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Spatial association between socio-economic health service factors and sepsis mortality in Thailand. 泰国社会经济卫生服务因素与败血症死亡率的空间关联
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-09-13 DOI: 10.4081/gh.2023.1215
Juree Sansuk, Wongsa Laohasiriwong, Kittipong Sornlorm

Sepsis is a significant global health issue causing organ failure and high mortality. The number of sepsis cases has recently increased in Thailand making it crucial to comprehend the factors behind these infections. This study focuses on exploring the spatial autocorrelation between socio-economic factors and health service factors on the one hand and sepsis mortality on the other. We applied global Moran's I, local indicators of spatial association (LISA) and spatial regression to examine the relationship between these variables. Based on univariate Moran's I scatter plots, sepsis mortality in all 77 provinces in Thailand were shown to exhibit a positive spatial autocorrelation that reached a significant value (0.311). The hotspots/ high-high (HH) clusters of sepsis mortality were mostly located in the central region of the country, while the coldspots/low-low (LL) clusters were observed in the north-eastern region. Bivariate Moran's I indicated a spatial autocorrelation between various factors and sepsis mortality, while the LISA analysis revealed 7 HH clusters and 5 LL clusters associated with population density. Additionally, there were 6 HH and 4 LL clusters in areas with the lowest average temperature, 4 HH and 2 LL clusters in areas with the highest average temperature, 8 HH and 5 LL clusters associated with night-time light and 6 HH and 5 LL clusters associated with pharmacy density. The spatial regression models conducted in this study determined that the spatial error model (SEM) provided the best fit, while the parameter estimation results revealed that several factors, including population density, average lowest and highest temperature, night-time light and pharmacy density, were positively correlated with sepsis mortality. The coefficient of determination (R2) indicated that the SEM model explained 56.4% of the variation in sepsis mortality. Furthermore, based on the Akaike Information Index (AIC), the SEM model slightly outperformed the spatial lag model (SLM) with an AIC value of 518.1 compared to 520.

败血症是一个重大的全球健康问题,导致器官衰竭和高死亡率。泰国败血症病例的数量最近有所增加,因此了解这些感染背后的因素至关重要。本研究主要探讨社会经济因素、卫生服务因素与败血症死亡率的空间自相关关系。我们运用全局Moran’s I、局部空间关联指标(LISA)和空间回归来检验这些变量之间的关系。基于单变量Moran’s I散点图,泰国所有77个省份的脓毒症死亡率显示出正的空间自相关,达到显著值(0.311)。败血症死亡率热点/高-高(HH)聚集型多位于中部地区,而冷点/低-低(LL)聚集型多位于东北部地区。双变量Moran's I显示各因素与脓毒症死亡率存在空间自相关,而LISA分析显示7个HH聚类和5个LL聚类与人口密度相关。平均气温最低的地区有6个HH和4个LL集群,平均气温最高的地区有4个HH和2个LL集群,与夜间光照相关的有8个HH和5个LL集群,与药房密度相关的有6个HH和5个LL集群。本研究的空间回归模型确定空间误差模型(SEM)拟合最佳,参数估计结果显示人口密度、平均最低和最高温度、夜间光照和药房密度等因素与脓毒症死亡率呈正相关。决定系数(R2)表明SEM模型解释了脓毒症死亡率变异的56.4%。此外,基于赤池信息指数(Akaike Information Index, AIC)的SEM模型的AIC值为518.1,略优于空间滞后模型(spatial lag model, SLM)的520。
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引用次数: 0
The spatial distribution of interleukin-4 (IL-4) reference values in China based on a back propagation (BP) neural network. 基于BP神经网络的中国白介素-4 (IL-4)参考值空间分布
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-09-13 DOI: 10.4081/gh.2023.1197
Zhao Rong Huang, Miao Ge, Xin Rui Pang, Pu Song, Congxia Wang

