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2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)最新文献

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Improving a Stochastic Algorithm for Regularized PET Image Reconstruction 改进一种正则化PET图像重构随机算法
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9508013
C. Delplancke, M. Gurnell, J. Latz, P. Markiewicz, C. Schönlieb, Matthias Joachim Ehrhardt
Positron Emission Tomography (PET) image reconstruction presents challenges related to the large scale of data to be processed, which affects reconstruction speed, and the need to include regularizers to improve image quality. Among the methods proposed to overcome these challenges, the recently introduced Stochastic Primal Dual Hybrid Gradient (SPDHG) algorithm combines the ability to deal with regularizers like Total Variation and to process large datasets by random subsampling. We present two contributions regarding the step-sizes of SPDHG: i) larger step-sizes facilitated by a new formula, and ii) a numerical method to calibrate, in the context of PET reconstruction, the tradeoff between primal and dual progression, which is common to all primal-dual algorithms. We validate improvements in speed reconstruction on real PET data from the Siemens Biograph mMR.
正电子发射断层扫描(PET)图像重建面临着与需要处理的大规模数据相关的挑战,这影响了重建速度,并且需要包含正则化器来提高图像质量。在克服这些挑战的方法中,最近引入的随机原始对偶混合梯度(SPDHG)算法结合了处理总变异等正则化器和通过随机子抽样处理大型数据集的能力。我们对SPDHG的步长提出了两个贡献:i)新公式促进了更大的步长,ii)在PET重建的背景下,校准原始和对偶级数之间的权衡的数值方法,这是所有原始-对偶算法所共有的。我们在西门子Biograph mMR的真实PET数据上验证了速度重建的改进。
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引用次数: 1
Multi-Level PET and CT Fusion Radiomics-based Survival Analysis of NSCLC Patients 基于多层次PET和CT融合放射组学的非小细胞肺癌患者生存分析
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507759
Mehdi Amini, M. Nazari, Isaac Shiri, G. Hajianfar, M. Deevband, H. Abdollahi, H. Zaidi
To provide a comprehensive characterization of intra-tumor heterogeneity, this study proposes multi-level multimodality radiomic models derived from 18F-FDG PET and CT images by feature- and image-level fusion. Specifically, we developed fusion radiomic models to improve overall survival prediction of NSCLC patients. In this work, a NSCLC dataset including patients from two different institutions (86 patients used as training and 95 patients used as testing) was included. By extracting 225 features from CT, PET, and fused images, radiomics analysis was used to build single-modality and multimodality models where the fused images are constructed by 3D-wavelet transform fusion (WF). Two models were also developed using two feature-level fusion strategies of feature concatenation (ConFea) and feature averaging (AvgFea). Cox proportional hazard (Cox PH) regression was utilized for survival analysis. Spearman's correlation was utilized as a measure of redundancy, and then best combination of 10 most related features (ranked by univariate Cox PH) were fed into multivariate Cox model. Moreover, the median prognostic score captured from training cohort was used as an untouched threshold in the test cohort to stratify patients into low- and high-risk groups. The difference between groups was assessed using log-rank test. Among all models, WF (C-index=0.708) had the highest index and significantly outperformed CT and PET (C-index = 0.616, 0.572, respectively). Image-level fusion model also outperformed feature-level fusion models ConFea and AvgFea (C-indices = 0.581, 0.641, respectively). Our results demonstrate that multimodal radiomics models especially models fused at image-level have the potential to improve prognosis by combining information from different tumor characteristics, including anatomical and metabolic captured by different imaging modalities.
