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Comparison of bone mineral density between female amateur triathletes and nonathletes: A cross-sectional study. 业余铁人三项女运动员与非运动员骨质密度的比较:横断面研究
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241261844
Guilherme Cruz Correa Netto Soares, José Geraldo Gomes Barbosa Junior, Aldo Seffrin, Lavínia Vivan, João Victor Rosa de Freitas, Gustavo De Conti Teixeita Costa, Claudio André Barbosa B de Lira, Rodrigo Luiz Vancini, Katja Weiss, Beat Knechtle, Marilia Santos Andrade

Purpose: Physical inactivity is considered an important risk factor for osteoporosis, however, some athletes performing extremely high training volumes can also develop bone mass loss. Moreover, the effect of total body mass or body surface area on bone mineral density remains controversial. Therefore, the aim of this study was to compare the absolute bone mineral density and bone mineral density adjusted to body surface area between amateur triathletes and nonactive women.

Methods: Forty-two healthy women (23 amateur triathletes and 19 nonactive individuals) were evaluated for body composition using a dual-energy X-ray absorptiometry system.

Results: Compared to nonactive women, amateur triathletes exhibited lower body mass index (p < 0.001), lower bone mineral density (p < 0.001), and body surface area (p < 0.001). However, bone mineral density adjusted by body surface area in the triathletes was higher than in the nonactive women (p = 0.03).

Conclusion: These findings showed that amateur triathles presented lower absolute bone mineral density, but higher bone mineral density adjusted to body surface area. Future studies are recommended to identify if the higher bone mineral density adjusted to body surface area are associated with a lower bone fragility.

目的:缺乏运动被认为是骨质疏松症的一个重要风险因素,然而,一些进行超高训练量的运动员也会出现骨质流失。此外,总体重或体表面积对骨矿物质密度的影响仍存在争议。因此,本研究旨在比较业余铁人三项运动员和非运动员女性的绝对骨矿物质密度和根据体表面积调整后的骨矿物质密度:方法:使用双能 X 射线吸收测量系统对 42 名健康女性(23 名业余铁人三项运动员和 19 名非运动员)的身体成分进行评估:结果:与非运动女性相比,业余铁人三项运动员的体重指数较低(p p p = 0.03):这些研究结果表明,业余铁人三项运动员的绝对骨矿物质密度较低,但根据体表面积调整后的骨矿物质密度较高。建议今后开展研究,以确定根据体表面积调整的较高骨矿物质密度是否与较低的骨脆性有关。
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引用次数: 0
Macroscopic and microscopic analysis of the effects of moisture content and dry density on the strength of loess. 含水量和干密度对黄土强度影响的宏观和微观分析。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241261592
Liangliang Bao, Feng Wei

To clarify the impact of moisture content and dry density on the strength of loess, the remolded loess samples with different moisture content and dry density were prepared, and the influence of moisture content and dry density on loess strength was explored from the macro level by direct shear test without suction control. On this basis, the mechanism of the influence of moisture content and dry density on loess strength was explored from the micro level by nuclear magnetic resonance method. The research results indicate that: In the case of low water content, there are peak points in the stress-strain curve of remolded loess, exhibiting strain softening characteristics. In the case of high water content, there is no obvious peak in the stress-strain curve, exhibiting strain hardening characteristics. Moisture has a significant impact on the shear strength of remolded loess. As the moisture content of the soil sample increases, the cohesion decreases significantly, and the change in internal friction angle is not obvious. As the moisture content continues to increase, the free water content continues to increase. Free water will continuously soften the soil particle structure, reduce the bonding force between soil particles, and cause the cohesion to decrease with the increase of moisture content. The change in dry density also has a significant impact on the shear strength parameters of remolded loess. As the dry density of the soil sample increases, the cohesion increases. The smaller the dry density, the larger the pore ratio, and the looser the contact between soil particles, weakening the bonding effect. The larger the pore ratio, the more bound water is converted to free water, and the strong bonding force between the water film and soil particles disappears. Both of these microscopic factors can lead to a decrease in cohesion with a decrease in dry density.

