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Sinapine suppresses ROS-induced C2C12 myoblast cell death through MAPK and autophagy pathways 西那平通过 MAPK 和自噬途径抑制 ROS 诱导的 C2C12 肌母细胞死亡
IF 2.4 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-30 DOI: 10.1007/s10068-024-01718-6
Jung Hyun Kang, Dong Hwan Kim, Jin Yoo, Jun Hong Shin, Ju Hyun Kim, Ji Won Lee, Seung Ho Shin

Oxidative stress in skeletal muscle can lead to muscle atrophy through reactive oxygen species (ROS)-induced damage and cell death. tert-Butyl hydroperoxide (TBHP), an exogenous ROS generator, induces oxidative stress and cell death in various cells. Sinapine from cruciferous plants possesses beneficial effects, but its role in protecting skeletal muscle cells against ROS-induced cell death remains unclear. This study demonstrates that sinapine pretreatment significantly reduced TBHP-induced cell death and ROS accumulation in a dose-dependent manner. TBHP activated mitogen-activated protein kinase (MAPK) pathways including Akt, p38, and JNK, and triggered autophagy. Sinapine suppressed the phosphorylation of Akt, MEK3/6, p38, MEK4, and JNK, and modulated key autophagy markers. Notably, the co-treatment of MAPK inhibitors attenuated TBHP-induced cell death and LC3B-II accumulation. These findings suggest that sinapine is a promising phytochemical for mitigating oxidative stress-mediated muscle injury, offering potential therapeutic strategies for maintaining skeletal muscle homeostasis and addressing muscle-related pathologies.

骨骼肌中的氧化应激可通过活性氧(ROS)诱导的损伤和细胞死亡导致肌肉萎缩。叔丁基过氧化氢(TBHP)是一种外源性ROS生成物,可诱导多种细胞中的氧化应激和细胞死亡。十字花科植物中的西那平具有有益的作用,但它在保护骨骼肌细胞免受 ROS 诱导的细胞死亡方面的作用仍不清楚。本研究表明,西那平预处理能以剂量依赖的方式显著减少TBHP诱导的细胞死亡和ROS积累。TBHP 激活了丝裂原活化蛋白激酶(MAPK)通路,包括 Akt、p38 和 JNK,并引发自噬。西那平抑制了 Akt、MEK3/6、p38、MEK4 和 JNK 的磷酸化,并调节了关键的自噬标记物。值得注意的是,同时使用 MAPK 抑制剂可减轻 TBHP 诱导的细胞死亡和 LC3B-II 积累。这些研究结果表明,西那平是一种很有前景的植物化学物质,可减轻氧化应激介导的肌肉损伤,为维持骨骼肌稳态和解决肌肉相关病症提供了潜在的治疗策略。
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引用次数: 0
Sweet flavor compounds produced by the endophytic fungus Talaromyces funiculosus 内生真菌 Talaromyces funiculosus 产生的甜味化合物
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-18 DOI: 10.1007/s10068-024-01694-x
Tianxiao Li, Yongwei Liang, Wu Wen, Honghui Dong, Wu Fan, Lingfeng Dong, Minchang Liu, Yaping Ma, Xuewei Jia, Lingbo Ji, Ting Zhou, Chunping Xu, Rongya Zhang

In this study, a sweet flavor producing endophytic fungus YN-F1 was screened and identified as Talaromyces funiculosus. The PDB broth of YN-F1 possessed strong sweet aroma together with fruity and floral flavors. The key flavor compounds were determined as 4-methyl-5,6-dihydropyran-2-one, 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one, 2-phenylethanol, and 2-(4-hydroxyphenyl)ethanol. The key flavor metabolite 4-methyl-5,6-dihydropyran-2-one was further isolated and identified by NMR and MS. Sensory evaluation suggested this compound exhibited strong sweet aroma with floral flavor. 4-Methyl-5,6-dihydropyran-2-one possessed a relatively strong binding energy with TAS1R2 of − 4.9 kcal/mol, and hydrogen bond sites of THR-A-796 and ASN-A-799 could be important since the binding energy could be mainly dominated by the hydrogen bond interaction. This is the first report of flavor producing ability and characteristic flavor compounds for the endophytic fungus T. funiculosus.

