Non-native invasive species pose an escalating threat to Brazil’s rich biodiversity and ecosystem services, yet their management remains limited to fragmented efforts, underfunded research, and a lack of institutional coordination. This paper outlines pivotal steps to advance invasion science in Brazil through an integrated framework that bridges science, policy, and society. Invasive species are still often promoted for economic or aesthetic reasons, and conflicting interests and insufficient scientific integration hinder their regulation. We highlight five strategic areas for action: (1) establishing targeted funding lines for invasive species research and management, aligned with One Biosecurity principles; (2) creating a national center for invasion science to coordinate efforts and promote innovation; (3) enhancing open data sharing and integrating Brazil’s databases with international platforms to strengthen surveillance networks; (4) incorporating invasion science into academic and technical curricula to build a skilled and responsive workforce; and (5) integrating biosecurity into broader policy agendas following One Biosecurity principles. We recommend an alignment of local and national biosecurity efforts with regional and global surveillance systems, particularly at transboundary ecosystems vulnerable to new introductions. Drawing on international best practices and local case studies, this framework provides a roadmap to make biosecurity a national priority in Brazil. By fostering collaboration among researchers, managers, educators, and policymakers, Brazil can develop a more resilient and evidence-based response to biological invasions, protecting not only biodiversity but also the socioeconomic and cultural foundations that depend on healthy ecosystems.
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