Science Progress最新文献_第6页

TVGCN: Time-varying graph convolutional networks for multivariate and multifeature spatiotemporal series prediction TVGCN：用于多变量和多特征时空序列预测的时变图卷积网络

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-09-14 DOI: 10.1177/00368504241283315

Feiyan Sun, Wenning Hao, Ao Zou, Kai Cheng

Spatiotemporal (ST) graph modeling has garnered increasing attention recently. Most existing methods rely on a predefined graph structure or construct a single learnable graph throughout training. However, it is challenging to use a predefined graph structure to capture dynamic ST changes effectively due to evolving node relationships over time. Furthermore, these methods typically utilize only the original data, neglecting external temporal factors. Therefore, we put forward a novel time-varying graph convolutional network model that integrates external factors for multifeature ST series prediction. Firstly, we construct a time-varying adjacency matrix using attention to capture dynamic spatial relationships among nodes. The graph structure adapts over time during training, validation, and testing phases. Then, we model temporal dependence by dilated causal convolution, leveraging gated activation unit and residual connection. Notably, the prediction accuracy is enhanced through the incorporation of embedding absolute time and the fusion of multifeature. This model has been applied to three real-world multifeature datasets, achieving state-of-the-art performance in all cases. Experiments show that the method has high accuracy and robustness when applied to multifeature and multivariate ST series problems.

时空（ST）图建模近来受到越来越多的关注。现有的大多数方法都依赖于预定义的图结构，或者在整个训练过程中构建一个单一的可学习图。然而，由于节点关系会随着时间的推移而不断演变，因此使用预定义的图结构来有效捕捉动态的 ST 变化具有挑战性。此外，这些方法通常只利用原始数据，忽略了外部时间因素。因此，我们提出了一种新颖的时变图卷积网络模型，该模型整合了外部因素，用于多特征 ST 序列预测。首先，我们利用注意力构建时变邻接矩阵，捕捉节点之间的动态空间关系。在训练、验证和测试阶段，图结构会随时间而调整。然后，我们利用门控激活单元和残差连接，通过扩张因果卷积对时间依赖性进行建模。值得注意的是，通过嵌入绝对时间和融合多特征，预测的准确性得到了提高。该模型已被应用于三个真实世界的多特征数据集，在所有情况下都达到了最先进的性能。实验表明，该方法在应用于多特征和多变量 ST 序列问题时具有很高的准确性和鲁棒性。

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引用次数: 0

The impact of the Cochlear™ Osia® 2 System on patients with mixed or conductive hearing loss: A comparison with Cochlear™ Baha® Attract System outcomes 科利耳™ Osia® 2 系统对混合性或传导性听力损失患者的影响：与科利耳™ Baha® Attract 系统效果的比较

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-09-12 DOI: 10.1177/00368504241280252

Kyeong-Suk Park, Hong-Chan Kim, Sungsu Lee, Hyong-Ho Cho

ObjectiveThis prospective study assessed the efficacy of the Cochlear™ Osia® 2 System compared to the previous Baha® Attract System in patients with mixed or conductive hearing loss (MHL/CHL).MethodsIn this prospective case-control study, 10 patients (2 men and 8 women) with MHL/CHL were implanted with the Osia® 2 System. Their audiological outcomes were compared with 13 patients (2 men and 11 women) who had previously been implanted with the transcutaneous Baha® Attract system. We compared the complications and compliance of the two groups. Also, in the Osia 2 System group, subjective satisfaction was assessed using the Korean version of the International Outcome Inventory for Hearing Aids (K-IOI-HA) questionnaire and the Abbreviated Profile of Hearing Aid Benefit (APHAB) questionnaire.ResultsComplications such as poor magnetization, pain & infection, and abnormal noise were more common in the Baha Attract group, although not statistically significant. Also, the Osia 2 group exhibited better compliance. Subjective satisfaction was assessed using the K-IOI-HA and APHAB questionnaires with the Osia 2 group, revealing significantly improved scores in ease of communication, reverberation, background noise, and higher K-IOI-HA scores post-implantation. Postoperative-aided thresholds with both systems were significantly lower than preoperative-unaided thresholds, with the Osia 2 System demonstrating notably high satisfaction levels. Although both systems showed similar preoperative and postoperative word-recognition scores, the Osia 2 System provided greater audiological gain, especially at 2 kHz and 4 kHz frequencies. Additionally, the functional gain of both systems was comparable across all frequencies.ConclusionsThe Osia 2 System demonstrated high subjective satisfaction and improved audiological outcomes compared to the Baha Attract system in patients with conductive or mixed hearing loss. Its superior audiological gain, particularly at critical frequencies, along with better compliance, suggests it as a favorable option for this patient population.

