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Spatial autocorrelation and heterogenicity of demographic and healthcare factors in the five waves of COVID-19 epidemic in Thailand. 泰国五波新冠肺炎疫情中人口与卫生保健因素的空间自相关及异质性
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1183
Ei Sandar U, Wongsa Laohasiriwong, Kittipong Sornlorm

A study of 2,569,617 Thailand citizens diagnosed with COVID-19 from January 2020 to March 2022 was conducted with the aim of identifying the spatial distribution pattern of incidence rate of COVID-19 during its five main waves in all 77 provinces of the country. Wave 4 had the highest incidence rate (9,007 cases per 100,000) followed by the Wave 5, with 8,460 cases per 100,000. We also determined the spatial autocorrelation between a set of five demographic and health care factors and the spread of the infection within the provinces using Local Indicators of Spatial Association (LISA) and univariate and bivariate analysis with Moran's I. The spatial autocorrelation between the variables examined and the incidence rates was particularly strong during the waves 3-5. All findings confirmed the existence of spatial autocorrelation and heterogenicity of COVID-19 with the distribution of cases with respect to one or several of the five factors examined. The study identified significant spatial autocorrelation with regard to the COVID-19 incidence rate with these variables in all five waves. Depending on which province that was investigated, strong spatial autocorrelation of the High-High pattern was observed in 3 to 9 clusters and of the Low-Low pattern in 4 to 17 clusters, whereas negative spatial autocorrelation was observed in 1 to 9 clusters of the High-Low pattern and in 1 to 6 clusters of Low-High pattern. These spatial data should support stakeholders and policymakers in their efforts to prevent, control, monitor and evaluate the multidimensional determinants of the COVID-19 pandemic.

对2020年1月至2022年3月期间诊断为COVID-19的2,569,617名泰国公民进行了一项研究,目的是确定该国所有77个省份COVID-19在其五个主要波浪期间发病率的空间分布格局。第4波发病率最高(每10万人中有9,007例),其次是第5波,每10万人中有8,460例。我们还利用地方空间关联指标(Local Indicators of spatial Association, LISA)和Moran's i的单变量和双变量分析,确定了5个人口和卫生保健因素与省内感染传播之间的空间自相关性。所有研究结果都证实了COVID-19与病例分布之间存在空间自相关性和异质性,这与所检查的五个因素中的一个或几个因素有关。该研究发现,在所有五波中,这些变量与COVID-19发病率存在显著的空间自相关性。在不同省份,3 ~ 9个“高-高”区和4 ~ 17个“低-低”区存在强空间自相关,1 ~ 9个“高-低”区和1 ~ 6个“低-高”区存在负空间自相关。这些空间数据应支持利益攸关方和决策者努力预防、控制、监测和评估COVID-19大流行的多维决定因素。
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引用次数: 2
Dynamic effect of economic growth on the persistence of suicide rates. 经济增长对自杀率持续性的动态影响。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1201
Tzu-Yi Yang, Yu-Tai Yang, Ssu-Han Chen, Yu-Ting Lan, Chia-Jui Peng

Positive and negative economic growth is closely related to the suicide rate. To answer the question whether economic development has a dynamic impact on this rate, we used a panel smooth transition autoregressive model to evaluate the threshold effect of economic growth rate on the persistence of suicide. The research period was from 1994 to 2020, and the results show that the suicide rate had a persistent effect, which varied over time depending on the transition variable within different threshold intervals. However, the persistent effect was manifested in different degrees with the change in the economic growth rate and as the lag period of the suicide rate increased, the effect of the influence gradually decreased. We investigated different lag periods and noted that the impact on the suicide rate was the strongest in the first year after an economic change and then reduced to be only marginal after three years. This means that the growth momentum of the suicide rate within the first two years after a change in the economic growth rate, should be included in policy considerations of how to prevent suicides.

