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An improved 10-tissue human head model with real anatomical structure and hexahedral discretization feature in magnetic induction measurement simulation 磁感应测量仿真中具有真实解剖结构和六面体离散特征的改进的10组织人头模型
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-26 DOI: 10.1080/24699322.2016.1240302
Ziyi Zhang, Peiguo Liu, Dongming Zhou, L. Ding
Abstract Magnetic induction measurement (MIM) is a promising technique for biomedical applications in craniocerebral disease detection and monitoring. For the purposes of the MIM simulation, a human head model with real anatomic structure is required. However, nearly anatomically realistic models used in the MIM simulations are discretized using tetrahedral elements of subsequent finite elements method computation. The head model supplied by the Third Military Medical University (TMMU) is currently the only model suitable for hexahedral discretization and finite difference/integral computation. This model has nonetheless number of defects. In order to deal with these, we construct an improved 10-tissue human head model with real anatomical structures and hexahedral discretization features. In this paper, the operation and optimization methods used to construct for the new head model are presented and discussed in detail. We use the 10-tissue head model to conduct the time sensitivity simulation of the magnetic induction sensor which was described in our previous publication and compare the simulation data with those based on the TMMU’s head model. The result shows that the new head model has a higher time sensitivity, meaning better performance in the MIM simulation.
磁感应测量(MIM)是一种很有前途的生物医学技术,可用于颅脑疾病的检测和监测。为了达到MIM仿真的目的,需要一个具有真实解剖结构的人体头部模型。然而,MIM仿真中使用的接近解剖真实的模型在随后的有限元方法计算中使用四面体单元进行离散化。第三军医大学提供的头部模型是目前唯一适用于六面体离散化和有限差分积分计算的模型。尽管如此,这个模型还是有一些缺陷。为了解决这些问题,我们构建了一个具有真实解剖结构和六面体离散特征的改进的10组织人头模型。本文详细介绍了新水头模型构建的操作和优化方法。我们使用10组织头部模型对我们之前发表的文章中描述的磁感应传感器进行了时间敏感性仿真,并将仿真数据与基于TMMU头部模型的仿真数据进行了比较。结果表明,新头部模型具有更高的时间灵敏度,在MIM仿真中具有更好的性能。
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引用次数: 2
Fabrication and characterization of disposable wireless electronic endoscope 一次性无线电子内窥镜的制造与表征
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240299
Ho Chang, C. Chen, Minghanbo Liu, Li-Ke Chien, Tung-Sun Huang, Bo-Hsiang Tu
Abstract A wireless electronic endoscope that transmits signals by Wi-Fi is developed for use in single-hole endoscopic surgery and future application to natural orifice surgery. The innovative electronic endoscope developed in this study has a disposable design, completely preventing patents from taking risks of cross infection. The main components of the endoscope are a disposable component of the front tip and the hand-held part of the rear tip. The front tip consists of a lens, metallic tube, and electronic joint whereas the rear tip consists of a power switch, image converter, wireless transceiver chip, and antenna. Experimental applications of the wireless electronic endoscope show that after 3 hours and 30 minutes of normal use, the temperature of metallic tube at the front tip averages 45 °C. Regarding the measured luminance result, when the focal distance is 5 cm, luminance reaches 1410 lux. In an indoor environment, when the measured distance is 3 m and there is no disruptor, the Wi-Fi transmitted signal of the endoscope is at strength −51 dBm. If the disruptor is established between the sending and receiving ends, signal strength is −53 dBm. Increasing the measured distance to 8 m obtains a signal strength of −74 dBm. Test practical applications indicate that the wireless Wi-Fi electronic endoscope fully meets the needs of surgery room.