方法在这项前瞻性病例对照研究中，10 名 MHL/CHL 患者（2 名男性和 8 名女性）植入了 Osia® 2 系统。他们的听力结果与之前植入经皮 Baha® Attract 系统的 13 名患者（2 名男性和 11 名女性）进行了比较。我们比较了两组患者的并发症和依从性。此外，在 Osia 2 系统组中，我们还使用韩文版国际助听器结果量表（K-IOI-HA）问卷和助听器效益简表（APHAB）问卷评估了患者的主观满意度。结果Baha Attract 组中磁化不良、疼痛、感染和异常噪音等并发症更为常见，但无统计学意义。此外，Osia 2 组的依从性更好。使用 K-IOI-HA 和 APHAB 问卷对 Osia 2 组的主观满意度进行了评估，结果显示，植入后，Osia 2 组在沟通便利性、混响、背景噪声方面的得分明显提高，K-IOI-HA 得分也更高。两种系统的术后辅助阈值均明显低于术前无辅助阈值，Osia 2 系统的满意度明显较高。虽然两种系统的术前和术后单词识别评分相似，但 Osia 2 系统的听力增益更大，尤其是在 2 kHz 和 4 kHz 频率上。结论与 Baha Att 系统相比，Osia 2 系统对传导性或混合性听力损失患者的主观满意度高，听力效果更好。其卓越的听觉增益（尤其是在临界频率）和更好的顺应性表明，它是这类患者的一个有利选择。

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引用次数: 0

A large thrombus within a giant coronary artery aneurysm in a child with Kawasaki disease: A case report 川崎病患儿巨大冠状动脉瘤内的大血栓：病例报告

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-09-12 DOI: 10.1177/00368504241284151

Nan Wang, Haiyong Wang

Kawasaki disease (KD) is an acute systemic vasculitis that preferentially involves coronary arteries in young children, and predominantly affects young children. Cardiovascular lesions are the most severe complications of this disease. Even though giant aneurysms are rare, they can complicate thrombus formation, leading to myocardial ischemia, myocardial infarction, and even cardiac death. Later in life, it can lead to steno-occlusive lesions. Follow-up led to coronary artery stenosis. In this article, we report a case of a pediatric patient with KD who presented with a large thrombus within a giant coronary aneurysm as a consequence of delayed treatment with intravenous immunoglobulin (IVIG) and IVIG resistance, which contributed to the formation of coronary artery lesions. Transthoracic echocardiography is a valuable tool for detecting coronary artery abnormalities; however, computed tomography coronary angiography is valuable for precisely delineating coronary anatomy and complications. It is important to maintain a slightly higher international normalized ratio to decrease the risk of thrombosis in coronary artery aneurysms.

川崎病（KD）是一种急性全身性血管炎，主要累及幼儿的冠状动脉。心血管病变是该病最严重的并发症。尽管巨大动脉瘤很少见，但会并发血栓形成，导致心肌缺血、心肌梗死，甚至心源性死亡。晚期可导致狭窄闭塞病变。随访导致冠状动脉狭窄。本文报告了一例儿童 KD 患者，由于延迟静脉注射免疫球蛋白（IVIG）治疗和 IVIG 耐药，导致冠状动脉病变形成，患者出现巨大冠状动脉瘤内的大血栓。经胸超声心动图是检测冠状动脉异常的重要工具；然而，计算机断层扫描冠状动脉造影术对精确划分冠状动脉解剖结构和并发症很有价值。保持稍高的国际正常化比率对降低冠状动脉瘤血栓形成的风险非常重要。