经济的正负增长与自杀率密切相关。为了回答经济发展是否对自杀持续率有动态影响的问题,我们使用面板平滑过渡自回归模型来评估经济增长率对自杀持续率的阈值效应。研究时间为1994年至2020年,结果表明自杀率具有持续性影响,且随时间的变化取决于不同阈值区间内的过渡变量。然而,随着经济增长率的变化,这种持续效应不同程度地表现出来,随着自杀率滞后期的增加,其影响效果逐渐减弱。我们调查了不同的滞后期,并注意到对自杀率的影响在经济变化后的第一年是最强的,然后在三年后减少到只有边际。这意味着,在经济增长率发生变化后的前两年内,自杀率的增长势头,应纳入如何预防自杀的政策考虑。
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引用次数: 0
Spatial analysis of the relationship between out-of-pocket expenditure and socioeconomic status in South Korea. 韩国自费支出与社会经济地位关系的空间分析。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1175
Young-Gyu Kwon, Man-Kyu Choi

The rapid increase in out-of-pocket expenditures regressively raises the issue of equity in medical access opportunities according to income class and negatively affects public health. Factors related to out-of-pocket expenses have been analyzed in previous studies using an ordinary regression model (Ordinary Least Squares [OLS]). However, as OLS assumes equal error variance, it does not consider spatial variation due to spatial heterogeneity and dependence. Accordingly, this study presents a spatial analysis of outpatient out-of-pocket expenses from 2015 to 2020, targeting 237 local governments nationwide, excluding islands and island regions. R (version 4.1.1) was used for statistical analysis, and QGIS (version 3.10.9), GWR4 (version 4.0.9), and Geoda (version 1.20.0.10) were used for the spatial analysis. As a result, in OLS, it was found that the aging rate and number of general hospitals, clinics, public health centers, and beds had a positive (+) significant effect on outpatient out-of-pocket expenses. The Geographically Weighted Regression (GWR) suggests regional differences exist concerning out-of-pocket payments. As a result of comparing the OLS and GWR models through the Adj. R² and Akaike's Information Criterion indices, the GWR model showed a higher fit. This study provides public health professionals and policymakers with insights that could inform effective regional strategies for appropriate out-of-pocket cost management.

自付支出的迅速增加,逐渐引起了按收入阶层公平获得医疗机会的问题,并对公共卫生产生负面影响。之前的研究使用普通回归模型(普通最小二乘法[OLS])分析了与自付费用相关的因素。然而,由于OLS假设误差方差相等,因此没有考虑空间异质性和依赖性带来的空间变异。据此,本研究对2015 - 2020年全国237个地方政府(不包括岛屿和岛屿地区)的门诊自付费用进行了空间分析。采用R(版本4.1.1)进行统计分析,采用QGIS(版本3.10.9)、GWR4(版本4.0.9)、Geoda(版本1.20.0.10)进行空间分析。结果发现,在OLS中,综合医院、诊所、公共卫生中心和床位的老龄化率和数量对门诊自付费用有正(+)显著影响。地理加权回归(GWR)表明,自费支付存在地区差异。通过Adj. R²和赤池信息准则指标对OLS模型和GWR模型进行比较,GWR模型具有较高的拟合性。这项研究为公共卫生专业人员和政策制定者提供了见解,可以为适当的自付费用管理的有效区域战略提供信息。
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引用次数: 0
Spatial and temporal clustering analysis of pulmonary tuberculosis and its associated risk factors in southwest China. 西南地区肺结核及其相关危险因素时空聚类分析
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1169
Jianjiao Wang, Xiaoning Liu, Zhengchao Jing, Jiawai Yang

Pulmonary tuberculosis (PTB) remains a serious public health problem, especially in areas of developing countries. This study aimed to explore the spatial-temporal clusters and associated risk factors of PTB in south-western China. Space-time scan statistics were used to explore the spatial and temporal distribution characteristics of PTB. We collected data on PTB, population, geographic information and possible influencing factors (average temperature, average rainfall, average altitude, planting area of crops and population density) from 11 towns in Mengzi, a prefecture-level city in China, between 1 January 2015 and 31 December 2019. A total of 901 reported PTB cases were collected in the study area and a spatial lag model was conducted to analyse the association between these variables and the PTB incidence. Kulldorff's scan results identified two significant space-time clusters, with the most likely cluster (RR = 2.24, p < 0.001) mainly located in northeastern Mengzi involving five towns in the time frame June 2017 - November 2019. A secondary cluster (RR = 2.09, p < 0.05) was located in southern Mengzi, covering two towns and persisting from July 2017 to December 2019. The results of the spatial lag model showed that average rainfall was associated with PTB incidence. Precautions and protective measures should be strengthened in high-risk areas to avoid spread of the disease.