本研究筛选了一种产生甜味的内生真菌 YN-F1,并确定其为 Talaromyces funiculosus。YN-F1 的 PDB 肉汤具有浓郁的甜香味、果香味和花香味。经测定,主要风味化合物为 4-甲基-5,6-二氢吡喃-2-酮、4-羟基-4-甲基四氢-2H-吡喃-2-酮、2-苯乙醇和 2-(4-羟基苯基)乙醇。关键的风味代谢物 4-甲基-5,6-二氢吡喃-2-酮被进一步分离出来,并通过核磁共振和质谱进行了鉴定。感官评估表明,这种化合物具有浓郁的甜香味和花香。4- 甲基-5,6-二氢吡喃-2-酮与 TAS1R2 的结合能较强,为 - 4.9 kcal/mol,THR-A-796 和 ASN-A-799 的氢键位点可能很重要,因为结合能可能主要由氢键相互作用主导。这是首次报道内生真菌 T. funiculosus 的风味产生能力和特征风味化合物。
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引用次数: 0
Sustainable food systems transformation in the face of climate change: strategies, challenges, and policy implications 面对气候变化的可持续粮食系统转型:战略、挑战和政策影响
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-18 DOI: 10.1007/s10068-024-01712-y
Babar Iqbal, Khulood Fahad Alabbosh, Abdul Jalal, Sultan Suboktagin, Noureddine Elboughdiri

Climate change-induced disruptions to agricultural systems and other socio-economic and geopolitical factors threaten food supply availability, access, and stability. The paper examines the crisis and explores the strategies, challenges, and policy implications of transforming food systems towards sustainability. It highlights the undeniable impact of climate change on agriculture, discussing how it affects crop yields and contributes to the increased frequency of extreme weather events. The paper discusses the extent and causes of food loss and waste in the supply chain, presents various technologies and initiatives to reduce it, and highlights models for efficient food distribution and surplus food redistribution. Lastly, it shifts its attention to food policy and governance, assessing the effectiveness of national and international policies in addressing food security and climate change. Conclusively, it underscores the pressing need for a holistic and sustainable approach to food systems transformation in the face of climate change.

气候变化对农业系统造成的破坏以及其他社会经济和地缘政治因素威胁着粮食供应的可用性、可及性和稳定性。本文探讨了这一危机,并探讨了粮食系统向可持续性转变的战略、挑战和政策影响。文件强调了气候变化对农业不可否认的影响,讨论了气候变化如何影响作物产量并导致极端天气事件更加频繁。文件讨论了供应链中粮食损失和浪费的程度和原因,介绍了减少粮食损失和浪费的各种技术和举措,并重点介绍了高效粮食分配和剩余粮食再分配的模式。最后,文件将注意力转移到粮食政策和治理方面,评估了国家和国际政策在应对粮食安全和气候变化方面的有效性。最后,报告强调,面对气候变化,迫切需要采取全面和可持续的方法来实现粮食系统的转型。
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引用次数: 0
Nutraceutical delivery vehicles: enhanced stability, bioavailability 营养品输送载体:提高稳定性和生物利用率
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-17 DOI: 10.1007/s10068-024-01687-w
Gargi Ghoshal

Nanotechnology has gained recognition as the next uprising technology in numerous sectors, together with food industry and agriculture. Diminution of particle size to nanoscale range enhances the surface area, eventually surface-to-volume ratio, subsequently enhances their reactivity by several times, modifying optical, electrical, and mechanical features. Nanotechnology can also modify the aqueous solubility, thermal stability, and bioavailability in oral delivery of bioactive nutraceuticals. Recent research developed number of suitable delivery systems that provide effective site specific release of the nutraceuticals in control way for better utilization. Phospholipid, liposomes, niosome, emulsion, microemulsion/ nanoemulsions, ethosomes, SNEDDS, SLN based delivery vehicles, Nanostructured lipid carriers (NLCs) for nutraceutical delivery systems will be discussed in this review. Mainly the formulations, principle of the above carrier along with recent researches of those technologies will be discussed.

