Background: Psoriasis is a chronic inflammatory skin disorder that has been increasingly linked to metabolic imbalances, particularly obesity. Conventional anthropometric indicators such as BMI and waist circumference (WC) may not sufficiently capture body fat distribution or reflect metabolic risk. The body roundness index (BRI), which integrates both height and waist measurements, has emerged as a potentially superior metric, though its relevance to psoriasis risk remains underexplored.
Objective: This study aimed to investigate the use of BRI as a digital biomarker for assessing psoriasis risk and to compare its predictive strength against BMI and WC across various demographic and metabolic subgroups using data from a nationally representative sample.
Methods: A cross-sectional analysis was conducted using data from 13,798 adults aged 20 to 59 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2006 as well as between 2009 and 2014. Psoriasis status was self-reported. Anthropometric measures (BRI, BMI, and WC) were calculated from standardized physical assessments. Weighted multivariable logistic regression models and restricted cubic spline analyses were used to examine associations while adjusting for demographic, metabolic, and lifestyle variables. A nomogram was constructed to quantify the relative predictive contributions of each metric.
Results: BRI exhibited a strong linear association with psoriasis risk (odds ratio [OR] 1.11 per unit increase, 95% CI 1.05-1.17; P<.001), outperforming BMI (OR 1.03) and WC (OR 1.01). Tertile analysis revealed a 1.73-fold increased risk of psoriasis in the highest BRI group (P=.003). Subgroup analyses confirmed consistent associations across age, sex, race or ethnicity, and metabolic status (P for interaction >.05). The nomogram highlighted BRI as the most influential predictor, indicated by its broad scoring range.
Conclusions: BRI shows stronger and more consistent associations with psoriasis risk than BMI or WC, supporting its potential role as a digital biomarker for early risk stratification. Incorporating BRI into clinical decision-making tools may enhance personalized approaches to psoriasis prevention and management.
Background: Autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition that can be quite difficult to diagnose due to a lack of objective diagnostic methods in the currently used behavioral assessments. Recent work has shown that children with ASD have a higher incidence of motor control differences. A compilation of studies indicates that between 50% and 88% of the children with ASD have issues with movement control based on standardized motor assessments or parent-reported questionnaires.
Objective: In this study, we assess a variety of deep learning approaches for the classification of ASD, utilizing data collected via inertial measurement unit (IMU) hand tracking during goal-directed arm movements.
Methods: IMU hand tracking data were recorded from 41 school-aged children both with and without an ASD diagnosis to track their arm movements during a reach-to-clean up task. The IMU data were then preprocessed using a moving average and z score normalization to prepare the data for deep learning models. We evaluated the effectiveness of different deep learning models using the preprocessed data and a k-fold validation approach, as well as a patient-separated approach.
Results: The best result was achieved with a convolutional autoencoder combined with long short-term memory layers, reaching an accuracy of 90.21% and an F1-score of 90.02%. Once the convolutional autoencoder+long short-term memory was determined to be the most effective model for this datatype, it was retrained and evaluated with a patient-separated dataset to assess the generalization capability of the model, achieving an accuracy of 91.87% and an F1-score of 93.66%.
Conclusions: Our deep learning approach demonstrates that our models hold potential for facilitating ASD diagnosis in clinical settings. This work validates that there are significant differences between the physical movements of typically developing children and children with ASD, and these differences can be identified by analyzing hand-eye coordination skills. Additionally, we have validated that small-scale models can still achieve a high accuracy and good generalization when classifying medical data, opening the door for future research into diagnostic models that may not require massive amounts of data.
Background: Electronic health records (EHRs) can aid in provider efficiency, but may also lead to unintended consequences, such as documentation burden and increased length of notes. To combat issues related to documentation, copying and pasting (CP) and copying or carrying forward (CF) are tools that have been used to aid in documentation burden. Multiple studies have identified the benefits and challenges of using these tools; however, few studies have identified the unintended consequences of CP and CF, and how the adoption of these tools may affect users.
Objective: The objective was to describe providers' perceptions and use of copying tools available in the EHR and describe their suggestions for improvement on these copying tools.