肺结核仍然是一个严重的公共卫生问题,特别是在发展中国家的一些地区。本研究旨在探讨中国西南地区肺结核的时空分布特征及其相关危险因素。采用时空扫描统计方法探讨PTB的时空分布特征。在2015年1月1日至2019年12月31日期间,我们收集了中国蒙自市11个镇的肺结核、人口、地理信息和可能的影响因素(平均温度、平均降雨量、平均海拔、作物种植面积和人口密度)数据。收集研究区901例PTB报告病例,采用空间滞后模型分析这些变量与PTB发病率之间的关系。Kulldorff的扫描结果确定了两个显著的时空集群,其中最可能的集群(RR = 2.24, p < 0.001)主要位于蒙自东北部,涉及2017年6月至2019年11月期间的五个城镇。第二个聚集区(RR = 2.09, p < 0.05)位于蒙自南部,覆盖两个镇,持续时间为2017年7月至2019年12月。空间滞后模型结果表明,平均降雨量与肺结核发病率相关。高危地区应加强预防和防护措施,避免疫情传播。
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引用次数: 0
Spatial analysis of antimicrobial resistance in the environment. A systematic review. 环境中抗菌素耐药性的空间分析。系统回顾。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1168
Patrick Spets, Karin Ebert, Patrik Dinnétz

Antimicrobial resistance (AMR) is a global major health concern. Spatial analysis is considered an invaluable method in health studies. Therefore, we explored the usage of spatial analysis in Geographic Information Systems (GIS) in studies on AMR in the environment. This systematic review is based on database searches, a content analysis, ranking of the included studies according to the preference ranking organization method for enrichment evaluations (PROMETHEE) and estimation of data points per km2. Initial database searches resulted in 524 records after removal of duplicates. After the last stage of full text screening, 13 greatly heterogeneous articles with diverse study origins, methods and design remained. In the majority of studies, the data density was considerably less than one sampling site per km2 but exceeded 1,000 sites per km2 in one study. The results of the content analysis and ranking showed a variation between studies that primarily used spatial analysis and those that used spatial analysis as a sec ondary method. We identified two distinct groups of GIS methods. The first was focused on sample collection and laboratory testing, with GIS as supporting method. The second group used overlay analysis as the primary method to combine datasets in a map. In one case, both methods were combined. The low number of articles that met our inclusion criteria highlights a research gap. Based on the findings of this study we encourage application of GIS to its full potential in studies of AMR in the environment.

抗菌素耐药性(AMR)是一个全球性的重大卫生问题。空间分析被认为是健康研究的宝贵方法。因此,我们探索了地理信息系统(GIS)空间分析在环境中抗菌素耐药性研究中的应用。该系统评价基于数据库搜索、内容分析、根据富集评价偏好排序组织方法(PROMETHEE)对纳入的研究进行排序和每平方公里数据点的估计。删除重复项后,初始数据库搜索得到524条记录。经过最后一阶段的全文筛选,仍有13篇研究来源、方法和设计差异很大的异质性文章。在大多数研究中,数据密度远远少于每平方公里一个采样点,但在一项研究中每平方公里超过1 000个采样点。内容分析和排名的结果显示,主要使用空间分析的研究与将空间分析作为次要方法的研究之间存在差异。我们确定了两组不同的GIS方法。第一个侧重于样本收集和实验室测试,以GIS作为辅助方法。第二组使用叠加分析作为在地图中组合数据集的主要方法。在一个案例中,两种方法结合在一起。符合我们纳入标准的文章数量少凸显了研究差距。基于这项研究的结果,我们鼓励GIS在环境抗菌素耐药性研究中充分发挥其潜力。
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引用次数: 0
Does mobility restriction significantly control infectious disease transmission? Accounting for non-stationarity in the impact of COVID-19 based on Bayesian spatially varying coefficient models. 限制行动是否能有效控制传染病的传播?基于贝叶斯空间变系数模型的新冠肺炎影响非平稳性分析
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1161
I Gede Nyoman Mindra Jaya, Anna Chadidjah, Farah Kristiani, Gumgum Darmawan, Jane Christine Princidy

COVID-19 is the most severe health crisis of the 21st century. COVID-19 presents a threat to almost all countries worldwide. The restriction of human mobility is one of the strategies used to control the transmission of COVID-19. However, it has yet to be determined how effective this restriction is in controlling the rise in COVID-19 cases, particularly in small areas. Using Facebook's mobility data, our study explores the impact of restricting human mobility on COVID-19 cases in several small districts in Jakarta, Indonesia. Our main contribution is showing how the restriction of human mobility data can give important information about how COVID-19 spreads in different small areas. We proposed modifying a global regression model into a local regression model by accounting for the spatial and temporal interdependence of COVID-19 transmission across space and time. We applied Bayesian hierarchical Poisson spatiotemporal models with spatially varying regression coefficients to account for non-stationarity in human mobility. We estimated the regression parameters using an Integrated Nested Laplace Approximation. We found that the local regression model with spatially varying regression coefficients outperforms the global regression model based on DIC, WAIC, MPL, and R2 criteria for model selection. In Jakarta's 44 districts, the impact of human mobility varies significantly. The impacts of human mobility on the log relative risk of COVID-19 range from -4.445 to 2.353. The prevention strategy involving the restriction of human mobility may be beneficial in some districts but ineffective in others. Therefore, a cost-effective strategy had to be adopted.

