B. Yousef, Z. Awad, S. Adam, Setalbanat Abdelgadir, Ansam Mergani
Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of Anacyclus pyrethrum on Pentylenetetrazole (PTZ)-induced seizure model in Wistar rats. Methods: The composition of the petroleum ether extract of A. pyrethrum was first analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Subsequently, the anticonvulsant activities of these extracts (70 and 140 mg/kg, intraperitoneal injection) were evaluated on PTZ-induced seizures in rats. The protection rate against induced seizures, latency, and duration of seizures, as well as neurological symptoms, were assessed and compared to those protected by phenobarbital. Results: GC/MS analysis of the petroleum ether extract showed that the main components were octadecadienoic acid, hexadecanoic acid, diheptylcyclopropene, naphthalene, and methyl stearate. The extract (70 and 140 mg/kg) was found to provide significant protection against PTZ-induced seizures. Moreover, compared to the negative control, the extracts increased the latency of induced-convulsion and reduced the duration of epilepsy. Interestingly, the extracts showed a reduction in neurological symptoms and the severity of seizures compared to the negative control. All of these outcomes manifested in a dose-dependent manner. Conclusion: The petroleum ether extract of A. pyrethrum may produce anticonvulsant effects by reducing the duration of seizures and delaying the latency of seizures induced by PTZ.
{"title":"Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats","authors":"B. Yousef, Z. Awad, S. Adam, Setalbanat Abdelgadir, Ansam Mergani","doi":"10.18502/pbr.v7i1.7356","DOIUrl":"https://doi.org/10.18502/pbr.v7i1.7356","url":null,"abstract":"Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. \u0000Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of Anacyclus pyrethrum on Pentylenetetrazole (PTZ)-induced seizure model in Wistar rats. \u0000Methods: The composition of the petroleum ether extract of A. pyrethrum was first analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Subsequently, the anticonvulsant activities of these extracts (70 and 140 mg/kg, intraperitoneal injection) were evaluated on PTZ-induced seizures in rats. The protection rate against induced seizures, latency, and duration of seizures, as well as neurological symptoms, were assessed and compared to those protected by phenobarbital. \u0000Results: GC/MS analysis of the petroleum ether extract showed that the main components were octadecadienoic acid, hexadecanoic acid, diheptylcyclopropene, naphthalene, and methyl stearate. The extract (70 and 140 mg/kg) was found to provide significant protection against PTZ-induced seizures. Moreover, compared to the negative control, the extracts increased the latency of induced-convulsion and reduced the duration of epilepsy. Interestingly, the extracts showed a reduction in neurological symptoms and the severity of seizures compared to the negative control. All of these outcomes manifested in a dose-dependent manner. \u0000Conclusion: The petroleum ether extract of A. pyrethrum may produce anticonvulsant effects by reducing the duration of seizures and delaying the latency of seizures induced by PTZ.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90264630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Crataegus spp. (Hawthorn) are used for horticultural and medicinal purposes. Objectives: In the present study, the genetic relationships among the five Iranian Crataegus species were evaluated by Inter Simple Sequence Repeats (ISSR) molecular marker Methods: PCR reactions were performed using six primers (811, 827, 834, 845, 856, and 868) and genetic similarity was calculated based on Jacquard’s similarity coefficient. Results: Six primers generated 79 products in total, of which 71 were polymorphic (89.9%), with an average of 13.1 bands per primer. The percentage of polymorphic bands ranged from 77 to 100. Primer 856 produced the highest number of bands, while the lowest was generated by primer 845. The Jacquard’s similarity coefficient, derived from ISSR marker analysis, ranged from 0.164 to 0.337, indicating high genetic variation among Crataegus species in Iran. Conclusion: This study provides important data for identifying species relationships and helps develop plant breeding strategies to improve the medicinal properties of this genus in the future.
