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Advances in minimally invasive surgery and clinical measurement. 微创手术与临床测量的进展。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-04-02 DOI: 10.1080/24699322.2018.1560103
Chengyu Liu, Lung-Kwang Pan
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引用次数: 2
Super resolution reconstruction for medical image based on adaptive multi-dictionary learning and structural self-similarity. 基于自适应多字典学习和结构自相似的医学图像超分辨率重建。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-01-28 DOI: 10.1080/24699322.2018.1560092
Fang Zhang, Yue Wu, Zhitao Xiao, Lei Geng, Jun Wu, Jia Wen, Wen Wang, Ping Liu

To improve the quality of the super-resolution (SR) reconstructed medical images, an improved adaptive multi-dictionary learning method is proposed, which uses the combined information of medical image itself and the natural images database. In training dictionary section, it uses the upper layer images of pyramid which are generated by the self-similarity of low resolution images. In reconstruction section, the top layer image of pyramid is taken as the initial reconstruction image, and medical image's SR reconstruction is achieved by regularization term which is the non-local structure self-similarity of the image. This method can make full use of the same scale and different scale similar information of medical images. Simulation experiments are carried out on natural images and medical images, and the experimental results show the proposed method is effective for improving the effect of medical image SR reconstruction.

为了提高重建的超分辨率医学图像的质量,提出了一种改进的自适应多字典学习方法,该方法将医学图像本身的信息与自然图像数据库相结合。在训练字典部分,使用低分辨率图像的自相似度生成的金字塔上层图像。在重建部分,以金字塔的顶层图像作为初始重建图像,通过正则化项即图像的非局部结构自相似性来实现医学图像的SR重建。该方法可以充分利用医学图像的相同尺度和不同尺度的相似信息。对自然图像和医学图像进行了仿真实验,实验结果表明,该方法能够有效提高医学图像SR重建的效果。
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引用次数: 7
Real-time tracking of surgical instruments based on spatio-temporal context and deep learning. 基于时空背景和深度学习的手术器械实时跟踪。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-02-14 DOI: 10.1080/24699322.2018.1560097
Zijian Zhao, Zhaorui Chen, Sandrine Voros, Xiaolin Cheng

ABSTARCT Real-time tool tracking in minimally invasive-surgery (MIS) has numerous applications for computer-assisted interventions (CAIs). Visual tracking approaches are a promising solution to real-time surgical tool tracking, however, many approaches may fail to complete tracking when the tracker suffers from issues such as motion blur, adverse lighting, specular reflections, shadows, and occlusions. We propose an automatic real-time method for two-dimensional tool detection and tracking based on a spatial transformer network (STN) and spatio-temporal context (STC). Our method exploits both the ability of a convolutional neural network (CNN) with an in-house trained STN and STC to accurately locate the tool at high speed. Then we compared our method experimentally with other four general of CAIs' visual tracking methods using eight existing online and in-house datasets, covering both in vivo abdominal, cardiac and retinal clinical cases in which different surgical instruments were employed. The experiments demonstrate that our method achieved great performance with respect to the accuracy and the speed. It can track a surgical tool without labels in real time in the most challenging of cases, with an accuracy that is equal to and sometimes surpasses most state-of-the-art tracking algorithms. Further improvements to our method will focus on conditions of occlusion and multi-instruments.

微创手术(MIS)中的实时工具跟踪在计算机辅助干预(CAIs)中有许多应用。视觉跟踪方法是实时手术工具跟踪的一个很有前途的解决方案,然而,当跟踪器受到运动模糊、不利光照、镜面反射、阴影和闭塞等问题的影响时,许多方法可能无法完成跟踪。提出了一种基于空间变压器网络(STN)和时空背景(STC)的二维刀具自动实时检测和跟踪方法。我们的方法利用卷积神经网络(CNN)与内部训练的STN和STC的能力,以高速准确定位工具。然后,我们利用八个现有的在线和内部数据集,将我们的方法与其他四种CAIs的视觉跟踪方法进行了实验比较,这些数据集涵盖了使用不同手术器械的体内腹部、心脏和视网膜临床病例。实验表明,该方法在精度和速度方面都取得了较好的效果。在最具挑战性的情况下,它可以在没有标签的情况下实时跟踪手术工具,其精度相当于甚至有时超过了最先进的跟踪算法。进一步改进我们的方法将集中在遮挡条件和多仪器。
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引用次数: 31
Minimally invasive surgical techniques for the therapy of far lateral disc herniation in middle-aged and elderly patients. 治疗中老年远外侧椎间盘突出症的微创手术技术。
IF 1.5 4区 医学 Q3 SURGERY Pub Date : 2019-10-01 Epub Date: 2019-01-28 DOI: 10.1080/24699322.2018.1557897
Weijian Ren, Yu Chen, Liangbi Xiang