为明确含水率和干密度对黄土强度的影响,制备了不同含水率和干密度的重塑黄土样品,并通过无吸力控制的直接剪切试验从宏观上探讨了含水率和干密度对黄土强度的影响。在此基础上,利用核磁共振方法从微观层面探讨了含水量和干密度对黄土强度的影响机理。研究结果表明在含水量较低的情况下,重塑黄土的应力-应变曲线存在峰值点,表现出应变软化特征。含水量高时,应力-应变曲线无明显峰值,表现出应变硬化特征。水分对重塑黄土的剪切强度有显著影响。随着土样含水量的增加,内聚力明显下降,内摩擦角变化不明显。随着含水量的不断增加,自由水含量也在不断增加。自由水会不断软化土粒结构,降低土粒间的结合力,使内聚力随着含水量的增加而减小。干密度的变化对重塑黄土的剪切强度参数也有很大影响。随着土样干密度的增加,内聚力也随之增加。干密度越小,孔隙比越大,土粒之间的接触越松散,粘结效果越弱。孔隙比越大,越多的结合水转化为自由水,水膜与土壤颗粒之间的强粘结力消失。这两个微观因素都会导致内聚力随着干密度的降低而降低。
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引用次数: 0
Sugar beet (Beta vulgaris L.) leaves as natural colorant for cotton dyeing using an ecofriendly approach toward industrial progress. 甜菜(Beta vulgaris L.)叶片作为棉花染色的天然着色剂,以生态友好的方式实现工业进步。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241271737
Fatima Batool, Naeem Iqbal, Shahid Adeel, Muhammad Azeem, Muhammad Hussaan, Rony Mia

In the industrial sector, vegetable residual materials have received attention in the production of bio-colorant for textile dyeing. The current research endeavor is centered on investigating the possibility of using sugar beet leaves as a natural source of dye for the purpose of dyeing cotton fabrics. Different extraction methods were utilized to isolate the bio-colorant present in sugar beet residual material, and the most favorable colorant yield was obtained using a 5% methanolic KOH solution. For optimal dyeing results, the cotton fabric performed dyeing for a duration of 45 min at a temperature of 60 °C, using a salt solution concentration of 6 g/100 mL and 50 mL of the extracted dye solution. Characterization of dye using Fourier transform infrared spectroscopy analysis confirmed the presence of quercetin in the leaf extract. For the creation of a range of color variations, mordants that were chemical in nature, such as tannic acid, iron sulfate, potassium dichromate, and copper sulfate, as well as mordants that were bio-based, such as onion peel, pomegranate peel, henna, golden shower bark, and turmeric, were employed in harmony. In comparison, the utilization of bio-mordants resulted in darker shades that exhibited enhanced color intensity and superior color fastness properties with the value of 4-5 for wash, 4 for wet rubbing, 4-5 for dry rubbing, and 4-5 for light. The findings of this study hold significant value in terms of ecofriendly waste management and contribute to advancements in the industrial sector by utilizing waste residual materials as a natural source of colorants.