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引用次数: 0

Adaptive neuro-fuzzy inference control for active stabilizer bars based on multiple data sources 基于多数据源的主动稳定杆自适应神经模糊推理控制

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-09-10 DOI: 10.1177/00368504241274976

Tuan Anh Nguyen

In this research, we propose using active stabilizer bars to prevent rollover when steering. An intelligent control solution, the adaptive neuro-fuzzy inference system (ANFIS), is established in this article to control the performance of the active anti-roll systems. In contrast to the previously published studies, the intelligent algorithm designed in this research has many outstanding advantages, such as generating a large impact force, a fast response time, a small phase difference, and high convergence ability. The data used to train ANFIS are carefully selected and combined from the previous studies. The initial simulation observes that the roll angle decreases significantly from 8.15° to 6.87° when the ANFIS algorithm is applied to regulate the anti-roll bars. In contrast, the roll angles for the proportional-integral-derivative (PID) and passive (Mechanical) situations are respectively recorded at 7.08° and 7.80°. The reduction of the vertical force at wheels is also solved when the ANFIS algorithm is applied instead of other methods. This value increases sharply from 671.06 N (without bars) to 3030.40 N (ANFIS control), while it only reaches 2544.27 N (PID control) and 1428.83 N (mechanical bars), according to the research findings. If the vehicle does not have the anti-roll bars, a rollover occurs in the second case when the vehicle steers at v3 (80 km/h) and v4 (90 km/h). In contrast, the interaction between the wheels and the road is well maintained when the automobile is equipped with active bars controlled by the ANFIS solution. This is demonstrated by the minimum vertical force value in the rear wheel, which reaches 2687.33 and 2447.33 N, respectively, for the abovementioned conditions. In general, the vehicle's rolling stability can be well guaranteed in all moving situations when using the ANFIS controller for the anti-roll system in the vehicle.

在这项研究中，我们建议使用主动稳定杆来防止转向时发生侧翻。本文建立了一种智能控制方案--自适应神经模糊推理系统（ANFIS），用于控制主动防侧倾系统的性能。与之前发表的研究相比，本研究设计的智能算法具有许多突出优势，如产生的冲击力大、响应时间快、相位差小、收敛能力强等。用于训练 ANFIS 的数据是从之前的研究中精心挑选和组合的。初步模拟观察到，当采用 ANFIS 算法调节防倾杆时，侧倾角从 8.15° 显著减小到 6.87°。相比之下，比例积分派生（PID）和被动（机械）情况下的侧倾角分别为 7.08°和 7.80°。当采用 ANFIS 算法而不是其他方法时，车轮垂直力的减少也得到了解决。根据研究结果，该值从 671.06 N（无防撞杆）急剧增加到 3030.40 N（ANFIS 控制），而仅达到 2544.27 N（PID 控制）和 1428.83 N（机械防撞杆）。如果车辆没有防倾杆，在第二种情况下，当车辆以 v3（80 km/h）和 v4（90 km/h）转向时，就会发生侧翻。与此相反，当汽车装有由 ANFIS 解决方案控制的主动防滚架时，车轮与路面之间的相互作用得以很好地保持。在上述条件下，后轮的最小垂直力值分别为 2687.33 牛顿和 2447.33 牛顿，就证明了这一点。总体而言，使用 ANFIS 控制器控制汽车防侧倾系统时，汽车在所有行驶情况下的滚动稳定性都能得到很好的保证。

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引用次数: 0

Mid-term outcomes of different treatments of internal iliac artery in endovascular aneurysm repair 血管内动脉瘤修补术中髂内动脉不同治疗方法的中期疗效

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-09-10 DOI: 10.1177/00368504241274998

Jie Ji, Jiaxue Bi, Yonghui Chen, Xiaoxing Zhang, Bin Zhao, Hao Liang, Jibo Fan, Xiangchen Dai