Methods: Research team members conducted semistructured interviews with faculty members, advanced practice providers, residents or fellow trainees, and medical students at a single academic health sciences center. The Diffusion of Innovations Theory of Unintended Consequences guided the analysis and interpretation of interview results.
Results: A total of 22 semistructured interviews were conducted in 2023 and analyzed during 2024. The findings showed that respondents use and value these tools for efficiency and communication purposes. The negative unintended consequences include inaccuracies and errors in documentation and increased patient safety risks. Some respondents experience inner angst or moral injury related to using CP/CF, but they feel that they must use them to satisfy organizational requirements surrounding documentation. The respondents suggested that artificial intelligence will likely help improve documentation tools, as would further training around these types of documentation tools.
Conclusions: Some respondents noted feeling both internal and external pressures that influenced when and how they use CP/CF. Respondents noted that they value EHR copying tools for efficiency purposes, but they also understand the risks involved. This tension may lead to moral angst or moral injury. They offered numerous suggestions for lowering the risk, especially by improving the documentation capabilities of the EHR through artificial intelligence. Future research should investigate both technical and educational solutions to relieve the documentation burden and moral angst they are experiencing.
Background: Accurately predicting the survival outcomes of patients with lung cancer receiving chemotherapy remains challenging.
Objective: To improve clinical management of this population, this study developed a multivariate machine learning (ML) model to assess all-cause mortality risk in chemotherapy-treated patients with lung cancer.
Methods: This study retrospectively recruited 1278 postchemotherapy patients with lung cancer from Guangzhou Chest Hospital between 2017 and 2019. Candidate features such as demographic characteristics, environmental exposures, clinical information, and patient-reported symptoms were collected via questionnaires and the electronic medical record system. The survival status and the deceased date were investigated twice a year. A total of 84 predictive models were constructed on the training set using 5 ML algorithms either individually or in pairwise combinations. The concordance index was used to identify the optimal model on the testing set, with performance validated via receiver operating characteristic curves, calibration curves, and decision curve analysis. Additionally, Shapley Additive Explanations and restricted cubic splines were applied for feature attribution analysis.
Results: The optimal model ultimately retained 21 prognosis-association features, including age, sex, BMI, smoking status, environmental smoke, the MD Anderson Symptom Inventory for Lung Cancer total score trajectories, cluster of differentiation 56, TNM stage, histology, and prechemotherapy blood biomarkers. On the testing set, the model acquired a concordance index of 0.702 (95% CI 0.652-0.753). The decision curves demonstrated positive clinical benefit when the risk thresholds were 0.40-0.69, 0.62-0.99, and 0.72-0.99 for 1-, 3-, and 5-year mortality predictions, respectively. The calibration curves showed that the predicted mortality probabilities fluctuated around the observed probabilities, and the Brier scores for 1-, 3-, and 5-year predictions were 0.20, 0.18, and 0.11, respectively. The area under the curve of the model was 0.740, 0.777, and 0.915 for 1-, 3-, and 5-year mortality predictions, respectively. Interpretability feature attribution analysis revealed that the significant features could predict all-cause mortality risk in chemotherapy-treated patients with lung cancer.
Conclusions: Our ML models exhibited acceptable discrimination, calibration, and clinical benefit in predicting the mortality risk of chemotherapy-treated patients with lung cancer, which could help clinicians in personalized prognostic management.
Background: Knee cartilage injury (KCI) poses significant challenges in the early clinical diagnosis process, primarily due to its high incidence, the complexity of healing, and the limited sensitivity of initial imaging modalities.
Objective: This study aims to employ magnetic resonance imaging and machine learning methods to enhance the classification accuracy of the classifier for KCI, improve the existing network structure, and demonstrate important clinical application value.
Methods: The proposed methodology is a multidimensional feature cross-level fusion classification network driven by the large separable kernel attention, which enables high-precision hierarchical diagnosis of KCI through deep learning. The network first fuses shallow high-resolution features with deep semantic features via the cross-level fusion module. Then, the large separable kernel attention module is embedded in the YOLOv8 network. This network utilizes the combined optimization of depth-separable and point-by-point convolutions to enhance features at multiple scales, thereby dramatically improving the hierarchical characterization of cartilage damage. Finally, five classifications of knee cartilage injuries are performed by classifiers.