在工业领域,植物残留物在纺织品染色生物着色剂的生产中备受关注。目前的研究工作主要是调查甜菜叶作为天然染料源用于棉织物染色的可能性。研究人员采用了不同的提取方法来分离甜菜残留物中的生物着色剂,其中以 5%甲醇 KOH 溶液的着色剂产量最高。为了获得最佳染色效果,棉织物在 60 °C 的温度下染色 45 分钟,使用的盐溶液浓度为 6 g/100 mL,提取的染料溶液为 50 mL。利用傅立叶变换红外光谱分析对染料进行表征,证实叶提取物中含有槲皮素。为了产生一系列颜色变化,化学媒染剂(如单宁酸、硫酸铁、重铬酸钾和硫酸铜)和生物媒染剂(如洋葱皮、石榴皮、指甲花、金银花树皮和姜黄)被协调使用。相比之下,使用生物媒染剂后,颜色更深,颜色强度更高,色牢度也更出色,水洗色牢度为 4-5,湿擦色牢度为 4,干擦色牢度为 4-5,浅色色牢度为 4-5。这项研究的结果在生态友好型废物管理方面具有重要价值,并通过利用废物残留材料作为天然着色剂来源,为工业领域的进步做出了贡献。
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引用次数: 0
Photoprotection-related properties of a raw extract from Gordonia hongkongensis EUFUS-Z928: A culturable rare actinomycete associated with the Caribbean octocoral Eunicea fusca. Gordonia hongkongensis EUFUS-Z928 提取物的光保护相关特性:一种可培养的稀有放线菌,与加勒比八瓣珊瑚Eunicea fusca有关。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241272454
Jeysson Sánchez-Suárez, Luisa Villamil, Ericsson Coy-Barrera, Luis Díaz

UV filters in current sunscreen formulations can have negative effects on human health, such as endocrine disruption and allergic reactions, as well as on the environment, including bioaccumulation and coral health toxicity. As a result, there is a need to find alternative compounds that serve as safer and more ecofriendly active ingredients. This study successfully isolated actinomycetes from the octocoral Eunicea fusca and assessed their potential as producers of photoprotective compounds. The use of bio-based chemical agents, particularly natural products, has been a highly effective strategy for discovering bioactive compounds, especially in marine invertebrates and their associated microbiota. Eighteen bacterial isolates were obtained and subsequently employed to prepare raw methanolic extracts from seven-day submerged cultures in Zobell marine broth. The resulting extracts were screened for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging capacity and characterized by total phenolic and flavonoid content measurements. After screening, the Gordonia hongkongensis EUFUS-Z928-derived raw extract exhibited the best antioxidant profile, i.e. DPPH and ABTS radical scavenging of 4.93 and 6.00 µmol Trolox per gram of extract, respectively, and selected for further photoprotection-related analysis. Thus, this extract demonstrated a UV-absorbing capacity of 46.33% of the in vitro sun protection factor calculated for 30 µg/mL oxybenzone but did not exhibit any cytotoxicity on human dermal fibroblasts (HDFa cell line) at concentrations up to 500 µg/mL. The liquid chromatography-mass spectrometry chemical characterization of this extract showed compounds with structural features associated with free radical scavenging and UV absorption (i.e. photoprotection-related activities). These findings highlighted the potential of the microbiota associated with E. fusca and confirmed the feasibility of exploiting its metabolites for photoprotection-related purposes.

目前防晒霜配方中的紫外线过滤剂会对人体健康产生负面影响,如干扰内分泌和过敏反应,也会对环境产生负面影响,包括生物蓄积性和珊瑚健康毒性。因此,有必要寻找可作为更安全、更环保的活性成分的替代化合物。这项研究成功地从章鱼Eunicea fusca中分离出放线菌,并评估了它们作为光保护化合物生产者的潜力。使用生物基化学制剂,特别是天然产品,一直是发现生物活性化合物的高效策略,尤其是在海洋无脊椎动物及其相关微生物群中。我们获得了 18 种细菌分离物,随后利用它们在 Zobell 海洋肉汤中进行为期 7 天的浸没培养,制备甲醇提取物原液。对所得提取物进行了 2,2-二苯基-1-苦基肼(DPPH)和 2,2'-偶氮-双(3-乙基苯并噻唑啉-6-磺酸)(ABTS)自由基清除能力筛选,并通过总酚和类黄酮含量测定对其进行表征。经过筛选,Gordonia hongkongensis EUFUS-Z928 提取物表现出最佳的抗氧化性,即每克提取物的 DPPH 和 ABTS 自由基清除能力分别为 4.93 和 6.00 µmol Trolox,并被选作进一步的光保护相关分析。因此,这种萃取物的紫外线吸收能力为体外防晒系数的 46.33%,而体外防晒系数是以 30 微克/毫升的羟苯甲酯计算得出的,但在浓度高达 500 微克/毫升时,它对人类真皮成纤维细胞(HDFa 细胞系)没有表现出任何细胞毒性。这种提取物的液相色谱-质谱化学特性分析表明,其化合物具有与清除自由基和吸收紫外线(即与光保护相关的活性)有关的结构特征。这些发现凸显了与 E. fusca 相关的微生物群的潜力,并证实了利用其代谢物实现光保护相关目的的可行性。
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引用次数: 0
Techno-economic analysis of off-grid hybrid wind-photovoltaic-battery power system by analyzing different batteries for the industrial plant in Shiraz Industrial Town, Iran. 通过分析伊朗设拉子工业城工业厂房的不同电池,对离网风力-光伏-电池混合发电系统进行技术经济分析。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241265003
Amin Jahed, Aria Abbaspour, Abolfazl Ahmadi