为了提供肿瘤内异质性的全面表征,本研究通过特征和图像级融合,提出了从18F-FDG PET和CT图像中提取的多层次多模态放射学模型。具体来说,我们开发了融合放射学模型来提高非小细胞肺癌患者的总体生存预测。在这项工作中,纳入了一个包括来自两个不同机构的患者的NSCLC数据集(86名患者作为培训,95名患者作为测试)。通过从CT、PET和融合图像中提取225个特征,利用放射组学分析构建单模态和多模态模型,其中融合图像通过3d -小波变换融合(WF)构建。采用两种特征级融合策略:特征拼接(ConFea)和特征平均(AvgFea)建立了两个模型。采用Cox比例风险(Cox PH)回归进行生存分析。利用Spearman相关性作为冗余度量,然后将10个最相关特征(按单变量Cox PH排序)的最佳组合输入多变量Cox模型。此外,从训练队列中获得的中位预后评分被用作测试队列中未受影响的阈值,以将患者分为低危组和高危组。组间差异采用log-rank检验。在所有模型中,WF (C-index=0.708)的指数最高,显著优于CT和PET (C-index分别为0.616、0.572)。图像级融合模型也优于特征级融合模型ConFea和AvgFea (c指数分别为0.581、0.641)。我们的研究结果表明,多模态放射组学模型,特别是在图像水平上融合的模型,通过结合不同肿瘤特征的信息,包括不同成像方式捕获的解剖和代谢信息,有可能改善预后。
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引用次数: 4
Detection sensitivity of optical property-based radiation detection for PET: refraction index modulation 基于光学特性的PET辐射检测灵敏度:折射率调制
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507926
Yuli Wang, S. Abbaszadeh
Optical properties modulation based ionization radiation detection method was used as a potential method for the TOF-PET detection, which is with the potential to improve the coincidence timing performance of current PET to picosecond. In this article, we present our simulation works on optical properties modulation based method and demonstrate the feasibility of the optical method for the future PET applications. We first simulate (using Monte Carlo simulation) the energy deposition track of 511 keV photons in the detector crystal, and use Matlab to convert it to the number of ionized charges generated. Then, we (using finite element calculation tools) simulate the distribution of carrier density and electric field modulation caused by ionized charges. Finally, we calculated the change in optical refractive index (n) caused by Pockels effect modulation. Cadmium Telluride (CdTe) was chosen as the detector for the simulation work. Based on our simulation conditions, a 511 keV photon depositing 350 keV energy, the induced optical photon-refraction modulation is around 4.9E-04 (in CdTe), 4.1E-04 refractive index measurement has been achieved by modern optics method. Therefore, the feasibility of the optical properties modulation method has been demonstrated.
基于光学性质调制的电离辐射检测方法是一种潜在的TOF-PET检测方法,具有提高当前PET到皮秒的符合定时性能的潜力。在本文中,我们介绍了基于光学特性调制方法的仿真工作,并证明了光学方法在未来PET应用中的可行性。我们首先模拟(使用蒙特卡罗模拟)511 keV光子在探测器晶体中的能量沉积轨迹,并使用Matlab将其转换为产生的电离电荷数。然后,我们(利用有限元计算工具)模拟了由电离电荷引起的载流子密度分布和电场调制。最后,我们计算了波克尔斯效应调制引起的光学折射率(n)变化。模拟工作选择碲化镉(CdTe)作为探测器。在我们的模拟条件下,一个511 keV的光子沉积350 keV的能量,诱导光学光子折射调制约为4.90 e -04(在CdTe中),用现代光学方法获得了4.1E-04的折射率测量。因此,证明了光学性质调制方法的可行性。
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引用次数: 0
U-Net for Multi-Organ Segmentation of SPECT Projection Data 基于U-Net的SPECT多器官分割
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507779
Nina Mürschberger, Maximilian P. Reymann, P. Ritt, T. Kuwert, A. Vija, M. Cachovan, A. Maier
In this work we investigate the usage of deep learning techniques on SPECT data solving a multi-organ segmentation problem. We extract projections from 21 Lu-177 MELP SPECT scans and obtain the corresponding ground truth labels from the accompanied CT scans by forward-projection of 3D CT organ segmentations. We train a U-Net to predict the area of the kidney, spleen, liver, and background seen in the projection data, using a weighted dice loss between prediction and target labels to account for class imbalance. With our method we achieved a mean dice coefficient of 72 % on the test set, encouraging us to perform further experiments using the U-Net.
在这项工作中,我们研究了在SPECT数据上使用深度学习技术来解决多器官分割问题。我们从21个Lu-177 MELP SPECT扫描中提取投影,并通过3D CT器官分割的前向投影从伴随的CT扫描中获得相应的地面真值标签。我们训练一个U-Net来预测投影数据中看到的肾、脾、肝和背景的面积,使用预测和目标标签之间的加权骰子损失来解释类别不平衡。通过我们的方法,我们在测试集上获得了72%的平均骰子系数,这鼓励我们使用U-Net进行进一步的实验。
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引用次数: 1
Sinogram Denoise Based on Generative Adversarial Networks 基于生成对抗网络的正弦图去噪
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507945
C. Chrysostomou
A novel method for sinogram denoise based on Generative Adversarial Networks (GANs) in the field of SPECT imaging is presented. Projection data from software phantoms were used to train the proposed model. For evaluation of the efficacy of the method Shepp Logan based phantom, with various noise levels added where used. The resulting denoised sinograms are reconstructed using Ordered Subset Expectation Maximization (OSEM) and compared to the reconstructions of the original noised sinograms. As the results show, the proposed method significantly denoise the sinograms and significantly improves the reconstructions. Finally, to demonstrate the efficacy and capability of the proposed method results from real-world DAT-SPECT sinograms are presented.