ObjectiveTo evaluate the mid-term outcomes of different treatment strategies for the internal iliac artery (IIA) during EVAR.MethodsThis was a retrospective study. All patients undergoing EVAR, who required treatment of at least one side of IIA from January 2013 to July 2022 in a single center, were included. According to the different treatment strategies for IIA, the patients were divided into UP (unilateral preservation), BP (bilateral preservation) and BE (bilateral embolization) groups. The primary outcomes included buttock claudication, bowel ischemia and iliac-related reintervention. Then patients who underwent IIA reconstruction were divided into IPG (iliac parallel stent graft) and IBG (iliac branch stent graft) groups according to the reconstruction technique. The primary outcomes included endoleak, iliac branch occlusion and iliac-related reintervention.ResultsA total of 237 patients were included, including 167 in the UP group, 9 in the BP group and 61 in the BE group. The mean follow-up time was 39.0 ± 27.7, 50.0 ± 22.1 and 25.8 ± 18.9 months in UP, BP and BE groups, respectively. Thirty cases (12.7%) of buttock claudication occurred, and it was significantly higher in the BE group than the UP group (26.2% vs. 7.8%, p < 0.001). There were no significant differences in the other follow-up outcomes among three groups. The K–M analysis indicated that the patients in the BE group had a lower survival rate than those in the other two groups (p = 0.024). 24 patients underwent IIA reconstruction, including 8 in the IPG group and 16 in the IBG group. The endoleak in the IBG group was significantly lower than that in the IPG group (0% vs. 25.0%, p = 0.041). The iliac-related reintervention, iliac occlusion and mortality were similar between the two groups.ConclusionOverall it is beneficial for patients to preserve at least one side of IIA during EVAR as much as possible. Compared with IPG, IBG might be more applicable for IIA reconstruction.

目的评价 EVAR 期间髂内动脉（IIA）不同治疗策略的中期疗效。纳入2013年1月至2022年7月在一个中心接受EVAR手术的所有患者，这些患者至少需要治疗一侧髂内动脉。根据IIA的不同治疗策略，患者被分为UP（单侧保留）组、BP（双侧保留）组和BE（双侧栓塞）组。主要结果包括臀部跛行、肠缺血和髂骨相关再介入。然后，根据重建技术将接受IIA重建的患者分为IPG（髂平行支架移植）组和IBG（髂支支架移植）组。结果共纳入 237 例患者，其中 UP 组 167 例，BP 组 9 例，BE 组 61 例。UP组、BP组和BE组的平均随访时间分别为（39.0 ± 27.7）、（50.0 ± 22.1）和（25.8 ± 18.9）个月。发生臀部跛行的病例有 30 例（12.7%），BE 组明显高于 UP 组（26.2% 对 7.8%，P < 0.001）。三组患者的其他随访结果无明显差异。K-M分析表明，BE组患者的存活率低于其他两组（P = 0.024）。24 名患者接受了 IIA 重建，其中 IPG 组 8 人，IBG 组 16 人。IBG 组的内漏率显着低于 IPG 组（0% 对 25.0%，P = 0.041）。两组患者的髂骨相关再介入、髂骨闭塞和死亡率相似。与 IPG 相比，IBG 可能更适用于 IIA 重建。

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引用次数: 0

Drug-related problems in elective surgical inpatients: A retrospective study 择期手术住院患者的药物相关问题：回顾性研究

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-08-07 DOI: 10.1177/00368504241263534