{"title":"Study of Genetic Diversity Among Crataegus Species (Hawthorn) Using ISSR Markers in Northwestern of Iran","authors":"Mina Beigmohamadi, F. Rahmani, L. Mirzaei","doi":"10.18502/pbr.v7i1.7357","DOIUrl":"https://doi.org/10.18502/pbr.v7i1.7357","url":null,"abstract":"Background: Crataegus spp. (Hawthorn) are used for horticultural and medicinal purposes. \u0000Objectives: In the present study, the genetic relationships among the five Iranian Crataegus species were evaluated by Inter Simple Sequence Repeats (ISSR) molecular marker \u0000Methods: PCR reactions were performed using six primers (811, 827, 834, 845, 856, and 868) and genetic similarity was calculated based on Jacquard’s similarity coefficient. \u0000Results: Six primers generated 79 products in total, of which 71 were polymorphic (89.9%), with an average of 13.1 bands per primer. The percentage of polymorphic bands ranged from 77 to 100. Primer 856 produced the highest number of bands, while the lowest was generated by primer 845. The Jacquard’s similarity coefficient, derived from ISSR marker analysis, ranged from 0.164 to 0.337, indicating high genetic variation among Crataegus species in Iran. \u0000Conclusion: This study provides important data for identifying species relationships and helps develop plant breeding strategies to improve the medicinal properties of this genus in the future. \u0000 ","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90206987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5662
Hamideh Abbaspour Kasgari, H. Samaee, S. A. Samakkhah, Parisa Moradimajd
In late December 2019, a global outbreak (pandemic) of the coronavirus was reported, which WHO named 2019-nCoV. The virus is now spreading rapidly and has affected manycountries, including Iran. There is no definitive and effective treatment for this virus yet. This report aimed to define the effect of Tocilizumab in patient with COVID-19. This case report isabout a 52-year-old man with COVID-19 that has been treated with tocilizumab. The reported patient had an acceptable improvement in oxygen saturation but no significant change inlung CT scan. After 3 days treatment patient with Tocilizumab, extensive bilateral lungs involvement still exist but SPO2 level iimprovement up to 90%. According to the results, thisdrug had a positive impact on oxygen saturation. However, we cannot be certain whether this drug positively affected the patient’s coronavirus disease.
{"title":"Treatment With Tocilizumab in a Patient With COVID-19","authors":"Hamideh Abbaspour Kasgari, H. Samaee, S. A. Samakkhah, Parisa Moradimajd","doi":"10.18502/PBR.V6I(S2).5662","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5662","url":null,"abstract":"In late December 2019, a global outbreak (pandemic) of the coronavirus was reported, which WHO named 2019-nCoV. The virus is now spreading rapidly and has affected manycountries, including Iran. There is no definitive and effective treatment for this virus yet. This report aimed to define the effect of Tocilizumab in patient with COVID-19. This case report isabout a 52-year-old man with COVID-19 that has been treated with tocilizumab. The reported patient had an acceptable improvement in oxygen saturation but no significant change inlung CT scan. After 3 days treatment patient with Tocilizumab, extensive bilateral lungs involvement still exist but SPO2 level iimprovement up to 90%. According to the results, thisdrug had a positive impact on oxygen saturation. However, we cannot be certain whether this drug positively affected the patient’s coronavirus disease.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77338743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5654
Ideh Ghafour, F. Elyasi
The article's abstract is not available.
这篇文章的摘要没有。
{"title":"The Neuropsychiatric Side Effects of Oseltamivir, an Early Solution in the Coronavirus","authors":"Ideh Ghafour, F. Elyasi","doi":"10.18502/PBR.V6I(S2).5654","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5654","url":null,"abstract":"The article's abstract is not available.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79576027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5661
E. Zaboli, R. Ghasemian, M. Abounoori, Mohammad Zahedi, S. Hashemi
The novel coronavirus disease 2019 (COVD-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunothrombosis could occur during infectionwith viruses. Deep vein thrombosis (DVT) is a devastating condition that usually involves the lower extremities. The typical course of DVT is associated with an episode of enormous limbswelling and pain. In this case report, we aimed to present one of the COVID-19 possible complications: DVT in a 38 years old man infected with SARS-CoV-2. A 38 years old manpresented with leg pain. He had a dry cough and fatigue suspicious symptoms of COVID-19. For further evaluations, the lung Computed Tomography scan (CT-scan), labratoricalassessments, and doppler sonography of the common femoral vein (CFV) of both legs were done. Also, for investigating the other underlying causes of DVT, abdominopelvic CT-scan andlumbosacral Magnetic Resonance Imaging (MRI) were done. The CT-scan showed GroundGlass Opacity (GGO) view. Labratorical assessment proposed a thrombotic condition. Thedoppler sonography of the CFV of both legs revealed a massive thrombosis in the left CFV suggesting an acute DVT. Abdominopelvic CT-scan and lumbosacral MRI were negativefor other underlying causes of DVT. COVID-19 is associated with the classical syndrome named disseminated intravascular coagulation and the subsequent consumption coagulopathypresented as DVT.
