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Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms. 应用三维透视技术对颅内动脉瘤进行血管造影放射设置的优化。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1894240
Thomas Linsenmann, Alexander März, Vera Duffner, Christian Stetter, Judith Weiland, Thomas Westermaier

Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation settings for the imaging of cerebral aneurysms before and after surgical occlusion. Eighteen patients with cerebral aneurysms with the indication for surgical clipping were included in this prospective analysis. Before surgery the patients were randomized into one of three different scan protocols according (default settings of the 3D fluoroscope): Group 1: 110 kV, 80 mA (enhanced cranial mode), group 2: 120 kV, 64 mA (lumbar spine mode), group 3: 120 kV, 25 mA (head/neck settings). Prior to surgery, a rotational fluoroscopy scan (duration 24 s) was performed without contrast agent followed by another scan with 50 ml of intravenous iodine contrast agent. The image files of both scans were transferred to an Apple PowerMac® workstation, subtracted and reconstructed using OsiriX® MD 10.0 software. The procedure was repeated after clip placement. The image quality regarding preoperative aneurysm configuration and postoperative assessment of aneurysm occlusion and vessel patency was analyzed by 2 independent reviewers using a 6-grade scale. This technique quickly supplies images of adequate quality to depict intracranial aneurysms and distal vessel patency after aneurysm clipping. Regarding these features, a further optimization to our previous protocol seems possible lowering the voltage and increasing tube current. For quick intraoperative assessment, image subtraction seems not necessary. Thus, a native scan without a contrast agent is not necessary. Further optimization may be possible using a different contrast injection protocol.

在神经外科手术室中,移动3D透视仪的应用越来越广泛。我们最近报道了它在脑血管畸形和动脉瘤成像中的应用。本研究旨在评估脑动脉瘤手术阻断前后不同的放射成像设置。本前瞻性分析包括18例有手术指征的脑动脉瘤患者。术前,患者根据(3D透视机的默认设置)随机分为三种不同的扫描方案之一:1组:110千伏,80毫安(增强颅骨模式),2组:120千伏,64毫安(腰椎模式),3组:120千伏,25毫安(头颈部设置)。手术前,在不使用造影剂的情况下进行旋转透视扫描(持续时间24秒),然后使用50ml静脉碘造影剂进行另一次扫描。将两次扫描的图像文件传输到Apple PowerMac®工作站,使用OsiriX®MD 10.0软件进行减法和重构。夹置入后重复该步骤。术前动脉瘤形态和术后动脉瘤闭塞和血管通畅评估的图像质量由2名独立评论者使用6级量表进行分析。该技术快速提供足够质量的图像来描绘颅内动脉瘤和动脉瘤夹闭后远端血管通畅。考虑到这些特点,进一步优化我们之前的协议似乎是可能的,降低电压和增加管电流。术中快速评估,图像减影似乎是不必要的。因此,没有造影剂的本机扫描是不必要的。可以使用不同的对比度注入协议进行进一步优化。
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引用次数: 1
Accuracy of cervical pedicle screw placement with four different designs of rapid prototyping navigation templates: a human cadaveric study. 四种不同设计快速原型导航模板的颈椎椎弓根螺钉置入精度:人体尸体研究。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1919210
Zhijing Wen, Teng Lu, Xijing He, Jialiang Li, Quanjin Zang, Yibin Wang, Zhengchao Gao, Pengzhen Gu

Purpose: Due to the high perforation rate of cervical pedicle screw placement, we have designed four different types of rapid prototyping navigation templates to enhance the accuracy of cervical pedicle screw placement.

Methods: Fifteen human cadaveric cervical spines from C2 to C7 were randomly divided into five groups, with three specimens in each group. The diameter of pedicle screw used in this study was 3.5 mm. Groups 1-4 were assisted by the two-level template, one-level bilateral template, one-level unilateral template and one-level point-contact template, respectively. Group 5 was without any navigation template. After the surgery, the accuracy of screw placement in the five groups was evaluated using postoperative computed tomographic scans to observe whether the screw breached the pedicle cortex.