Graphical abstract

纳米技术已被公认为食品工业和农业等众多领域的下一个新兴技术。将颗粒尺寸缩小到纳米级范围可增加表面积,最终提高表面体积比,从而使其反应活性提高数倍,并改变光学、电学和机械特性。纳米技术还能改变生物活性营养保健品的水溶性、热稳定性和口服生物利用度。最近的研究开发出了许多合适的给药系统,能以可控的方式有效地释放特定部位的营养保健品,以便更好地利用。本综述将讨论用于营养保健品给药系统的磷脂、脂质体、niosome、乳液、微乳液/纳米乳液、ethosomes、SNEDDS、基于SLN的给药载体、纳米结构脂质载体(NLCs)。主要讨论上述载体的配方、原理以及这些技术的最新研究。
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引用次数: 0
Enhanced oxygen barrier properties of sodium alginate coatings in humid environments: ionic crosslinking of sodium alginate by calcium ions released from calcium hydrogen phosphate and calcium carbonate 增强海藻酸钠涂层在潮湿环境中的氧气阻隔性能:磷酸氢钙和碳酸钙释放的钙离子使海藻酸钠离子交联
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-14 DOI: 10.1007/s10068-024-01711-z
Hong-geon Song, Seongyun Lee, Jaejoon Han

Sodium alginate (SA) was crosslinked by calcium hydrogen phosphate and calcium carbonate (CC), of which the rate was controlled by glucono-delta-lactone to decrease the pH and induce a slow release of Ca2+ ions. The crosslinked SA was coated on oriented polypropylene (OPP). The coated films exhibited a low oxygen transmission rate (OTR) under 0% relative humidity (RH). The SA coating crosslinked with CC 0.07 g/g SA exhibited a lower OTR under 50% RH than the OPP/pure SA film due to the dense matrix and the exposure of hydrophobic groups. The coated film was laminated with cast polypropylene, decreasing an OTR by 0.11 cm3/m2·day (0% RH). Additionally, the pouches using the resultant multilayer films exhibited stable oxygen barrier properties against the environment which weakly simulates a boiling process. Furthermore, the pouches efficiently delayed the oxidation of grapeseed oil. Overall, the developed coatings show potential as oxygen barrier layers in food packaging.

海藻酸钠(SA)由磷酸氢钙和碳酸钙(CC)交联,交联速度由葡萄糖醛酸-δ-内酯控制,以降低 pH 值并诱导 Ca2+ 离子缓慢释放。交联的 SA 被涂布在拉伸聚丙烯(OPP)上。在相对湿度(RH)为 0% 的条件下,涂层薄膜的氧气透过率(OTR)较低。与 OPP/ 纯 SA 薄膜相比,CC 0.07 g/g SA 交联的 SA 涂层在 50% 相对湿度下的氧气透过率更低,这是由于基质致密和疏水基团暴露所致。涂膜与浇注聚丙烯层压后,OTR 降低了 0.11 立方厘米/平方米-天(0% 相对湿度)。此外,使用这种多层薄膜制成的小袋在弱模拟沸腾过程的环境中表现出稳定的氧气阻隔性能。此外,小袋还能有效延缓葡萄籽油的氧化。总之,所开发的涂层显示出在食品包装中用作氧气阻隔层的潜力。
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引用次数: 0
Novel mangosteen peel prebiotic with cardamom oil supports probiotic growth and preservation of rice sausage 含有豆蔻油的新型山竹皮益生元有助于益生菌的生长和米肠的保存
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-12 DOI: 10.1007/s10068-024-01710-0
Kitiya Suhem, Pailin Chaidech, Nattana Kongchoosi, Narumol Matan