提出了一种基于生成对抗网络(GANs)的SPECT图像去噪方法。使用来自软件幻影的投影数据来训练所提出的模型。为了评估基于Shepp Logan的方法的有效性,在使用的地方添加了不同的噪音水平。使用有序子集期望最大化(OSEM)重建得到的去噪信号图,并与原始去噪信号图的重建结果进行比较。实验结果表明,该方法对图像去噪效果显著,重构效果显著。最后,为了证明所提方法的有效性和能力,给出了实际的DAT-SPECT图的结果。
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引用次数: 2
Readout System for ePixHR X-ray Detectors: A Framework and Case Study ePixHR x射线探测器读出系统:框架和案例研究
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507754
D. Doering, M. Kwiatkowski, Umanath Kamath, C. Tamma, L. Rota, L. Ruckman, R. Herbst, B. Reese, P. Caragiulo, G. Blaj, C. Kenney, G. Haller, A. Dragone
LCLS-II, a Free Electron Laser (FEL) X-ray light source, started operations at SLAC National lab in 2020. This new machine will produce X-ray pulses with a repetition rate up to 1,000,000 times per second. To take advantage of its high pulse rate, detectors and readout systems that can operate at the same frequency and cope with the generated data volumes are being developed. In this paper, we present the readout system for the first generation of ePixHR high rate detectors including the first readout ASIC, namely, ePixHR10k, the first prototype of this family. This system aims at sustaining readout rates higher than 5,000 frames per second for the matrix of the ePixHR10k sensor/ASIC module (288 rows x 384 columns and 2 bytes per pixel). The proposed electronic system uses an FPGA to perform data capture and transmission to a host computer. The firmware is developed using a custom public library called SURF where building blocks such as ASIC register access, high speed communication links, protocols for data stream, and register configuration exist. The user interface uses a companion framework called ROGUE, which implements the software modules for the elements that exist in SURF. Initial results from X-ray tests using Fe55 source are presented.
LCLS-II是一个自由电子激光(FEL) x射线光源,于2020年在SLAC国家实验室开始运行。这台新机器将产生重复率高达每秒100万次的x射线脉冲。为了利用其高脉冲率,正在开发能够以相同频率工作并处理生成的数据量的探测器和读出系统。本文介绍了用于第一代ePixHR高速率检测器的读出系统,包括该系列的第一个读出ASIC,即ePixHR10k。该系统旨在为ePixHR10k传感器/ASIC模块(288行x 384列,每像素2字节)的矩阵保持高于每秒5000帧的读出率。所提出的电子系统使用FPGA来执行数据捕获和传输到主机。该固件是使用名为SURF的自定义公共库开发的,其中存在ASIC寄存器访问、高速通信链路、数据流协议和寄存器配置等构建块。用户界面使用名为ROGUE的配套框架,它为SURF中存在的元素实现软件模块。本文给出了用Fe55源进行x射线试验的初步结果。
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引用次数: 2
Crystal Area Segmentation for a Scintillation Detector based on Convolutional Neural Network 基于卷积神经网络的闪烁检测器晶体区域分割
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507967
Seowung Leem, Byeong-Yeol Yu, H. Cha, Kyeyoung Cho, R. Miyaoka, Cheolung Kang, Jongmyoung Lee, Seungbin Bae, Hakjae Lee, Kisung Lee
Crystal area segmentation is one of the critical procedures for decoding the detector module coupled with scintillation crystal. However, the blurring effect makes the decoding procedure challenging. For precise decoding, we propose a crystal area segmentation method based on convolutional neural network (CNN). The method is divided into training stage and evaluation stage. In the training stage, data set was extracted from five flood maps in blocks. These blocks went over preprocessing with bandpass filter (BPF) and thresholding. Then the processed blocks were used to train and test the CNN. In evaluation stage, flood map from 2 positron emission tomography (PET) scanners were tested. The method showed 99.5% and 99.4% of peak detection accuracy for each test samples while existing method achieved 91.1% and 95.4%. The proposed algorithm detected center peaks almost perfectly and improved detectability of boundary peaks. Also, the whole decoding process was done in short amount of time. However, the algorithm proposed in this paper only considered the spatial information of the peaks in flood map. In further studies we will develop improved algorithm with using both spatial and energy information to develop more precise and practical decoding algorithm.