To examine the clinical results of different minimally invasive techniques for the therapy of far lateral disc herniation in middle-aged and elderly patients. An endoscopic approach (percutaneous endoscopic lumbar discectomy; PELD), MIS-TLIF combined with contralateral translaminar screw (MIS-TLIF CTS), and MIS-TLIF combined with bilateral pedicle screws (MIS-TLIF BPS) were evaluated via a retrospective chart review. Data from 74 consecutive middle-aged and elderly patients with far lateral disc herniation were analyzed. All patients underwent surgery; 19 with PELD, 24 with MIS-TLIF CTS, and 31 with MIS-TLIF BPS. Clinical data included the length of the incision, duration of the operation, estimated blood loss, hospitalization time, operation cost, recurrence rate, and fusion rate. Preoperative and postoperative patient outcomes including the VAS, ODI scores and MacNab criteria were assessed and recorded. The mean follow-up time was 26.4 months (range from 14 to 46 months). Compared with the internal fixation groups, the length of the incision, duration of operation, estimated blood loss, and hospitalization time were obviously lower in the PELD group. The difference in operation cost among the three methods was statistically significant. The postoperative VAS scores for LBP and LP decreased significantly as compared with those recorded preoperatively. The postoperative ODI scores were lower than those recorded preoperatively. MacNab criteria rating excellent, good and fair results were in 27, 37 and 10 patients, respectively. Conclusion: PELD, MIS-TLIF CTS, and MIS-TLIF BPS are all effective minimally invasive techniques for the therapy of single segment far lateral lumbar disc herniation in middle-aged and elderly patients. PELD had a shorter operation time and less surgical trauma, being a less invasive and more economical method; however, there was no recurrence of disc herniation after fixation. Compared with MIS-TLIF BPS, MIS-TLIF CTS obtained a similar clinical effect and certain costs were saved.

研究不同微创技术治疗中老年远外侧椎间盘突出症的临床效果。通过回顾性病历审查评估了内窥镜方法(经皮内窥镜腰椎间盘切除术;PELD)、MIS-TLIF 联合对侧椎板间螺钉术(MIS-TLIF CTS)和 MIS-TLIF 联合双侧椎弓根螺钉术(MIS-TLIF BPS)。研究分析了 74 名连续的远外侧椎间盘突出症中老年患者的数据。所有患者都接受了手术,其中19人接受了PELD手术,24人接受了MIS-TLIF CTS手术,31人接受了MIS-TLIF BPS手术。临床数据包括切口长度、手术时间、估计失血量、住院时间、手术费用、复发率和融合率。对患者术前和术后的结果进行了评估和记录,包括 VAS、ODI 评分和 MacNab 标准。平均随访时间为 26.4 个月(14 至 46 个月)。与内固定组相比,PELD 组的切口长度、手术时间、估计失血量和住院时间明显更短。三种方法的手术费用差异具有统计学意义。与术前相比,术后 LBP 和 LP 的 VAS 评分明显下降。术后 ODI 评分低于术前记录。按照 MacNab 标准评定,结果为优、良和一般的患者分别为 27、37 和 10 人。结论PELD、MIS-TLIF CTS和MIS-TLIF BPS都是治疗中老年单节段远外侧腰椎间盘突出症的有效微创技术。PELD 的手术时间更短,手术创伤更小,是一种创伤更小、更经济的方法;但固定后椎间盘突出症没有复发。与 MIS-TLIF BPS 相比,MIS-TLIF CTS 取得了相似的临床效果,并节省了一定的费用。
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引用次数: 0
Physiological interference reduction for near infrared spectroscopy brain activity measurement based on recursive least squares adaptive filtering and least squares support vector machines. 基于递推最小二乘自适应滤波和最小二乘支持向量机的近红外光谱脑活动测量生理干扰抑制。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-01-28 DOI: 10.1080/24699322.2018.1557901
Xin Liu, Yan Zhang, Dan Liu, Qisong Wang, Ou Bai, Jinwei Sun, Peter Rolfe

Near infrared spectroscopy is the promising and noninvasive technique that can be used to detect the brain functional activation by monitoring the concentration alternations in the haemodynamic concentration. The acquired NIRS signals are commonly contaminated by physiological interference caused by breathing and cardiac contraction. Though the adaptive filtering method with least mean squares algorithm or recursive least squares algorithm based on multidistance probe configuration could improve the quality of evoked brain activity response, both methods can only remove the physiological interference occurred in superficial layers of the head tissue. To overcome the shortcoming, we combined the recursive least squares adaptive filtering method with the least squares support vector machine to suppress physiological interference both in the superficial layers and deeper layers of the head tissue. The quantified results based on performance measures suggest that the estimation performances of the proposed method for the evoked haemodynamic changes are better than the traditional recursive least squares method.