This study aimed to investigate the geospatial distribution of normal reference values of Interleukin 4 (IL-4) in healthy Chinese adults and to provide a basis for the development of standard references. IL-4 values of 5,221 healthy adults from 64 cities in China were collected and analyzed for a potential correlation with 24 topographical, climatic and soil factors. Seven of these factors were extracted and used to build a back propagation (BP) neural network model that was used to predict IL-4 reference values in healthy individuals from 2,317 observation sites nationwide. The predicted values were tested for normality and geographic distribution by analytic Kriging interpolation to map the geographic distribution of IL-4 reference values in healthy Chinese subjects. The results showed that IL-4 values generally decreased and then increased from the South to the North. We concluded that the BP neural network model applies to this approach, where certain geographical factors determine levels of various biochemical and immunological standards in healthy adults in regions with different topography, climate and soil indices.

本研究旨在探讨中国健康成人白细胞介素4 (IL-4)正常参考值的地理空间分布,为标准参考的制定提供依据。收集了中国64个城市5221名健康成人的IL-4值,分析了其与24个地形、气候和土壤因子的潜在相关性。提取其中的7个因子,构建BP神经网络模型,用于预测全国2317个观察点健康个体的IL-4参考值。采用Kriging插值法检验预测值的正态性和地理分布,绘制中国健康受试者IL-4参考值的地理分布图。结果表明,IL-4值总体上由南向北先降低后升高。我们得出结论,BP神经网络模型适用于该方法,其中某些地理因素决定了具有不同地形,气候和土壤指数的地区健康成人的各种生化和免疫标准水平。
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引用次数: 1
Province clustering based on the percentage of communicable disease using the BCBimax biclustering algorithm. 使用bcmax双聚类算法基于传染病百分比的省聚类。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-09-12 DOI: 10.4081/gh.2023.1202
Muhammad Nur Aidi, Cynthia Wulandari, Sachnaz Desta Oktarina, Taufiqur Rakhim Aditra, Fitrah Ernawati, Efriwati Efriwati, Nunung Nurjanah, Rika Rachmawati, Elisa Diana Julianti, Dian Sundari, Fifi Retiaty, Aya Yuriestia Arifin, Rita Marleta Dewi, Nazarina Nazaruddin, Salimar Salimar, Noviati Fuada, Yekti Widodo, Budi Setyawati, Nuzuliyati Nurhidayati, Sudikno Sudikno, Irlina Raswanti Irawan, Widoretno Widoretno

Indonesia needs to lower its high infectious disease rate. This requires reliable data and following their temporal changes across provinces. We investigated the benefits of surveying the epidemiological situation with the imax biclustering algorithm using secondary data from a recent national scale survey of main infectious diseases from the National Basic Health Research (Riskesdas) covering 34 provinces in Indonesia. Hierarchical and k-means clustering can only handle one data source, but BCBimax biclustering can cluster rows and columns in a data matrix. Several experiments determined the best row and column threshold values, which is crucial for a useful result. The percentages of Indonesia's seven most common infectious diseases (ARI, pneumonia, diarrhoea, tuberculosis (TB), hepatitis, malaria, and filariasis) were ordered by province to form groups without considering proximity because clusters are usually far apart. ARI, pneumonia, and diarrhoea were divided into toddler and adult infections, making 10 target diseases instead of seven. The set of biclusters formed based on the presence and level of these diseases included 7 diseases with moderate to high disease levels, 5 diseases (formed by 2 clusters), 3 diseases, 2 diseases, and a final order that only included adult diarrhoea. In 6 of 8 clusters, diarrhea was the most prevalent infectious disease in Indonesia, making its eradication a priority. Direct person-to-person infections like ARI, pneumonia, TB, and diarrhoea were found in 4-6 of 8 clusters. These diseases are more common and spread faster than vector-borne diseases like malaria and filariasis, making them more important.