COVID-19是21世纪最严重的健康危机。COVID-19对全球几乎所有国家都构成威胁。限制人员流动是控制COVID-19传播的策略之一。然而,这一限制在控制COVID-19病例增加方面的效果如何,特别是在小地区,还有待确定。利用Facebook的流动性数据,我们的研究探讨了限制人员流动对印度尼西亚雅加达几个小地区的COVID-19病例的影响。我们的主要贡献是展示了限制人员流动数据如何提供有关COVID-19如何在不同小区域传播的重要信息。考虑到COVID-19传播在时空上的相互依赖性,我们提出将全局回归模型修正为局部回归模型。我们应用贝叶斯层次泊松时空模型与空间变化的回归系数来解释人类流动性的非平稳性。我们使用集成嵌套拉普拉斯近似估计回归参数。我们发现,具有空间变化回归系数的局部回归模型在模型选择上优于基于DIC、WAIC、MPL和R2标准的全局回归模型。在雅加达的44个区,人口流动的影响差别很大。人员流动对新冠肺炎对数相对风险的影响范围为-4.445 ~ 2.353。限制人员流动的预防战略在某些地区可能是有益的,但在其他地区则无效。因此,必须采取具有成本效益的战略。
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引用次数: 0
Exploring the distribution of risk factors for drop-out from Ponseti treatment for clubfoot across Bangladesh using geospatial cluster analysis. 使用地理空间聚类分析探讨孟加拉国各地因俱乐部足Ponseti治疗而辍学的风险因素分布。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1174
Manon Pigeolet, Tarinee Kucchal, Matthew T Hey, Marcia C Castro, Angela Margaret Evans, Tarsicio Uribe-Leitz, Mohommad Mamun Hossen Chowhury, Sabrina Juran

Clubfoot is a congenital anomaly affecting 1/1,000 live births. Ponseti casting is an effective and affordable treatment. About 75% of affected children have access to Ponseti treatment in Bangladesh, but 20% are at risk of drop-out. We aimed to identify the areas in Bangladesh where patients are at high or low risk for drop-out. This study used a cross-sectional design based on publicly available data. The nationwide clubfoot program: 'Walk for Life' identified five risk factors for drop-out from the Ponseti treatment, specific to the Bangladeshi setting: household poverty, household size, population working in agriculture, educational attainment and travel time to the clinic. We explored the spatial distribution and clustering of these five risk factors. The spatial distribution of children <5 years with clubfoot and the population density differ widely across the different sub-districts of Bangladesh. Analysis of risk factor distribution and cluster analysis showed areas at high risk for dropout in the Northeast and the Southwest, with poverty, educational attainment and working in agriculture as the most prevalent driving risk factor. Across the entire country, twenty-one multivariate high-risk clusters were identified. As the risk factors for drop-out from clubfoot care are not equally distributed across Bangladesh, there is a need in regional prioritization and diversification of treatment and enrolment policies. Local stakeholders and policy makers can identify high-risk areas and allocate resources effectively.

Clubfoot是一种先天性畸形,影响千分之一的活产婴儿。Ponseti铸造是一种有效且价格合理的治疗方法。在孟加拉国,大约75%的受影响儿童可以接受庞塞蒂治疗,但20%的儿童有辍学的风险。我们旨在确定孟加拉国患者辍学风险高或低的地区。本研究采用了基于公开数据的横断面设计。全国性的clubfoot项目:“终身行走”确定了五个退出Ponseti治疗的风险因素,具体针对孟加拉国环境:家庭贫困、家庭规模、农业人口、教育程度和去诊所的旅行时间。我们探讨了这五个风险因素的空间分布和聚类。儿童的空间分布
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引用次数: 0
Spatiotemporal heterogeneity of SARS-CoV-2 diffusion at the city level using geographically weighted Poisson regression model: The case of Bologna, Italy. 基于地理加权泊松回归模型的SARS-CoV-2城市扩散时空异质性研究——以意大利博洛尼亚为例
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2022-12-01 DOI: 10.4081/gh.2022.1145
Addisu Jember Zeleke, Rossella Miglio, Pierpaolo Palumbo, Paolo Tubertini, Lorenzo Chiari

