Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8873896
Jhih-Hong Cheng, R. C. Jones, O. Sushko, Bin Yang, Yumiko Tashiro, R. Donnan
A sub-terahertz (sub-THz) Circular Dichroism (CD) quasi-optical (QO) system has shown utility in acquiring electromagnetic absorption signatures of solvated protein samples over H-band frequencies (220 - 325 GHz). We report the sub-THz CD signature of Myoglobin in particular. Spectra are reproducible within experimental error.
{"title":"Application of sub-THz Circular Dichroism Quasi-Optics to Probe the Conformality of Solvated Protein","authors":"Jhih-Hong Cheng, R. C. Jones, O. Sushko, Bin Yang, Yumiko Tashiro, R. Donnan","doi":"10.1109/IRMMW-THz.2019.8873896","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8873896","url":null,"abstract":"A sub-terahertz (sub-THz) Circular Dichroism (CD) quasi-optical (QO) system has shown utility in acquiring electromagnetic absorption signatures of solvated protein samples over H-band frequencies (220 - 325 GHz). We report the sub-THz CD signature of Myoglobin in particular. Spectra are reproducible within experimental error.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"54 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80189571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8874000
H. Hoshina, Yuichi Saito, T. Furuhashi, T. Shimazaki, M. Sawada, Yasunori Hioki, C. Otani
Terahertz (THz) absorption spectra of the cross-linked polyurethane films are observed at the temperature between 30–180 °C. The obtained spectra show characteristic absorption band at 3 THz assigned as hydrogen bonded urethane group. Another band at 7 THz was assigned as intermolecular vibration of cross-linked structures between polymer chains. The temperature dependent spectra were analyzed by the perturbation correlation moving window two-dimensional spectroscopy (PCMW2D) to clarify the slight spectral change. The thermal behavior of the absorption intensities shows the dynamics of hydrogen bonds and cross-linked structures in the polyurethane films.
{"title":"Dynamics of Hydrogen Bonds and Cross-Linked Structures in Polyurethane Film Observed by Terahertz Spectroscopy","authors":"H. Hoshina, Yuichi Saito, T. Furuhashi, T. Shimazaki, M. Sawada, Yasunori Hioki, C. Otani","doi":"10.1109/IRMMW-THz.2019.8874000","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8874000","url":null,"abstract":"Terahertz (THz) absorption spectra of the cross-linked polyurethane films are observed at the temperature between 30–180 °C. The obtained spectra show characteristic absorption band at 3 THz assigned as hydrogen bonded urethane group. Another band at 7 THz was assigned as intermolecular vibration of cross-linked structures between polymer chains. The temperature dependent spectra were analyzed by the perturbation correlation moving window two-dimensional spectroscopy (PCMW2D) to clarify the slight spectral change. The thermal behavior of the absorption intensities shows the dynamics of hydrogen bonds and cross-linked structures in the polyurethane films.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"37 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79413428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/irmmw-thz.2019.8874181
Min Zhai, A. Locquet, C. Roquelet, D. Citrin
Terahertz imaging is a relatively new technique for nondestructive evaluation. Compared with the destructive micro-cut technique that provides information along the line of cut only, THz imaging nondestructively provides a global mapping of a sample. Hence, this technique has been applied to characterize coated materials and composite laminates. In this work, we characterize optically thin wüstite layers on steel leveraging signal-processing techniques.
{"title":"Terahertz Non-Destructive Thickness Characterization of Optically Thin Scale Layers on Steel","authors":"Min Zhai, A. Locquet, C. Roquelet, D. Citrin","doi":"10.1109/irmmw-thz.2019.8874181","DOIUrl":"https://doi.org/10.1109/irmmw-thz.2019.8874181","url":null,"abstract":"Terahertz imaging is a relatively new technique for nondestructive evaluation. Compared with the destructive micro-cut technique that provides information along the line of cut only, THz imaging nondestructively provides a global mapping of a sample. Hence, this technique has been applied to characterize coated materials and composite laminates. In this work, we characterize optically thin wüstite layers on steel leveraging signal-processing techniques.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"1 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81877676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8873764
Mattias Verstuyft, E. Akiki, B. Walter, Marc Faucher, Mathias Vanwolleghem, B. Kuyken
An on-chip gas detector that transduces absorbed terahertz light to a mechanical motion using photoacoustics is proposed. The silicon chip confines light in an optical cavity, wherein an acousto-mechanical cavity is housed. The concentration of a trace gas can be determined from the amplitude of a membrane’s motion. The simulations presented predict a minimum detectable limit of 1 ppm of methanol for 1 mW of terahertz power and an integration time of 25 ms.