近红外光谱技术是一种很有前途的无创技术,它可以通过监测血流动力学浓度的变化来检测脑功能的激活。获得的近红外光谱信号通常受到呼吸和心脏收缩引起的生理干扰的污染。采用最小均方算法的自适应滤波方法或基于多距离探头配置的递推最小二乘算法虽然可以提高脑活动诱发反应的质量,但这两种方法都只能去除头部组织浅层的生理干扰。为了克服这一缺点,我们将递归最小二乘自适应滤波方法与最小二乘支持向量机相结合,对头部组织的表层和深层进行生理干扰抑制。基于性能测量的量化结果表明,该方法对诱发血流动力学变化的估计性能优于传统的递推最小二乘法。
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引用次数: 0
Multi-feature fusion method for medical image retrieval using wavelet and bag-of-features. 基于小波和特征袋的医学图像检索多特征融合方法。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-01-28 DOI: 10.1080/24699322.2018.1560087
Liu Shuang, Chen Deyun, Chen Zhifeng, Pang Ming

Color, texture, and shape are the common features used for the retrieval systems. However, many medical images have a spot of color information. Therefore, the discriminative texture and shape features should be extracted to obtain a satisfied retrieval result. In order to increase the credibility of the retrieval process, many features can be combined to be used for medical image retrieval. Meanwhile, more features require more processing time, which will decrease the retrieval speed. In this paper, wavelet decomposition is adopted to generate different resolution images. Bag-of-feature, texture, and LBP feature are extracted from three different-level wavelet images. Finally, the similarity measure function is obtained by fusing these three types of features. Experimental results show that the proposed multi-feature fusion method can achieve a higher retrieval accuracy with an acceptable retrieval time.

颜色、纹理和形状是检索系统使用的共同特征。然而,许多医学图像有一个斑点的颜色信息。因此,为了获得满意的检索结果,需要提取具有区别性的纹理和形状特征。为了增加检索过程的可信度,可以将许多特征组合起来用于医学图像检索。同时,更多的特征需要更多的处理时间,这将降低检索速度。本文采用小波分解生成不同分辨率的图像。从三个不同层次的小波图像中提取特征袋、纹理和LBP特征。最后,将这三类特征融合得到相似度度量函数。实验结果表明,所提出的多特征融合方法可以在可接受的检索时间内获得较高的检索精度。
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引用次数: 8
Experimental study on the detection of cerebral hemorrhage in rabbits based on broadband antenna technology. 基于宽带天线技术检测家兔脑出血的实验研究。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-01-28 DOI: 10.1080/24699322.2018.1557893
Haisheng Zhang, Mingsheng Chen, Gui Jin, Jia Xu, Mingxin Qin

Hematoma enlargement often occurs in patients with spontaneous intracerebral hemorrhage (ICH), so it is necessary to monitor the amount of intracranial hemorrhage in patients after admission. At present, the commonly used intracranial pressure (ICP) method has the disadvantages of trauma and infection, and the Computer Tomography (CT) method cannot achieve continuous monitoring. So it is urgent to develop a non-contact and non-invasive method for continuous monitoring of cerebral hemorrhage. The dielectric properties of blood are different from those of brain tissue, so the hematoma will affect the amplitude and phase of the electromagnetic waves passing through the head. A microstrip antenna was designed to construct the detection system for cerebral hemorrhage. Based on the animal model of acute cerebral hemorrhage, the detecting experiment was carried out on thirteen rabbits. Each rabbit had three bleeding states: 1, 2, and 3 ml, which represented the severity of cerebral hemorrhage. According to the measured data of high dimension and small sample, the support vector machine (SVM) algorithm was used to assess the severity of cerebral hemorrhage. According to simulation results, the antenna's forward radiation was 5 dB larger than the backward radiation, which ensured the antenna being not affected by external signals during the measurement. According to test results, the -10 dB workband of the antenna was 1.55-2.05 GHz and the frequency range of the transmission parameters S21 above -30 dB is 1.2 - 3 GHz. In the animal experiment, the phase difference of Transmission coefficient S21 was gradually increased with the increase of bleeding volume. Through the classification of 39 bleeding states of the 13 rabbits, the total accuracy was about 77%. Through animal experiments, the feasibility of detection method has been proved. But the classification accuracy need to be further improved. The detection system is based on broadband antenna has the potential to realize non-contact, non-invasive and continuous monitoring for cerebral hemorrhage.

