Pub Date : 2021-05-28DOI: 10.4236/jbnb.2021.123004
S. Latifi, Christina Tang, H. Donahue
In this study, the effect of silica/calcium phosphate (SiCaP) nanocomposite particles on the properties of a novel chitosan-based thermosensitive hydrogel system was examined. SiCaP nanocomposite powder was fabricated using a sol-gel method and then used to fabricate nanocomposite hydrogels (Ch- β/7.5SiCaP and Ch-β/15SiCaP) including chitosan and β-glycerophosphate (Ch-β) as a matrix. Results revealed that compared to the Ch-β hydrogel without SiCaP, the presence of SiCaP particles in nanocomposite hydrogels maintained pH stability during the sol-gel transition, accelerated the gelation and improved the stiffness of nanocomposite hydrogels. Gelation time at 37℃ was reduced approximately 75% and stiffness was increased approximately 115%. Both of these changes are attributed to chemical and physical interactions of the SiCaP bioactive particles with chitosan. Furthermore, compared to the Ch-β hydrogel, the presence of SiCaP in the Ch-β/7.5SiCaP nanocomposite hydrogel did not affect biocompatibility negatively, but improved osteoblastic cell differentiation. Our studies suggest that these nanocomposite hydrogels may offer an innovative approach to bone regeneration strategies.
{"title":"Fabrication and Characterization of Chitosan Based Injectable Thermosensitive Hydrogels Containing Silica/Calcium Phosphate Nanocomposite Particles","authors":"S. Latifi, Christina Tang, H. Donahue","doi":"10.4236/jbnb.2021.123004","DOIUrl":"https://doi.org/10.4236/jbnb.2021.123004","url":null,"abstract":"In this study, the effect of silica/calcium phosphate (SiCaP) nanocomposite particles on the properties of a novel chitosan-based thermosensitive hydrogel system was examined. SiCaP nanocomposite powder was fabricated using a sol-gel method and then used to fabricate nanocomposite hydrogels (Ch- β/7.5SiCaP and Ch-β/15SiCaP) including chitosan and β-glycerophosphate (Ch-β) as a matrix. Results revealed that compared to the Ch-β hydrogel without SiCaP, the presence of SiCaP particles in nanocomposite hydrogels maintained pH stability during the sol-gel transition, accelerated the gelation and improved the stiffness of nanocomposite hydrogels. Gelation time at 37℃ was reduced approximately 75% and stiffness was increased approximately 115%. Both of these changes are attributed to chemical and physical interactions of the SiCaP bioactive particles with chitosan. Furthermore, compared to the Ch-β hydrogel, the presence of SiCaP in the Ch-β/7.5SiCaP nanocomposite hydrogel did not affect biocompatibility negatively, but improved osteoblastic cell differentiation. Our studies suggest that these nanocomposite hydrogels may offer an innovative approach to bone regeneration strategies.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46878577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, gold nanoparticles and thermochromic composite films modified screen-printed carbon electrodes (TM-AuNPsSPCEs) were developed as a platform for the simultaneous detection of protein and temperature. The TM-AuNPs composited film had better sensitivity resulting from the gold nanoparticles amplification effect. A phase transition model analysis of TM-AuNPs films found that the TM-AuNPs films had three-phase transition intervals ( 80℃) which accommodated the temperature requirements for protein denaturation. When used to detect different concentrations of haemoglobin (Hb) solution, the TM-AuNPs modified SPCEs had a better sensitivity in detecting the different concentrations in comparison to TM and AuNP modified SPCEs which showed no clear sensitivity towards the different Hb concentrations. The dual detection and excellent sensitivity show a good application prospect for the study of the TM-AuNPs composite film.
