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Addressing public health and health system challenges in Greece: reform priorities in a changing landscape 应对希腊的公共卫生和卫生系统挑战:变化形势下的改革重点
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00188-4
Ilias Kyriopoulos, Kostas Athanasakis, Stergiani Tsoli, Elias Mossialos, Irene Papanicolas
Health systems are under growing pressure from ageing populations, chronic diseases, and financial constraints, compounded by challenges, such as COVID-19 and climate change. In Greece, these pressures have converged in the past 15 years, exposing structural weaknesses and testing the health system's resilience. Despite successive reforms targeting funding, care delivery, and public health, persistent structural weaknesses, poor planning, and limited monitoring have undermined progress. Most policy responses have remained fragmented and are unable to fulfil their potential to address current public health challenges or prepare for future crises. Building health system sustainability and resilience requires more than enacting reforms. The reform process demands evidence-informed policy making, sustained political commitment, strong institutional capacity, and effective multisectoral coordination. Greece offers valuable lessons for countries facing similar pressures: resilience depends not only on policy adoption, but also on the institutions, resources, and accountability mechanisms that support implementation and translate policies into sustained action.
人口老龄化、慢性病和财政限制,再加上COVID-19和气候变化等挑战,使卫生系统面临越来越大的压力。在希腊,这些压力在过去15年中已经汇聚,暴露出结构性弱点,考验着卫生系统的复原力。尽管针对资金、保健服务和公共卫生进行了一系列改革,但持续存在的结构性弱点、规划不周和监测有限阻碍了进展。大多数政策对策仍然是支离破碎的,无法发挥其潜力来应对当前的公共卫生挑战或为未来的危机做好准备。建立卫生系统的可持续性和复原力需要的不仅仅是实施改革。改革进程需要循证决策、持续的政治承诺、强大的机构能力和有效的多部门协调。希腊为面临类似压力的国家提供了宝贵的经验:韧性不仅取决于政策的采用,还取决于支持政策实施并将政策转化为持续行动的机构、资源和问责机制。
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引用次数: 0
Modelling the case for alcohol pricing policy in the USA 美国酒精定价政策的案例建模
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00189-6
Mark Robinson, Lennert Veerman
Alcohol has become increasingly affordable in the USA in recent decades, coinciding with rising alcohol related harms.1, 2 Yet, in contrast to many other high-income countries, and despite increased alcohol pricing being identified as a WHO best buy policy, there has been scarce research on the potential effects of price changes on alcohol-related outcomes in the USA. In this context, the study by Carolin Kilian and colleagues provides timely and policy-relevant evidence.3
近几十年来,酒精在美国变得越来越便宜,与此同时,酒精相关的危害也在增加。1,2然而,与许多其他高收入国家不同,尽管提高酒精价格被确定为世卫组织的最佳购买政策,但在美国,关于价格变化对酒精相关结果的潜在影响的研究很少。在此背景下,Carolin Kilian及其同事的研究提供了及时且与政策相关的证据
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引用次数: 0
Maternal ethnic group, socioeconomic status, and neonatal and child mortality: a nationwide cohort study in England and Wales 母亲族群、社会经济地位、新生儿和儿童死亡率:英格兰和威尔士的一项全国性队列研究
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00167-7
Isobel L Ward, Sarah L Barrett, Cameron Razieh, Charlotte Standeven, Ania Zylbersztejn, Emyr John, Francesco Zaccardi, Neena Modi, Kamlesh Khunti, Daniel Ayoubkhani, Vahé Nafilyan

Background

The UK currently has one of the highest rates of child mortality in Europe. Robust population-level estimates of differences in neonatal and child mortality by ethnic and socioeconomic group are currently scarce for England and Wales. We aimed to examine variation in neonatal and child mortality by maternal ethnic group and indicators of socioeconomic status to help understand which groups are most at risk of neonatal and child mortality.