{"title":"An Integrated Photoacoustic Terahertz Gas Sensor","authors":"Mattias Verstuyft, E. Akiki, B. Walter, Marc Faucher, Mathias Vanwolleghem, B. Kuyken","doi":"10.1109/IRMMW-THz.2019.8873764","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8873764","url":null,"abstract":"An on-chip gas detector that transduces absorbed terahertz light to a mechanical motion using photoacoustics is proposed. The silicon chip confines light in an optical cavity, wherein an acousto-mechanical cavity is housed. The concentration of a trace gas can be determined from the amplitude of a membrane’s motion. The simulations presented predict a minimum detectable limit of 1 ppm of methanol for 1 mW of terahertz power and an integration time of 25 ms.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"51 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84269532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8873881
A. Sorolla, Sergii Romanenko, P. Siegel, V. Wallace
Triple-negative breast cancers (TNBC) are highly aggressive malignancies comprising ~15-20 % of all breast cancers. TNBCs quickly acquire drug resistance mechanisms and are inherently resistant to radiotherapy, which significantly limits therapeutic options. Thus, there is a need to develop more selective and efficient therapeutic approaches to target this cancer subtype. In this study we investigate the applicability of MMW radiation as co-factor for prolonged sensitisation of TRPV1 receptor to promote the maximal channel activation with minimal tachyphylaxis to increase cancer cell death in TNBC.
{"title":"Utilisation of MMW Radiation to Facilitate Apoptosis in Triple Negative Breast Cancer Cell Lines via TRPV1 Receptor Sensitization","authors":"A. Sorolla, Sergii Romanenko, P. Siegel, V. Wallace","doi":"10.1109/IRMMW-THz.2019.8873881","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8873881","url":null,"abstract":"Triple-negative breast cancers (TNBC) are highly aggressive malignancies comprising ~15-20 % of all breast cancers. TNBCs quickly acquire drug resistance mechanisms and are inherently resistant to radiotherapy, which significantly limits therapeutic options. Thus, there is a need to develop more selective and efficient therapeutic approaches to target this cancer subtype. In this study we investigate the applicability of MMW radiation as co-factor for prolonged sensitisation of TRPV1 receptor to promote the maximal channel activation with minimal tachyphylaxis to increase cancer cell death in TNBC.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"34 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84283269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8874358
F. Mooshammer, F. Sandner, M. Huber, M. Zizlsperger, H. Weigand, M. Plankl, Christian Weyrich, M. Lanius, J. Kampmeier, G. Mussler, D. Grützmacher, J. Boland, T. Cocker, R. Huber
We retrieve the local dielectric function of a fewnanometer-thick surface layer on the three-dimensional topological insulator (Bi0.5 Sb0.5)2 Te3 using mid-infrared nanotomography. Thereby, we identify the contributions of two types of surface states: Band bending leads to an intersubband transition within a massive two-dimensional electron gas, which gives rise to a sharp resonance. Conversely, an additional broadband absorption background may be caused by the topologically protected surface states. Tracing the dielectric response across a nanostructure reveals local changes to the resonance frequency of the intersubband transition, pointing towards nanoscale fluctuations of the doping or the Bi-to-Sb-ratio.
{"title":"Mid-Infrared Nano-Tomography of Topological Insulator Surfaces","authors":"F. Mooshammer, F. Sandner, M. Huber, M. Zizlsperger, H. Weigand, M. Plankl, Christian Weyrich, M. Lanius, J. Kampmeier, G. Mussler, D. Grützmacher, J. Boland, T. Cocker, R. Huber","doi":"10.1109/IRMMW-THz.2019.8874358","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8874358","url":null,"abstract":"We retrieve the local dielectric function of a fewnanometer-thick surface layer on the three-dimensional topological insulator (Bi0.5 Sb0.5)2 Te3 using mid-infrared nanotomography. Thereby, we identify the contributions of two types of surface states: Band bending leads to an intersubband transition within a massive two-dimensional electron gas, which gives rise to a sharp resonance. Conversely, an additional broadband absorption background may be caused by the topologically protected surface states. Tracing the dielectric response across a nanostructure reveals local changes to the resonance frequency of the intersubband transition, pointing towards nanoscale fluctuations of the doping or the Bi-to-Sb-ratio.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"2 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85725267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8874212
Y. Kistenev, Alexey V.Borisov, Viktor V.Nikolaev, Denis A.Vrazhnov, A. I. Knyazkova
A gold standard of a cancer diagnosis is an expert evaluation of histological biopsy sections. The accuracy of classification depends on the experimental data dimension, that can be increased using spectral information of the samples. An approach of computer-aided paraffin-embedded cancer tissue samples analysis, using IR and THz imaging technique and machine learning, is discussed.