Mangosteen peel (MP) is being studied for its prebiotic potential due to its high dietary fiber and bioactive compounds. This research evaluated MP combined with cardamom oil (CM) at 300 µl, examining its effects on probiotic growth and antibacterial activity against foodborne pathogens (Escherichia coli, Salmonella Typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Clostridium perfringens). Additionally, CM-treated MP was tested to extend the shelf life of rice sausage. CM-treated MP showed significant dietary fiber (58%) and bioactive compounds, including total phenolics (18.5 mgGAE/100 g), flavonoids (50.5 mgQE/100 g), and strong antioxidant activity (IC50 of ABTS: 8.3 µg/mL, DPPH: 9.4 µg/mL). It promoted probiotic growth, lowered pH, and inhibited pathogens. The shelf life of rice sausage extended from 7 to 21 days at 4 °C. The color of the treated sausage showed the highest red–yellow after fermenting for 21 days, with maximum a* (10.49 ± 0.51) and b* (22.40 ± 0.97), compared to the control (a* ~ 3.88 ± 0.35, b* ~ 11.66 ± 1.67). It also increased lactic acid bacteria and prevented pathogen growth. These findings suggest that CM-treated MP shows promise as a prebiotic for enhancing the safety of fermented foods and could be particularly beneficial in the fermented rice sausage industry due to its low production cost. MP, produced from waste, is an inexpensive ingredient that is easy to incorporate into rice sausage production. This enhances the product’s value, provides prebiotic benefits, and boosts both marketability and consumer interest in healthy food options.

山竹果皮(MP)具有高膳食纤维和生物活性化合物,其益生元潜力正在被研究。这项研究评估了山竹皮与小豆蔻油(CM)(300 µl)的组合,考察了其对益生菌生长的影响以及对食源性病原体(大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生李斯特菌、金黄色葡萄球菌和产气荚膜梭菌)的抗菌活性。此外,还测试了经 CM 处理的 MP 能否延长米肠的保质期。经 CM 处理的 MP 含有大量膳食纤维(58%)和生物活性化合物,包括总酚(18.5 mgGAE/100 g)、类黄酮(50.5 mgQE/100 g)和较强的抗氧化活性(ABTS 的 IC50 值为 8.3 µg/mL,DPPH 为 9.4 µg/mL)。它能促进益生菌生长,降低 pH 值,抑制病原体。在 4 °C 下,米香肠的保质期从 7 天延长到 21 天。与对照组(a* ~ 3.88 ± 0.35,b* ~ 11.66 ± 1.67)相比,经过处理的香肠在发酵 21 天后呈现出最高的红黄色,a*(10.49 ± 0.51)和 b*(22.40 ± 0.97)最大。它还能增加乳酸菌数量,防止病原体生长。这些研究结果表明,经 CM 处理的 MP 有希望成为提高发酵食品安全性的益生元,而且由于其生产成本低,对发酵米肠行业尤其有益。从废弃物中提取的 MP 是一种价格低廉的配料,很容易添加到米肠生产中。这可以提高产品的价值,提供益生元益处,并提高市场销售能力和消费者对健康食品的兴趣。
{"title":"Novel mangosteen peel prebiotic with cardamom oil supports probiotic growth and preservation of rice sausage","authors":"Kitiya Suhem, Pailin Chaidech, Nattana Kongchoosi, Narumol Matan","doi":"10.1007/s10068-024-01710-0","DOIUrl":"https://doi.org/10.1007/s10068-024-01710-0","url":null,"abstract":"<p>Mangosteen peel (MP) is being studied for its prebiotic potential due to its high dietary fiber and bioactive compounds. This research evaluated MP combined with cardamom oil (CM) at 300 µl, examining its effects on probiotic growth and antibacterial activity against foodborne pathogens (<i>Escherichia coli</i>, <i>Salmonella</i> Typhimurium, <i>Listeria monocytogenes, Staphylococcus aureus</i>, and <i>Clostridium perfringens</i>). Additionally, CM-treated MP was tested to extend the shelf life of rice sausage. CM-treated MP showed significant dietary fiber (58%) and bioactive compounds, including total phenolics (18.5 mgGAE/100 g), flavonoids (50.5 mgQE/100 g), and strong antioxidant activity (IC50 of ABTS: 8.3 µg/mL, DPPH: 9.4 µg/mL). It promoted probiotic growth, lowered pH, and inhibited pathogens. The shelf life of rice sausage extended from 7 to 21 days at 4 °C. The color of the treated sausage showed the highest red–yellow after fermenting for 21 days, with maximum <i>a*</i> (10.49 ± 0.51) and <i>b*</i> (22.40 ± 0.97), compared to the control (<i>a*</i> ~ 3.88 ± 0.35, b* ~ 11.66 ± 1.67). It also increased lactic acid bacteria and prevented pathogen growth. These findings suggest that CM-treated MP shows promise as a prebiotic for enhancing the safety of fermented foods and could be particularly beneficial in the fermented rice sausage industry due to its low production cost. MP, produced from waste, is an inexpensive ingredient that is easy to incorporate into rice sausage production. This enhances the product’s value, provides prebiotic benefits, and boosts both marketability and consumer interest in healthy food options.</p>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Freeze drying microencapsulation using whey protein, maltodextrin and corn powder improved survivability of probiotics during storage 使用乳清蛋白、麦芽糊精和玉米粉进行冷冻干燥微胶囊技术可提高益生菌在储存期间的存活率
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-12 DOI: 10.1007/s10068-024-01706-w
Benjamaporn Poopan, Anongnard Kasorn, Narathip Puttarat, Kittiwut Kasemwong, Ulisa Pachekrepapol, Malai Taweechotipatr

