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Biomedical classification application and parameters optimization of mixed kernel SVM based on the information entropy particle swarm optimization 基于信息熵粒子群优化的混合核支持向量机生物医学分类应用及参数优化
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240300
Mi Li, Xiaofeng Lu, Xiaodong Wang, Shengfu Lu, Ning Zhong
Abstract The types of kernel function and relevant parameters’ selection in support vector machine (SVM) have a major impact on the performance of the classifier. In order to improve the accuracy and generalization ability of the model, we used mixed kernel function SVM classification algorithm based on the information entropy particle swarm optimization (PSO): on the one hand, the generalization ability of classifier is effectively enhanced by constructing a mixed kernel function with global kernel function and local kernel function; on the other hand, the accuracy of classification is improved through optimization for related kernel parameters based on information entropy PSO. Compared with PSO-RBF kernel and PSO-mixed kernel, the improved PSO-mixed kernel SVM can effectively improve the classification accuracy through the classification experiment on biomedical datasets, which would not only prove the efficiency of this algorithm, but also show that the algorithm has good practical application value in biomedicine prediction.
支持向量机(SVM)中核函数的类型和相关参数的选择对分类器的性能有很大的影响。为了提高模型的准确率和泛化能力,我们采用了基于信息熵粒子群优化(PSO)的混合核函数SVM分类算法:一方面,通过构造具有全局核函数和局部核函数的混合核函数,有效增强了分类器的泛化能力;另一方面,通过基于信息熵粒子群算法对相关核参数进行优化,提高分类精度。通过对生物医学数据集的分类实验,与PSO-RBF核和pso -混合核进行比较,改进的pso -混合核SVM可以有效提高分类精度,不仅证明了该算法的有效性,而且表明该算法在生物医学预测中具有良好的实际应用价值。
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引用次数: 12
Activities of the sinus node pacemaking during the simulated atrial reentry 模拟心房再入时窦房结起搏活动
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240307
Hong Zhang, Rui-juan Li, Xinxin Huang, Zhao Yang
Abstract Numerous studies implicated the relationship between the sinus node dysfunction (SND) and atrial arrhythmias, but the pacemaker activities of sinoatrial node (SAN) during the atrial reentry before the formation of structural and electrophysiological remodeling in SAN were not well investigated. In the present study, a gradient two-dimensional model including SAN and atrium was built to reflect heterogeneities of the SAN. The reentrant wave was induced by the cross field method in the atrium. The simulation demonstrated a suppressed SAN spontaneous firing by the invading reentry and a 4:1 entrance block into the SAN at a reentrant cycle length of 80 ms. When the retrograde electrical excitation from atrium captured the SAN cell, the maximum diastolic potential of its action potential was found to become more negative with increased upstroke velocity. At the same time, the amplitudes of If, ICaL and IKs were enlarged. Besides, the interactions of the atrium and SAN presented a block of the sinus firing from exiting to the atrium while protecting the central SAN from the effects of the invading reentry. These findings suggested a link between SND and atrial reentry, and therefore were helpful in explaining the role of atrial arrhythmias in SND.
大量研究提示窦房结功能障碍(SND)与心房心律失常之间的关系,但窦房结(SAN)在心房再入期结构重构和电生理重构形成前的起搏器活动尚未得到很好的研究。在本研究中,建立了一个包括SAN和心房的梯度二维模型,以反映SAN的异质性。用交叉场法在心房内诱发重入波。模拟结果表明,在80ms的重入周期内,入侵再入和4:1的入口阻塞抑制了SAN自发发射。当心房逆行电兴奋捕获SAN细胞时,发现其动作电位的最大舒张电位随着上冲速度的增加而变得更加负。同时,If、ICaL和IKs的振幅增大。此外,心房和SAN的相互作用阻断了窦性心房的放电,同时保护了中央SAN免受侵入性再入的影响。这些发现提示SND与心房再入之间存在联系,因此有助于解释心房心律失常在SND中的作用。
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引用次数: 1
Acne scar and scar synthesis system using height map and improved subsurface scattering color model 痤疮疤痕和疤痕合成系统采用高度图和改进的亚表面散射颜色模型
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240305
Taeyoung Choi, S. Chin
Abstract Recently, people have paid more attention to skin that seems determine age, beauty and appearance. In particular, acne scar that tends to grow in young generation. Synthetic model can help to prevent them to care beforehand. This study proposes a representation for acne scars and general scars using a height map and an improved subsurface scattering color model. In consideration of the geometric properties of acne scars classified into ice pick, rolling and boxcar, a height map is used. Where the improved subsurface scattering color model and shading are applied, convenient system interfaces are provided to represent wounds and scars conveniently. An automation function is added for the user to control the height map, as well as four shading functions comparable with the shading function proposed in this study. In addition, a user study is performed to validate the proposed method.