The world has moved toward renewable energy resources for three major reasons: (1) to mitigate climate change arising from the excessive emission of greenhouse gases, (2) to protect health by lowering greenhouse gas emissions, and (3) to meet ever-increasing demands for energy. Shiraz is a major city in Iran and struggles with pollution challenges due to the presence of highly polluting industries. The increased energy demand and the lack of a demand-supply trade-off have led to frequent power outages in Shiraz in recent years. Batteries have been of great interest to researchers as they have a wide range of compounds and variety in the market and strongly influence the function and initial costs of hybrid energy systems. This study models a hybrid renewable energy system using four different batteries, that is, lead-acid, Li-ion, vanadium redox, and zinc-bromine batteries. These four scenarios were subjected to techno-economic analysis in HOMER. The system was assumed to generate 3000 kW of industrial power and 300 kWh of office/domestic power. It was demonstrated that the hybrid system with the lead-acid battery was the most optimal system to supply power to the case-study industrial plant for both industrial and domestic load, with a levelized cost of energy of 0.47 USD/kWh and an initial cost of 6.02 million USD. However, the hybrid system with the Li-ion battery will become more optimal than the system with the lead-acid battery if Li-ion batteries continue to become more affordable in < 5 years. This system would decrease CO2 emissions by 1,060,133 kg every year as compared to the diesel system.

全球转向可再生能源有三大原因:(1) 缓解温室气体过度排放导致的气候变化,(2) 通过减少温室气体排放保护健康,(3) 满足日益增长的能源需求。设拉子是伊朗的一个主要城市,由于高污染工业的存在,该市正努力应对污染挑战。近年来,能源需求的增加和供需权衡的缺失导致设拉子市经常停电。研究人员对电池非常感兴趣,因为市场上的电池化合物种类繁多,对混合能源系统的功能和初始成本有很大影响。本研究使用四种不同的电池,即铅酸电池、锂离子电池、钒氧化还原电池和锌溴电池,对混合可再生能源系统进行建模。在 HOMER 中对这四种方案进行了技术经济分析。假定该系统可产生 3000 千瓦的工业电力和 300 千瓦时的办公/家用电力。结果表明,使用铅酸电池的混合动力系统是为案例研究中的工业厂房提供工业和生活用电的最佳系统,其平准化能源成本为 0.47 美元/千瓦时,初始成本为 602 万美元。然而,如果锂离子电池的价格在 < 5 年内继续降低,那么使用锂离子电池的混合动力系统将比使用铅酸电池的系统更为理想。与柴油系统相比,该系统每年可减少 1,060,133 千克二氧化碳排放量。
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引用次数: 0
Extremal properties of connected 4-cyclic graphs of a topological index related to chemical graphs. 与化学图谱相关的拓扑索引的连通四环图的极值特性。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241275374
Riffat Rehman, M Tariq Rahim, Haseeb Muzaffar, Fawad Hussain

Augmented Zagreb index (AZI) is an important vertex-degree-based topological index with many applications especially in chemistry. In this article, minimum value of AZI(G) is obtained and the corresponding extremal graph is characterized in the class of connected 4-cyclic graphs with seven or more vertices. These results can be used to characterize numerous chemical properties of chemical compounds having 4-cyclic structures.