Various studies demonstrated that probiotics play important roles in maintaining the balance of microorganisms in the body. Some strains produce bile salt hydrolase enzyme (BSH), which is an indirect mechanism for lowering cholesterol. BSH-producing probiotics as a supplement might be an alternative way to help reducing cholesterol in the body. The aim of this study was to investigate the effects of different microcapsule formulations with selected vegetable powders on growth characteristics of 3 Thai probiotic strains, Lactobacillus gasseri TM1, Lacticaseibacillus rhamnosus TM7, and L. rhamnosus TM14. Probiotics were cultured in MRS broth supplemented with 5 vegetable powders. Corn powder significantly increased growth rate of probiotics from 109 to 1012 CFU/ml. Therefore, different microcapsule formulations by Maillard reaction of whey protein isolate and maltodextrin mixed with and without corn powder were studied. The results showed that probiotic microcapsules formulated with corn powder significantly effectively sustained probiotic viability under gastrointestinal and storage conditions.

多项研究表明,益生菌在维持体内微生物平衡方面发挥着重要作用。有些菌株能产生胆盐水解酶(BSH),这是一种降低胆固醇的间接机制。作为一种补充剂,产生 BSH 的益生菌可能是帮助降低体内胆固醇的另一种方法。本研究的目的是调查不同的微胶囊配方与精选蔬菜粉对 3 种泰国益生菌株(Lactobacillus gasseri TM1、Lacticaseibacillus rhamnosus TM7 和 L. rhamnosus TM14)生长特性的影响。益生菌在添加了 5 种蔬菜粉的 MRS 肉汤中进行培养。玉米粉能明显提高益生菌的生长率,从 109 CFU/ml 提高到 1012 CFU/ml。因此,研究了乳清蛋白分离物和麦芽糊精混合玉米粉和不混合玉米粉的马氏反应微胶囊配方。结果表明,用玉米粉配制的益生菌微胶囊能显著有效地维持益生菌在胃肠道和储存条件下的存活率。
{"title":"Freeze drying microencapsulation using whey protein, maltodextrin and corn powder improved survivability of probiotics during storage","authors":"Benjamaporn Poopan, Anongnard Kasorn, Narathip Puttarat, Kittiwut Kasemwong, Ulisa Pachekrepapol, Malai Taweechotipatr","doi":"10.1007/s10068-024-01706-w","DOIUrl":"https://doi.org/10.1007/s10068-024-01706-w","url":null,"abstract":"<p>Various studies demonstrated that probiotics play important roles in maintaining the balance of microorganisms in the body. Some strains produce bile salt hydrolase enzyme (BSH), which is an indirect mechanism for lowering cholesterol. BSH-producing probiotics as a supplement might be an alternative way to help reducing cholesterol in the body. The aim of this study was to investigate the effects of different microcapsule formulations with selected vegetable powders on growth characteristics of 3 Thai probiotic strains, <i>Lactobacillus gasseri</i> TM1, <i>Lacticaseibacillus rhamnosus</i> TM7, and <i>L. rhamnosus</i> TM14. Probiotics were cultured in MRS broth supplemented with 5 vegetable powders. Corn powder significantly increased growth rate of probiotics from 10<sup>9</sup> to 10<sup>12</sup> CFU/ml. Therefore, different microcapsule formulations by Maillard reaction of whey protein isolate and maltodextrin mixed with and without corn powder were studied. The results showed that probiotic microcapsules formulated with corn powder significantly effectively sustained probiotic viability under gastrointestinal and storage conditions.</p>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"106 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of NET-2201 (Capsicum chinense L. cv.) on brown adipose tissue activation and white adipose tissue browning in high-fat-diet-induced obese mice NET-2201(辣椒素)对高脂饮食诱导的肥胖小鼠棕色脂肪组织活化和白色脂肪组织棕色化的影响
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-11 DOI: 10.1007/s10068-024-01692-z
Yoon-Young Han, Ha-Neul Jo, Bo-Mi Kim, Jae-Sun Lee, Ji-Min Kim, Dae-Ho Ryu, Dong-Hee Kim, Chan-Sung Park, Byoung-Cheorl Kang, Yong-Wook Lee