近年来,人们越来越关注皮肤,皮肤似乎决定了年龄、美丽和外表。特别是痤疮疤痕,往往生长在年轻一代。综合模型可以帮助预防他们提前护理。本研究提出使用高度图和改进的亚表面散射颜色模型来表示痤疮疤痕和一般疤痕。考虑到冰锥型、滚动型和车箱型痤疮疤痕的几何特性,采用了高度图。采用改进的亚表面散射颜色模型和阴影,提供方便的系统接口,方便地表示伤口和疤痕。增加了用户控制高度图的自动化功能,以及与本研究提出的遮阳功能相媲美的四个遮阳功能。此外,还进行了用户研究以验证所提出的方法。
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引用次数: 0
Intuitive control algorithm of a novel minimally invasive surgical robot 一种新型微创手术机器人的直观控制算法
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240296
Guojun Niu, Bo Pan, Yue Ai, Yili Fu
Abstract Background: Minimally invasive surgery (MIS) based on computer and robot-assisted technology is becoming more and more popular. Methods: Intuitive motion control implemented by kinematic algorithm of the slave manipulator based on the 3D Display (DD) is proposed to eliminate absonant hand-eye coordination, kinematic dissimilarity and workspace mismatch of the master-slave manipulator and is applied in the novel minimally invasive surgical (MIS) robot developed in our lab. Forward and inverse kinematics of MIS robot are analyzed based on the screw theory. The kinematic algorithm of MIS robot based on the DD is achieved. Results: The trajectory tracking results that the movement trends between the master and slave manipulators consistently validate the effectiveness of forward and inverse kinematics. The simulation results of the kinematic algorithm by virtue of Simulink and SimMechanics sub-modules of the MATLAB and intuitive control experiment that the root mean square error of cumulative position increments is less than 0.5 mm validate effectiveness of intuitive control algorithm. Conclusion: Successful animal experiments furthermore validate the effectiveness of intuitive control algorithm.
背景:基于计算机和机器人辅助技术的微创手术(MIS)越来越受欢迎。方法:针对主从机械手手眼协调不协调、运动不一致和工作空间不匹配等问题,提出了基于3D显示器(DD)的从机械手运动学算法实现直观运动控制的方法,并将其应用于本实验室研制的新型微创手术机器人。基于螺旋理论对MIS机器人的正运动学和逆运动学进行了分析。实现了基于DD的MIS机器人的运动学算法。结果:轨迹跟踪结果表明,主、从机械手之间的运动趋势一致,验证了正逆运动学的有效性。利用MATLAB的Simulink和SimMechanics子模块以及直观控制实验对运动学算法进行了仿真,结果表明累计位置增量的均方根误差小于0.5 mm,验证了直观控制算法的有效性。结论:成功的动物实验进一步验证了直觉控制算法的有效性。
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引用次数: 4
Long-term effects of robotic hippotherapy on dynamic postural stability in cerebral palsy 机器人海马疗法对脑瘫动态姿势稳定性的长期影响
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240297
Youngjoo Cha, Megan Stanley, T. Shurtleff, J. H. You
Abstract Background: Dynamic postural instability is a common neuromuscular impairment in cerebral palsy (CP), which often includes balance dysfunction and an associated risk of serious falls. Robotic hippotherapy has recently become a widespread clinical application to facilitate postural core stabilization, strength, and endurance through repetitive vestibular and proprioceptive stimulation to the spine via the sensorimotor system pathways. However, the long-term effects of robotic hippotherapy on dynamic postural instability in CP remain unclear. Objective: To examine the long-term effects of robotic hippotherapy on dynamic postural stability in CP. Methods: An advanced three-dimensional biomechanical eight-camera video motion capture (VMC) system was used to compute the center of mass (COM) pathway, which represents intervention-related spinal core instability. The robotic hippotherapy system was used to improve dynamic postural stability and associated balance performance. Robotic hippotherapy exercise was provided for 45 minutes/session, 2–3 times a week over the 12-week period. Results: Abnormal mean COM pathway length, standard deviation, and range substantially decreased after 12 weeks of robotic hippotherapy. The initial x-axis COM was greater than that of the y-axis. However, the amount of abnormal anterior–posterior and medio-lateral postural sway substantially decreased after robotic hippotherapy. Conclusions: This study provides the first compelling evidence that the robotic hippotherapy is safe and effective for postural instability control and sitting balance dysfunction that mitigates the risk of falls in CP.