开发了一种通过Wi-Fi传输信号的无线电子内窥镜,用于单孔内窥镜手术,未来将应用于自然口手术。本研究开发的创新电子内窥镜采用一次性设计,完全避免了专利交叉感染的风险。内窥镜的主要部件是前尖端的一次性部件和后尖端的手持部分。前尖端由透镜、金属管和电子接头组成,后尖端由电源开关、图像转换器、无线收发芯片和天线组成。无线电子内窥镜的实验应用表明,正常使用3小时30分钟后,前尖端金属管的平均温度为45℃。对于测量亮度结果,当焦距为5 cm时,亮度达到1410勒克斯。在室内环境下,当测量距离为3m且无干扰时,内窥镜的Wi-Fi传输信号强度为−51 dBm。如果在发送端和接收端之间建立干扰,信号强度为- 53dbm。将测量距离增加到8m,信号强度为−74dbm。测试实际应用表明,无线Wi-Fi电子内窥镜完全满足手术室的需要。
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引用次数: 1
A novel master–slave teleoperation robot system for diaphyseal fracture reduction: a preliminary study 一种新型主从远程操作骨干骨折复位机器人系统的初步研究
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240304
Changsheng Li, Tianmiao Wang, Lei Hu, P. Tang, Li-feng Wang, Lihai Zhang, Na Guo, Yiming Tan
Abstract We developed a novel master–slave teleoperation robot system for diaphyseal fracture reduction. This paper details the mechanical design and the control system as a preliminary study. The fracture reduction accuracy and the performance of the control system are experimentally tested. The mean error in the axial and lateral displacements was below 3 mm; the mean side angle and inward turn errors were below 4°. As a preliminary study, the feasibility of the novel master–slave teleoperation robot system for diaphyseal fracture reduction is verified. The robot system fulfills the reduction requirements in accuracy and operating performance.
摘要研制了一种新型主从式骨干骨折复位机器人系统。本文详细介绍了机械设计和控制系统的初步研究。实验验证了该控制系统的断口复位精度和性能。轴向和横向位移的平均误差在3 mm以下;平均侧角和向内转弯误差均在4°以下。作为初步研究,验证了新型主从式远程操作机器人系统用于骨干骨折复位的可行性。该机器人系统在精度和操作性能上满足了降低的要求。
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引用次数: 18
Automatic guidance of laparoscope based on the region of interest for robot assisted laparoscopic surgery 机器人辅助腹腔镜手术中基于感兴趣区域的腹腔镜自动引导
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240309
Lingtao Yu, Hongwei Li, Lingyan Zhao, Sixu Ren, Qing Gu
Abstract Background: Minimally invasive surgeries rely on laparoscopic camera views to guide the procedure. Traditionally, an expert surgical assistant operates laparoscopic camera. This process is distracting, and the camera is not always placed in an ideal location. To mitigate these problems, we have developed a laparoscopic automatic navigation method. Methods: In this article, a way to determining surgery status based on the distance of surgical instruments is presented. Combining with the surgery status, the region of interest (ROI) in laparoscopic image is defined, and related parameters are given in detail. Comprehensive the above content, the method of laparoscopic automatic navigation based on the ROI is proposed. Results: Finally, introducing the method into a kind of typical minimally invasive laparoscopic surgery robot system (MLSRS), and the method is simulated by using some typical surgical tasks. Conclusion: The results show that this method is feasible.
背景:微创手术依赖于腹腔镜下的摄像机视图来指导手术。传统上,专家外科助理操作腹腔镜相机。这个过程是分散注意力的,而且相机并不总是放在一个理想的位置。为了减轻这些问题,我们开发了一种腹腔镜自动导航方法。方法:提出一种基于手术器械距离判断手术状态的方法。结合手术状态,定义了腹腔镜图像中的感兴趣区域(ROI),并给出了相关参数。综合上述内容,提出了基于ROI的腹腔镜自动导航方法。结果:最后,将该方法引入到一种典型的微创腹腔镜手术机器人系统(MLSRS)中,并通过一些典型的手术任务对该方法进行了仿真。结论:该方法是可行的。
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引用次数: 7
Development of a new characteristic parameter – waveform index of finger blood volume pulse 一种新的特征参数——手指血容量脉搏波形指标的建立
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240295
Wen-Jui Wu, Lin Yang, Song Zhang, Dongmei Hao, Yimin Yang, Xuwen Li, Guanghui Wu, Lei Zhang, Z. Luo
Abstract Background: Finger blood volume pulse (F-BVP) contains abundant human cardiovascular system information, including information regarding circulation in the heart, blood vessel function, and the microcirculation system. Pulse waveform analysis is a method for analyzing F-BVP. Methods and results: A new parameter of F-BVP, called waveform index (WI), was extracted, defined, subsequently compared between groups of different cardiovascular function, and compared with age and systolic blood pressure. WI values of the negative and positive groups were 0.209 ± 0.066 (p < .001) and 0.305 ± 0.066 (p < .001), respectively. The classification threshold value of WI was 0.24, revealing a sensitivity of 77%, a specificity of 68% and a classification accuracy of 73%. The odds ratio (OR) was 7.164, indicating that subjects with WI >0.24 had a 7.164 times greater risk of suffering from cardiovascular disease than of not suffering from cardiovascular disease. Age and systolic blood pressure had consistent correlation with WI, in addition, WI had the same trend with age and systolic blood pressure. Conclusion: Because WI of F-BVP was determined according to only F-BVP waveform and increases in age and systolic blood pressure, different values of WI represent different cardiovascular physiological conditions. To a certain extent, the changes of WI reflect the changes of human cardiovascular function. Therefore, WI has the potential to be widely used in disease screening and clinical practice.