自发性脑出血(自发性颅内出血)患者常发生血肿增大,因此有必要在入院后监测患者颅内出血量。目前常用的颅内压(ICP)法存在创伤和感染的缺点,计算机断层扫描(CT)法无法实现连续监测。因此,开发一种非接触、无创的脑出血持续监测方法迫在眉睫。血液的介电特性与脑组织不同,因此血肿会影响通过头部的电磁波的振幅和相位。设计微带天线,构建脑出血检测系统。以急性脑出血动物模型为基础,对13只家兔进行检测实验。每只家兔有1、2、3 ml三种出血状态,分别代表脑出血的严重程度。根据高维、小样本的测量数据,采用支持向量机(SVM)算法对脑出血的严重程度进行评估。仿真结果表明,天线的正向辐射比反向辐射大5db,保证了天线在测量过程中不受外界信号的影响。测试结果表明,天线- 10db工作频带为1.55 ~ 2.05 GHz, - 30db以上传输参数S21的频率范围为1.2 ~ 3ghz。在动物实验中,透射系数S21的相位差随着出血量的增加而逐渐增大。通过对13只家兔39种出血状态的分类,总准确率约为77%。通过动物实验,验证了检测方法的可行性。但分类精度有待进一步提高。基于宽带天线的脑出血检测系统具有实现脑出血非接触、非侵入性连续监测的潜力。
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引用次数: 7
The process of 3D printed skull models for anatomy education. 3D打印颅骨模型用于解剖学教育的过程。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-04-23 DOI: 10.1080/24699322.2018.1560101
Zhen Shen, Yong Yao, Yi Xie, Chao Guo, Xiuqin Shang, Xisong Dong, Yuqing Li, Zhouxian Pan, Shi Chen, Gang Xiong, Fei-Yue Wang, Hui Pan

In general, the 3 D printed medical models are made based on virtual digital models obtained from machines such as the computed tomography scanner. However, due to the limited accuracy of CT scanning technology, which is usually 1 millimeter, there are differences between scanned results and the real structure. Besides, the collected data can hardly be printed directly because of some errors in the model. In this paper, we present a general and efficient procedure to process the digital skull data to make the printed structures meet the requirements of anatomy education, which combines the use of five 3 D manipulation tools and the procedure can be finished within 6 hours. Then the model is printed and compared with the cadaveric skull from frontal, left, right and anterior views respectively. The printed model can describe the correct structure and details of the skull clearly, which can be considered as a good alternative to the cadaveric skull. The manipulation procedure presented in this study is an easily available and cost-effective way to obtain a printed skull model from the original CT data, which has a considerable economic and social benefit for the medical education. The steps of the data processing can be performed easily. The cost for the 3 D printed model is also low. Outcomes of this study can be applied widely in processing skull data.

一般来说,3d打印医学模型是基于从计算机断层扫描仪等机器获得的虚拟数字模型制作的。然而,由于CT扫描技术的精度有限,通常为1毫米,因此扫描结果与真实结构存在差异。此外,由于模型存在一些误差,采集到的数据很难直接打印出来。本文结合五种三维操作工具的使用,提出了一种通用、高效的处理数字颅骨数据的流程,使打印的结构符合解剖教学的要求,该流程可在6小时内完成。然后将模型打印出来,并分别从正视图、左视图、右视图和正视图与尸体颅骨进行对比。打印出来的模型可以清晰地描述颅骨的正确结构和细节,可以认为是一种很好的替代尸体颅骨的方法。本研究提出的操作程序是一种简单易行、成本低廉的从原始CT数据中获得颅骨打印模型的方法,对医学教育具有可观的经济效益和社会效益。数据处理的步骤可以很容易地执行。3d打印模型的成本也很低。本研究结果可广泛应用于颅骨数据处理。
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引用次数: 21
Unsupervised binocular depth prediction network for laparoscopic surgery. 腹腔镜手术无监督双目深度预测网络。
IF 2.1 4区 医学 Q1 Medicine Pub Date : 2019-10-01 Epub Date: 2019-01-16 DOI: 10.1080/24699322.2018.1557889
Ke Xu, Zhiyong Chen, Fucang Jia