Clara Simon, Olaf Rose, Karin Kanduth, Johanna Pachmayr, Stephanie Clemens

Objectives:Patients with drug-related problems are at high risk for perioperative complications. The study aimed to determine the prevalence, number, characteristics, clinical significance and the involved drugs of drug-related problems in inpatients, who were admitted to elective surgery, as well as their burden of comorbidity.Methods:The study design was a retrospective, observational study across nine different surgical sites. Patients at admission for elective surgery with ≥ 1 drug-related problem, a hospital stay of ≥ 24 h and at age ≥ 18 years were included. The outcomes of interest were the prevalence and nature of drug-related problems, assessed by pharmacists at hospital admission. The Pharmaceutical Network Europe classification V9.1, the Hatoum scale of clinical significance, the Anatomical-Therapeutic-Chemical classification scheme of the World Health Organization were engaged to categorize drug-related problems and their clinical significance. The Charlson Comorbidity Index was applied to assess the comorbidity of participants.Results:The final data set included 11,176 elective surgical inpatients. Of these, a sample of 284 (2.54%) patients was analysed. It was found that 9.89% of the patients showed at least one drug-related problem (average 1.43, SD 0.7). Major causes were drug-drug interactions (30.3%) and supra-therapeutic doses (18.0%). Most drug-related problems were referred to a prescriber for intervention (61.3%). Eighty-two percent of drug-related problems were rated as clinically significant. Cardiovascular drugs were of major concern. Participants’ most common comorbidities were tumour diagnosis (34%), diabetes mellitus with end organ damage (26%) and peripheral vascular diseases (19%).Conclusions:Although the prevalence of drug-related problems in this diverse study population was low, drug-related problems were of great importance in terms of their cause and clinical significance. Patients with drug-related problems showed a moderate burden of physiological illness. Study results suggest a need to identify exposed patients with drug-related problems.

目的：存在药物相关问题的患者是围手术期并发症的高危人群。该研究旨在确定住院择期手术患者药物相关问题的发生率、数量、特征、临床意义和涉及的药物，以及他们的合并症负担。研究对象包括入院接受择期手术的患者，这些患者都存在≥1个与药物相关的问题，住院时间≥24小时，年龄≥18岁。药剂师在患者入院时对其药物相关问题的发生率和性质进行了评估。欧洲药学网络分类 V9.1、Hatoum 临床意义量表、世界卫生组织解剖-治疗-化学分类计划被用来对药物相关问题及其临床意义进行分类。结果：最终数据集包括 11,176 名择期手术住院患者。对其中 284 例（2.54%）患者进行了抽样分析。结果发现，9.89% 的患者至少出现过一次与药物相关的问题（平均 1.43 次，标准差 0.7 次）。主要原因是药物相互作用（30.3%）和超治疗剂量（18.0%）。大多数与药物有关的问题都交由处方医生进行干预（61.3%）。82%的药物相关问题被评为具有临床意义。心血管药物是主要问题。参与者最常见的合并症是肿瘤诊断（34%）、糖尿病合并终末器官损伤（26%）和外周血管疾病（19%）。结论：尽管在这一多样化的研究人群中，药物相关问题的发生率较低，但就其原因和临床意义而言，药物相关问题非常重要。有药物相关问题的患者表现出中等程度的生理疾病负担。研究结果表明，有必要识别暴露于毒品相关问题的患者。

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引用次数: 0

Electrodiagnosis of polyneuropathy, organmegaly, endocrinopathy, M-protein, skin changes syndrome patients with peripheral neuropathy and potential-related risk factors 多发性神经病、器官异常、内分泌病、M 蛋白、周围神经病变患者皮肤变化综合征的电诊断及潜在的相关风险因素

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-07-23 DOI: 10.1177/00368504241264989

Guanru Niu, Yuchen Liu, Zhen Zhang, Siyuan Song, Tian Li, Yijun Shen, Jihong Dong

Objectives:To explore the correlation between classification and electrophysiology of polyneuropathy, organmegaly, endocrinopathy, M-protein, skin changes syndrome (POEMS)-related peripheral neuropathy (PN).Methods:We analyzed the data of 30 POEMS patients admitted to Zhongshan Hospital affiliated with Fudan University between February 2017 and February 2023. The degree of PN was determined according to its classification. All three groups of patients underwent neuroelectromyography, and the nerve conduction velocity and amplitude of the three groups were analyzed.Results:The compound motor active potentials (CMAP) of the peroneal, tibial, and ulnar nerves decreased significantly with increasing disease grade, and the motor conduction velocity of the peroneal, median, and tibial nerves decreased significantly in grade 3 compared with grade 1 and 2. The action potential of sensory nerves (sensory nerve action potential) and the conduction speed of sensory impulses (sensory conduction velocity (SCV) in the sural nerve in grade 3 were significantly lower than those in grades 1 and 2. Linear regression analysis showed that there was a linear correlation between CMAP of peroneal nerve and vascular endothelial growth factor. The SCV of the ulnar nerve significantly correlated with the course of the disease.Discussion:Neuroelectromyography can effectively evaluate the degree of PN in patients with POEMS, providing a reliable reference for further clinical treatment.