背景:动态姿势不稳定是脑瘫(CP)中常见的神经肌肉损害,通常包括平衡功能障碍和相关的严重跌倒风险。机器人海马疗法最近已成为一种广泛的临床应用,通过感觉运动系统途径对脊柱进行前庭和本体感觉的重复刺激,促进体位核心的稳定、力量和耐力。然而,机器人海马疗法对CP动态体位不稳定性的长期影响尚不清楚。目的:研究机器人海马疗法对CP动态姿势稳定性的长期影响。方法:采用先进的三维生物力学八摄像头视频运动捕捉(VMC)系统计算质量中心(COM)通路,该通路代表干预相关的脊柱核心不稳定。机器人海马疗法系统用于改善动态姿势稳定性和相关的平衡性能。机器人海马疗法运动45分钟/次,每周2-3次,持续12周。结果:机器人海马疗法12周后,异常的平均COM通路长度、标准差和范围显著减少。初始x轴COM大于y轴COM。然而,机器人海马疗法后,异常前后和中外侧体位摆动的数量大大减少。结论:本研究首次提供了令人信服的证据,证明机器人海马疗法对于降低CP患者跌倒风险的姿势不稳定控制和坐位平衡功能障碍是安全有效的。
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引用次数: 4
Mental workload prediction model based on information entropy 基于信息熵的心理工作量预测模型
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240298
Xiang Li, Weining Fang, Ying-jie Zhou
Abstract This paper introduces the concept of information entropy in studying mental workloads to predict the mental workload of an urban railway dispatcher and thereby ensure safe rail system operation. This study combines factors that can influence mental workload, including visual behaviors required for dispatchers to obtain information, information display duration, and the amount of information in order to establish a comprehensive mental workload prediction model. Experimental monitoring tasks were carried out on a simulation dispatch interface platform to verify the model’s validity. Three assessment methods (task performance assessment, subjective assessment, and physiological assessment) were adopted to measure the mental workload levels of dispatchers under different task conditions. The results demonstrate that the model’s theoretical prediction value significantly correlates with the various experimental results, thereby verifying the model validity and indicating that it can be used to predict the mental workload for different dispatch tasks, to provide a reference for work performance evaluation, and in designing optimized dispatch display interfaces.