{"title":"Deep Vein Thrombosis Associated With COVID-19","authors":"E. Zaboli, R. Ghasemian, M. Abounoori, Mohammad Zahedi, S. Hashemi","doi":"10.18502/PBR.V6I(S2).5661","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5661","url":null,"abstract":"The novel coronavirus disease 2019 (COVD-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunothrombosis could occur during infectionwith viruses. Deep vein thrombosis (DVT) is a devastating condition that usually involves the lower extremities. The typical course of DVT is associated with an episode of enormous limbswelling and pain. In this case report, we aimed to present one of the COVID-19 possible complications: DVT in a 38 years old man infected with SARS-CoV-2. A 38 years old manpresented with leg pain. He had a dry cough and fatigue suspicious symptoms of COVID-19. For further evaluations, the lung Computed Tomography scan (CT-scan), labratoricalassessments, and doppler sonography of the common femoral vein (CFV) of both legs were done. Also, for investigating the other underlying causes of DVT, abdominopelvic CT-scan andlumbosacral Magnetic Resonance Imaging (MRI) were done. The CT-scan showed GroundGlass Opacity (GGO) view. Labratorical assessment proposed a thrombotic condition. Thedoppler sonography of the CFV of both legs revealed a massive thrombosis in the left CFV suggesting an acute DVT. Abdominopelvic CT-scan and lumbosacral MRI were negativefor other underlying causes of DVT. COVID-19 is associated with the classical syndrome named disseminated intravascular coagulation and the subsequent consumption coagulopathypresented as DVT.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89033416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5658
Ramakant Yadav, K. Pathak, D. Pathak, Raj Kumar
The world is grappling for US FDA-approved therapies for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). It is the virus that has caused Coronavirus Disease 2019 (COVID-19). Several pharmacological drugs are under various phases of clinical trials, and their current clinical use is primarily based on the in vitro activity against SARS-CoV-2 or related coronaviruses. While the efficacy of drug therapies is yet to be established, and the efficacy of the vaccine for COVID-19 is to be accomplished, we need to focus on prophylactic measures. The current article describes the chemoprophylactic, Ayurvedic, homeopathic, and Unani prophylactic approaches for combating COVID-19 based on the guidelines issued by the Ministry of AYUSH, India. The article is based on the guidelines issued by the Ministry of AYUSH, India. The proposed approaches have been supported by scientific evidence. The article also provides an outlook on the global scenario of herbal practices. In the absence of effective treatment, efforts to control the COVID-19 pandemic heavily rely on non-pharmaceutical interventions such as personal preventive measures. The alternative system of medicine offers prophylactic solutions that are simple and inexpensive. These simple measures will go a long way in tackling the pandemic.
{"title":"Chemoprophylatic, Ayurvedic, Homeopathic Approaches for COVID-19 Prophylaxis","authors":"Ramakant Yadav, K. Pathak, D. Pathak, Raj Kumar","doi":"10.18502/PBR.V6I(S2).5658","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5658","url":null,"abstract":"The world is grappling for US FDA-approved therapies for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). It is the virus that has caused Coronavirus Disease 2019 (COVID-19). Several pharmacological drugs are under various phases of clinical trials, and their current clinical use is primarily based on the in vitro activity against SARS-CoV-2 or related coronaviruses. While the efficacy of drug therapies is yet to be established, and the efficacy of the vaccine for COVID-19 is to be accomplished, we need to focus on prophylactic measures. The current article describes the chemoprophylactic, Ayurvedic, homeopathic, and Unani prophylactic approaches for combating COVID-19 based on the guidelines issued by the Ministry of AYUSH, India. The article is based on the guidelines issued by the Ministry of AYUSH, India. The proposed approaches have been supported by scientific evidence. The article also provides an outlook on the global scenario of herbal practices. In the absence of effective treatment, efforts to control the COVID-19 pandemic heavily rely on non-pharmaceutical interventions such as personal preventive measures. The alternative system of medicine offers prophylactic solutions that are simple and inexpensive. These simple measures will go a long way in tackling the pandemic.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88673785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5655
Nileswar Das, Shubham Narnoli, A. Kaur
The article's abstract is not available.
这篇文章的摘要没有。
{"title":"COVID-19 and the Role of Mental Health Professionals","authors":"Nileswar Das, Shubham Narnoli, A. Kaur","doi":"10.18502/PBR.V6I(S2).5655","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5655","url":null,"abstract":"The article's abstract is not available.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73155459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5653
J. Ghaffari
The article's abstract is not available.
这篇文章的摘要没有。
{"title":"Biological Agents in Allergic Disorders During COVID-19","authors":"J. Ghaffari","doi":"10.18502/PBR.V6I(S2).5653","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5653","url":null,"abstract":"The article's abstract is not available.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80701585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5660
J. Kirigia, Rose Nabi Deborah Karimi Muthuri
Background: The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity and premature mortality and ravage the socio-economic sectors in Canada.Objectives: The study aimed to appraise the Total Dollar Value of Human Life Losses (TDVHL) associated with COVID-19 in Canada. Methods: The net output approach was applied in the dollar valuation of the 8810 human life losses associated with COVID-19 in Canada as of July 16, 2020. The economic model wasrerun assuming 3%, 5%, and 10% discount rates with Canada’s life expectancy of 83 years, the world’s average life expectancy of 73 years, the world’s highest average life expectancy of88 years, and a 3% discount rate. Results: The human lives lost to COVID-19 had an estimated value of the international dollar (Int$) 2037021173 and an average of Int$ 231217 per human life lost. Quebec and Ontarioprovinces alone accounted for 94.99% of the TDVHL. Reanalysis of the economic model with discount rates of 5% and 10% resulted in declines in TDVHL of Int$ 192721390 (9%)and Int$ 530132423 (26%), respectively. Substitution of the nation with the word’s average life expectancy shrank the TDVHL by Int$ 1754972473 (86%) while applying the world’shighest life expectancy triggered a growth in the TDVHL of Int$ 498674987 (24%).