印度尼西亚需要降低其高传染病率。这需要可靠的数据,并跟踪各省的时间变化。我们调查了使用imax双聚类算法调查流行病学情况的好处,这些数据来自最近覆盖印度尼西亚34个省的国家基础卫生研究(Riskesdas)对主要传染病进行的全国范围调查。分层聚类和k-means聚类只能处理一个数据源,但bcmax双聚类可以聚类数据矩阵中的行和列。几个实验确定了最佳行和列阈值,这对于有用的结果至关重要。印度尼西亚七种最常见的传染病(急性呼吸道感染、肺炎、腹泻、结核病、肝炎、疟疾和丝虫病)的百分比按省排序,不考虑邻近性,因为聚集性病群通常相距很远。急性呼吸道感染、肺炎和腹泻被分为幼儿感染和成人感染,使目标疾病从7种增加到10种。根据这些疾病的存在和水平形成的一组双聚类包括7种中度至高度疾病、5种疾病(由2个聚类组成)、3种疾病、2种疾病,以及一个仅包括成人腹泻的最终顺序。在印度尼西亚8个群集中的6个群集中,腹泻是最普遍的传染病,因此将其根除列为优先事项。在8个聚集性病例中,有4-6例发现了急性呼吸道感染、肺炎、结核病和腹泻等直接人际感染。这些疾病比疟疾和丝虫病等病媒传播疾病更常见,传播速度更快,因此更为重要。
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引用次数: 0
Spatial association and modelling of under-5 mortality in Thailand, 2020. 2020年泰国5岁以下儿童死亡率的空间关联和建模。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-08-31 DOI: 10.4081/gh.2023.1220
Suparerk Suerungruang, Kittipong Sornlorm, Wongsa Laohasiriwong, Roshan Kumar Mahato

Under-5 mortality rate (U5MR) is a key indicator of child health and overall development. In Thailand, despite significant steps made in child health, disparities in U5MR persist across different provinces. We examined various socio-economic variables, health service availability and environmental factors impacting U5MR in Thailand to model their influences through spatial analysis. Global and Local Moran's I statistics for spatial autocorrelation of U5MR and its related factors were used on secondary data from the Ministry of Public Health, National Centers for Environmental Information, National Statistical Office, and the Office of the National Economic and Social Development Council in Thailand. The relationships between U5MR and these factors were modelled using ordinary least squares (OLS) estimation, spatial lag model (SLM) and spatial error model (SEM). There were significant spatial disparities in U5MR across Thailand. Factors such as low birth weight, unemployment rate, and proportion of land use for agricultural purposes exhibited significant positive spatial autocorrelation, directly influencing U5MR, while average years of education, community organizations, number of beds for inpatients per 1,000 population, and exclusive breastfeeding practices acted as protective factors against U5MR (R2 of SEM = 0.588).The findings underscore the need for comprehensive, multi-sectoral strategies to address the U5MR disparities in Thailand. Policy interventions should consider improving socioeconomic conditions, healthcare quality, health accessibility, and environmental health in high U5M areas. Overall, this study provides valuable insights into the spatial distribution of U5MR and its associated factors, which highlights the need for tailored and localized health policies and interventions.

5岁以下儿童死亡率(U5MR)是儿童健康和全面发展的关键指标。在泰国,尽管在儿童健康方面取得了重大进展,但5岁以下儿童死亡率在不同省份之间仍然存在差异。我们研究了影响泰国U5MR的各种社会经济变量、卫生服务可获得性和环境因素,通过空间分析对其影响进行建模。全球和地方Moran's I统计数据用于U5MR及其相关因素的空间自相关,使用来自泰国公共卫生部、国家环境信息中心、国家统计局和国家经济和社会发展理事会办公室的二手数据。利用普通最小二乘(OLS)估计、空间滞后模型(SLM)和空间误差模型(SEM)对U5MR与这些因素之间的关系进行了建模。泰国的U5MR存在显著的空间差异。低出生体重、失业率、农业用地比例等因素具有显著的空间正相关,直接影响U5MR,而平均受教育年限、社区组织、每千人口住院床位数和纯母乳喂养是U5MR的保护因素(SEM的R2 = 0.588)。调查结果强调需要制定全面的多部门战略来解决泰国5岁以下儿童死亡率的差距。政策干预措施应考虑改善U5M高地区的社会经济条件、卫生保健质量、卫生可及性和环境卫生。总体而言,本研究对u5死亡率的空间分布及其相关因素提供了有价值的见解,这突出了量身定制和本地化卫生政策和干预措施的必要性。
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引用次数: 0
Correction. Spatial cluster analysis of COVID-19 in Malaysia (Mar-Sep, 2020). 修正。2020年3 - 9月马来西亚新冠肺炎疫情空间聚类分析
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-08-01 DOI: 10.4081/gh.2023.1233
The Publisher