目的：探讨多发性神经病、器官异常、内分泌病、M蛋白、皮肤改变综合征（POEMS）相关周围神经病变（PN）的分类与电生理学之间的相关性。方法：我们分析了复旦大学附属中山医院在2017年2月至2023年2月期间收治的30例POEMS患者的数据。PN的程度根据其分类确定。结果：随着疾病分级的增加，腓总神经、胫神经和尺神经的复合运动活动电位（CMAP）明显下降，腓总神经、正中神经和胫神经的运动传导速度3级较1级和2级明显下降。感觉神经的动作电位（感觉神经动作电位）和感觉冲动的传导速度（感觉传导速度（SCV））在 3 级明显低于 1 级和 2 级。线性回归分析表明，腓总神经的 CMAP 与血管内皮生长因子呈线性相关。讨论：神经肌电图能有效评估 POEMS 患者的腓总神经损伤程度，为进一步临床治疗提供可靠的参考。

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引用次数: 0

Combined underwater endoscopic and microscopic surgery for tympanic paraganglioma: A case report. 鼓室旁神经管瘤水下内窥镜和显微镜联合手术：病例报告。

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-07-01 DOI: 10.1177/00368504241263524

Yusuke Takata, Takashi Anzai, Kenji Sonoda, Hiroko Okada, Erina Ishimizu, Masahiro Nakamura, Satoshi Hara, Takumi Nakayama, Fumihiko Matsumoto

The resection of middle ear paragangliomas can be challenging given their vascular nature and the small volume of the tympanic cavity, particularly when the tumor in the hypotympanum is close or attached to the internal carotid artery (ICA). We performed combined underwater endoscopic and microscopic surgery for a Class B1 middle ear paraganglioma according to the modified Fisch classification. The suspicious bone in the hypotympanum and around the petrous ICA was drilled with underwater endoscopy. The feeding arteries, the caroticotympanic and inferior tympanic arteries, were suctioned and cauterized under microscopy. To the best of our knowledge, no case of middle ear paraganglioma treated with underwater endoscopy has been reported. Underwater endoscopy, providing a clear operative field with blood and bone dust irrigation, is a good indication for middle ear paragangliomas. In contrast, microscopic preparation for unexpected bleeding is important, particularly when the tumor closely extends to vital structures, such as the ICA or the jugular bulb.

鉴于中耳副神经节瘤的血管性质和鼓室的狭小容积，切除中耳副神经节瘤具有挑战性，尤其是当下鼓室的肿瘤靠近或附着于颈内动脉（ICA）时。根据改良的 Fisch 分类法，我们对 B1 级中耳副神经节瘤进行了水下内窥镜和显微镜联合手术。我们在水下内窥镜下钻取了下鼓室和隐窝 ICA 周围的可疑骨头。在显微镜下抽吸并烧灼了供血动脉、鼓室动脉和下鼓室动脉。据我们所知，还没有用水下内窥镜治疗中耳副神经节瘤的病例报道。水下内窥镜可提供清晰的手术视野，并可进行血液和骨粉灌洗，是中耳副神经节瘤的良好适应症。相比之下，显微镜下的准备工作对意外出血非常重要，尤其是当肿瘤紧贴重要结构时，如 ICA 或颈静脉球。

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引用次数: 0

Revisiting Rorschach test and Minnesota Multiphasic Personality Inventory-II patterns in Kraepelinian vs. DSM-wise Schizophrenia: How They Differ and What It Means for Diagnosis. 重新审视克雷佩林精神分裂症与 DSM 精神分裂症的罗夏克测试和明尼苏达多相人格清单-II 模式：它们之间的差异及其对诊断的意义。

