Pub Date : 2022-01-01DOI: 10.4236/ojbiphy.2022.121003
A. Szász
The malignant processes deviate from the healthy homeostatic control, and various “tricks” enable malignant cells to avoid the healthy regulation. Consequently, the malignant structures miss the apoptosis and proliferate without restriction, and without the formation of communication networks in the newly formed cells. The modulation supports the homeostatic control to rearrange the health regulation processes in various ways. The modulation acts with stochastic processes, using stochastic resonances for molecular excitations, supporting the regulative enzymatic processes. The number of stochastic resonant frequencies is as many as the number of enzymatic reactions. The malignant cells differ structurally and dynamically in their connections and interactions from their healthy host tissues. The radiofrequency carrier is modulated with an appropriate time-fractal (1/f) noise to select the autonomic cancer-cells, destroy them, or force the precancerous, semi-individual cells to participate in the networking connections. The modulation in this way limits the cellular autonomy of malignant cells and boosts the healthy control. The resonant energy triggers apoptotic processes and helps immunogenic actions deliver extracellular genetic information for antigen-presentation. The modulation is applied in clinical practice. The therapy (modulated electro-hyperthermia, mEHT) is intensively used in oncology in complementary applications and for palliative stages, and occasionally even as a monotherapy.
{"title":"Time-Fractal Modulation—Possible Modulation Effects in Human Therapy","authors":"A. Szász","doi":"10.4236/ojbiphy.2022.121003","DOIUrl":"https://doi.org/10.4236/ojbiphy.2022.121003","url":null,"abstract":"The malignant processes deviate from the healthy homeostatic control, and various “tricks” enable malignant cells to avoid the healthy regulation. Consequently, the malignant structures miss the apoptosis and proliferate without restriction, and without the formation of communication networks in the newly formed cells. The modulation supports the homeostatic control to rearrange the health regulation processes in various ways. The modulation acts with stochastic processes, using stochastic resonances for molecular excitations, supporting the regulative enzymatic processes. The number of stochastic resonant frequencies is as many as the number of enzymatic reactions. The malignant cells differ structurally and dynamically in their connections and interactions from their healthy host tissues. The radiofrequency carrier is modulated with an appropriate time-fractal (1/f) noise to select the autonomic cancer-cells, destroy them, or force the precancerous, semi-individual cells to participate in the networking connections. The modulation in this way limits the cellular autonomy of malignant cells and boosts the healthy control. The resonant energy triggers apoptotic processes and helps immunogenic actions deliver extracellular genetic information for antigen-presentation. The modulation is applied in clinical practice. The therapy (modulated electro-hyperthermia, mEHT) is intensively used in oncology in complementary applications and for palliative stages, and occasionally even as a monotherapy.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojbiphy.2022.124010
F. Gasparyan, L. Gasparyan, V. Simonyan
{"title":"SFET Based Immunosensor","authors":"F. Gasparyan, L. Gasparyan, V. Simonyan","doi":"10.4236/ojbiphy.2022.124010","DOIUrl":"https://doi.org/10.4236/ojbiphy.2022.124010","url":null,"abstract":"","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojbiphy.2022.124013
Xinzhou Yuan, Jafeng Yuan, Qiao Bi, K. Song
{"title":"Study on Plant Radiation Signal Transduction for Human Self-Healing","authors":"Xinzhou Yuan, Jafeng Yuan, Qiao Bi, K. Song","doi":"10.4236/ojbiphy.2022.124013","DOIUrl":"https://doi.org/10.4236/ojbiphy.2022.124013","url":null,"abstract":"","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-06DOI: 10.4236/ojbiphy.2021.114014
A. N. Shoutko
The migrating TdT+ thymocytes can die in other tissues, promoting the surrounding cells’ renewing likes holocrine secretion does. To clarify the role of TdT-enzyme for this function of progenitor lymphocytes, their extracellular media with its components included by living cells analyzed in vitro before and after in vivo irradiation of donor rats. The nucleoid with DNase-sensitive (free) DNA and TdT activity discovered in extracellular media conditioned preliminary by spontaneous apoptotic death of a minor part of the thymocyte’s suspension in vitro. The penetration of labeled products of non-template synthesis with free DNA’ primers from media into cells by pinocytosis confirmed by exogenous polymeric DNA marked artificially. The DNA penetration into cells follows an increase of the cell’s viability and acceleration of spontaneous intracellular DNA-synthesis controlled with labeled thymidine uptake. Both phenomena are typical for either the lowest initial concentration of intact cells or their preliminary irradiation in vivo. The data point to possible involvement of apoptotic decay of TdT+ cells in the reutilization of the extracellular DNA fragments for reparation/regeneration of surrounding living cells.