Methods

In this nationwide cohort study, we used linked population-level data for England and Wales, comprising birth registrations and notifications (2011–16), Census 2011, and death registrations (2011–21). Our population was restricted to livebirths, post-24 weeks’ gestation, and to mothers aged 12 years or older at time of birth. Our primary exposures were self-reported maternal ethnic group, household socioeconomic position, and maternal education from Census 2011. We estimated mortality rates and hazard ratios from Cox proportional hazards models for different ethnic and socioeconomic groups separately for neonatal (<28 days) and child (from ≥28 days to 10 years) mortality. We adjusted for sex of baby; birth term; suspected congenital anomaly; maternal age; disability; country of birth; main language; and household tenure, region, and rural or urban location. Babies were followed from birth for up to 10 years and until Dec 31, 2021, or death, whichever occurred earlier.

Findings

A total of 3 018 020 babies were included in our cohort, with the average age of the mother at delivery being 29·8 years (IQR 26–34). There were 4750 neonatal deaths and 5205 child deaths in the follow-up period. Compared with White British mothers, babies born to Pakistani mothers (hazard ratio [HR] 2·39 [95% CI 2·15–2·66]) or Black African mothers (HR 1·65 [1·43–1·91]) had the highest risk of neonatal mortality. These differences remained after fully adjusting the models for maternal, household, and gestational characteristics (adjusted HR 1·95 [95% CI 1·72–2·22] and HR 1·38 [1·15–1·66], for babies born to Pakistani and Black African mothers, respectively). The differences in child mortality by maternal ethnic group were similar and remained after accounting for maternal, household, and gestational characteristics. For socioeconomic factors, babies born to mothers with no formal education (HR 1·55 [95% CI 1·42–1·69]) or living in households with long-term unemployment (HR 1·93 [95% CI 1·69–2·19]) were most at risk from neonatal death compared with babies born to mothers who had school- level qualifications or in households where the main earner was employed in a higher managerial, administrative and professional occupation, respectively. Differences in neonatal and child mortality by education persisted for the models, accounting for maternal, household, and gestational characteristics.

Interpretation

Health inequalities exist from birth; the present findings identify the most at-risk gr
英国目前是欧洲儿童死亡率最高的国家之一。在英格兰和威尔士,目前还缺乏按种族和社会经济群体对新生儿和儿童死亡率差异的人口水平的可靠估计。我们的目的是检查产妇种族和社会经济地位指标在新生儿和儿童死亡率方面的差异,以帮助了解哪些群体的新生儿和儿童死亡率最高。方法在这项全国性队列研究中,我们使用了英格兰和威尔士的相关人口水平数据,包括出生登记和通知(2011 - 16年)、2011年人口普查和死亡登记(2011 - 21年)。我们的人群仅限于活产,妊娠24周后,以及出生时年龄在12岁或以上的母亲。我们的主要暴露是2011年人口普查中自我报告的母亲种族、家庭社会经济地位和母亲教育程度。我们根据不同种族和社会经济群体的Cox比例风险模型分别估计了新生儿(28天)和儿童(≥28天至10岁)死亡率和风险比。我们根据婴儿的性别进行了调整;出生术语;疑似先天性异常;母亲的年龄;残疾;出生国家;主要语言;以及家庭所有制、地区、农村或城市位置。婴儿从出生到2021年12月31日(或死亡,以较早者为准)被跟踪长达10年。结果本队列共纳入3 018 020例婴儿,产妇平均分娩年龄为29.8岁(IQR 26-34)。在随访期间,有4750名新生儿死亡,5205名儿童死亡。与英国白人母亲相比,巴基斯坦母亲(危险比[HR] 2.39 [95% CI 2.15 - 2.66])或非洲黑人母亲(危险比[HR] 1.65[1.43 - 1·91])所生婴儿的新生儿死亡风险最高。在完全调整了母亲、家庭和妊娠特征的模型后,这些差异仍然存在(调整后的HR分别为1.95 [95% CI 1.72 - 2·22]和1.38[1.15 - 1.66],分别针对巴基斯坦和非洲黑人母亲所生的婴儿)。在考虑了母亲、家庭和妊娠特征后,不同种族的儿童死亡率的差异是相似的。在社会经济因素方面,母亲未受过正规教育(HR 1.55 [95% CI 1.42 - 1·69])或生活在长期失业家庭(HR 1.93 [95% CI 1.69 - 2·19])的婴儿与母亲受过学校教育或主要收入来源从事较高管理、行政和专业职业的家庭所生的婴儿相比,新生儿死亡风险最高。考虑到母亲、家庭和妊娠期的特征,在模型中,新生儿和儿童死亡率因教育而存在差异。健康不平等从出生就存在;目前的发现确定了最危险的群体,未来的研究应该针对这些群体,以揭示新生儿和儿童死亡的因果关系。
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引用次数: 0
Life-years lost in people experiencing homelessness and other high-risk groups in Denmark: a population-based, register-based, cohort study 丹麦无家可归者和其他高危人群的生命年损失:一项以人口为基础、以登记为基础的队列研究
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00171-9
Sandra Feodor Nilsson, Annette Erlangsen, Camilla Munch Nielsen, Merete Nordentoft, Seena Fazel, Thomas Munk Laursen