晶体面积分割是与闪烁晶体耦合的探测器模块译码的关键步骤之一。然而,模糊效应使解码过程具有挑战性。为了精确解码,我们提出了一种基于卷积神经网络(CNN)的晶体面积分割方法。该方法分为训练阶段和评估阶段。在训练阶段,从5个块的洪水地图中提取数据集。这些块经过预处理带通滤波器(BPF)和阈值。然后使用处理后的块对CNN进行训练和测试。在评价阶段,对两台正电子发射断层扫描(PET)扫描仪的洪水图进行了测试。该方法对每个样品的峰值检测准确率分别为99.5%和99.4%,而现有方法的峰值检测准确率分别为91.1%和95.4%。该算法几乎可以很好地检测到中心峰,提高了边界峰的可检测性。此外,整个解码过程在很短的时间内完成。然而,本文提出的算法仅考虑洪水图中峰值的空间信息。在进一步的研究中,我们将利用空间信息和能量信息来开发更精确和实用的解码算法。
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引用次数: 0
High Brilliance Fast Scintillator for Neutron Detection and Imaging 用于中子探测和成像的高亮度快速闪烁体
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507810
P. Bhattacharya, C. Brown, C. Sosa, S. Miller, C. Brecher, V. Nagarkar, R. Riedel
High data rate detectors are needed for neutron reflectometer instruments and diffractometers require high spatial resolution detectors. Scintillators are the predominant material for the neutron converters in single crystal detector instruments, with GS20 being the most common choice. Here we report on the development and properties of Ce3+ activated 6LiI crystal scintillator grown with the aim of minimizing the decay time to support the high data rate applications while providing high brightness and high efficiency compared to GS20. The LiI crystals doped with Ce3+ were grown by the vertical Bridgman technique using 95%-enriched 6Li. It demonstrates two decay components with the primary decay of 43- 50 ns (93%) and the secondary decay of ~300 ns (7%), significantly faster than the Eu2+ doped 6LiI decay (~1 µs). Light yield for thermal neutron interactions was measured to be ~18,500 photons/interaction, which is a factor of 3 higher than the GS20. The X-ray excited radioluminescence spectrum of Ce3+ activator in LiI at room temperature shows three well-defined emission bands in the range of 400 to 700 nm, peaking at 430, 474, and 590 nm, which are due to 4f-5d transitions of Ce, The crystals also demonstrate high gamma equivalent energy (GEE) of nearly 3 MeV, thereby permitting effective pulse height neutron/gamma discrimination
中子反射仪需要高数据速率的探测器,而衍射仪需要高空间分辨率的探测器。闪烁体是单晶探测器中子变换器的主要材料,其中GS20是最常见的选择。在这里,我们报告了Ce3+激活的6LiI晶体闪烁体的开发和性能,其目的是最大限度地减少衰减时间,以支持高数据速率应用,同时提供与GS20相比的高亮度和高效率。采用垂直Bridgman技术,用富集95%的6Li生长掺杂Ce3+的LiI晶体。结果表明,掺Eu2+的6LiI的衰减速度为~1µs,主衰减速度为43 ~ 50 ns(93%),次衰减速度为~300 ns(7%)。热中子相互作用的光产率测量为~18,500光子/相互作用,比GS20高3倍。Ce3+激活剂在LiI中室温下的x射线激发辐射发光光谱显示,在400 ~ 700 nm范围内有三个明确的发射带,分别在430、474和590 nm处达到峰值,这是由于Ce的4f-5d跃迁造成的。该晶体还显示出接近3 MeV的高伽马当量能量(GEE),从而实现了有效的脉冲高度中子/伽马判别
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引用次数: 0
New Radiation Tolerant LGAD for High Energy Physics 新型高能物理耐辐射LGAD
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507740
J. Segal, C. Kenney, R. Patti, Benjamin Parpillon, Sangki Hong
Low Gain Avalanche Detectors (LGADs) have recently been studied for applications in high energy physics. They provide the advantages of built-in gain and fast read-out. However, radiation hardness remains a problem, reduced effective boron doping concentration (acceptor removal) after hadron irradiation that dramatically reduces LGAD gain. We propose a new LGAD process flow that allows for creation of a very steep boron profile in the multiplication region, reducing the fractional acceptor removal and resulting performance degradation. The new LGAD process flow requires a low temperature silicon-silicon wafer bonding process, which is currently under development. TCAD process simulations are used to demonstrate feasibility of the new structure, and TCAD device simulations are used to characterize LGAD performance before and after irradiation.