The present study explored the anti-obesity effects of NET-2201 (Capsicum chinense L. cv.), a non-pungent cultivated variety of chili pepper, and its underlying molecular mechanism in high-fat-diet (HFD)-induced obese mice. Administration of 50 mg/kg NET-2201 significantly inhibited body weight (BW) gain and reduced adipose tissue weight in obese mice. NET-2201 caused improvement in the expression levels of genes associated with lipid metabolism in white adipose tissue (WAT) to near-normal levels. Furthermore, NET-2201 significantly increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and uncoupling protein 1 (UCP1) protein expressions in brown adipose tissue (BAT). Moreover, NET-2201 activated WAT browning by altering the expression levels of brown and beige adipocyte-selective genes, including UCP1, PGC-1α, and PR domain containing 16. Our results indicate that dietary NET-2201 mitigates BW gain by activating BAT and inducing WAT browning.

本研究探讨了一种无刺激性的辣椒栽培品种--NET-2201(Capsicum chinense L. cv.)对高脂饮食(HFD)诱导的肥胖小鼠的抗肥胖作用及其潜在的分子机制。服用 50 毫克/千克的 NET-2201 能显著抑制肥胖小鼠体重(BW)的增加,并降低脂肪组织的重量。NET-2201 使白色脂肪组织(WAT)中与脂质代谢相关的基因表达水平提高到接近正常水平。此外,NET-2201 还能明显增加棕色脂肪组织(BAT)中过氧化物酶体增殖激活受体 gamma 辅激活因子 1-α(PGC-1α)和解偶联蛋白 1(UCP1)蛋白的表达。此外,NET-2201 还通过改变棕色和米色脂肪细胞选择性基因(包括 UCP1、PGC-1α 和含 PR 结构域 16 的基因)的表达水平来激活 WAT 棕色化。我们的研究结果表明,膳食 NET-2201 可通过激活 BAT 和诱导 WAT 棕色化来减轻体重增加。
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引用次数: 0
Effect of Ixeris dentata extract on anti-inflammatory by inhibition of Nf-kb and cytokine levels Ixeris dentata 提取物通过抑制 Nf-kb 和细胞因子水平对抗炎药物的影响
IF 2.9 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-11 DOI: 10.1007/s10068-024-01654-5
Min Ho Kang, So Hee Kim, Jae Hoon Park, Suh Hee Yeom, Jung Eun Park, Jin Woo Kim