Background

People experiencing homelessness have a high mortality risk. Estimates of absolute risk, such as life-years lost, provide a more accurate measure of mortality differences in transient populations than conventional life expectancy estimates and enable direct comparisons with the general population and other high-risk populations. We aimed to examine mortality risks and life-years lost in people experiencing homelessness and other high-risk groups by sex, age group, and cause of death.

Methods

We conducted a nationwide, register-based cohort study of people aged 17–100 years living in Denmark between Jan 1, 2002, and Dec 31, 2020. Data from the Danish Civil Registration System was linked to the Homeless Register and the Cause of Death Register. The outcome was overall and cause-specific mortality during follow-up. We estimated mortality rates per 10 000 person-years at risk and estimated adjusted mortality rate ratios using Poisson regression analysis. We calculated both average and age-specific life expectancy and life-years lost for people experiencing homelessness and compared these figures with those of the general population, as well as with individuals with schizophrenia, alcohol use disorder, and drug use disorder.

Findings

Among 6 286 512 Danish residents, 58 376 (0·9%) people had at least one homeless shelter contact during the study period. Among people with a history of homelessness, the mortality rate was 240·3 (95% CI 236·3–244·4) per 10 000 person-years. In the general population with no history of homelessness, the mortality rate per 10 000 person-years was 117·8 (95% CI 117·6–118·1) in the general population with no history of homelessness, which resulted in an absolute difference of 122·5 (118·5–126·5). The mean excess life-years lost was 15·9 (95% CI 15·8–16·2) for males and 15·3 (14·8–15·7) for females compared with the general population, which was higher than in other high-risk groups, such as people with schizophrenia, alcohol use disorder, and drug use disorder (with and without homelessness history). Most of this excess mortality in people experiencing homelessness was attributed to external causes of death, psychiatric disorders, and diseases of the liver and digestive system. Life-years lost from external causes of death, including suicide and unintentional injuries, was 5·2 (95% CI 5·0–5·5) for males and 3·9 (3·5–4·2) for females, compared with the general population.

Interpretation

The substantial number of life-years lost among people experiencing homelessness is a key public health concern, highlighting pronounced inequalities in health among some of the most vulnerable individuals. Such metrics should be useful to inform policies and preventive efforts to reduce excess mortality in this population.