增强萨格勒布指数(AZI)是一种重要的基于顶点度的拓扑指数,在化学领域有很多应用。本文获得了 AZI(G)的最小值,并描述了具有七个或七个以上顶点的连通四环图类中相应极值图的特征。这些结果可用于表征具有四环结构的化合物的许多化学特性。
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引用次数: 0
Exploring influencing factors and predictive analysis of sarcopenia in the Chinese population using the body composition analyzer. 利用人体成分分析仪探讨中国人群肌肉疏松症的影响因素和预测分析。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241257047
Shaotian Li, Jingfeng Zou, Liping Wang, Guqiao Nie, Wen Peng

Objective: Employing body composition analysis, this study aims to examine the influencing factors and conduct predictive analysis regarding sarcopenia incidence in the middle-aged and elderly population in China.

Methods: This study recruited inpatients from the General Medicine Department of Tongji Medical College Affiliated Union Hospital, Huazhong University of Science and Technology, as the subjects for a single-center retrospective study. Diagnosis was conducted according to the 2019 criteria from the Asian Working Group for Sarcopenia. Binary logistic regression analysis was utilized to identify factors influencing sarcopenia, and predictive modeling for sarcopenia occurrence was performed based on the area under the ROC curve (AUC).

Results: This study comprised 1258 hospitalized patients, of whom 340 were diagnosed with sarcopenia and 918 were not, resulting in a prevalence of 27%. The baseline characteristics showed statistically significant differences between the two groups. Binary logistic regression analysis revealed that low protein, low total body water, low minerals, low basal metabolic rate, and age were risk factors for sarcopenia (OR > 1, P < 0.05). Conversely, being male, having a higher BMI, greater fat-free mass index, and a higher InBody score were identified as protective factors against sarcopenia (OR < 1, P < 0.05). The AUC values for predicting sarcopenia occurrence based on low protein, low total body water, low minerals, low basal metabolic rate, and age were 0.871, 0.846, 0.757, 0.645, and 0.649, respectively, indicating their significance as predictive indicators. Combining these five indicators into a new predictive model for sarcopenia yielded an area under the curve (AUC) value of 0.932, demonstrating excellent sensitivity and specificity concurrently.

Conclusion: The results of body composition analysis indicate that sarcopenia occurrence in the middle-aged and elderly population in China is associated with factors such as low protein, low total body water, low minerals, low basal metabolic rate, age, gender, BMI, fat-free mass index, and InBody score. The combination of specific body composition indicators facilitates the effective prediction of sarcopenia. Clinical practitioners should proactively identify the risk factors influencing sarcopenia, accurately predict.

摘要本研究采用身体成分分析方法,探讨中国中老年人群肌肉疏松症发病率的影响因素并进行预测分析:本研究以华中科技大学同济医学院附属协和医院全科医学科住院患者为研究对象,进行单中心回顾性研究。诊断根据亚洲肌少症工作组的 2019 年标准进行。研究采用二元逻辑回归分析来确定肌少症的影响因素,并根据ROC曲线下面积(AUC)对肌少症的发生进行预测建模:这项研究包括 1258 名住院患者,其中 340 人被诊断为肌少症,918 人未被诊断为肌少症,患病率为 27%。两组患者的基线特征在统计学上存在显著差异。二元逻辑回归分析显示,低蛋白、低体内总水分、低矿物质、低基础代谢率和年龄是导致肌肉疏松症的风险因素(OR > 1,P 结论):身体成分分析结果表明,中国中老年人群发生肌少症与低蛋白、低总水分、低矿物质、低基础代谢率、年龄、性别、体重指数、无脂质量指数和 InBody 评分等因素有关。结合特定的身体成分指标可有效预测肌肉疏松症。临床医师应主动识别影响肌肉疏松症的风险因素,准确预测。
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引用次数: 0
The distribution of the extrachromosomal DNA molecules in early lung cancer. 早期肺癌中染色体外 DNA 分子的分布。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241276771
Jianfei Fang, Lisha Ying, Zhengxiao Ma, Ying Yang, Rui Zhu, Dan Su

