Journal of Radioanalytical and Nuclear Chemistry最新文献

The preliminary role of [¹⁸F]fluoro-5α-dihydrotestosterone ([¹⁸F]FDHT) in identifying receptor status and managing cancer patients is promising. In this work, we compiled studies regarding the ability of [¹⁸F]FDHT to predict response to treatment in different stages of drug development. In the chemical development, the androgen receptor (AR) ligands of [¹⁸F]FDHT were the candidates evaluated and identified using preclinical methods. High uptake of [¹⁸F]FDHT levels was observed in cell lines and xenograft tumours in mice having glucuronidation-competent cells mimicking the sensitive type of castration-resistant prostate cancer (CRPC) treated with androgen deprivation therapy (ADT). In clinical trials, the detection of lesions with [¹⁸F]FDHT was in agreement with the standard radiotracer [¹⁸F]FDG in advanced prostate cancer (PC) and was even better in AR-positive without glycolytic activity (AR₁Glyc₀) subtypes, demonstrating the specific role of [¹⁸F]FDHT for the detection of tumour localisation. Moreover, the immunohistochemistry (IHC) correlation between [¹⁸F]FDHT and AR was stronger than the correlation between [⁶⁸ Ga]Ga-PSMA-11 and prostate-specific membrane antigen (PSMA), suggesting that [¹⁸F]FDHT can be a standalone modality for the monitoring of AR-targeted therapy.

The elemental composition of coral skeletons supplies essential information about palaeoceanographic reconstructions. The present work aims to optimize the neutron activation analysis (NAA) protocol for determining Ca-substituting elements in coral skeletons, which can be considered as a potential indicator for reconstructing past climate variability. Conventional and epithermal NAA schemes have been applied to determine 22 elements. The results reveal that the use of epithermal NAA significantly improved the limits of detection, up to 10 times, for specific elements, e.g. As, Ba, Cd, Mn, Sr, etc. The Compton suppression counting regime yielded an additional improvement in the limits of detection.

This paper explores the correlation between soil radon and thoron concentrations and seismic events at Chite fault in Aizawl over a three year period using SSNTDs. The data analysis was done using STL method which decomposes a time series into three components: seasonal, trend, and remainder. Elevated residual concentrations of these gases were observed prior to the M5.4 earthquake that occurred at a distance of 123.9 km from the monitoring station, suggesting a potential link between gas emanation and seismicity. The results of the study demonstrated the effectiveness of the STL method in detecting anomalies in diverse time series datasets.

A new polymer hyrogel dosimeter based on acrylic acid in polyvinyl alcohol hydrogel matrix was prepared to be used in radiation measurments for radiotherapy treatment. The hydrogel dosimeters were exposed to ionizing radiation using a medical linear accelerator. The hydrogel samples were irradiated at 6 MV beam energy, 600 cGy min⁻¹ dose rate, and various doses up to 50 Gy. UV–VIS Spectrophotometry was used to readout the dose response of non-irradiated and irradiated hydrogel samples at absorbance of 630 nm. The results show the dose response increases strongly with increasing abosrbed doses, with a large linear dose range (2–30 Gy) and dose sensitivity of 0.013 Gy⁻¹ s⁻¹. Moreover, no significant variation in dose response was obseved when the gel samples are irridiated under different dose-rates as well as radiation beam energies. A noticeble change in the stability of the irradiated hydrogel samples was found within the first three days of irradiation, followed by a high post-irradiation stability, for the next 14 days. The non-irridiated samples were stable, up to 10 weeks.

Radon is a natural radioactive gas, which has great radiation hazards. Mastering the radon exhalation law under complex conditions is of great significance to the safety and stability of uranium tailings pond. Based on the self-developed artificial microclimate chamber, the single factor influence of water content, temperature and crack rate of overburden soil on radon exhalation rate of uranium tailings pond was explored through simulation experiments, and the corresponding single factor mathematical model was obtained. The response surface model of radon exhalation rate was constructed by combining whale optimization algorithm to achieve accurate prediction of radon exhalation rate. The test results of simulated seismic station vibration test also confirm the scientificity of the model. The results of this study can be used not only to guide the prediction and prevention of radon, but also to guide the early warning of uranium tailings pond instability.