In the Article titled "Spatial cluster analysis of COVID-19 in Malaysia (Mar-Sep, 2020)." published May 5th, 2021, in Vol. 16(1) of Geospatial Health, an author's name was misspelled. The seventh author's name should be "Alamgir".   Reference: Ullah S, Mohd Nor NH, Daud H, Zainuddin N, Gandapur MS J, Ali I, Khalil A, 2021. Spatial cluster analysis of COVID-19 in Malaysia (Mar-Sep, 2020). Geospatial Health, 16:961. https://doi.org/10.4081/gh.2021.961.

2021年5月5日发表在《地理空间卫生》第16卷第1期的一篇题为“2019冠状病毒病在马来西亚的空间聚类分析(2020年3月- 9月)”的文章中,作者的名字拼写错误。第七位作者的名字应该是“Alamgir”。参考文献:Ullah S, Mohd Nor NH, Daud H, Zainuddin N, Gandapur MS J, Ali I, Khalil A, 2021。2020年3 - 9月马来西亚新冠肺炎疫情空间聚类分析地理空间卫生,16:961。https://doi.org/10.4081/gh.2021.961。
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引用次数: 0
Correction. Detecting space-time disease clusters with arbitrary shapes and sizes using a co-clustering approach.. 修正。利用共聚类方法检测任意形状和大小的时空疾病簇
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-08-01 DOI: 10.4081/gh.2023.1232
The Publisher

In the Article titled "Detecting space-time disease clusters with arbitrary shapes and sizes using a co-clustering approach." published November 6th, 2017, in Vol 12(2) of Geospatial Health, an author's name was misspelled. The fifth author's name should be "Alamgir". Reference: Ullah S, Daud H, Dass SC, Khan HN, Khalil A, 2017. Detecting space-time disease clusters with arbitrary shapes and sizes using a co-clustering approach. Geospatial Health, 12:567. https://doi.org/10.4081/gh.2017.567.

2017年11月6日发表在《地理空间卫生》第12卷第2期的一篇题为《利用共聚类方法检测任意形状和大小的时空疾病簇》的文章中,作者的名字被拼错了。第五作者的名字应该是“Alamgir”。参考文献:Ullah S, Daud H, Dass SC, Khan HN, Khalil A, 2017。利用共聚类方法检测任意形状和大小的时空疾病簇。地理空间卫生,12:567。https://doi.org/10.4081/gh.2017.567。
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引用次数: 0
Geospatial analysis in the United States reveals the changing roles of temperature on COVID-19 transmission. 美国的地理空间分析揭示了温度在COVID-19传播中的作用变化。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-07-20 DOI: 10.4081/gh.2023.1213
Ruiwen Xiong, Xiaolong Li

Environmental factors are known to affect outbreak patterns of infectious disease, but their impacts on the spread of COVID-19 along with the evolution of this relationship over time intervals and in different regions are unclear. This study utilized 3 years of data on COVID-19 cases in the continental United States from 2020 to 2022 and the corresponding weather data. We used regression analysis to investigate weather impacts on COVID-19 spread in the mainland United States and estimate the changes of these impacts over space and time. Temperature exhibited a significant and moderately strong negative correlation for most of the US while relative humidity and precipitation experienced mixed relationships. By regressing temperature factors with the spreading rate of waves, we found temperature change can explain over 20% of the spatial-temporal variation in the COVID-19 spreading, with a significant and negative response between temperature change and spreading rate. The pandemic in the continental United States during 2020-2022 was characterized by seven waves, with different transmission rates and wave peaks concentrated in seven time periods. When repeating the analysis for waves in the seven periods and nine climate zones, we found temperature impacts evolve over time and space, possibly due to virus mutation, changes in population susceptibility, social behavior, and control measures. Temperature impacts became weaker in 6 of 9 climate zones from the beginning of the epidemic to the end of 2022, suggesting that COVID-19 has increasingly adapted to wider weather conditions.