Funding

Independent Research Fund Denmark.
无家可归的人有很高的死亡风险。对绝对风险的估计,如生命年损失,比传统的预期寿命估计更准确地衡量了流动人口的死亡率差异,并能够与一般人口和其他高风险人口进行直接比较。我们的目的是按性别、年龄组和死亡原因检查无家可归者和其他高危人群的死亡风险和寿命损失。方法:我们在2002年1月1日至2020年12月31日期间对居住在丹麦的17-100岁人群进行了一项全国性的、基于登记册的队列研究。来自丹麦民事登记系统的数据与无家可归者登记册和死亡原因登记册相关联。结果是随访期间的总死亡率和原因特异性死亡率。我们使用泊松回归分析估计了每10000人年的危险死亡率,并估计了校正死亡率。我们计算了无家可归者的平均寿命和特定年龄的预期寿命以及寿命损失,并将这些数据与一般人群以及患有精神分裂症、酒精使用障碍和药物使用障碍的个体进行了比较。在6 286 512名丹麦居民中,58 376人(0.9%)在研究期间至少与一个无家可归者收容所有过接触。在有无家可归史的人群中,死亡率为每1万人年240·3(95%可信区间为236·3 - 244·4)。在无无家可归史的普通人群中,每10000人年的死亡率为117·8 (95% CI为117·6-118·1),与无无家可归史的普通人群的绝对差异为122·5(118·5 - 126·5)。与一般人群相比,男性的平均额外生命年损失为15.9 (95% CI为15.8 - 16.2),女性为15.3(14.8 - 15.7),高于其他高危人群,如精神分裂症、酒精使用障碍和药物使用障碍(有或没有无家可归史)的人群。无家可归者的超额死亡率大部分归因于外部死亡原因、精神疾病以及肝脏和消化系统疾病。与一般人群相比,男性因外部原因死亡(包括自杀和意外伤害)而损失的生命年为5.2 (95% CI为5.0 - 5.5),女性为3.9(3.5 - 4.2)。无家可归者生命年损失的数量之多是一个重要的公共卫生问题,突出表明一些最脆弱的个人在健康方面存在明显的不平等。这些指标应有助于为降低这一人群的过高死亡率的政策和预防工作提供信息。丹麦独立研究基金。
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引用次数: 0
Mortality risk from first shelter contact: rethinking exposure 首次接触避难所的死亡风险:重新考虑接触
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00193-8
Lucie Richard
Excess and premature mortality among people experiencing homelessness has been documented for over half a century.1, 2 Studies in high-income countries consistently show mortality rates that are several times higher among people experiencing homelessness compared with those among housed individuals,1, 2, 3, 4, 5 even after accounting for income and other markers of social disadvantage.3, 4, 5 These disparities persist across the life course but are most pronounced among youth and young adults,4, 5 leading to drastically reduced overall life expectancies. Despite this troubling consensus, most evidence to date comes from studies using prevalent cohorts.1, 2, 3, 4, 5 These studies recruit individuals who have been homeless for some unknown and potentially lengthy period. This approach introduces potential selection and survival bias and limits our understanding of when excess risk begins and how it changes over time.
半个多世纪以来,无家可归者的过度死亡和过早死亡都有记录。1,2高收入国家的研究一致表明,无家可归者的死亡率比有住房者的死亡率高几倍,即使考虑到收入和其他社会不利因素。3,4,5这些差异在整个生命过程中持续存在,但在青年和年轻成人中最为明显,4,5导致总体预期寿命急剧缩短。尽管存在这种令人不安的共识,但迄今为止,大多数证据都来自使用流行队列的研究。1、2、3、4、5这些研究招募的是那些在未知的、可能很长一段时间内无家可归的人。这种方法引入了潜在的选择和生存偏差,限制了我们对过度风险何时开始以及如何随时间变化的理解。
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引用次数: 0
Correction to Lancet Public Health 2025; 10: e668–81 《柳叶刀公共卫生2025》更正;10: e668 - 81
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00199-9
No Abstract
没有抽象的
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引用次数: 0
Addressing ethnic and socio-economic inequalities in child mortality in the UK 解决英国儿童死亡率中的种族和社会经济不平等问题
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00190-2
David Taylor-Robinson, Oluwaseun B Esan
In The Lancet Public Health, Isobel Ward and colleagues1 used linked longitudinal data for 3 million children born in England and Wales to assess ethnic and socioeconomic inequalities in neonatal and child deaths. By linking census data and birth and death registrations over a 10-year period, they constructed birth cohorts and used rich census data to evaluate inequalities in mortality in the neonatal period and for children (>28 days to 10 years) based on ethnicity, maternal education, and occupational social class. They explored how these relationships are attenuated after adjusting for potential mediators of these inequalities such as household, maternal, and birth characteristics.
在《柳叶刀公共卫生》杂志上,伊泽贝尔·沃德(Isobel Ward)和他的同事使用了英格兰和威尔士出生的300万儿童的纵向数据,以评估新生儿和儿童死亡中的种族和社会经济不平等。通过将人口普查数据与10年期间的出生和死亡登记联系起来,他们构建了出生队列,并使用丰富的人口普查数据来评估基于种族、母亲教育和职业社会阶层的新生儿期和儿童(28天至10年)死亡率的不平等。他们探讨了在调整了这些不平等的潜在中介因素(如家庭、母亲和出生特征)后,这些关系是如何减弱的。
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引用次数: 0
Salt substitutes and misrepresentation of WHO recommendations – Authors' reply 盐替代品和对世卫组织建议的歪曲——作者的答复
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-27 DOI: 10.1016/s2468-2667(25)00170-7
Elisa Pineda, Thomas E Beaney
No Abstract
没有抽象的
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引用次数: 0
Estimated health impact, cost, and cost-effectiveness of taxation on unhealthy packaged foods in the Philippines: a modelling study 菲律宾对不健康包装食品征税的估计健康影响、成本和成本效益:一项模型研究
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-25 DOI: 10.1016/s2468-2667(25)00191-4
Akshar Saxena, Adam D Koon, Christine Johnson Curtis, Eva A Goyena, Josie P Desnacido, Apple Joy D Ducay, Eldridge B Ferrer, Lindsay Steele, Laura K Cobb, Megan E Henry, Lawrence J Appel, Imelda Angeles-Agdeppa, Matti Marklund