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-07-01 DOI: 10.1177/00368504241266366

Young Tak Jo, Myung Joo Lee, Ji Soo Lee, Yeon Ho Joo

Objective: This retrospective chart review study aimed to investigate the differences in the Rorschach test and Minnesota Multiphasic Personality Inventory (MMPI)-II profiles among patients with Kraepelinian schizophrenia, those with DSM-wise schizophrenia, and controls. Kraepelinian schizophrenia is characterised by a chronic, deteriorative disease course and a predominance of negative symptoms.

Methods: Patients with Kraepelinian schizophrenia were selected based on medical record reviews. We then compared their Rorschach test and MMPI-II results with those of the DSM-wise schizophrenia group and the control group.

Results: The Rorschach test revealed a significant increase in DV2 score and a decrease in D score in patients with Kraepelinian schizophrenia compared to those with DSM-wise schizophrenia. In the MMPI-II profiles, patients with Kraepelinian schizophrenia exhibited an elevated L relative to those with DSM-wise schizophrenia.

Conclusion: Our results suggested the value of revisiting psychological tests in clinically delineated subgroups, such as Kraepelinian schizophrenia. Although patients fall under the same diagnostic category of schizophrenia, considering different phenotypes is important when interpreting psychological test outcomes. Additionally, our study indicated that both schizophrenia groups did not show as many abnormalities as expected compared to controls. This highlights the potential value of revisiting established profiles of certain psychological tests and calls for further research on other psychological tests.

研究目的这项回顾性病历研究旨在调查克雷伯林型精神分裂症患者、DSM-Wise 精神分裂症患者和对照组患者在罗夏测验和明尼苏达多相人格量表（MMPI）-II 资料方面的差异。克雷伯精神分裂症的特点是慢性、恶化的病程和阴性症状为主：方法：我们根据病历审查筛选出克拉佩利精神分裂症患者。然后，我们将他们的罗夏测验和 MMPI-II 结果与 DSM-wise精神分裂症组和对照组的结果进行了比较：结果：罗夏克测验显示，与 DSM-明智型精神分裂症患者相比，克拉佩林型精神分裂症患者的 DV2 得分显著增加，D 得分显著降低。在 MMPI-II 分析中，克拉佩利精神分裂症患者的 L 值高于 DSM-wise精神分裂症患者：我们的研究结果表明，在临床上划分的亚组（如克雷伯林型精神分裂症）中重新进行心理测试具有重要价值。虽然患者属于同一精神分裂症诊断类别，但在解释心理测试结果时，考虑不同的表型非常重要。此外，我们的研究表明，与对照组相比，两组精神分裂症患者并没有表现出预期的那么多异常。这凸显了重新审视某些心理测试既定特征的潜在价值，并呼吁对其他心理测试开展进一步研究。

{"title":"Revisiting Rorschach test and Minnesota Multiphasic Personality Inventory-II patterns in Kraepelinian vs. DSM-wise Schizophrenia: How They Differ and What It Means for Diagnosis.","authors":"Young Tak Jo, Myung Joo Lee, Ji Soo Lee, Yeon Ho Joo","doi":"10.1177/00368504241266366","DOIUrl":"10.1177/00368504241266366","url":null,"abstract":"Objective: This retrospective chart review study aimed to investigate the differences in the Rorschach test and Minnesota Multiphasic Personality Inventory (MMPI)-II profiles among patients with Kraepelinian schizophrenia, those with DSM-wise schizophrenia, and controls. Kraepelinian schizophrenia is characterised by a chronic, deteriorative disease course and a predominance of negative symptoms.Methods: Patients with Kraepelinian schizophrenia were selected based on medical record reviews. We then compared their Rorschach test and MMPI-II results with those of the DSM-wise schizophrenia group and the control group.Results: The Rorschach test revealed a significant increase in DV2 score and a decrease in D score in patients with Kraepelinian schizophrenia compared to those with DSM-wise schizophrenia. In the MMPI-II profiles, patients with Kraepelinian schizophrenia exhibited an elevated L relative to those with DSM-wise schizophrenia.Conclusion: Our results suggested the value of revisiting psychological tests in clinically delineated subgroups, such as Kraepelinian schizophrenia. Although patients fall under the same diagnostic category of schizophrenia, considering different phenotypes is important when interpreting psychological test outcomes. Additionally, our study indicated that both schizophrenia groups did not show as many abnormalities as expected compared to controls. This highlights the potential value of revisiting established profiles of certain psychological tests and calls for further research on other psychological tests.","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241266366"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the tumor immune microenvironment and tumor-infiltrating lymphocyte subgroups on laryngeal cancer prognosis. 肿瘤免疫微环境和肿瘤浸润淋巴细胞亚群对喉癌预后的影响