{"title":"The Possible Involvement of Apoptotic Decay of Terminal Deoxynucleotidyl Transferase-Positive Lymphocytes in the Reutilization of the Extracellular DNA Fragments by Surrounding Living Cells","authors":"A. N. Shoutko","doi":"10.4236/ojbiphy.2021.114014","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.114014","url":null,"abstract":"The migrating TdT+ thymocytes can die in other tissues, promoting the surrounding cells’ renewing likes holocrine secretion does. To clarify the role of TdT-enzyme for this function of progenitor lymphocytes, their extracellular media with its components included by living cells analyzed in vitro before and after in vivo irradiation of donor rats. The nucleoid with DNase-sensitive (free) DNA and TdT activity discovered in extracellular media conditioned preliminary by spontaneous apoptotic death of a minor part of the thymocyte’s suspension in vitro. The penetration of labeled products of non-template synthesis with free DNA’ primers from media into cells by pinocytosis confirmed by exogenous polymeric DNA marked artificially. The DNA penetration into cells follows an increase of the cell’s viability and acceleration of spontaneous intracellular DNA-synthesis controlled with labeled thymidine uptake. Both phenomena are typical for either the lowest initial concentration of intact cells or their preliminary irradiation in vivo. The data point to possible involvement of apoptotic decay of TdT+ cells in the reutilization of the extracellular DNA fragments for reparation/regeneration of surrounding living cells.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48345227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-06DOI: 10.4236/ojbiphy.2021.114013
A. Szász
Background: Allometric scaling is a well-known research tool used for the metabolic rates of organisms. It measures the living systems with fractal physiology. The metabolic rate versus the mass of the living species has a definite scaling and behaves like a four-dimensional phenomenon. The extended investigations focus on the mass-dependence of the various physiological parameters. Objective: Proving the length of vascularization is the scaling parameter instead of mass in allometric relation. Method: The description of the energy balance of the ontogenic growth of the tumor is an extended cell-death parameter for studying the mass balance at the cellular level. Results: It is shown that when a malignant cellular cluster tries to maximize its metabolic rate, it changes its allometric scaling exponent. A growth description could follow the heterogenic development of the tumor. The mass in the allometric scaling could be replaced by the average length of the circulatory system in each case. Conclusion: According to this concept, the dependence of the mass in allometric scaling is replaced with a more fundamental parameter, the length character of the circulatory system. The introduced scaling parameter has primary importance in cancer development, where the elongation of the circulatory length by angiogenesis is in significant demand.
{"title":"Allometric Scaling by the Length of the Circulatory Network","authors":"A. Szász","doi":"10.4236/ojbiphy.2021.114013","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.114013","url":null,"abstract":"Background: Allometric scaling is a well-known research tool used for the metabolic rates of organisms. It measures the living systems with fractal physiology. The metabolic rate versus the mass of the living species has a definite scaling and behaves like a four-dimensional phenomenon. The extended investigations focus on the mass-dependence of the various physiological parameters. Objective: Proving the length of vascularization is the scaling parameter instead of mass in allometric relation. Method: The description of the energy balance of the ontogenic growth of the tumor is an extended cell-death parameter for studying the mass balance at the cellular level. Results: It is shown that when a malignant cellular cluster tries to maximize its metabolic rate, it changes its allometric scaling exponent. A growth description could follow the heterogenic development of the tumor. The mass in the allometric scaling could be replaced by the average length of the circulatory system in each case. Conclusion: According to this concept, the dependence of the mass in allometric scaling is replaced with a more fundamental parameter, the length character of the circulatory system. The introduced scaling parameter has primary importance in cancer development, where the elongation of the circulatory length by angiogenesis is in significant demand.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48119165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-26DOI: 10.4236/ojbiphy.2021.113010
A. Szász
The local-regional oncological hyperthermia has various electromagnetic methods for energy-transfer. The differences involve conceptual considerations and technical solutions. The most frequently applied energy transfer is capacitive coupling, concentrating the electric field to be the active heating component. The realization of the capacitive coupling set-up is divided into two different categories based on their goals for heating: 1) the homogeneous (conventional) heating, using isothermal conditions for dosing, and 2) the selective heterogeneous heating, using cellularly absorbed energy for dosing. The homogeneous heating utilizes plane-wave matching, absorbing the wave for energy transfer. The heterogenic heating uses impedance matching, selecting the malignant cells by their electromagnetic specialties, like their heterogenic impedance, higher membrane-raft density, and different spatio-temporal (pathologic pattern) arrangements. This article’s objective is to compare and discuss the details of the two kinds of capacitive coupling techniques.