Background

In 2018, the Philippines implemented a tax on sugar-sweetened beverages. A broader tax on unhealthy foods is being considered. We aimed to estimate the effect of a tax on unhealthy packaged foods.

Methods

In this modelling study, we used a multiple-cohort, proportional multistate life table model to estimate the effect of a 20% tax on packaged foods exceeding WHO thresholds for sodium or sugar, excluding beverages already taxed. Using nationally representative nutrition, sales, and Global Burden of Diseases, Injuries, and Risk Factors Study data, we projected changes in sodium and sugar intake and related health outcomes (cardiovascular disease and type 2 diabetes) and economic outcomes (health-care costs, tax revenue, and implementation costs) over 20 years, comparing Filipino adults aged 25 years and older in 2020 (reference population) with the same population under the intervention with reduced intakes from the tax, assuming 100% pass-through to prices. Cost-effectiveness was estimated from extended health-care and government perspectives and stratified by wealth quintile.

Findings

Compared with the base-case scenario (ie, the status quo), the tax was estimated to avert 2775 deaths (95% uncertainty interval 2685–2853), 13 632 incident ischaemic heart disease events (13 153–14 029), 5287 ischaemic strokes (5090–5445), and 21 763 type 2 diabetes cases (21 532–22 006) over 20 years, generating 326 253 health-adjusted life-years (321 577–330 434). The tax could be cost saving from the government perspective and cost-effective from the health-care perspective, with an estimated 2·37 billion Philippine pesos (PHP; 2·32–2·42) in health-care savings, PHP 647·99 billion (646·42–649·45) in tax revenue, and PHP 12·96 billion (12·93–12·99) in implementation costs over 20 years. Estimated health gains were concentrated among people in middle-income groups, whereas tax revenue increased with income.