{"title":"Gold Nanoparticles/Thermochromic Composite Film on Screen-Printed Electrodes for Simultaneous Detection of Protein and Temperature","authors":"Dorothy Araba Yakoba Agyapong, Hanjia Jiang, Xin-Ye Ni, Jingwen Wu, Hong-juan Zeng","doi":"10.4236/JBNB.2021.122002","DOIUrl":"https://doi.org/10.4236/JBNB.2021.122002","url":null,"abstract":"In this study, gold nanoparticles and thermochromic composite films modified screen-printed carbon electrodes (TM-AuNPsSPCEs) were developed as a platform for the simultaneous detection of protein and temperature. The TM-AuNPs composited film had better sensitivity resulting from the gold nanoparticles amplification effect. A phase transition model analysis of TM-AuNPs films found that the TM-AuNPs films had three-phase transition intervals ( 80℃) which accommodated the temperature requirements for protein denaturation. When used to detect different concentrations of haemoglobin (Hb) solution, the TM-AuNPs modified SPCEs had a better sensitivity in detecting the different concentrations in comparison to TM and AuNP modified SPCEs which showed no clear sensitivity towards the different Hb concentrations. The dual detection and excellent sensitivity show a good application prospect for the study of the TM-AuNPs composite film.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":"12 1","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44310810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/jbnb.2021.121001
P. Basmaji, Gabriel Molina de Olyveira, Mohamed M. Kanjou
Cancer cells can be proliferating in a few months and years. It depends on cancer stage. Chemotherapy, immunotherapy and anti-metabolic drugs have been used in order to kill cancer cells and prevent immune system weakly and metastasis. However, such drugs can damage healthy cells too. Natural ways to cancer treatments may help whole body to cancer cells. In this work, it was taking off cancer nodule to skin cancer by surgery and we treat the nodule as wound, using Nanoskin® advance cell therapy (ACT), natural extra cellular matrix which releases nutrients to the skin cancer. Our result shows that the cancer nodule disappears in few weeks in skin, because of natural membrane treatment. In addition, we obtained complete wound healing due anticancer nutrients (beta-glucan) delivery to skin.
{"title":"Skin Cancer Treatment by Nanoskin Cellulose: Future Cancer Wound Healing","authors":"P. Basmaji, Gabriel Molina de Olyveira, Mohamed M. Kanjou","doi":"10.4236/jbnb.2021.121001","DOIUrl":"https://doi.org/10.4236/jbnb.2021.121001","url":null,"abstract":"Cancer cells can be proliferating in a few months and years. It depends on cancer stage. Chemotherapy, immunotherapy and anti-metabolic drugs have been used in order to kill cancer cells and prevent immune system weakly and metastasis. However, such drugs can damage healthy cells too. Natural ways to cancer treatments may help whole body to cancer cells. In this work, it was taking off cancer nodule to skin cancer by surgery and we treat the nodule as wound, using Nanoskin® advance cell therapy (ACT), natural extra cellular matrix which releases nutrients to the skin cancer. Our result shows that the cancer nodule disappears in few weeks in skin, because of natural membrane treatment. In addition, we obtained complete wound healing due anticancer nutrients (beta-glucan) delivery to skin.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70897179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/jbnb.2021.124006
M. Albakry
{"title":"Insightful Understanding of the Role of the Mechanical Properties in Defining the Reliability of All-Ceramic Dental Restorations: A Review","authors":"M. Albakry","doi":"10.4236/jbnb.2021.124006","DOIUrl":"https://doi.org/10.4236/jbnb.2021.124006","url":null,"abstract":"","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70897209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/jbnb.2021.124007
Fahad Alanazi, D. Salah
Cyclodextrins are naturally oligosaccharides which had cyclic glucopyrano-side units even if six units to form α-cyclodextrin (α-CD), seven units β-cyclodextrin (β-CD) or eight units γ-cyclodextrin (γ-CD) and some other derivatives. It has a truncated cone shape with a hydrophobic cavity and a hydrophilic from the external surface of cyclodextrins. Gold nanoparticles incorporated with cyclodextrins enhanced optical and electrical properties of the resulting conjugates, due to the gold nanoparticles’ unique physical and chemical properties because of their surface plasmon resonance. Here is a review of gold nanoparticles/cyclodextrin’s different applications including sensing, antimicrobial effect, and their variable medical/pharmaceutical applications. Generally, gold nanoparticles and cyclodextrin conjugates showed developed and pronounced advantages due to their biocompatibility and enhanced physical and electric properties.
{"title":"Gold Nanoparticles Incorporated with Cyclodextrins and Its Applications","authors":"Fahad Alanazi, D. Salah","doi":"10.4236/jbnb.2021.124007","DOIUrl":"https://doi.org/10.4236/jbnb.2021.124007","url":null,"abstract":"Cyclodextrins are naturally oligosaccharides which had cyclic glucopyrano-side units even if six units to form α-cyclodextrin (α-CD), seven units β-cyclodextrin (β-CD) or eight units γ-cyclodextrin (γ-CD) and some other derivatives. It has a truncated cone shape with a hydrophobic cavity and a hydrophilic from the external surface of cyclodextrins. Gold nanoparticles incorporated with cyclodextrins enhanced optical and electrical properties of the resulting conjugates, due to the gold nanoparticles’ unique physical and chemical properties because of their surface plasmon resonance. Here is a review of gold nanoparticles/cyclodextrin’s different applications including sensing, antimicrobial effect, and their variable medical/pharmaceutical applications. Generally, gold nanoparticles and cyclodextrin conjugates showed developed and pronounced advantages due to their biocompatibility and enhanced physical and electric properties.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70896911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-20DOI: 10.4236/jbnb.2020.114018
V. Agarwal, S. Agarwal, R. Kaur, Pranav Pancham, Harleen Kaur, Siddhi Bhardwaj, Manisha Singh
Background: Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. Objective: The current study is aimed at the in-silico validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. Methods: A successful in-silico validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis. Results & Conclusion: The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of −17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation.