This paper aimed to analyse the spatio-temporal patterns of the diffusion of SARS-CoV-2, the virus causing coronavirus 2019 (COVID-19, in the city of Bologna, the capital and largest city of the Emilia-Romagna Region in northern Italy. The study took place from February 1st, 2020 to November 20th, 2021 and accounted for space, sociodemographic characteristics and health conditions of the resident population. A second goal was to derive a model for the level of risk of being infected by SARS-CoV-2 and to identify and measure the place-specific factors associated with the disease and its determinants. Spatial heterogeneity was tested by comparing global Poisson regression (GPR) and local geographically weighted Poisson regression (GWPR) models. The key findings were that different city areas were impacted differently during the first three epidemic waves. The area-to-area influence was estimated to exert its effect over an area with 4.7 km radius. Spatio-temporal heterogeneity patterns were found to be independent of the sociodemographic and the clinical characteristics of the resident population. Significant single-individual risk factors for detected SARS-CoV-2 infection cases were old age, hypertension, diabetes and co-morbidities. More specifically, in the global model, the average SARS-CoV-2 infection rate decreased 0.93-fold in the 21-65 years age group compared to the >65 years age group, whereas hypertension, diabetes, and any other co-morbidities (present vs absent), increased 1.28-, 1.39- and 1.15-fold, respectively. The local GWPR model had a better fit better than GPR. Due to the global geographical distribution of the pandemic, local estimates are essential for mitigating or strengthening security measures.

本文旨在分析引起2019冠状病毒(COVID-19)的病毒SARS-CoV-2在意大利北部艾米利亚-罗马涅大区首府和最大城市博洛尼亚市传播的时空格局。该研究于2020年2月1日至2021年11月20日进行,考虑了居住人口的空间、社会人口特征和健康状况。第二个目标是推导出SARS-CoV-2感染风险水平的模型,并确定和测量与该疾病及其决定因素相关的地方特异性因素。通过比较全球泊松回归(GPR)模型和局部地理加权泊松回归(GWPR)模型,检验其空间异质性。主要发现是,在前三波流行期间,不同城市地区受到的影响不同。据估计,对区域的影响将对半径4.7公里的区域产生影响。时空异质性模式独立于社会人口学和常住人口的临床特征。检测到的SARS-CoV-2感染病例的显著单个体危险因素为年龄、高血压、糖尿病和合并症。更具体地说,在全球模型中,与>65岁年龄组相比,21-65岁年龄组的平均SARS-CoV-2感染率下降了0.93倍,而高血压、糖尿病和任何其他合合症(存在与不存在)分别增加了1.28倍、1.39倍和1.15倍。局部GWPR模型拟合效果优于GPR模型。由于大流行病的全球地理分布,当地估计对于减轻或加强安全措施至关重要。
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引用次数: 0
Comparison of complete and spatial sampling frames for estimation of the prevalence of hypertension and diabetes mellitus. 估算高血压和糖尿病患病率的完整和空间抽样框架的比较。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2022-11-30 DOI: 10.4081/gh.2022.1097
Vasna Joshua, Kamaraj Pattabi, Yuvaraj Jeyaraman, Prabhdeep Kaur, Tarun Bhatnagar, Suresh Arunachalam, Sabarinathan Ramasamy, Venkateshprabhu Janagaraj, Manoj V Murhekar

A complete sampling frame (CSF) is needed for the development of probability sampling structures; utilisation of a spatial sampling frame (SSF) was the objective of the present study. We used two sampling methods, simple random sampling (SRS) and stratified random sampling (STRS), to compare the prevalence estimates delivered by a CSF to that by a SSF when applied to self-reported hypertension and diabetes mellitus in a semi-urban setting and in a rural one. A CSF based on Geodatabase of all households and all individuals was available for our study that focused on adults aged 18-69 years in the two settings. A single digitized shapefile of solely household regions/structures as SSF was developed using Google Earth and employed for the study. The results from the two sampling frames were similar and not significantly different. All 95%CI calculations contained the prevalence rates of the two medical conditions except for one occasion based on STRS and CSF. The SRS based on CSF showed a minimum 95% CI width for diabetes mellitus, whereas SSF showed a minimum 95% CI width for hypertension. The coefficient of variation exceeded 10.0% on six occasions for CSF but only once for SSF, which was found to be as efficient as CSF.