众所周知,环境因素会影响传染病的暴发模式,但它们对COVID-19传播的影响以及这种关系在不同时间间隔和不同地区的演变尚不清楚。这项研究利用了美国大陆从2020年到2022年的3年COVID-19病例数据和相应的天气数据。我们使用回归分析来调查天气对COVID-19在美国大陆传播的影响,并估计这些影响随时间和空间的变化。在美国大部分地区,温度表现出显著且中等强度的负相关,而相对湿度和降水则表现出混合关系。通过对气温因子与传播速度的回归分析,发现气温变化可以解释20%以上的新冠肺炎传播时空变化,气温变化与传播速度呈显著负相关。2020-2022年美国大陆大流行的特点是七波,不同的传播率和波峰集中在七个时间段。在对7个时期和9个气候带的波浪进行重复分析时,我们发现温度影响随时间和空间而变化,可能是由于病毒突变、人群易感性、社会行为和控制措施的变化。从疫情开始到2022年底,9个气候带中有6个区的温度影响减弱,这表明COVID-19越来越适应更广泛的天气条件。
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引用次数: 0
Where to place emergency ambulance vehicles: use of a capacitated maximum covering location model with real call data. 在何处放置紧急救护车辆:使用具有真实呼叫数据的可容最大覆盖位置模型。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-07-20 DOI: 10.4081/gh.2023.1198
Soheil Hashtarkhani, Stephen A Matthews, Ping Yin, Alireza Mohammadi, Shahab MohammadEbrahimi, Mahmood Tara, Behzad Kiani

This study integrates geographical information systems (GIS) with a mathematical optimization technique to enhance emergency medical services (EMS) coverage in a county in the northeast of Iran. EMS demand locations were determined through one-year EMS call data analysis. We formulated a maximal covering location problem (MCLP) as a mixed-integer linear programming model with a capacity threshold for vehicles using the CPLEX optimizer, an optimization software package from IBM. To ensure applicability to the EMS setting, we incorporated a constraint that maintains an acceptable level of service for all EMS calls. Specifically, we implemented two scenarios: a relocation model for existing ambulances and an allocation model for new ambulances, both using a list of candidate locations. The relocation model increased the proportion of calls within the 5-minute coverage standard from 69% to 75%. With the allocation model, we found that the coverage proportion could rise to 84% of total calls by adding ten vehicles and eight new stations. The incorporation of GIS techniques into optimization modelling holds promise for the efficient management of scarce healthcare resources, particularly in situations where time is of the essence.

本研究将地理资讯系统(GIS)与数学优化技术整合,以提高伊朗东北部一个县的紧急医疗服务(EMS)覆盖率。通过一年的EMS呼叫数据分析确定EMS需求地点。我们使用IBM的优化软件包CPLEX优化器将最大覆盖位置问题(MCLP)表述为具有车辆容量阈值的混合整数线性规划模型。为了确保对EMS设置的适用性,我们合并了一个约束,为所有EMS调用维持可接受的服务水平。具体来说,我们实现了两种场景:现有救护车的重新安置模型和新救护车的分配模型,两者都使用候选地点列表。重新定位模型将5分钟覆盖标准内的呼叫比例从69%提高到75%。通过分配模型,我们发现增加10辆车和8个新站点,覆盖率可以提高到总呼叫的84%。将地理信息系统技术纳入优化建模有望有效管理稀缺的医疗保健资源,特别是在时间紧迫的情况下。
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引用次数: 0
Association of socioeconomic indicators with COVID-19 mortality in Brazil: a population-based ecological study. 巴西社会经济指标与 COVID-19 死亡率的关系:一项基于人口的生态研究。
IF 1 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-07-13 DOI: 10.4081/gh.2023.1206
João Batista Cavalcante Filho, Marco Aurélio de Oliveira Góes, Damião da Conceição Araújo, Marcus Valerius da Silva Peixoto, Marco Antônio Prado Nunes