Results: To overcome the limitations of network models trained with single-plane images, this study presents the first hospital-based multidimensional magnetic resonance imaging real dataset for KCI, on which the classification accuracy is 99.7%, the Kappa statistic is 99.6%, the F-measure is 99.7%, the sensitivity is 99.7%, and the specificity is 99.9%. The experimental results validate the feasibility of the proposed method.
Conclusions: The experimental outcomes confirm that the proposed methodology not only achieves exceptional performance in classifying knee cartilage injuries but also offers substantial improvements over existing techniques. This underscores its potential for clinical deployment in enhancing diagnostic precision and efficiency.
Background: We designed learning assignments for students to develop knowledge, skills, and professional attitudes about generative artificial intelligence (AI) in 2 different Master's level courses in health informatics. Our innovative approach assumed that the students had no technical background or experience in using generative AI tools.
Objective: This study aims to offer generalizable methods and experiences on integration and assessment of generative AI content into the higher education's health informatics curricula. The study's central driver is the preparation of graduate students with generative AI tools, skills, ethical discernment, and critical thinking capacities aligned with the rapidly shifting job-market requirements, independent of graduate students' backgrounds and technical expertise.
Methods: During the semester, students completed a pretest and posttest to assess knowledge about generative AI. Reflections explored their expectations and experiences using generative AI to complete their assignments and projects during the semester. Strong emphasis was placed on building skills and professional attitudes by using generative AI. Student engagement in behavioral, emotional, and cognitive domains was explored via detailed analysis of student reflections by faculty.
Results: Students at the University of Illinois Chicago increased their knowledge about generative AI from 81% to 93% through research of the basic generative AI concepts, as evidenced from outcomes of the open-book pre-and posttests given at the beginning and end of the capstone course. University of San Francisco students also improved from 77% to 80% by the end of the semester. Faculty analysis of student reflections upon completion of the course revealed primary interests in the essentials of generative AI, AI transformations to information and knowledge, and organizational changes influenced by AI adoption in the health care organizations, with ethics being a primary driver of students' interests and engagement.
Conclusions: Data from student reflections provided insight into generative AI skills that students developed and that health informatics programs can consider incorporating into their curricula. Building competencies in generative AI will prepare students for the 21st century workforce and enable them to build skills employers are seeking in the new digital health environment.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a leading cause of chronic disease and can progress to liver fibrosis or hepatocellular carcinoma. Its subtypes-obese, diabetic, and lean-are associated with varying degrees of fibrotic burden and different complications, yet the existing analytics methods often overlook its multisystem nature, intraphenotype variability, and disease dynamics. These limitations hinder accurate risk stratification and restrict personalized intervention planning.
Objective: This study developed a novel, 2-stage, contrastive learning-based method to predict the phenotype of MAFLD among adults. This method leverages multiview contrastive learning; it models individual heterogeneities and important relationships in clinical and survey-based data to predict phenotypes among adults, thus supporting clinical decision-making and personalized care.
Methods: Demographic, clinical, lifestyle, and genetic family history data of 4408 adults revealed how capturing essential relationships in patient data from different sources can transform individual-level representations into multiple, complementary views. Evaluation of the predictive efficacy of the proposed method in comparison with 8 prevalent methods relied on recall, precision, F1-score, and area under the curve values. Moreover, a Shapley additive explanation analysis was performed for interpretability.
Results: The proposed method consistently and significantly outperformed all benchmark methods. It attained the highest F1-score, showing a 32.8% improvement for nondiabetic MAFLD (0.531 vs 0.400) and 30.4% improvement for diabetic MAFLD (0.519 vs 0.398) over the respective best-performing benchmark. The results underscore the clinical value and utility of integrating clinical and survey-based data in the prediction of MAFLD phenotypes among adults.
Conclusions: The proposed method is a viable approach for MAFLD phenotype prediction. It is more effective in identifying at-risk adults than many prevalent data-driven analytics methods and thereby can enhance clinical decision-making and support patient-centric care and management.
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