开发概率抽样结构需要一个完整的抽样框架(CSF);利用空间采样帧(SSF)是本研究的目的。我们使用两种抽样方法,简单随机抽样(SRS)和分层随机抽样(STRS),来比较CSF和SSF在半城市环境和农村环境中对自我报告的高血压和糖尿病的患病率估计。基于所有家庭和个人地理数据库的CSF可用于我们的研究,该研究的重点是两种环境中18-69岁的成年人。使用Google Earth开发了一个单独的家庭区域/结构的数字化形状文件,作为SSF,并用于研究。两个采样帧的结果相似,没有显著差异。除了基于STRS和CSF的一种情况外,所有95%CI计算都包含这两种疾病的患病率。基于脑脊液的SRS显示糖尿病的最小95% CI宽度,而SSF显示高血压的最小95% CI宽度。CSF有6次变异系数超过10.0%,而SSF只有1次变异系数超过10.0%,SSF与CSF一样有效。
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引用次数: 0
Spatial distribution and identifying biochemical factors affecting haemoglobin levels among women of reproductive age for each province in Indonesia: A geospatial analysis. 空间分布和确定影响印度尼西亚各省育龄妇女血红蛋白水平的生化因素:地理空间分析。
IF 1.7 4区 医学 Q2 Social Sciences Pub Date : 2022-11-30 DOI: 10.4081/gh.2022.1118
Muhammad Nur Aidi, Fitrah Ernawati, Efriwati Efriwati, Nunung Nurjanah, Rika Rachmawati, Elisa Diana Julianti, Dian Sundari, Fifi Retiaty, Anwar Fitrianto, Khalilah Nurfadilah, Aya Yuriestia Arifin

Anaemia is still a public health problem in Indonesia. The iron supplement program, known as Tablet Tambah Darah (Blood Add Tablet) has not yet produced optimal results. This study aimed to identify the cause of anaemia and the factors that influence it. Biochemical indicator data are haemoglobin (Hb), C-reactive protein (CRP), ferritin and serum transferrin receptor (sTfR) from 9,463 women of reproduction age. Data from the Basic Health Research (Riskesdas) project of 2013 were used for the study. ANOVA as well as global and local regression approaches (classical regression and geo-weighted regression) were used to compare the mean Hb and CRP values between provinces and to determine the factors that influence Hb concentrations. The results showed that the distribution of anaemia in Indonesia is uneven and not always caused by iron deficiency. The lowest Hb mean coupled with the highest iron deficiency was found in Papua, where there are high rates of parasitic infections. In contrast, the highest mean Hb coupled with low iron deficiency, and also low infection rates, was found in North Sulawesi. The Hb concentrations were significantly associated by ferritin, CRP and sTfR and there were varying magnitudes between provinces. Although anaemia is mainly influenced by the iron concentration, CRP, ferritin and sTfR can also affect it through their association with inflammatory reactions. Identification of all causes of anaemia in each province needs to be done in the future, while blanket iron supplementation should be reviewed.

在印度尼西亚,贫血仍然是一个公共卫生问题。铁补充计划,被称为Tambah Darah(血液补充片)尚未产生最佳效果。这项研究旨在确定贫血的原因和影响贫血的因素。生化指标数据为9463名育龄妇女的血红蛋白(Hb)、c反应蛋白(CRP)、铁蛋白和血清转铁蛋白受体(sTfR)。本研究使用了2013年基础健康研究(Riskesdas)项目的数据。方差分析以及全局和局部回归方法(经典回归和地理加权回归)用于比较各省之间的平均Hb和CRP值,并确定影响Hb浓度的因素。结果表明,贫血症在印度尼西亚的分布是不均匀的,并不总是由缺铁引起的。最低的血红蛋白平均值和最高的缺铁是在巴布亚发现的,那里寄生虫感染率很高。相比之下,北苏拉威西岛的平均Hb最高,缺铁率低,感染率也低。血红蛋白浓度与铁蛋白、CRP和sTfR有显著相关性,且各省之间存在差异。虽然贫血主要受铁浓度的影响,但CRP、铁蛋白和sTfR也可通过与炎症反应的关联影响贫血。今后需要确定每个省贫血的所有原因,同时应审查全面补铁。
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引用次数: 1
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