背景:手指血容量脉冲(F-BVP)包含丰富的人体心血管系统信息,包括心脏循环、血管功能和微循环系统的信息。脉冲波形分析是分析F-BVP的一种方法。方法与结果:提取并定义F-BVP的新参数波形指数(WI),比较不同心血管功能组之间的差异,并与年龄、收缩压进行比较。阴性组和阳性组的WI值为0.209±0.066 (p 0.24),患心血管疾病的风险是未患心血管疾病的7.164倍。年龄、收缩压与WI的相关性一致,WI与年龄、收缩压的变化趋势一致。结论:由于F-BVP的WI仅根据F-BVP波形及年龄、收缩压的升高来确定,因此不同的WI值代表不同的心血管生理状态。WI的变化在一定程度上反映了人体心血管功能的变化。因此,WI具有广泛应用于疾病筛查和临床实践的潜力。
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引用次数: 1
Biomedical classification application and parameters optimization of mixed kernel SVM based on the information entropy particle swarm optimization 基于信息熵粒子群优化的混合核支持向量机生物医学分类应用及参数优化
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240300
Mi Li, Xiaofeng Lu, Xiaodong Wang, Shengfu Lu, Ning Zhong
Abstract The types of kernel function and relevant parameters’ selection in support vector machine (SVM) have a major impact on the performance of the classifier. In order to improve the accuracy and generalization ability of the model, we used mixed kernel function SVM classification algorithm based on the information entropy particle swarm optimization (PSO): on the one hand, the generalization ability of classifier is effectively enhanced by constructing a mixed kernel function with global kernel function and local kernel function; on the other hand, the accuracy of classification is improved through optimization for related kernel parameters based on information entropy PSO. Compared with PSO-RBF kernel and PSO-mixed kernel, the improved PSO-mixed kernel SVM can effectively improve the classification accuracy through the classification experiment on biomedical datasets, which would not only prove the efficiency of this algorithm, but also show that the algorithm has good practical application value in biomedicine prediction.
支持向量机(SVM)中核函数的类型和相关参数的选择对分类器的性能有很大的影响。为了提高模型的准确率和泛化能力,我们采用了基于信息熵粒子群优化(PSO)的混合核函数SVM分类算法:一方面,通过构造具有全局核函数和局部核函数的混合核函数,有效增强了分类器的泛化能力;另一方面,通过基于信息熵粒子群算法对相关核参数进行优化,提高分类精度。通过对生物医学数据集的分类实验,与PSO-RBF核和pso -混合核进行比较,改进的pso -混合核SVM可以有效提高分类精度,不仅证明了该算法的有效性,而且表明该算法在生物医学预测中具有良好的实际应用价值。
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引用次数: 12
Activities of the sinus node pacemaking during the simulated atrial reentry 模拟心房再入时窦房结起搏活动
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240307
Hong Zhang, Rui-juan Li, Xinxin Huang, Zhao Yang
Abstract Numerous studies implicated the relationship between the sinus node dysfunction (SND) and atrial arrhythmias, but the pacemaker activities of sinoatrial node (SAN) during the atrial reentry before the formation of structural and electrophysiological remodeling in SAN were not well investigated. In the present study, a gradient two-dimensional model including SAN and atrium was built to reflect heterogeneities of the SAN. The reentrant wave was induced by the cross field method in the atrium. The simulation demonstrated a suppressed SAN spontaneous firing by the invading reentry and a 4:1 entrance block into the SAN at a reentrant cycle length of 80 ms. When the retrograde electrical excitation from atrium captured the SAN cell, the maximum diastolic potential of its action potential was found to become more negative with increased upstroke velocity. At the same time, the amplitudes of If, ICaL and IKs were enlarged. Besides, the interactions of the atrium and SAN presented a block of the sinus firing from exiting to the atrium while protecting the central SAN from the effects of the invading reentry. These findings suggested a link between SND and atrial reentry, and therefore were helpful in explaining the role of atrial arrhythmias in SND.