{"title":"The Capacitive Coupling Modalities for Oncological Hyperthermia","authors":"A. Szász","doi":"10.4236/ojbiphy.2021.113010","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.113010","url":null,"abstract":"The local-regional oncological hyperthermia has various electromagnetic methods for energy-transfer. The differences involve conceptual considerations and technical solutions. The most frequently applied energy transfer is capacitive coupling, concentrating the electric field to be the active heating component. The realization of the capacitive coupling set-up is divided into two different categories based on their goals for heating: 1) the homogeneous (conventional) heating, using isothermal conditions for dosing, and 2) the selective heterogeneous heating, using cellularly absorbed energy for dosing. The homogeneous heating utilizes plane-wave matching, absorbing the wave for energy transfer. The heterogenic heating uses impedance matching, selecting the malignant cells by their electromagnetic specialties, like their heterogenic impedance, higher membrane-raft density, and different spatio-temporal (pathologic pattern) arrangements. This article’s objective is to compare and discuss the details of the two kinds of capacitive coupling techniques.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44496732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-26DOI: 10.4236/ojbiphy.2021.113012
B. Ndong, M. S. Djigo, G. Akpo, E. Bathily, O. Diop, A. Sanou, A. Koutouan, N. Badji, F. Badji, J. Wezzani, K. Ka, I. Thiam, G. Mbaye, O. Ndoye, M. Mbodj, E. Niang
The aim of this study was to evaluate the dose delivered to patients during scannographic examinations at the Kaolack Regional Hospital (one of the 14 regions of Senegal located in the center-west of the country, 192 km from Dakar) and to compare these irradiation doses at diagnostic reference levels found in the literature in order to optimize our scanning protocols. To achieve this goal, we carried out a prospective study involving 218 CT scans. These examinations focused on cerebral, thoracic, abdominopelvic and lumbar spine acquisitions made in adults and cerebral only in children. We compared the median values of dosimetric indicators (CTDIvol and DLP) per acquisition with NRDs in the literature. During the course of this study, we found a dosimetric ratio lower than that of the NRDs for thoracic, abdomino-pelvic and lumbar spine CT scans in adults and a significant dosimetric exceedance for brain scans in adults and in children. These results encourage us to extend these dosimetric evaluations to other hospital structures in order to establish rigorous monitoring of dosimetric indicators and to respect the principles of radiation protection and good practice.
{"title":"Dosimetric Evaluation of the Scanning Activity at the Regional Hospital of Kaolack (Senegal)","authors":"B. Ndong, M. S. Djigo, G. Akpo, E. Bathily, O. Diop, A. Sanou, A. Koutouan, N. Badji, F. Badji, J. Wezzani, K. Ka, I. Thiam, G. Mbaye, O. Ndoye, M. Mbodj, E. Niang","doi":"10.4236/ojbiphy.2021.113012","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.113012","url":null,"abstract":"The aim of this study was to evaluate the dose delivered to patients during scannographic examinations at the Kaolack Regional Hospital (one of the 14 regions of Senegal located in the center-west of the country, 192 km from Dakar) and to compare these irradiation doses at diagnostic reference levels found in the literature in order to optimize our scanning protocols. To achieve this goal, we carried out a prospective study involving 218 CT scans. These examinations focused on cerebral, thoracic, abdominopelvic and lumbar spine acquisitions made in adults and cerebral only in children. We compared the median values of dosimetric indicators (CTDIvol and DLP) per acquisition with NRDs in the literature. During the course of this study, we found a dosimetric ratio lower than that of the NRDs for thoracic, abdomino-pelvic and lumbar spine CT scans in adults and a significant dosimetric exceedance for brain scans in adults and in children. These results encourage us to extend these dosimetric evaluations to other hospital structures in order to establish rigorous monitoring of dosimetric indicators and to respect the principles of radiation protection and good practice.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44628137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-26DOI: 10.4236/OJBIPHY.2021.113008
Fritz Lewertoff
Even today in light of the pandemic spread of the corona virus COVID 19, the debate amongst biologists which concerns whether viruses are alive or not still remains unresolved. This, however, revolves around the argument that viruses cannot produce their own adenosine triphosphate molecule (ATP) through metabolism and, therefore, must rely on other living microorganisms that can produce it in order to access the energy that ATP provides upon hydrolysis. It is mainly on account of this distinction that viruses are relegated to an ill-defined area that separates living things from nonliving things. Nevertheless, apparently viruses possess an inherent capacity that enables them to cross this invisible dividing line in order to link up with the ATP molecule through which they sustain their activities. The following presents a review of these issues with regard to microbiology, biochemistry and physics.