Results: A total of 180 pedicle screws were inserted without any accidents. The accuracy rate was 75%, 100%, 100%, 91.7%, and 63.9%, respectively, from Groups 1 to 5. All the template groups were significantly higher than Group 5, though the two-level navigation template group was significantly lower than the other three template groups. The operation time was 4.72 ± 0.28, 4.81 ± 0.29, 5.03 ± 0.35, 8.42 ± 0.36, and 10.05 ± 0.52 min, respectively, from Groups 1 to 5. The no template and point-contact procedures were significantly more time-consuming than the template procedures.

Conclusion: This study demonstrated that four different design types of navigation templates achieved a higher accuracy in assisting cervical pedicle screw placement than no template insertion. However, the two-level template's accuracy was the lowest compared to the other three templates. Meanwhile, these templates avoided fluoroscopy during the surgery and decreased the operation time. It is always very challenging to translate cadaveric studies to clinical practice. Hence, the one-level bilateral, unilateral, and point-contact navigation templates designed by us need to be meticulously tested to verify their accuracy and safety.

目的:针对颈椎椎弓根螺钉置入穿孔率高的问题,我们设计了四种不同类型的快速原型导航模板,以提高颈椎椎弓根螺钉置入的准确性。方法:取15例人体C2 ~ C7颈椎标本,随机分为5组,每组3例。本研究使用的椎弓根螺钉直径为3.5 mm。1 ~ 4组分别采用二级模板、一级双侧模板、一级单侧模板和一级点接触模板辅助。第5组没有任何导航模板。手术后,通过术后计算机断层扫描评估五组螺钉放置的准确性,观察螺钉是否破坏椎弓根皮质。结果:共钉入椎弓根螺钉180枚,无意外发生。1 ~ 5组的准确率分别为75%、100%、100%、91.7%、63.9%。所有模板组均显著高于第5组,但二级导航模板组显著低于其他3个模板组。1 ~ 5组手术时间分别为4.72±0.28 min、4.81±0.29 min、5.03±0.35 min、8.42±0.36 min、10.05±0.52 min。无模板和点接触程序明显比模板程序更费时。结论:本研究表明,四种不同设计类型的导航模板在辅助颈椎椎弓根螺钉置入方面比不植入模板具有更高的准确性。然而,与其他三个模板相比,二级模板的准确性是最低的。同时,这些模板避免了术中透视检查,缩短了手术时间。将尸体研究转化为临床实践总是非常具有挑战性的。因此,我们设计的一级双侧、单侧和点接触导航模板需要经过细致的测试,以验证其准确性和安全性。
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引用次数: 2
Challenges in surgical video annotation. 手术视频注释的挑战。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1937320
Thomas M Ward, Danyal M Fer, Yutong Ban, Guy Rosman, Ozanan R Meireles, Daniel A Hashimoto

Annotation of surgical video is important for establishing ground truth in surgical data science endeavors that involve computer vision. With the growth of the field over the last decade, several challenges have been identified in annotating spatial, temporal, and clinical elements of surgical video as well as challenges in selecting annotators. In reviewing current challenges, we provide suggestions on opportunities for improvement and possible next steps to enable translation of surgical data science efforts in surgical video analysis to clinical research and practice.

在涉及计算机视觉的外科数据科学工作中,手术视频的注释对于建立基础事实非常重要。随着该领域在过去十年中的发展,在注释手术视频的空间、时间和临床元素以及选择注释者方面存在一些挑战。在回顾当前的挑战时,我们提出了改进的机会和可能的下一步措施,以使外科手术视频分析中的外科数据科学工作能够转化为临床研究和实践。
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引用次数: 30
Three-dimension correction of Charcot ankle deformity with a titanium implant. 钛植入体三维矫正Charcot踝关节畸形。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1887356
Gang Wang, Junhao Lin, Hong Zhang, Yantao Pei, Lei Zhu, Qingjia Xu

Background: Charcot neuroarthropathy of the ankle is an extremely challenging clinical dilemma, and its surgical management can be highly complicated. The goal of Charcot ankle treatment is to to restore a plantigrade and stable foot, and thus to avoid ulceration with subsequent infection. This report aims to introduce a method of correcting ankle deformity using a novel 3D printing technique.

Patient and methods: One patient with Charcot ankle deformity was operated in this study. The ankle deformity of this patient was quantified in three dimensions through computed tomography. On the basis of the computed tomography scans, a new titanium implant was designed and manufactured using 3D printing. The implant was applied in the surgery of tibio-talo-calcaneal arthrodesis to restore local anatomy of the affected ankle of the patient with Charcot neuroarthropathy.