摘要:本文将信息熵的概念引入到心理负荷研究中,以预测城市轨道交通调度员的心理负荷,保证轨道交通系统的安全运行。本研究结合调度员获取信息所需的视觉行为、信息显示时间、信息量等影响心理工作量的因素,建立综合心理工作量预测模型。在仿真调度接口平台上进行了实验监测任务,验证了模型的有效性。采用任务绩效评估、主观评估和生理评估三种评估方法,对不同任务条件下调度员的心理工作量水平进行测量。结果表明,该模型的理论预测值与各项实验结果显著相关,从而验证了模型的有效性,表明该模型可用于预测不同调度任务的心理工作量,为工作绩效评估和优化调度显示界面的设计提供参考。
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引用次数: 3
Application of bonebed-malleus short process registration in minimally invasive cochlear implantation 骨-踝短突配准在微创人工耳蜗植入中的应用
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-25 DOI: 10.1080/24699322.2016.1240306
J. Ke, Shaoxing Zhang, Changsheng Li, Yun-Feng Zhu, Lei Hu, Furong Ma
Abstract Purpose: This article proposed and investigated the application of bonebed-malleus short process registration in minimally invasive cochlear implantation, and assessed the value of the proposed strategy for image-guided otologic surgery. Materials and methods: Ten temporal bone specimens were marked with both shallow and deep targets in order to measure registration resolutions. Two registration methods were applied. Method A (a new registration method) consisted of bonebed-malleus short process registration, while method B (traditional registration method) comprised registration using four titanium screws attached at the mastoid surface. The target registration errors (TRE) were measured at both the shallow and deep fiducial targets. After registration achieved by method A, percutaneous cochlear drilling was conducted on the other eight temporal bone specimens in order to observe the deviation from the target point and entry point. Results: Using method A, the error observed at the shallow fiducial markers of specimens was less than 1 mm, while the error observed at the deep fiducial markers was approximately equal to 1 mm. No significant difference was observed when results were compared with the application of method B. In eight studied cases using method A, drilling operations were successfully conducted. The deviations from the target point and the entry point were 0.84 ± 0.30 and 0.66 ± 0.51 mm, respectively. Conclusions: Results of the present study indicated that the new registration method demonstrated identical accuracy when compared to traditional registration method, achieved less invasiveness. Thus, the proposed method might be a feasible registration method for image-guided otologic surgery due to its mild invasiveness and high accuracy.
摘要目的:本文提出并探讨骨-踝短突配准在微创人工耳蜗植入中的应用,并评价该策略在图像引导耳科手术中的应用价值。材料和方法:用浅靶和深靶标记10个颞骨标本,测量配准分辨率。采用了两种配准方法。方法A(新型配准方法)为骨-踝短突配准,方法B(传统配准方法)为乳突面附着4枚钛螺钉配准。在浅基准目标和深基准目标上测量目标配准误差(TRE)。A方法配准后,对另外8个颞骨标本进行经皮耳蜗钻孔,观察与靶点和入点的偏差。结果:A方法在标本浅层基准点处观察到的误差小于1 mm,在深层基准点处观察到的误差近似等于1 mm。与方法b相比,结果没有显著差异。在使用方法A的8个研究案例中,成功进行了钻井作业。与靶点和入点的偏差分别为0.84±0.30 mm和0.66±0.51 mm。结论:本研究结果表明,新配准方法与传统配准方法相比具有相同的精度,且具有较小的侵入性。因此,该方法具有侵入性小、准确性高的特点,可能是一种可行的图像引导耳科手术配准方法。
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引用次数: 3
Computerized analysis of acceleration parameter for the non-stress test normal and potentially abnormal fetuses 无应力试验正常胎儿和潜在异常胎儿加速度参数的计算机分析
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-24 DOI: 10.1080/24699322.2016.1240293
Guangfei Li, Song Zhang, Lin Yang, Shufang Li, Yan Wang, Dongmei Hao, Yimin Yang, Xuwen Li, Lei Zhang, Mingzhou Xu
Abstract Non-stress testing (NST) is the primary method of determining fetal condition during the perinatal period, and as such, has high specificity. However, short-term monitoring and visual inspection of the cardiotocogram demonstrates several limitations in understanding fetal status which can be mistaken as predictors of neonatal asphyxia. Fetal electrocardiography (FECG) is a novel, long-term monitoring method which can reflect more objective and accurate fetal information. This article presents experimental results of four fetal heart rate (FHR) acceleration features of 44 fetuses extracted from FECG. The novelty of this approach lies in its combined use of parameters which can express both duration and amplitude of heart rate acceleration. Results demonstrate that most parameters significantly differ between normal fetuses and fetuses with suspected abnormalities. Results are promising for the identification of a set or parameters which may be used as classifiers to improve the success rate when distinguishing between normal and abnormal fetuses.