{"title":"IR and THz imaging of paraffin embedded cancer tissues","authors":"Y. Kistenev, Alexey V.Borisov, Viktor V.Nikolaev, Denis A.Vrazhnov, A. I. Knyazkova","doi":"10.1109/IRMMW-THz.2019.8874212","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8874212","url":null,"abstract":"A gold standard of a cancer diagnosis is an expert evaluation of histological biopsy sections. The accuracy of classification depends on the experimental data dimension, that can be increased using spectral information of the samples. An approach of computer-aided paraffin-embedded cancer tissue samples analysis, using IR and THz imaging technique and machine learning, is discussed.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"2675 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85983725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8874403
F. Dutin, J. Degert, M. Tondusson, Eric Freysz
We study, by terahertz time-domain and optical pump-THz probe spectroscopies, the optical and electrical properties of the PEDOT/PSTFSIK polymer. The latter is designed to get reed of some drawbacks of the well-known and widely used conducting polymer: the PEDOT/PSS. The optoelectronic properties in the THz range of both compounds are compared, as well as the relaxation mechanisms taking place after their photoexcitation by ultrashort optical pulses.
{"title":"Time-resolved THz spectroscopy of conducting polymers","authors":"F. Dutin, J. Degert, M. Tondusson, Eric Freysz","doi":"10.1109/IRMMW-THz.2019.8874403","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8874403","url":null,"abstract":"We study, by terahertz time-domain and optical pump-THz probe spectroscopies, the optical and electrical properties of the PEDOT/PSTFSIK polymer. The latter is designed to get reed of some drawbacks of the well-known and widely used conducting polymer: the PEDOT/PSS. The optoelectronic properties in the THz range of both compounds are compared, as well as the relaxation mechanisms taking place after their photoexcitation by ultrashort optical pulses.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"679 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76866718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8873933
Q. Jin, Y. E, S. H. Gao, L. Zhang, C.L. Zhang, A. Tcypkin, S. Kozlov, X. Zhang
THz wave emission from liquids under intense optical excitation provides a new way to generate intense and broadband THz signals. Here, we show that the use of water lines in place of water films as THz emitters to obtain stronger THz signals. In addition, we observe that the polarity of liquid has a significant influence on the THz wave generation. Besides paving the way to develop intense liquid THz sources, our report could be useful for the further study of laser-liquid interaction.
{"title":"Terahertz Aqueous Photonics and Beyond","authors":"Q. Jin, Y. E, S. H. Gao, L. Zhang, C.L. Zhang, A. Tcypkin, S. Kozlov, X. Zhang","doi":"10.1109/IRMMW-THz.2019.8873933","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8873933","url":null,"abstract":"THz wave emission from liquids under intense optical excitation provides a new way to generate intense and broadband THz signals. Here, we show that the use of water lines in place of water films as THz emitters to obtain stronger THz signals. In addition, we observe that the polarity of liquid has a significant influence on the THz wave generation. Besides paving the way to develop intense liquid THz sources, our report could be useful for the further study of laser-liquid interaction.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76872765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1109/IRMMW-THz.2019.8874321
Xiaodong Wang, Yulu Chen, B. Wang, Chuansheng Zhang, Haoxing Zhang
Silicon-based blocked-impurity-band (BIB) array detector has been fabricated. The dark current densities versus anode bias with anode bias scanning from -4V to 4V for four different pixels on a single array chip have been measured in order to study the nonuniformity of terahertz array detector. It has been demonstrated that the minimum nonuniformity of 7.6% can be achieved for our fabricated Silicon-based BIB array detector.
{"title":"Nonuniformity study for silicon-based BIB terahertz detectors","authors":"Xiaodong Wang, Yulu Chen, B. Wang, Chuansheng Zhang, Haoxing Zhang","doi":"10.1109/IRMMW-THz.2019.8874321","DOIUrl":"https://doi.org/10.1109/IRMMW-THz.2019.8874321","url":null,"abstract":"Silicon-based blocked-impurity-band (BIB) array detector has been fabricated. The dark current densities versus anode bias with anode bias scanning from -4V to 4V for four different pixels on a single array chip have been measured in order to study the nonuniformity of terahertz array detector. It has been demonstrated that the minimum nonuniformity of 7.6% can be achieved for our fabricated Silicon-based BIB array detector.","PeriodicalId":6686,"journal":{"name":"2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)","volume":"296 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77097485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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