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress

Pub Date : 2024-07-01 DOI: 10.1177/00368504241266087

Fırat Tevetoğlu, Nil Çomunoğlu, Haydar Murat Yener

The absence of improvement in survival rates across various cancers, including laryngeal cancer, has led to an increasing interest in understanding the immune response to cancer. In head and neck cancers, immune modulatory mechanisms such as immune microenvironment and immune infiltration are important in cancer pathogenesis. This study aims to explore the distribution of tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment and evaluate their impact on tumor histopathological characteristics and prognosis. The study included 50 patients who underwent laryngectomy for laryngeal squamous cell carcinoma, in Istanbul University - Cerrahpaşa, Faculty of Medicine Department of Otorhinolaryngology, between January 2016 and January 2018. Pathology specimens were evaluated using immunohistochemistry to assess the expressions of the CD3, CD20, CD8, CD4, CD25, and FoxP3 markers, identifying subgroups of TILs. The investigation aimed to uncover how these subgroups influence tumor histopathological features and survival outcomes. The high infiltration of CD3, CD20, and CD4 had a positive impact on disease-specific survival, disease-free survival, and recurrence-free survival. In addition, overall survival was positively affected by high CD3 and CD4 infiltrations. However, no significant relationship was observed between the expressions of CD8, FoxP3, and CD25 and any of the survival parameters. The infiltration of CD3, CD20, and CD4 positive cells indicative of a robust antitumoral immune response-emerged as favorable prognostic factors in laryngeal cancer. These findings suggest that enhancing the infiltration of CD3, CD20, and CD4 lymphocytes could be a therapeutic strategy worth exploring in clinical trials.

由于包括喉癌在内的各种癌症的生存率都没有提高，人们对了解癌症的免疫反应越来越感兴趣。在头颈部癌症中，免疫微环境和免疫浸润等免疫调节机制在癌症发病机制中起着重要作用。本研究旨在探索肿瘤浸润淋巴细胞（TIL）亚群在免疫微环境中的分布，并评估其对肿瘤组织病理学特征和预后的影响。研究纳入了2016年1月至2018年1月期间在伊斯坦布尔大学（Istanbul University - Cerrahpaşa, Faculty of Medicine）耳鼻喉科接受喉鳞癌切除术的50名患者。病理标本采用免疫组化方法进行评估，以评估 CD3、CD20、CD8、CD4、CD25 和 FoxP3 标记的表达，从而确定 TILs 亚群。调查旨在揭示这些亚群如何影响肿瘤组织病理学特征和生存结果。CD3、CD20和CD4的高浸润率对疾病特异性生存率、无病生存率和无复发生存率有积极影响。此外，CD3和CD4高浸润对总生存率也有积极影响。然而，CD8、FoxP3 和 CD25 的表达与任何生存参数之间都没有明显的关系。CD3、CD20和CD4阳性细胞的浸润表明了强大的抗肿瘤免疫反应，成为喉癌的有利预后因素。这些发现表明，增强 CD3、CD20 和 CD4 淋巴细胞的浸润可能是一种值得在临床试验中探索的治疗策略。

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引用次数: 0