Results: Evaluation of the post-operative radiography indicated union in the affected ankle. After surgery, the planar foot in this patient was restored. The patient was satisfied with the post-operative course, and joint fusion was successful as indicated by 2-year post-operative evaluation. The results of post-operative follow-up showed that the lower limb length of the patient with Charcot neuroarthropathy was salvaged, and the patient retained the plantigrade foot.

Conclusion: Three-dimensional printing technique combined with tibio-talo-calcaneal arthrodesis may help to correct ankle deformity in patients with Charcot neuroarthropathy.

背景:踝关节Charcot神经关节病是一个极具挑战性的临床难题,其手术治疗可能非常复杂。Charcot踝关节治疗的目的是恢复跖屈和稳定的足部,从而避免溃疡和随后的感染。本报告旨在介绍一种使用新型3D打印技术纠正踝关节畸形的方法。患者和方法:本研究对1例Charcot踝关节畸形患者进行手术治疗。通过计算机断层扫描对该患者的踝关节畸形进行了三维量化。在计算机断层扫描的基础上,利用3D打印技术设计和制造了一种新的钛种植体。该植入物用于胫骨距跟关节融合术,以恢复Charcot神经关节病患者患踝的局部解剖。结果:术后x线检查显示患踝愈合。手术后,该患者的平面足得以恢复。患者对术后过程满意,2年的术后评估显示关节融合成功。术后随访结果显示,Charcot神经关节病患者下肢长度得到挽救,患者保留足底足。结论:三维打印技术联合胫距跟关节融合术可有效矫正Charcot神经关节病患者踝关节畸形。
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引用次数: 1
A real time image-guided reposition system for the loosed bone graft in orthognathic surgery. 一种用于正颌手术中松动骨移植的实时图像引导复位系统。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1874535
Xiaojun Chen, Yang Li, Lu Xu, Yi Sun, Constantinus Politis, Xiaoyi Jiang

In traditional orthognathic surgery, the dental splint technique is typically used to assist surgeons to reposition the maxilla or mandible. However, the design and manufacturing of dental splints is time-consuming and labor-intensive, and the templates may not applicable for some complicated cases due to the anatomic intricacies in the maxillofacial region. During recent years, computer-aided navigation technology has been widely used in oral and maxillofacial surgery. However, due to the limitation of current calibration and registration methods, it has been rarely reported for the motion tracking of intraoperative reposition for the loosed bone graft. In this study, a novel surgical navigation system was developed. With the use of this system, not only the surgical saw can be tracked in real-time, but also the loosed bone graft can be navigated under the guidance of the interactive 2D and 3D views until it is aligned with the preoperatively planned position. The phantom experiments validated the feasibility of our surgical navigation system, and the mean error of image-guided reposition was 1.03 ± 0.10 mm, which was significantly more accurate than the mean error of 5.57 ± 1.40 mm based on the non-navigated methods.

在传统的正颌手术中,牙夹板技术通常用于帮助外科医生重新定位上颌骨或下颌骨。然而,牙夹板的设计和制造是费时费力的,并且由于颌面区域的解剖复杂性,模板可能不适用于一些复杂的病例。近年来,计算机辅助导航技术在口腔颌面外科手术中得到了广泛的应用。然而,由于目前标定和配准方法的限制,对术中松动植骨复位的运动跟踪报道甚少。在这项研究中,开发了一种新的手术导航系统。使用该系统,不仅可以实时跟踪手术锯,还可以在交互式二维和三维视图的指导下对松动的骨移植物进行导航,直到其与术前计划的位置对齐。幻影实验验证了我们的手术导航系统的可行性,图像引导复位的平均误差为1.03±0.10 mm,明显高于非导航方法的平均误差5.57±1.40 mm。
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引用次数: 2
Improved procedure for Brown's Class III maxillary reconstruction with composite deep circumflex iliac artery flap using computer-assisted technique. 应用计算机辅助技术改进的复合旋髂深动脉瓣重建上颌布朗氏III类手术方法。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1876168
Wen-Bo Zhang, Hui Yuh Soh, Yao Yu, Chuan-Bin Guo, Guang-Yan Yu, Xin Peng