Minimally invasive laparoscopic surgery is associated with small wounds and short recovery time, reducing postoperative infections. Traditional two-dimensional (2D) laparoscopic imaging lacks depth perception and does not provide quantitative depth information, thereby limiting the field of vision and operation during surgery. However, three-dimensional (3D) laparoscopic imaging from 2 D images lets surgeons have a depth perception. However, the depth information is not quantitative and cannot be used for robotic surgery. Therefore, this study aimed to reconstruct the accurate depth map for binocular 3 D laparoscopy. In this study, an unsupervised learning method was proposed to calculate the accurate depth while the ground-truth depth was not available. Experimental results proved that the method not only generated accurate depth maps but also provided real-time computation, and it could be used in minimally invasive robotic surgery.

微创腹腔镜手术伤口小,恢复时间短,减少术后感染。传统的二维(2D)腹腔镜成像缺乏深度感知,不能提供定量的深度信息,从而限制了手术过程中的视野和操作。然而,三维(3D)腹腔镜成像从二维图像让外科医生有深度感知。然而,深度信息不是定量的,不能用于机器人手术。因此,本研究旨在重建双目三维腹腔镜的精确深度图。在本研究中,提出了一种无监督学习方法,用于在无法获得真实深度的情况下计算准确深度。实验结果表明,该方法不仅可以生成准确的深度图,而且可以提供实时计算,可用于微创机器人手术。
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引用次数: 13
Analysis and recognition of characteristics of digitized tongue pictures and tongue coating texture based on fractal theory in traditional Chinese medicine. 基于分形理论的中药数字化舌象及舌苔纹理特征分析与识别
IF 1.5 4区 医学 Q3 SURGERY Pub Date : 2019-10-01 Epub Date: 2019-01-21 DOI: 10.1080/24699322.2018.1560081
Ji Zhang, Jun Qian, Tao Yang, Hai-Yan Dong, Rui-Juan Wang

Simple fractal dimensions have been proposed for use in the analysis of the characteristics of digitized tongue pictures and tongue coating texture, which could further the establishment of objectified classification criteria under the conditions of expanding sample size. However, detailed descriptions on simple fractal dimensions have been limited. Therefore, BP (back propagation) neural network model classifiers could be designed by further calculation of the multiple fractal spectrum characteristics of digitized tongue pictures in order to classify and recognize the thin/thick or greasy characteristics of tongue coating. The fractal dimensions of sample data of 587 digitized tongue pictures were collected in a standard environment. A statistical analysis was conducted on the calculation results of the sample data, and the sensitivity of the fractal dimensions to the thin/thick and greasy characteristics of digitized tongue pictures was observed. As the overlap region resulted from a range of values of a single parameter, another 8 characteristic parameters of the multiple fractal spectra of the digitized tongue pictures were further proposed as the elements in the input layer of the three-layers BP neural network. Automatic recognition classifiers were designed and trained for the characteristics of digitized tongue pictures and tongue coating textures. The simple fractal dimension was sensitive to the thin/thick and greasy characteristics of digitized tongue pictures and could better judge the characteristics of the thickness of the tongue coating. A classifier with characteristic parameters of multiple fractal spectra as the input vectors identified by the BP neural network models could effectively increase the accuracy rate judged by the characteristics of the tongue coating texture.

有人提出将简单分形维度用于分析数字化舌头图片和舌苔纹理的特征,这可以在样本量不断扩大的条件下进一步建立客观化的分类标准。然而,对简单分形维度的详细描述还很有限。因此,可以通过进一步计算数字化舌苔图片的多重分形谱特征来设计 BP(反向传播)神经网络模型分类器,从而对舌苔的薄/厚或油腻特征进行分类和识别。在标准环境中收集了 587 张数字化舌苔图片样本数据的分形维度。对样本数据的计算结果进行了统计分析,观察了分形维数对数字化舌苔薄/厚和油腻特征的敏感性。由于单个参数的取值范围会导致重叠区域的出现,因此进一步提出了数字化舌头图片多重分形光谱的另外 8 个特征参数作为三层 BP 神经网络输入层的元素。针对数字化舌图和舌苔纹理的特征,设计并训练了自动识别分类器。简单分形维度对数字化舌苔图片的薄/厚和油腻特征很敏感,能更好地判断舌苔的厚度特征。以多个分形光谱的特征参数作为 BP 神经网络模型识别的输入向量的分类器可有效提高舌苔纹理特征判断的准确率。
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引用次数: 0
期刊
Computer Assisted Surgery
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