近年来,低增益雪崩探测器(LGADs)在高能物理中的应用得到了广泛的研究。它们具有内置增益和快速读出的优点。然而,辐射硬度仍然是一个问题,强子辐照后有效硼掺杂浓度(受体去除)降低,大大降低了lga增益。我们提出了一种新的LGAD工艺流程,该流程允许在增殖区域产生非常陡峭的硼剖面,减少了部分受体去除和由此导致的性能下降。新的LGAD工艺流程需要低温硅硅晶圆键合工艺,该工艺目前正在开发中。利用TCAD过程模拟验证了新结构的可行性,并利用TCAD器件模拟表征了辐照前后LGAD的性能。
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引用次数: 0
Optimization Simulations of Micro-Layer Geometries with 10B/ZnO for Neutron Detection 用于中子探测的10B/ZnO微层几何结构优化模拟
Pub Date : 2020-10-31 DOI: 10.1109/NSS/MIC42677.2020.9507961
Faruk Logoglu, M. Flaska
Detection of fast neutrons is of utmost importance in many scenarios including calibration of neutron sources, neutron imaging and detection of special nuclear materials (SNM) [1], [2]. Neutron detection frequently relies on converting neutrons to charged particles via elastic scattering or neutron capture. The resulting charged particles interact with the surrounding atoms through Coulomb interactions and deposit their energies in the medium. In this work, efficiency of micro-layered scintillating neutron detectors is investigated with extensive Geant4 simulations. Micro-layer geometries can improve the neutron detection efficiency while decreasing the gamma sensitivity. The proposed detection module consists of neutron capture layers made of boron metal enriched to 95% in 10B, scintillating crystals (ZnO) covering each 10B layer from both sides for light production, and neutron moderators placed between individual 10B/ZnO sandwiches to thermalize fast neutrons. The moderator must be optically transparent so that the light created in the scintillators can travel to photosensors without any significant attenuation. Polyethylene is chosen as the moderator in this work due to its low-Z content and optically transparent nature. Photosensors are placed at four corners of the detector module to detect optical photons. After optimizing the detector components, neutron detection efficiency for 1 MeV neutrons was estimated to be 6.8%, 3.2%, and 1.5% for 5, 10, and 20 photon thresholds at the photosensors, respectively. Finally, the gamma sensitivity of the detector module was estimated to be in the range of 10−3-10−4 for 1 MeV gamma rays.
快中子的探测在中子源校准、中子成像和特殊核材料(SNM)探测等许多场景中都至关重要[1],[2]。中子探测通常依赖于通过弹性散射或中子捕获将中子转化为带电粒子。由此产生的带电粒子通过库仑相互作用与周围的原子相互作用,并将它们的能量沉积在介质中。在本工作中,通过大量的Geant4模拟研究了微层闪烁中子探测器的效率。微层几何形状可以提高中子探测效率,同时降低伽马灵敏度。所提出的探测模块包括由富含95% 10B的硼金属制成的中子捕获层,从两侧覆盖每层10B的闪烁晶体(ZnO)用于发光,以及放置在单个10B/ZnO三明治之间的中子减速剂用于加热快中子。慢化剂必须是光学透明的,这样在闪烁体中产生的光可以在没有任何明显衰减的情况下传输到光传感器。由于聚乙烯的低z含量和光学透明的性质,在这项工作中选择聚乙烯作为慢化剂。光电传感器被放置在检测器模块的四个角来检测光光子。优化探测器组件后,在光子阈值为5、10和20的光传感器上,对1 MeV中子的中子探测效率分别为6.8%、3.2%和1.5%。最后,探测器模块对1 MeV伽马射线的灵敏度估计在10−3-10−4之间。
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引用次数: 0
期刊
2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
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