Lung cancer (LC) is a highly lethal cancer worldwide. Research on the distribution and nature of extrachromosomal DNA molecules (EcDNAm) in early LC is scarce. In this study, after removing linear DNA and mitochondrial circular DNA, EcDNAm were extracted from two paired LC tissue samples and amplified using rolling circle amplification. High throughput extrachromosomal DNA (EcDNA) or RNA sequencing and bioinformatics analysis were subsequently utilized to explore the distribution and nature of the EcDNAm. Additionally, to elucidate the role of oncogenes with large EcDNAm sizes, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed. The RNA sequencing results revealed significant differences in certain genes between tumors and corresponding normal samples. At the same time, slight distinctions were observed between relapsed and non-relapsed tumor samples. The nature of the EcDNAm was compared between LC samples and matched normal samples. There was a tendency for the number of EcDNAm with longer size (EcDNA) and its containing driver oncogenes to be higher in cancer samples. Enrichment analysis of the cancer samples revealed enrichment in biological processes, such as positive regulation of protein localization, axon development, and in-utero embryonic development. This study highlights the universal distribution and characteristics of EcDNAm in early LC. Moreover, our work fills the investigation of the EcDNAm gap and future studies should focus on the application of EcDNA as a potential biomarker in patients with early LC.

肺癌(Lung cancer,LC)是全球致死率极高的癌症。有关早期肺癌中染色体外DNA分子(EcDNAm)的分布和性质的研究很少。在这项研究中,在去除线性DNA和线粒体环状DNA后,从两个配对的肺癌组织样本中提取了EcDNAm,并使用滚圆扩增法进行扩增。随后利用高通量染色体外DNA(EcDNA)或RNA测序和生物信息学分析来探索EcDNAm的分布和性质。此外,为了阐明EcDNAm较大的癌基因的作用,还进行了基因本体论和京都基因组百科全书的通路分析。RNA 测序结果显示,肿瘤和相应正常样本中的某些基因存在显著差异。同时,复发和非复发肿瘤样本之间也有细微差别。比较了 LC 样本和匹配的正常样本中 EcDNAm 的性质。在癌症样本中,大小较长的 EcDNAm(EcDNA)及其包含的驱动癌基因的数量有增加的趋势。对癌症样本进行的富集分析表明,在蛋白质定位的正调控、轴突发育和胎儿胚胎发育等生物过程中都存在富集现象。这项研究强调了 EcDNAm 在早期 LC 中的普遍分布和特征。此外,我们的研究填补了 EcDNAm 研究的空白,未来的研究应关注 EcDNA 作为潜在生物标志物在早期 LC 患者中的应用。
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引用次数: 0
Innovative entrepreneurial market trend prediction model based on deep learning: Case study and performance evaluation. 基于深度学习的创新创业市场趋势预测模型:案例研究与性能评估。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241272722
Kongyao Huang, Yongjun Zhou, Xiehua Yu, Xiaohong Su