{"title":"In-Silico Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders","authors":"V. Agarwal, S. Agarwal, R. Kaur, Pranav Pancham, Harleen Kaur, Siddhi Bhardwaj, Manisha Singh","doi":"10.4236/jbnb.2020.114018","DOIUrl":"https://doi.org/10.4236/jbnb.2020.114018","url":null,"abstract":"Background: Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. Objective: The current study is aimed at the in-silico validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. Methods: A successful in-silico validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis. Results & Conclusion: The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of −17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48030138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-20DOI: 10.4236/jbnb.2020.114017
K. Saitoh, Tomohiro Sato, M. Takuma, Y. Takahashi
Collagen is a basic biopolymer usually found in animal bodies, but its mechanical property and behavior are not sufficiently understood so as to apply to effective regenerative medicine and so on. Since the collagen material is composed of many hierarchical structures from atomistic level to tissue or organ level, we need to well understand fundamental and atomistic mechanism of the collagen in mechanical response. First, we approach at exactly atomistic level by using all-atom modeling of tropocollagen (TC) molecule, which is a basic structural unit of the collagen. We perform molecular dynamics (MD) simulations concerning tensile loading of a single TC model. The main nature of elastic (often superelastic) behavior and the dependency on temperature and size are discussed. Then, to aim at coarse-graining of atomic configuration into some bundle structure of TC molecules (TC fibril), as a model of higher collagen structure, we construct a kind of mesoscopic model by adopting a simulation framework of beads-spring model which is ordinarily used in polymer simulation. Tensile or compression simulation to the fibril model reveals that the dependency of yield or buckling limit on the number of TCs in the model. Also, we compare the models with various molecular orientations in winding process of initial spiral of TC. The results are analyzed geometrically and it shows that characteristic orientational change of molecules increases or decreases depending on the direction and magnitude of longitudinal strain.
{"title":"Molecular Dynamics Study of Collagen Fibrils: Relation between Mechanical Properties and Molecular Chirality","authors":"K. Saitoh, Tomohiro Sato, M. Takuma, Y. Takahashi","doi":"10.4236/jbnb.2020.114017","DOIUrl":"https://doi.org/10.4236/jbnb.2020.114017","url":null,"abstract":"Collagen is a basic biopolymer usually found in animal bodies, but its mechanical property and behavior are not sufficiently understood so as to apply to effective regenerative medicine and so on. Since the collagen material is composed of many hierarchical structures from atomistic level to tissue or organ level, we need to well understand fundamental and atomistic mechanism of the collagen in mechanical response. First, we approach at exactly atomistic level by using all-atom modeling of tropocollagen (TC) molecule, which is a basic structural unit of the collagen. We perform molecular dynamics (MD) simulations concerning tensile loading of a single TC model. The main nature of elastic (often superelastic) behavior and the dependency on temperature and size are discussed. Then, to aim at coarse-graining of atomic configuration into some bundle structure of TC molecules (TC fibril), as a model of higher collagen structure, we construct a kind of mesoscopic model by adopting a simulation framework of beads-spring model which is ordinarily used in polymer simulation. Tensile or compression simulation to the fibril model reveals that the dependency of yield or buckling limit on the number of TCs in the model. Also, we compare the models with various molecular orientations in winding process of initial spiral of TC. The results are analyzed geometrically and it shows that characteristic orientational change of molecules increases or decreases depending on the direction and magnitude of longitudinal strain.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45460771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-11DOI: 10.4236/jbnb.2020.113013
Jingwen Zhou
Heparin monitoring is widely used to measure the anticoagulant effect of unfractionated heparin and adjust the dose to keep within the target treatment range. This technology has applications in many fields and also prospects in the future. Its application has the advantages of rapidity, high throughput and minimum sample consumption. Many point of care devices for heparin monitoring are available. The CoaguChek device only requires a small sample size, which is obtained through a fingerstick. Over the last few years, the point-of-care (POC) testing was used widely for its convenience, efficiency, and faster turnaround times.