Reconstruction of Brown's Class III maxillary defect can be challenging due to the complex geometry of maxilla. We aimed to introduce an improved method for maxillary reconstruction with a composite deep circumflex iliac artery (DCIA) flap aided by virtual surgical planning and intraoperative navigation. A 27-year-old woman diagnosed with left maxillary fibromyxoma was admitted to our institution in December 2018. Pre-operative facial and iliac computed tomography data were obtained for virtual surgical planning. Personalized cutting template, tooth-supported surgical guide, and rapid prototype model with reconstructed orbital floor were printed for pre-operative preparation. Surgery was completely guided by the intraoperative navigation system. The root mean square estimate of the reconstructed area was 3.68 mm. The average errors measured on the lateral and medial DCIA segments were 0.61 and 0.85 mm, respectively. Application of virtual surgical planning and intraoperative navigation could potentially enhance the reconstruction outcomes.

由于上颌复杂的几何形状,重建布朗的上颌III类缺损具有挑战性。我们的目的是在虚拟手术计划和术中导航的辅助下,介绍一种改进的上颌重建方法,即复合旋髂深动脉(DCIA)皮瓣。一名27岁女性于2018年12月被诊断为左侧上颌纤维黏液瘤。术前获得面部和髂骨计算机断层数据,用于虚拟手术计划。打印个性化切割模板、牙支撑手术指南、重建眶底快速原型模型,进行术前准备。手术完全由术中导航系统引导。重建面积的均方根估计为3.68 mm。DCIA外侧节段和内侧节段的平均误差分别为0.61和0.85 mm。应用虚拟手术计划和术中导航可以潜在地提高重建效果。
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引用次数: 1
Using standard X-ray images to create 3D digital bone models and patient-matched guides for aiding implant positioning and sizing in total knee arthroplasty. 使用标准x射线图像创建3D数字骨模型和患者匹配的指南,以帮助全膝关节置换术中的植入物定位和大小。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1894239
Vincent Massé, Raju S Ghate

X-Atlas™ is a new imaging technology intended to advance the state of the art in patient-specific instrumentation. It uses standard AP and lateral radiographs instead of CT or MRI scans to create 3D bone models, which can be used to perform pre-operative surgical planning and fabricate TKA personalized guides. The aim of this study was to validate X-Atlas™ and evaluate the accuracy of personalized guides created with this imaging technology. Its ability to predict implant size was also determined. The accuracy of the X-Atlas™ imaging technology was evaluated by comparing the landmarks of X-Atlas™ 3D Bone models to MRI-reconstructed bone models. The accuracy of PSI guides created with X-Atlas™ (X-PSI™ guides) was evaluated during a validation study (16 specimen knees) and a clinical study (50 patients; Health Canada #CSU2015-12K). Optical navigation was used to measure positioning accuracy. In addition, the ability of X-Atlas™ to predict implant size was assessed. The accuracy of the X-Atlas™ imaging technology was below 0.87 and 1.28 mm for the femoral and tibial landmarks, respectively. The accuracy of X-PSI™ guides to reproduce the pre-operative planned HKA was within ± 3° in 100% and 86.1% of cases, for the laboratory and clinical study respectively, which was significantly better than historical data for conventional instrumentation. X-Atlas™ was able to predict implant size to ± 1 size in 95.6% and 100%, for the femur and tibia component respectively. The X-Atlas™ imaging technology demonstrated excellent accuracy for reconstructing a 3D bone model. The results show that PSI guides created with X-Atlas™ (X-PSI™ guides) provide greater implant positioning accuracy than conventional instrumentation, without the requirement of advanced imaging. Furthermore, the X-Atlas™ imaging technology could effectively predict implant sizing, potentially reducing the number of instrument trays and improving surgical efficiency.