大量研究提示窦房结功能障碍(SND)与心房心律失常之间的关系,但窦房结(SAN)在心房再入期结构重构和电生理重构形成前的起搏器活动尚未得到很好的研究。在本研究中,建立了一个包括SAN和心房的梯度二维模型,以反映SAN的异质性。用交叉场法在心房内诱发重入波。模拟结果表明,在80ms的重入周期内,入侵再入和4:1的入口阻塞抑制了SAN自发发射。当心房逆行电兴奋捕获SAN细胞时,发现其动作电位的最大舒张电位随着上冲速度的增加而变得更加负。同时,If、ICaL和IKs的振幅增大。此外,心房和SAN的相互作用阻断了窦性心房的放电,同时保护了中央SAN免受侵入性再入的影响。这些发现提示SND与心房再入之间存在联系,因此有助于解释心房心律失常在SND中的作用。
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引用次数: 1
Acne scar and scar synthesis system using height map and improved subsurface scattering color model 痤疮疤痕和疤痕合成系统采用高度图和改进的亚表面散射颜色模型
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240305
Taeyoung Choi, S. Chin
Abstract Recently, people have paid more attention to skin that seems determine age, beauty and appearance. In particular, acne scar that tends to grow in young generation. Synthetic model can help to prevent them to care beforehand. This study proposes a representation for acne scars and general scars using a height map and an improved subsurface scattering color model. In consideration of the geometric properties of acne scars classified into ice pick, rolling and boxcar, a height map is used. Where the improved subsurface scattering color model and shading are applied, convenient system interfaces are provided to represent wounds and scars conveniently. An automation function is added for the user to control the height map, as well as four shading functions comparable with the shading function proposed in this study. In addition, a user study is performed to validate the proposed method.
近年来,人们越来越关注皮肤,皮肤似乎决定了年龄、美丽和外表。特别是痤疮疤痕,往往生长在年轻一代。综合模型可以帮助预防他们提前护理。本研究提出使用高度图和改进的亚表面散射颜色模型来表示痤疮疤痕和一般疤痕。考虑到冰锥型、滚动型和车箱型痤疮疤痕的几何特性,采用了高度图。采用改进的亚表面散射颜色模型和阴影,提供方便的系统接口,方便地表示伤口和疤痕。增加了用户控制高度图的自动化功能,以及与本研究提出的遮阳功能相媲美的四个遮阳功能。此外,还进行了用户研究以验证所提出的方法。
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引用次数: 0
Intuitive control algorithm of a novel minimally invasive surgical robot 一种新型微创手术机器人的直观控制算法
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240296
Guojun Niu, Bo Pan, Yue Ai, Yili Fu
Abstract Background: Minimally invasive surgery (MIS) based on computer and robot-assisted technology is becoming more and more popular. Methods: Intuitive motion control implemented by kinematic algorithm of the slave manipulator based on the 3D Display (DD) is proposed to eliminate absonant hand-eye coordination, kinematic dissimilarity and workspace mismatch of the master-slave manipulator and is applied in the novel minimally invasive surgical (MIS) robot developed in our lab. Forward and inverse kinematics of MIS robot are analyzed based on the screw theory. The kinematic algorithm of MIS robot based on the DD is achieved. Results: The trajectory tracking results that the movement trends between the master and slave manipulators consistently validate the effectiveness of forward and inverse kinematics. The simulation results of the kinematic algorithm by virtue of Simulink and SimMechanics sub-modules of the MATLAB and intuitive control experiment that the root mean square error of cumulative position increments is less than 0.5 mm validate effectiveness of intuitive control algorithm. Conclusion: Successful animal experiments furthermore validate the effectiveness of intuitive control algorithm.