Chronic inflammation is persistent disease caused by unregulated activation of Nf-kb pathway and production of pro-inflammatory cytokines, induced by accumulation of reactive oxygen species above thresholds. The purpose of this study was to evaluate the anti-oxidant, anti-lipidemia, inhibition Nf-kb pathway, and reduction of pro-inflammatory cytokine activities of Ixeris dentata extract (IDE) to demonstrate its inhibitory ability against chronic inflammatory in RAW264.7. Polyphenol content, radical scavenging activity, and lipase activity inhibition of IDE were 9.2 ± 0.2 GAE mg/g dry matter, 84.7%, and 72.4%, respectively, showing high effects against anti-oxidant and lipolysis inhibitory. Furthermore, anti-inflammatory effects of IDE on LPS-induced RAW 264.7 were investigated, and expression of inflammatory genes such as Cox-2, Inos, Tnf-α, Il-6, Nf-kb, and Il-1β were decreased by 36.5%–83.4%. Studies have confirmed that IDE has excellent antioxidant, lipolysis inhibitory, and anti-inflammatory effects, and Ixeris dentata can be used as natural ingredients for food and medicine to prevent.

慢性炎症是由于活性氧积累超过阈值,导致 Nf-kb 通路不规则激活并产生促炎细胞因子而引起的顽固性疾病。本研究的目的是评估牙鲆提取物(IDE)的抗氧化、抗血脂、抑制 Nf-kb 通路和减少促炎细胞因子活性,以证明其对 RAW264.7 慢性炎症的抑制能力。IDE的多酚含量、自由基清除活性和脂肪酶活性抑制率分别为9.2±0.2 GAE mg/g干物质、84.7%和72.4%,显示出较高的抗氧化和脂肪分解抑制作用。此外,还研究了 IDE 对 LPS 诱导的 RAW 264.7 的抗炎作用,结果显示,Cox-2、Inos、Tnf-α、Il-6、Nf-kb 和 Il-1β 等炎症基因的表达量下降了 36.5%-83.4%。研究证实,IDE具有很好的抗氧化、抑制脂肪分解和抗炎作用,可以作为食品和药物的天然成分来预防。
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引用次数: 0
Transforming plant proteins into plant-based meat alternatives: challenges and future scope 将植物蛋白转化为植物肉类替代品:挑战与未来空间
IF 2.4 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-10 DOI: 10.1007/s10068-024-01683-0
Priyanka Prajapati, Meenakshi Garg, Neha Singh, Rajni Chopra, Avneesh Mittal, Prabhjot K. Sabharwal

The global transition towards sustainable living has led to a growing demand for innovative food products that enhance environmental sustainability. Traditional meat production is known for its high energy consumption and significant carbon emissions, necessitating alternative approaches. Plant-based meat (PBM) offers a promising solution to reduce the ecological footprint of animal agriculture. This paper examines various challenges in PBM development, including nutritional equivalence, industrial scalability, organoleptic properties, and digestibility. Addressing these challenges requires interdisciplinary collaboration to ensure consumer acceptance, regulatory compliance, and environmental stewardship. Advanced technologies like nanotechnology, fermentation, and enzymatic hydrolysis, along with automation and repurposing cattle farms, offer solutions to enhance PBM’s quality and production efficiency. By integrating these innovations, PBM has the potential to revolutionize the food industry, offering sustainable and nutritious alternatives that meet global dietary needs while significantly reducing environmental impact.

Graphical abstract

随着全球向可持续生活转型,人们对提高环境可持续性的创新食品的需求日益增长。众所周知,传统肉类生产能耗高、碳排放量大,因此有必要采用替代方法。植物基肉类(PBM)为减少畜牧业的生态足迹提供了一个前景广阔的解决方案。本文探讨了 PBM 开发过程中面临的各种挑战,包括营养等同性、工业可扩展性、感官特性和消化率。应对这些挑战需要跨学科合作,以确保消费者接受、符合法规要求和环境管理。纳米技术、发酵和酶水解等先进技术以及自动化和养牛场再利用技术为提高 PBM 的质量和生产效率提供了解决方案。通过整合这些创新技术,PBM 有可能彻底改变食品行业,提供可持续的营养替代品,满足全球饮食需求,同时显著减少对环境的影响。
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引用次数: 0
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