X-Atlas™是一种新的成像技术,旨在推动患者特定仪器的最新发展。它使用标准的AP和侧位x线片代替CT或MRI扫描来创建3D骨模型,可用于进行术前手术计划和制作TKA个性化导板。本研究的目的是验证X-Atlas™,并评估使用该成像技术创建的个性化导尿管的准确性。其预测种植体大小的能力也被确定。通过比较X-Atlas™3D骨模型与mri重建骨模型的地标来评估X-Atlas™成像技术的准确性。用X-Atlas™(X-PSI™导轨)制作的PSI导轨的准确性在验证研究(16个膝关节标本)和临床研究(50例患者;加拿大卫生部#CSU2015-12K)。采用光学导航测量定位精度。此外,还评估了X-Atlas™预测种植体大小的能力。X-Atlas™成像技术在股骨和胫骨标记处的准确性分别低于0.87和1.28 mm。在实验室和临床研究中,X-PSI™指南再现术前计划HKA的准确性分别在100%和86.1%的病例中在±3°以内,这明显优于传统仪器的历史数据。X-Atlas™能够分别为95.6%和100%预测股骨和胫骨的植入物尺寸为±1。X-Atlas™成像技术在重建3D骨模型方面具有出色的准确性。结果表明,使用X-Atlas™(X-PSI™导轨)创建的PSI导轨比传统仪器提供更高的种植体定位精度,而不需要先进的成像。此外,X-Atlas™成像技术可以有效地预测种植体的大小,有可能减少器械托盘的数量,提高手术效率。
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引用次数: 11
A systematic review of common landmarks in navigated endoscopic sinus surgery (NESS). 导航内镜鼻窦手术(NESS)常见标志的系统回顾。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1992504
Tomislav Baudoin, Tomislav Gregurić, Filip Bacan, Boris Jelavić, Goran Geber, Andro Košec

Background: Navigation brought about a tremendous improvement in functional endoscopic sinus surgery (FESS). When upgraded accordingly, FESS becomes navigated endoscopic sinus surgery (NESS). Indications for intraoperative use of navigation can be broadened to almost any FESS case. NESS in advanced sinus surgery is currently still not used routinely and requires systematic practice guidelines.

Purpose: The purpose of this paper is to report on commonly identified landmarks while performing advanced NESS according to evidence-based medicine (EBM) principles.

Material and methods: This review paper has been assembled following PRISMA guidelines. A PubMed and Scopus (EMBASE) search on anatomical landmarks in functional endoscopic and navigated sinus surgery resulted in 47 results. Of these, only 14 (29.8%) contained original data, constituting the synthesis of best-quality available evidence.

Results: Anatomical landmarks are considered to be the most important points of orientation for optimal use of navigation systems during FESS surgery. The most commonly identified significant landmarks are as follows: (1) Maxillary sinus ostium; (2) Orbital wall; (3) Frontal recess; (4) Skull base; (5) Ground lamella; (6) Fovea posterior; (7) Sphenoid sinus ostium. Conclusions: Establishing common landmarks are essential in performing NESS. This is true for advanced and novice surgeons alike and offers a possibility to use navigation systems systematically, taking advantage of all the benefits of endoscopic navigated surgery.

背景:导航技术为功能性内窥镜鼻窦手术(FESS)带来了巨大的进步。当相应升级后,FESS成为导航内窥镜鼻窦手术(NESS)。术中导航的适应症可以扩展到几乎所有FESS病例。在晚期鼻窦手术中,NESS目前仍未被常规使用,需要系统的实践指南。目的:本文的目的是报告根据循证医学(EBM)原则执行高级NESS时常见的地标。材料和方法:这篇综述论文是按照PRISMA指南汇编的。PubMed和Scopus (EMBASE)检索功能性内窥镜和导航鼻窦手术的解剖标志,结果为47例。其中,只有14篇(29.8%)包含原始数据,构成了现有证据质量最高的综合。结果:解剖标志被认为是FESS手术中导航系统最佳使用的最重要的定位点。最常见的显著标志如下:(1)上颌窦口;(2)眶壁;(3)额隐窝;(4)颅底;(5)地面片层;(6)后中央窝;(7)蝶窦口。结论:建立共同的地标是执行NESS的必要条件。这对高级和新手外科医生都是如此,并提供了系统地使用导航系统的可能性,利用内窥镜导航手术的所有好处。
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引用次数: 1
Comparison of the accuracies of computed tomography-based navigation and image-free navigation for acetabular cup insertion in total hip arthroplasty in the lateral decubitus position. 侧卧位全髋关节置换术中基于计算机断层导航与无图像导航的髋臼杯置入精度比较。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1949494
Masahiro Hasegawa, Shine Tone, Yohei Naito, Hiroki Wakabayashi, Akihiro Sudo