Interpretation

A nutrient-based tax on unhealthy packaged foods could reduce diet-related disease burden and generate sustained tax revenue in the Philippines. These findings support nutrient-based food taxes as a cost-effective strategy to reduce disease burden, and raise revenue in low-income and middle-income countries.

Funding

Resolve to Save Lives funded by Bloomberg Philanthropies.
2018年,菲律宾对含糖饮料征税。政府正在考虑对不健康食品征收更广泛的税。我们的目的是估计对不健康包装食品征税的影响。在这项建模研究中,我们使用了一个多队列、比例多状态生命表模型来估计对钠或糖含量超过世卫组织阈值的包装食品征收20%税的影响,不包括已经征税的饮料。利用具有全国代表性的营养、销售和全球疾病、伤害和风险因素负担研究数据,我们预测了20年来钠和糖摄入量以及相关健康结果(心血管疾病和2型糖尿病)和经济结果(医疗保健成本、税收收入和实施成本)的变化。将2020年25岁及以上的菲律宾成年人(参考人口)与在税收减少的干预下的相同人口进行比较,假设100%转嫁到价格上。从广泛的保健和政府角度估计了成本效益,并按财富五分位数分层。与基本情况(即现状)相比,该税估计在20年内避免了2775例死亡(95%不确定区间为2685-2853),13632例缺血性心脏病事件(13153 - 14029),5287例缺血性中风(5090-5445)和21763例2型糖尿病(21532 - 22006),产生326253个健康调整生命年(321 577-330 434)。从政府的角度来看,该税可以节省成本,从保健的角度来看,它具有成本效益,在20年的时间里,估计可节省2.37亿菲律宾比索(2.32 - 2.42)的保健费用,647.99亿菲律宾比索(646.42 - 649.45)的税收收入,以及129.6亿菲律宾比索(12.93 - 12.99)的实施费用。估计的健康收益集中在中等收入群体中,而税收则随着收入的增加而增加。在菲律宾,对不健康包装食品征收营养税可以减少与饮食有关的疾病负担,并产生持续的税收。这些发现支持以营养为基础的食品税作为一种具有成本效益的战略,以减轻低收入和中等收入国家的疾病负担并增加收入。由彭博慈善基金会资助的“拯救生命的决心”。
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引用次数: 0
Tackling health inequalities in Indigenous Peoples 解决土著人民的保健不平等问题
IF 5 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-08-14 DOI: 10.1016/s2468-2667(25)00200-2
Aug 9th marked the International Day of the World's Indigenous Peoples—a moment to reflect on the profound inequalities affecting Indigenous Peoples worldwide. Representing 476 million people across more than 90 countries, Indigenous Peoples today are arguably among the most disadvantaged and vulnerable groups of people. With worse health outcomes than non-Indigenous populations and a substantially lower life expectancy, Indigenous Peoples suffer considerable health inequalities—shaped by historical injustices, persistent structural, economic, and cultural barriers, and inequitable health systems. A series of papers published this month in The Lancet Public Health and The Lancet Regional Health–Western Pacific shed light on cancer inequalities affecting Indigenous Peoples and offer valuable insights for policy makers.
8月9日是世界土著人民国际日,这是一个反思影响世界各地土著人民的严重不平等现象的时刻。今天,土著人民代表着90多个国家的4.76亿人,可以说是最弱势和最脆弱的群体之一。与非土著人口相比,土著人民的健康状况更差,预期寿命也低得多。由于历史上的不公正、持续存在的结构、经济和文化障碍以及不公平的卫生系统,土著人民遭受了相当大的健康不平等。本月发表在《柳叶刀公共卫生》和《柳叶刀区域卫生-西太平洋》上的一系列论文揭示了影响土著人民的癌症不平等现象,并为决策者提供了宝贵的见解。
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引用次数: 0
期刊
Lancet Public Health
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