摘要:非应激测试(NST)是确定围生期胎儿状况的主要方法,因此具有很高的特异性。然而,短期监测和心电图的目视检查表明,在了解胎儿状态方面存在一些局限性,这可能被误认为是新生儿窒息的预测因素。胎儿心电图(FECG)是一种新的长期监测方法,能更客观、准确地反映胎儿信息。本文介绍了44例胎儿超声心动图提取的四种胎儿心率加速特征的实验结果。该方法的新颖之处在于它结合使用了可以表示心率加速持续时间和幅度的参数。结果表明,大多数参数在正常胎儿和疑似异常胎儿之间存在显著差异。该结果有望用于识别一组或参数,可作为分类器,以提高区分正常和异常胎儿的成功率。
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引用次数: 2
A first step in finite-element simulation of a grasping task 抓握任务有限元模拟的第一步
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-10-24 DOI: 10.1080/24699322.2016.1240294
D. Chamoret, M. Bodo, S. Roth
Abstract This paper investigates a biomechanical aspect of human hand during grasping, using the finite-element method. A realistic three-dimensional finite–element (FE) model of a human hand is developed, including wrist bones, phalanges, soft tissues and skin, reconstructed from medical computed tomography (CT) scan images. Material laws of the literature have been implemented in the model, in order to be able to simulate a simple activity of grasping. In a human design context, this model allows an interesting biomechanical study, which simulates the grasping task in a biofidelic manner. This model is a first step in the modeling of the human hand that can lead to future studies dealing with the interaction of the hand with its environment for the improvement of safety requirements of future products development.
摘要:本文采用有限元方法研究了人手在抓取过程中的生物力学方面。建立了一个真实的人手三维有限元模型,包括腕骨、指骨、软组织和皮肤,由医学计算机断层扫描(CT)图像重建。在模型中实现了文献中的物质规律,以便能够模拟一个简单的抓取活动。在人类设计的背景下,这个模型允许一个有趣的生物力学研究,它以一种仿生的方式模拟抓取任务。该模型是人手建模的第一步,可以引导未来研究处理手与环境的相互作用,以提高未来产品开发的安全要求。
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引用次数: 16
A computer-assisted robotic platform for vascular procedures exploiting 3D US-based tracking 计算机辅助的血管手术机器人平台,利用基于美国的3D跟踪
IF 2.1 4区 医学 Q3 SURGERY Pub Date : 2016-01-01 DOI: 10.1080/24699322.2016.1185467
Marco Mura, S. Parrini, G. Ciuti, V. Ferrari, C. Freschi, M. Ferrari, P. Dario, A. Menciassi
Abstract Background: Cardiovascular diseases are the first cause of death globally: an estimated 17.5 million people died in 2012. By combining the benefits of magnetic navigation and ultrasound (US) imaging, the authors proposed a robotic platform (i.e. the MicroVAST platform) for intravascular medical procedures. Methods: A 3D imaging US-based tracking algorithm is implemented for the navigation of a magnetic-dragged soft-tethered device. Tests were performed to evaluate the algorithm in terms of tracking error and precision of locomotion. Results: The 3D imaging US-based algorithm tracked the endovascular device with an error of 6.4 ± 2.8 pixels and a mean displacement between the endovascular device and the preoperative path of 13.6 ± 4.5 mm (computational time of 12.2 ± 1.5 ms and 30.7 ± 6.1 matched features). Conclusions: The MicroVAST platform includes innovative solutions for navigation allowing for an assisted magnetic locomotion of medical devices in the cardiovascular district by combining a 3D imaging US-based tracking algorithm with pre-operative data.
背景:心血管疾病是全球第一大死亡原因:2012年估计有1750万人死亡。通过结合磁导航和超声成像的优点,作者提出了一种用于血管内医疗程序的机器人平台(即MicroVAST平台)。方法:采用基于三维成像的跟踪算法实现磁拖软系装置的导航。通过实验对算法的跟踪误差和运动精度进行了评价。结果:基于3D成像的算法对血管内装置的跟踪误差为6.4±2.8像素,血管内装置与术前路径的平均位移为13.6±4.5 mm(计算时间为12.2±1.5 ms,匹配特征为30.7±6.1)。结论:MicroVAST平台包括创新的导航解决方案,通过将基于3D成像的跟踪算法与术前数据相结合,允许心血管区医疗设备的辅助磁运动。
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引用次数: 7
期刊
Computer Assisted Surgery
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