Image-free navigation has been proven as reliable as that using computed tomography (CT) in positioning the acetabular cup in total hip arthroplasty (THA), but previous studies rarely included hip dysplasia cases. The purpose of the present study was to determine the accuracies of CT-based navigation and image-free navigation for acetabular cup insertion, including hip dysplasia cases. Sixty-three hips were studied, including 57 with hip dysplasia. The hips were divided into two groups based on the registration point of image-free navigation. In Group I, the ipsilateral anterior superior iliac spine (ASIS) and the L5 spinous process were registered in 31 hips. In Group II, bilateral ASIS points were registered in 32 hips. Final component orientation was measured from postoperative CT scans. The accuracy of cup orientation was compared between CT-based and image-free navigation. In Group I, the cup inclination was more accurate with CT-based navigation (1.9°) than with image-free navigation (4.4°, p=.009). Cup anteversion was also more accurate with CT-based navigation (2.9°) than with image-free navigation (7.1°, p<.001). In Group II, the accuracies of cup inclination and anteversion showed no differences between CT-based and image-free navigation. The accuracy of cup positioning was better with CT-based navigation than with image-free navigation when the ipsilateral ASIS and L5 spinous process were digitized. However, accuracy was similar when bilateral ASIS points were digitized.

在全髋关节置换术(THA)中,无图像导航已被证明与使用计算机断层扫描(CT)定位髋臼杯一样可靠,但先前的研究很少包括髋关节发育不良的病例。本研究的目的是确定基于ct的导航和无图像导航在髋臼杯插入中的准确性,包括髋关节发育不良病例。研究了63个髋关节,包括57个髋关节发育不良。根据无图像导航配准点将舰船分为两组。在第一组,31髋的同侧髂前上棘(ASIS)和L5棘突被登记。在第二组中,在32个髋侧登记了双侧ASIS点。通过术后CT扫描测量最终组件的方向。比较了基于ct和无图像导航的杯形定位精度。在第一组中,基于ct导航的杯倾角(1.9°)比无图像导航(4.4°,p= 0.009)更准确。基于ct的导航(2.9°)比无图像导航(7.1°,p
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引用次数: 5
Radiomics in surgical oncology: applications and challenges. 放射组学在外科肿瘤学中的应用与挑战。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2021-12-01 DOI: 10.1080/24699322.2021.1994014
Travis L Williams, Lily V Saadat, Mithat Gonen, Alice Wei, Richard K G Do, Amber L Simpson

Surgery is a curative treatment option for many patients with malignant tumors. Increased attention has focused on the combination of surgery with chemotherapy, as multimodality treatment has been associated with promising results in certain cancer types. Despite these data, there remains clinical equipoise on optimal timing and patient selection for neoadjuvant or adjuvant strategies. Radiomics, an emerging field involving the extraction of advanced features from radiographic images, has the potential to revolutionize oncologic treatment and contribute to the advance of personalized therapy by helping predict tumor behavior and response to therapy. This review analyzes and summarizes studies that use radiomics with machine learning in patients who have received neoadjuvant and/or adjuvant chemotherapy to predict prognosis, recurrence, survival, and therapeutic response for various cancer types. While studies in both neoadjuvant and adjuvant settings demonstrate above average performance on ability to predict progression-free and overall survival, there remain many challenges and limitations to widespread implementation of this technology. The lack of standardization of common practices to analyze radiomics, limited data sharing, and absence of auto-segmentation have hindered the inclusion and rapid adoption of radiomics in prospective, clinical studies.

手术是许多恶性肿瘤患者的治疗选择。越来越多的注意力集中在手术与化疗的结合上,因为多模式治疗在某些癌症类型中具有良好的效果。尽管有这些数据,在新辅助或辅助策略的最佳时机和患者选择上仍然存在临床平衡。放射组学是一个新兴领域,涉及从放射图像中提取高级特征,有可能彻底改变肿瘤治疗,并通过帮助预测肿瘤的行为和对治疗的反应,促进个性化治疗的进步。这篇综述分析和总结了在接受新辅助和/或辅助化疗的患者中使用放射组学和机器学习来预测各种癌症类型的预后、复发、生存和治疗反应的研究。虽然新辅助和辅助治疗的研究表明,在预测无进展和总生存期方面的表现高于平均水平,但该技术的广泛应用仍存在许多挑战和限制。放射组学分析缺乏标准化,数据共享有限,缺乏自动分割,这些都阻碍了放射组学在前瞻性临床研究中的纳入和快速采用。
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引用次数: 2
期刊
Computer Assisted Surgery
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