inconclusive results on two occasions, likely because of cystic degeneration. The patient developed facial paralysis, tongue deviation, and vocal cord paralysis. Biopsy confirmed papillary thyroid carcinoma with poorly differentiated areas. The patient elected the best supportive care and passed away four months after diagnosis. Cranial progression was likely facilitated by venous stasis due to an intraluminal tumor thrombus combined with the biological aggressiveness of dedifferentiation. To the best of our knowledge, this is the first documented case of thyroid cancer with retrograde IJV tumor embolism that led to skull base invasion and jugular foramen syndrome. This case highlights the variability in thyroid cancer extension patterns, which can occasionally result in highly atypical and clinically significant manifestations.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 76-79"},"PeriodicalIF":1.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEXAS syndrome with cochleovestibular involvement","authors":"Keishi Fujiwara ,&nbsp;Shinya Morita ,&nbsp;Kimiko Hoshino ,&nbsp;Hideaki Takeda ,&nbsp;Kento Komatsuda ,&nbsp;Kaoru Kahata ,&nbsp;Yuji Nakamaru ,&nbsp;Akihiro Homma","doi":"10.1016/j.anl.2025.12.010","DOIUrl":"10.1016/j.anl.2025.12.010","url":null,"abstract":"<div><div>We report a case of VEXAS syndrome in a 71-year-old man presenting with auricular chondritis, scleritis, hearing loss, and vestibular dysfunction. Although the clinical picture initially suggested relapsing polychondritis, hematologic findings and <em>UBA1</em> variant confirmed VEXAS syndrome. Comprehensive audiovestibular testing revealed bilateral sensorineural hearing loss and global vestibular impairment. Steroid therapy led to partial improvement. This case highlights the potential for inner ear involvement in VEXAS syndrome, underscoring the importance of systematic audiovestibular evaluation and clinical awareness to differentiate it from similar conditions such as relapsing polychondritis.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 70-75"},"PeriodicalIF":1.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of self-reported olfactory dysfunction in Japan: Findings from a nationwide web-based cross-sectional survey","authors":"Jun Suzuki ,&nbsp;Yuta Kobayashi ,&nbsp;Yoshihisa Fujino ,&nbsp;Takahiro Tabuchi ,&nbsp;Yukio Katori","doi":"10.1016/j.anl.2025.12.008","DOIUrl":"10.1016/j.anl.2025.12.008","url":null,"abstract":"<div><h3>Objective</h3><div>Olfactory dysfunction (OD) compromises safety and well-being in humans; however, large-scale Japanese data are lacking. We quantified the prevalence of subjective chronic OD (self-reported olfactory impairment persisting ≥3 months), identified associated health and occupational factors, and evaluated determinants for severity using data from a nationwide web-based survey in Japan.</div></div><div><h3>Methods</h3><div>We analyzed data from the Japan coronavirus disease 2019 and Society Internet Survey 2023, a stratified, nationwide, cross-sectional survey of community-dwelling residents in Japan. From the initial 33,000 participants, we used the data of 25,569 participants (12,323 men, 13,246 women), after excluding those with implausible responses and missing data, to calculate prevalence. Inverse probability weighting was used to align the sample with the 2019 National Living Conditions Survey. Group differences concerning the presence and severity of OD were tested with χ² or Wilcoxon tests after excluding participants with additional missing data; independent associations were examined using weighted multivariable logistic regression analyses.</div></div><div><h3>Results</h3><div>The weighted prevalence for chronic subjective OD was 1.3 % (95 % confidence interval [CI] 1.1–1.4); age-specific rates ranged from 0.6 % (40–49 years) to 2.1 % (60–69 years). Independent OD correlates included the factors current smoking (odds ratio [OR] 2.09, <em>p</em> = 0.016), homeworking (OR 2.75, <em>p</em> = 0.004), somatic symptoms (Somatic Symptom Scale-8 score ≥ 12; OR 2.66, <em>p</em> = 0.009), dysgeusia (OR 193.2, <em>p</em> &lt; 0.001), current hypertension (OR 3.69, <em>p</em> = 0.005), current bronchial asthma (OR 6.09, <em>p</em> &lt; 0.001), current allergic rhinitis (OR 1.97, <em>p</em> = 0.012), and moderate-severe presenteeism (Work Functioning Impairment Scale score ≥ 21; OR 3.04, <em>p</em> &lt; 0.020). Being a woman was associated with lower OD severity (OR 0.34, <em>p</em> = 0.035, for moderate-severe vs mild), whereas having ≥ 1 day of sick absences in the previous month was associated with higher OD severity (OR 3.17, <em>p</em> = 0.044).</div></div><div><h3>Conclusion</h3><div>Subjective OD prevalence in Japan was 1.3 %. Presenteeism was associated with OD and absenteeism was associated with moderate-severe OD. Further studies on the relationship between OD and work productivity are warranted.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 61-69"},"PeriodicalIF":1.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible patulous Eustachian tube: Clinical characteristics and diagnostic transition according to the Japan Otological Society criteria","authors":"Marin Yoshida ,&nbsp;Hidetoshi Oshima ,&nbsp;Hideshi Shindo ,&nbsp;Ryoji Hirai ,&nbsp;Takeshi Oshima","doi":"10.1016/j.anl.2025.11.005","DOIUrl":"10.1016/j.anl.2025.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>The 2016 diagnostic criteria for patulous Eustachian tube (PET) proposed by the Japan Otological Society classify cases as “definite” or “possible.” However, the clinical characteristics and natural course of possible cases remain unclear. This study aimed to clarify the clinical profiles and diagnostic transition of possible PET by subclassifying them into two groups.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the records of 292 patients diagnosed as possible PET at their first visit to our specialized outpatient clinic between June 2019 and May 2025. Patients were categorized as group A (symptom relief with Eustachian tube–closing maneuvers but lacking objective findings) or group B (objective findings present but without symptom relief). Clinical features, symptom profiles, and diagnostic transitions were analyzed. Survival analyses using the Kaplan–Meier method, Cox proportional hazards model, Weibull parametric model, and restricted mean survival time (RMST) were conducted to evaluate transition to definite PET.</div></div><div><h3>Results</h3><div>Voice autophony (81.8%¦vs. 59.9%) and breathing autophony (47.1%¦vs. 35.3%) were significantly more frequent in group A, whereas hearing loss was more common in group B (34.1%¦vs. 16.5%, p &lt; 0.001). During follow-up, 30 patients (25 in group A, 5 in group B) progressed to definite PET. Kaplan–Meier analysis showed a significantly higher transition rate in group A (log-rank, p &lt; 0.0001). Cox regression demonstrated a nearly five-fold higher hazard of progression in group A (HR = 4.95, 95% CI: 1.89–12.95, p = 0.001). RMST analysis indicated that group B required on average 1.5 more visits to reach diagnosis. Weibull analysis revealed that most group A patients were diagnosed by the third visit, whereas group B patients frequently remained undiagnosed.</div></div><div><h3>Conclusion</h3><div>Possible PET cases comprise heterogeneous conditions, with group A containing a higher proportion of true PET and group B including more non-PET cases with hearing loss. Careful follow-up and additional testing are warranted for group A, while differential diagnosis should be prioritized in group B. Subgroup-based evaluation may contribute to a more precise and practical diagnostic process for PET.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 55-60"},"PeriodicalIF":1.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}