In the current economic landscape, the growing importance of innovation and entrepreneurship underscores an urgent need for accurate market trend prediction. Addressing this challenge, our study introduces an innovative entrepreneurial market trend prediction model based on deep learning principles. Through detailed case studies and performance evaluations, this paper demonstrates the model's effectiveness and its potential to enhance decision-making capabilities in a competitive business environment. Accurate market trend prediction is crucial in the fields of innovation and entrepreneurship, and our approach meets this demand. Our model leverages the power of deep learning technology, combining historical market data with diverse market indicators, including sentiment analysis derived from social media, to create an advanced predictive model that surpasses traditional methods. By analyzing data from multiple channels, our model exhibits exceptional accuracy in forecasting future market trends. The case study provides strong evidence of our model's performance and precision, showcasing its significant support for innovators and entrepreneurs navigating complex market trends. Furthermore, this study highlights the vast potential of deep learning technology in the economic sector. We emphasize the importance of developing innovative entrepreneurial market trend prediction models and foresee an increase in project success rates for innovators and entrepreneurs by enhancing decision quality through the adoption of deep learning.

在当前的经济形势下,创新和创业的重要性日益凸显,因此迫切需要准确的市场趋势预测。针对这一挑战,我们的研究引入了基于深度学习原理的创新创业市场趋势预测模型。通过详细的案例研究和性能评估,本文展示了该模型的有效性及其在竞争激烈的商业环境中提高决策能力的潜力。准确的市场趋势预测在创新和创业领域至关重要,我们的方法满足了这一需求。我们的模型利用了深度学习技术的力量,将历史市场数据与各种市场指标(包括从社交媒体中获得的情感分析)相结合,创建了一个超越传统方法的先进预测模型。通过分析来自多个渠道的数据,我们的模型在预测未来市场趋势方面表现出了非凡的准确性。该案例研究有力地证明了我们模型的性能和精确度,展示了它对创新者和企业家驾驭复杂市场趋势的重要支持。此外,这项研究还凸显了深度学习技术在经济领域的巨大潜力。我们强调了开发创新型创业市场趋势预测模型的重要性,并预计通过采用深度学习提高决策质量,创新者和创业者的项目成功率将会提高。
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引用次数: 0
Nuclear factor Y, a key player in neuronal gene regulation. 核因子 Y,神经元基因调控的关键角色。
IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1177/00368504241264998
Pedro Moreira, Roger Pocock

Establishing a functional nervous system is a complex process requiring tightly controlled gene expression programs to achieve the correct differentiation of distinct neuronal subtypes. The molecular programs required for neurons to acquire neuron-type-specific, and core pan-neuronal features mostly rely on sequence-specific transcription factors (TFs), which recognize and bind to cis-regulatory motifs present in the promoters of target genes. Recently, we investigated the role and mode of action of the NF-Y complex, a ubiquitously expressed transcriptional master regulator, in the Caenorhabditis elegans nervous system. We found that NFYA-1 is a pervasive regulator of neuron-specific and pan-neuronal gene batteries that are essential for neuronal development and function. Furthermore, we concluded that NFYA-1 acts cell autonomously by either directly binding to conserved motifs in target gene promoter regions or indirectly by regulating other transcriptional regulators to fine-tune gene expression. However, further studies are required to fully define the impact of the NF-Y complex on nervous system regulatory networks and how NF-Y coordinates with other TFs in this regard.

建立功能神经系统是一个复杂的过程,需要严格控制基因表达程序,以实现不同神经元亚型的正确分化。神经元获得神经元类型特异性和泛神经元核心特征所需的分子程序主要依赖于序列特异性转录因子(TFs),它们能识别并结合靶基因启动子中的顺式调控基序。最近,我们研究了NF-Y复合物(一种普遍表达的转录主调节因子)在草履虫神经系统中的作用和作用模式。我们发现,NFYA-1 是神经元特异性和泛神经元基因组的普遍调控因子,对神经元的发育和功能至关重要。此外,我们还得出结论,NFYA-1通过直接与目标基因启动子区域的保守基团结合或间接调节其他转录调节因子来微调基因表达,从而发挥细胞自主作用。然而,要全面确定 NF-Y 复合物对神经系统调控网络的影响以及 NF-Y 在这方面如何与其他 TF 相互协调,还需要进一步的研究。
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