背景:基于计算机和机器人辅助技术的微创手术(MIS)越来越受欢迎。方法:针对主从机械手手眼协调不协调、运动不一致和工作空间不匹配等问题,提出了基于3D显示器(DD)的从机械手运动学算法实现直观运动控制的方法,并将其应用于本实验室研制的新型微创手术机器人。基于螺旋理论对MIS机器人的正运动学和逆运动学进行了分析。实现了基于DD的MIS机器人的运动学算法。结果:轨迹跟踪结果表明,主、从机械手之间的运动趋势一致,验证了正逆运动学的有效性。利用MATLAB的Simulink和SimMechanics子模块以及直观控制实验对运动学算法进行了仿真,结果表明累计位置增量的均方根误差小于0.5 mm,验证了直观控制算法的有效性。结论:成功的动物实验进一步验证了直觉控制算法的有效性。
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引用次数: 4
Long-term effects of robotic hippotherapy on dynamic postural stability in cerebral palsy 机器人海马疗法对脑瘫动态姿势稳定性的长期影响
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240297
Youngjoo Cha, Megan Stanley, T. Shurtleff, J. H. You
Abstract Background: Dynamic postural instability is a common neuromuscular impairment in cerebral palsy (CP), which often includes balance dysfunction and an associated risk of serious falls. Robotic hippotherapy has recently become a widespread clinical application to facilitate postural core stabilization, strength, and endurance through repetitive vestibular and proprioceptive stimulation to the spine via the sensorimotor system pathways. However, the long-term effects of robotic hippotherapy on dynamic postural instability in CP remain unclear. Objective: To examine the long-term effects of robotic hippotherapy on dynamic postural stability in CP. Methods: An advanced three-dimensional biomechanical eight-camera video motion capture (VMC) system was used to compute the center of mass (COM) pathway, which represents intervention-related spinal core instability. The robotic hippotherapy system was used to improve dynamic postural stability and associated balance performance. Robotic hippotherapy exercise was provided for 45 minutes/session, 2–3 times a week over the 12-week period. Results: Abnormal mean COM pathway length, standard deviation, and range substantially decreased after 12 weeks of robotic hippotherapy. The initial x-axis COM was greater than that of the y-axis. However, the amount of abnormal anterior–posterior and medio-lateral postural sway substantially decreased after robotic hippotherapy. Conclusions: This study provides the first compelling evidence that the robotic hippotherapy is safe and effective for postural instability control and sitting balance dysfunction that mitigates the risk of falls in CP.
背景:动态姿势不稳定是脑瘫(CP)中常见的神经肌肉损害,通常包括平衡功能障碍和相关的严重跌倒风险。机器人海马疗法最近已成为一种广泛的临床应用,通过感觉运动系统途径对脊柱进行前庭和本体感觉的重复刺激,促进体位核心的稳定、力量和耐力。然而,机器人海马疗法对CP动态体位不稳定性的长期影响尚不清楚。目的:研究机器人海马疗法对CP动态姿势稳定性的长期影响。方法:采用先进的三维生物力学八摄像头视频运动捕捉(VMC)系统计算质量中心(COM)通路,该通路代表干预相关的脊柱核心不稳定。机器人海马疗法系统用于改善动态姿势稳定性和相关的平衡性能。机器人海马疗法运动45分钟/次,每周2-3次,持续12周。结果:机器人海马疗法12周后,异常的平均COM通路长度、标准差和范围显著减少。初始x轴COM大于y轴COM。然而,机器人海马疗法后,异常前后和中外侧体位摆动的数量大大减少。结论:本研究首次提供了令人信服的证据,证明机器人海马疗法对于降低CP患者跌倒风险的姿势不稳定控制和坐位平衡功能障碍是安全有效的。
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引用次数: 4
期刊
Computer Assisted Surgery
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