{"title":"On the Importance of ATP Energy in Biology with Regard to Viruses","authors":"Fritz Lewertoff","doi":"10.4236/OJBIPHY.2021.113008","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2021.113008","url":null,"abstract":"Even today in light of the pandemic spread of the corona virus COVID 19, the debate amongst biologists which concerns whether viruses are alive or not still remains unresolved. This, however, revolves around the argument that viruses cannot produce their own adenosine triphosphate molecule (ATP) through metabolism and, therefore, must rely on other living microorganisms that can produce it in order to access the energy that ATP provides upon hydrolysis. It is mainly on account of this distinction that viruses are relegated to an ill-defined area that separates living things from nonliving things. Nevertheless, apparently viruses possess an inherent capacity that enables them to cross this invisible dividing line in order to link up with the ATP molecule through which they sustain their activities. The following presents a review of these issues with regard to microbiology, biochemistry and physics.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48320653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-26DOI: 10.4236/ojbiphy.2021.113011
A. Szász
The medical application of electromagnetic resonances is a controversial area of knowledge. Numerous unproven statements and some medical quackeries were published and distributed in informal channels among suffering patients. The fake information is hazardous in such severe diseases as cancer. The optimal, high efficacy energy transport by resonances attracts the interest of the experts and the public. The focus of the attention is technical and concentrates on the careful selection and excitation of the target compounds or cells, expecting helpful modifications. The complication is the complexity of the living systems. The targets are interconnected with an extensive network in the tissues where homeostasis, a dynamic equilibrium, regulates and controls changes. The broad range of energy-transfer variants could cause resonant effects, but the necessary criteria for the selection and proper action have numerous limits. The modulated high-frequency carrier may solve a part of the problem. This mixed solution uses the carrier and modulation’s particular properties to solve some of the obstacles of selection and excitation processes. One of the advantages of modulation is its adaptive ability to the living complexity. The modulated signal uses the homeostatic time-fractal pattern (1/f noise). The task involves finding and providing the best available mode to support the healthy state of the body. The body’s reaction to the therapy remains natural; the modulation boosts the body’s ability for the homeostatic regulation to reestablish the healthy state.
{"title":"Therapeutic Basis of Electromagnetic Resonances and Signal-Modulation","authors":"A. Szász","doi":"10.4236/ojbiphy.2021.113011","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.113011","url":null,"abstract":"The medical application of electromagnetic resonances is a controversial area of knowledge. Numerous unproven statements and some medical quackeries were published and distributed in informal channels among suffering patients. The fake information is hazardous in such severe diseases as cancer. The optimal, high efficacy energy transport by resonances attracts the interest of the experts and the public. The focus of the attention is technical and concentrates on the careful selection and excitation of the target compounds or cells, expecting helpful modifications. The complication is the complexity of the living systems. The targets are interconnected with an extensive network in the tissues where homeostasis, a dynamic equilibrium, regulates and controls changes. The broad range of energy-transfer variants could cause resonant effects, but the necessary criteria for the selection and proper action have numerous limits. The modulated high-frequency carrier may solve a part of the problem. This mixed solution uses the carrier and modulation’s particular properties to solve some of the obstacles of selection and excitation processes. One of the advantages of modulation is its adaptive ability to the living complexity. The modulated signal uses the homeostatic time-fractal pattern (1/f noise). The task involves finding and providing the best available mode to support the healthy state of the body. The body’s reaction to the therapy remains natural; the modulation boosts the body’s ability for the homeostatic regulation to reestablish the healthy state.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44462169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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