The article presents an analysis of the spatial distribution of mortality from COVID-19 and its association with socioeconomic indicators in the north-eastern region of Brazil - an area particularly vulnerable with regard to these indicators. This populationbased ecology study was carried out at the municipal level in the years 2020 and 2021, with analyses performed by spatial autocorrelation, multiple linear regression and spatial autoregressive models. The results showed that mortality from COVID-19 in this part of Brazil was higher in the most populous cities with better socioeconomic indicators. Factors such as the onset of the COVID-19 pandemic in large cities, the agglomerations existing within them, the pressure to maintain economic activities and mistakes in the management of the pandemic by the Brazilian federal Government were part of the complex scenario related to the spread of COVID-19 in the country and this study was undertaken in an attempt to understand this situation. Analysing the different scenarios is essential to face the challenges posed by the pandemic to the world's health systems.

文章分析了巴西东北部地区 COVID-19 死亡率的空间分布及其与社会经济指标的关联,该地区在这些指标方面尤为脆弱。这项以人口为基础的生态学研究于 2020 年和 2021 年在市一级进行,分析方法包括空间自相关、多元线性回归和空间自回归模型。结果显示,在巴西的这一地区,人口最多、社会经济指标较好的城市 COVID-19 死亡率较高。COVID-19 大流行病在大城市的爆发、大城市中存在的城市群、维持经济活动的压力以及巴西联邦政府在管理大流行病方面的失误等因素,都是与 COVID-19 在巴西的传播有关的复杂情况的一部分,本研究就是为了了解这种情况而进行的。分析不同的情况对于应对该流行病给世界卫生系统带来的挑战至关重要。
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引用次数: 0
Spatiotemporal distribution and geostatistically interpolated mapping of the melioidosis risk in an endemic zone in Thailand. 泰国某流行区类鼻疽病风险的时空分布和地理统计插值图。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-07-05 DOI: 10.4081/gh.2023.1189
Jaruwan Wongbutdee, Jutharat Jittimanee, Wacharapong Saengnill

Melioidosis, a bacterial, infectious disease contracted from contaminated soil or water, is a public health problem identified in tropical regions and endemic several regions of Thailand. Surveillance and prevention are important for determining its distribution patterns and mapping its risk, which have been analysed in the present study. Case reports in Thailand were collected from 1 January 2016 to 31 December 2020. Spatial autocorrelation was analyzed using Moran's I and univariate local Moran's I. Spatial point data of melioidosis incidence were calculated, with riskmapping interpolation performed by Kriging. It was highest in 2016, at 32.37 cases per 100,000 people, and lowest in 2020, at 10.83 cases per 100,000 people. General observations revealed that its incidence decreased slightly from 2016 to 2018 and drastically in 2019 and 2020. The Moran's I values for melioidosis incidence exhibited a random spatial pattern in 2016 and clustered distribution from 2017 to 2020. The risk and variance maps show interval values. These findings may contribute to the monitoring and surveillance of melioidosis outbreaks.

类鼻疽病是一种由受污染的土壤或水感染的细菌性传染病,是在热带地区和泰国若干地区发现的一个公共卫生问题。监测和预防对于确定其分布模式和绘制其风险地图非常重要,本研究已对此进行了分析。从2016年1月1日至2020年12月31日收集了泰国的病例报告。利用Moran’s I和单变量局部Moran’s I进行空间自相关分析,利用Kriging进行风险映射插值,计算类鼻疽发病的空间点数据。2016年最高,为每10万人32.37例,2020年最低,为每10万人10.83例。总体观察显示,2016年至2018年,其发病率略有下降,2019年和2020年急剧下降。2016年类鼻疽发病Moran’s I值呈随机空间分布,2017 - 2020年呈聚类分布。风险和方差图显示区间值。这些发现可能有助于监测和监测类鼻疽病暴发。
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引用次数: 0
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