{"title":"The Dollar Value of Human Life Losses Associated With COVID-19 in Canada","authors":"J. Kirigia, Rose Nabi Deborah Karimi Muthuri","doi":"10.18502/PBR.V6I(S2).5660","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5660","url":null,"abstract":"Background: The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity and premature mortality and ravage the socio-economic sectors in Canada.Objectives: The study aimed to appraise the Total Dollar Value of Human Life Losses (TDVHL) associated with COVID-19 in Canada. \u0000Methods: The net output approach was applied in the dollar valuation of the 8810 human life losses associated with COVID-19 in Canada as of July 16, 2020. The economic model wasrerun assuming 3%, 5%, and 10% discount rates with Canada’s life expectancy of 83 years, the world’s average life expectancy of 73 years, the world’s highest average life expectancy of88 years, and a 3% discount rate. \u0000Results: The human lives lost to COVID-19 had an estimated value of the international dollar (Int$) 2037021173 and an average of Int$ 231217 per human life lost. Quebec and Ontarioprovinces alone accounted for 94.99% of the TDVHL. Reanalysis of the economic model with discount rates of 5% and 10% resulted in declines in TDVHL of Int$ 192721390 (9%)and Int$ 530132423 (26%), respectively. Substitution of the nation with the word’s average life expectancy shrank the TDVHL by Int$ 1754972473 (86%) while applying the world’shighest life expectancy triggered a growth in the TDVHL of Int$ 498674987 (24%).","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77376031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.18502/PBR.V6I(S2).5659
A. Alausa, Rofiat Adeyemi, Barakat Olaleke, Aminat Ismail, F. Oyelere
COVID-19 infection, a ravaging disease attributed to a SARS-CoV-like illness, has brought the world to its knee, causing a pandemic, with human-human transmission as a major source of the spread of this ailment. Alarmingly, this infection based on clinical manifestations is diagnosed as virus-induced pneumonia, with over 5 million cases with a mortality rate of about 7% (based on the recently published global report). However, most deaths have been associated with patients with underlying immune dysfunction or a compromised immunesystem. As no specific therapeutics and vaccines have been reported, the strengthening of the immune system through nutritional intake and exercise is essential. Also, previous studies have documented the immune-activating capabilities of Vitamin A and D, along with supplementary induction, yielding positive results in combating previous viral challenges. Typically, the gradual upsurge of T-lymphocytes and immune cell activities has been implemented by moderate exercise activities. This review examines the role of nutrition and exercise in immune system enhancement and proposes the possible mechanism of nutrition and exercise in combating COVID-19 infection.
{"title":"Immune Response to the Pathogenesis of COVID-19 Infection: Possible Mechanism of Nutrition (Vitamins, Supplement) and Exercise","authors":"A. Alausa, Rofiat Adeyemi, Barakat Olaleke, Aminat Ismail, F. Oyelere","doi":"10.18502/PBR.V6I(S2).5659","DOIUrl":"https://doi.org/10.18502/PBR.V6I(S2).5659","url":null,"abstract":"COVID-19 infection, a ravaging disease attributed to a SARS-CoV-like illness, has brought the world to its knee, causing a pandemic, with human-human transmission as a major source of the spread of this ailment. Alarmingly, this infection based on clinical manifestations is diagnosed as virus-induced pneumonia, with over 5 million cases with a mortality rate of about 7% (based on the recently published global report). However, most deaths have been associated with patients with underlying immune dysfunction or a compromised immunesystem. As no specific therapeutics and vaccines have been reported, the strengthening of the immune system through nutritional intake and exercise is essential. Also, previous studies have documented the immune-activating capabilities of Vitamin A and D, along with supplementary induction, yielding positive results in combating previous viral challenges. Typically, the gradual upsurge of T-lymphocytes and immune cell activities has been implemented by moderate exercise activities. This review examines the role of nutrition and exercise in immune system enhancement and proposes the possible mechanism of nutrition and exercise in combating COVID-19 infection.","PeriodicalId":6323,"journal":{"name":"2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90374720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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