{"title":"The Development of the Heparin Monitoring System Based on Microfluidics Technology","authors":"Jingwen Zhou","doi":"10.4236/jbnb.2020.113013","DOIUrl":"https://doi.org/10.4236/jbnb.2020.113013","url":null,"abstract":"Heparin monitoring is widely used to measure the anticoagulant effect of unfractionated heparin and adjust the dose to keep within the target treatment range. This technology has applications in many fields and also prospects in the future. Its application has the advantages of rapidity, high throughput and minimum sample consumption. Many point of care devices for heparin monitoring are available. The CoaguChek device only requires a small sample size, which is obtained through a fingerstick. Over the last few years, the point-of-care (POC) testing was used widely for its convenience, efficiency, and faster turnaround times.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48556635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-11DOI: 10.4236/jbnb.2020.113009
I. Brum, M. A. Carvalho, P. Santos, R. Devita, J. Pires, J. J. Carvalho
Following the worldwide trend of developing heavy metal free materials, dental implants aren’t out of this tendency. Over the years, a number of techniques to condition the surface of dental implants have been designed and used such as oxide blasting, however the scientific medical community has been concerned about the use of these heavy metals which leads us to investigate and develop new conditioning techniques. The aim of the study was the analysis of the Systhex® implant surface in automatic system for the treatment of the surface with acid, where we can identify the surfaces purity level, pore size, deepness and especially the roughness proportionated by the technology of acid conditioning on the titanium surfaces of degree IV dental implants. We conclude that the automatic conditioning of acid attack promoted cleanliness, homogeneity and ideal roughness for the osseointegration process.
{"title":"Ultrastructural Characterization of the Titanium Surface Degree IV in Dental Implant Aluminum Free (Acid Attack)","authors":"I. Brum, M. A. Carvalho, P. Santos, R. Devita, J. Pires, J. J. Carvalho","doi":"10.4236/jbnb.2020.113009","DOIUrl":"https://doi.org/10.4236/jbnb.2020.113009","url":null,"abstract":"Following the worldwide trend of developing heavy metal free materials, dental implants aren’t out of this tendency. Over the years, a number of techniques to condition the surface of dental implants have been designed and used such as oxide blasting, however the scientific medical community has been concerned about the use of these heavy metals which leads us to investigate and develop new conditioning techniques. The aim of the study was the analysis of the Systhex® implant surface in automatic system for the treatment of the surface with acid, where we can identify the surfaces purity level, pore size, deepness and especially the roughness proportionated by the technology of acid conditioning on the titanium surfaces of degree IV dental implants. We conclude that the automatic conditioning of acid attack promoted cleanliness, homogeneity and ideal roughness for the osseointegration process.","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":"11 1","pages":"151-160"},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48436303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-11DOI: 10.4236/jbnb.2020.113012
P. Basmaji, nia Martins, M. Kanjo
Epidermolysis Bullosa (EB) is a group of rare genetic skin conditions, which is characterised by extremely fragile skin and recurrent blister formation, resulting from minor mechanical friction or trauma. Sufferers of EB have compared the sores to third-degree burns. Stevens-Johnson syndrome is a rare but very serious skin problem, which causes the appearance of reddish lesions throughout the body and other changes, such as difficulty in breathing and fever, which can endanger the life of the affected person. The aim of this study was to show efficacy of a NANOSKIN ACT, AND NANOSKIN ACT SOFT wound dressing on the wound care management in patients with EB AND Stevens-Johnson syndrome (SJS).
{"title":"Natural Nanoskin ACT Management of the Rare Disease as Burnt Patient with Epidermolysis Bullosa and Stevens-Johnson","authors":"P. Basmaji, nia Martins, M. Kanjo","doi":"10.4236/jbnb.2020.113012","DOIUrl":"https://doi.org/10.4236/jbnb.2020.113012","url":null,"abstract":"Epidermolysis Bullosa (EB) is a group of rare genetic skin conditions, which is characterised by extremely fragile skin and recurrent blister formation, resulting from minor mechanical friction or trauma. Sufferers of EB have compared the sores to third-degree burns. Stevens-Johnson syndrome is a rare but very serious skin problem, which causes the appearance of reddish lesions throughout the body and other changes, such as difficulty in breathing and fever, which can endanger the life of the affected person. The aim of this study was to show efficacy of a NANOSKIN ACT, AND NANOSKIN ACT SOFT wound dressing on the wound care management in patients with EB AND Stevens-Johnson syndrome (SJS).","PeriodicalId":68623,"journal":{"name":"生物材料与纳米技术(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49566634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：