A. Chant, Ahmad Chaudary, Christina M. Kraemer-Chant
{"title":"A Study of Radiation-Induced Instability for the Gene Locus Associated with Intellectual Disorders or Developmental Delays","authors":"A. Chant, Ahmad Chaudary, Christina M. Kraemer-Chant","doi":"10.4236/abc.2023.134010","DOIUrl":"https://doi.org/10.4236/abc.2023.134010","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Novel Nanoplatforms for Delivery of an Anticataract Drug in Whole Lens Cultures","authors":"A. Pfaff, Anna V. Chernatynskaya, N. Ercal","doi":"10.4236/abc.2022.125015","DOIUrl":"https://doi.org/10.4236/abc.2022.125015","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47831530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Fluorescent Chemosensor for Selective and Sensitive Detection of Mn<sup>2+</sup> in Acidic Medium","authors":"A. Umit","doi":"10.4236/abc.2022.125014","DOIUrl":"https://doi.org/10.4236/abc.2022.125014","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Inoculum Size of <i>Afifella marina</i> in the Bioprocessing of <i>Sargassum</i> spp. Meal","authors":"Sujjat Al Azad, Mohammad Tamrin Mohamad Lal","doi":"10.4236/abc.2022.126016","DOIUrl":"https://doi.org/10.4236/abc.2022.126016","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Della Giustina, R. Frassini, S. Moura, F. J. Scariot, S. Echeverrigaray, Vanessa Sayuri Osaki, Franciane M. Pellizari, P. Colepicolo, J. P. Henriques, Janaina da Silva Crespo, M. Roesch-Ely
{"title":"Antarctic Macroalgae <i>Palmaria decipiens</i> (Rhodophyta, Palmariales) Extracts Present Antioxidant and Antitumor Activity against Colorectal Cancer","authors":"Marina Della Giustina, R. Frassini, S. Moura, F. J. Scariot, S. Echeverrigaray, Vanessa Sayuri Osaki, Franciane M. Pellizari, P. Colepicolo, J. P. Henriques, Janaina da Silva Crespo, M. Roesch-Ely","doi":"10.4236/abc.2022.126022","DOIUrl":"https://doi.org/10.4236/abc.2022.126022","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leukovir, an enteric-coated tablet, is the original drug product for internal use. The well-known nucleosides cladribine and ribavirin are the active ingredients of the drug product leukovir. Pharmacokinetic parameters of the drug product for the internal use of leukovir active ingredients have been es-tablished. The cladribine half-absorption period was t 1/2a = 49.5 h, C 0 = 276.4 μg/ml, C max = 6.0 μg/ml. Distribution and accumulation parameters (V d , V ss and AUC) have indicated that the drug distribution between the blood cells and blood plasma takes place in the same way, irrespective of the dosage form. Cladribine half-life period is t 1/2e = 0.62 hours. The molecule total clearance and average lifetime in the body in the case of subcutaneous drug administration are approximately the same. Ribavirin is characterized by a half-absorption period of t 1/2a = 0.71 h, C 0 = 115.6 μg/ml and C max = 75.5 μg/ml. Ribavirin total volume of distribution (V d = 1.3 l/kg) and stationary volume of distribution (V ss = 1.64 l/kg) were practically similar to leukovir when administered subcutaneously. The AUC value = 504.2 μg h/ml, which is 2.5 times less than that in the case of drug form administration. Leukovir was regarded as slightly toxic in an acute toxicity study. The risk of cumulation for this drug product is low.
{"title":"Pharmacokinetic Study and Toxicity of Leukovir: A New Combined Drug for the Treatment of Multiple Sclerosis","authors":"E. Kalinichenko, I. V. Ponteleeva, M. Golubeva","doi":"10.4236/abc.2022.121001","DOIUrl":"https://doi.org/10.4236/abc.2022.121001","url":null,"abstract":"Leukovir, an enteric-coated tablet, is the original drug product for internal use. The well-known nucleosides cladribine and ribavirin are the active ingredients of the drug product leukovir. Pharmacokinetic parameters of the drug product for the internal use of leukovir active ingredients have been es-tablished. The cladribine half-absorption period was t 1/2a = 49.5 h, C 0 = 276.4 μg/ml, C max = 6.0 μg/ml. Distribution and accumulation parameters (V d , V ss and AUC) have indicated that the drug distribution between the blood cells and blood plasma takes place in the same way, irrespective of the dosage form. Cladribine half-life period is t 1/2e = 0.62 hours. The molecule total clearance and average lifetime in the body in the case of subcutaneous drug administration are approximately the same. Ribavirin is characterized by a half-absorption period of t 1/2a = 0.71 h, C 0 = 115.6 μg/ml and C max = 75.5 μg/ml. Ribavirin total volume of distribution (V d = 1.3 l/kg) and stationary volume of distribution (V ss = 1.64 l/kg) were practically similar to leukovir when administered subcutaneously. The AUC value = 504.2 μg h/ml, which is 2.5 times less than that in the case of drug form administration. Leukovir was regarded as slightly toxic in an acute toxicity study. The risk of cumulation for this drug product is low.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Plazanet, Christelle Gady, S. Lhernould, R. Zerrouki, D. Montplaisir, G. Costa
{"title":"Ionic Liquid Efficiency on Wood Dissolution and Polysaccharide Identification","authors":"I. Plazanet, Christelle Gady, S. Lhernould, R. Zerrouki, D. Montplaisir, G. Costa","doi":"10.4236/abc.2022.126021","DOIUrl":"https://doi.org/10.4236/abc.2022.126021","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Igeh, Elkanah Ishaku, J. G. Nangbes, S. Choji, F. O. Okonkwo
Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by es-timating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p < 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.
{"title":"Aqueous Extract of <i>Erythrina senegalensis</i> Exhibits Dose-Dependent Hepatoprotective Activity on Paracetamol-Induced Liver Damage in Wistar Rats","authors":"P. Igeh, Elkanah Ishaku, J. G. Nangbes, S. Choji, F. O. Okonkwo","doi":"10.4236/abc.2022.122005","DOIUrl":"https://doi.org/10.4236/abc.2022.122005","url":null,"abstract":"Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by es-timating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p < 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kouraogo, F. Soudre, A. Kiba, R. Karfo, O. Da, E. Zongo, E. Kabré, J. Sakandé
{"title":"Abnormalities of Serum Protein Fractions in Hemodialysis Patients with Chronic Renal Failure at Ouagadougou, Burkina Faso","authors":"A. Kouraogo, F. Soudre, A. Kiba, R. Karfo, O. Da, E. Zongo, E. Kabré, J. Sakandé","doi":"10.4236/abc.2022.126017","DOIUrl":"https://doi.org/10.4236/abc.2022.126017","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Positive Effects of Proprietary Undenatured B-Glucans on Growing Pigs","authors":"B. Kristiansen, R. Amen","doi":"10.4236/abc.2022.126020","DOIUrl":"https://doi.org/10.4236/abc.2022.126020","url":null,"abstract":"","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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