Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00391
Jun Chen, Yun-fu Zhao, Qing-fu Zhang, Guo-qin Liu, Man-jiao Liu, Tian Yao
{"title":"Cryopreserved platelet-rich plasma enhancing calvarial bone defect repair in rabbits: an observation of outcome","authors":"Jun Chen, Yun-fu Zhao, Qing-fu Zhang, Guo-qin Liu, Man-jiao Liu, Tian Yao","doi":"10.3724/SP.J.1008.2015.00391","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00391","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69846200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00447
Lei Li, Z. Cao, X. Chuanliang, Rongchao Wei, Zhensheng Zhang, Yinghao Sun
{"title":"Solifenacin succinate in improving bladder irritative symptoms after transurethral resection of bladder tumors","authors":"Lei Li, Z. Cao, X. Chuanliang, Rongchao Wei, Zhensheng Zhang, Yinghao Sun","doi":"10.3724/SP.J.1008.2015.00447","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00447","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69847179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00434
Qing Gu, Zhi-Min Liu
Metabolic syndrome is characterized by simultaneous occurrence of central obesity,hyperglycemia,dyslipidemia and hypertension,posing a serious health problem.Exercise plays a pivotal role in preventing and treating metabolic syndrome:it can(1)reduce weight and improve the fat deposit in organs;(2)improve insulin sensitivity and glucose transporter4 level and down-regulate blood glucose by promoting muscle glucose utilization;(3)improve the vascular endothelial function,increase the secretion of nitric oxide,decrease the secretion of endothelin,and finally reduce blood pressure;and(4)decrease blood levels of triglyceride and low density lipoprotein cholesterol,and increase the level of high density lipoprotein cholesterol.This paper is to review the effect of exercise on metabolic syndrome in an all around manner.
{"title":"Exercise and metabolic syndrome","authors":"Qing Gu, Zhi-Min Liu","doi":"10.3724/SP.J.1008.2015.00434","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00434","url":null,"abstract":"Metabolic syndrome is characterized by simultaneous occurrence of central obesity,hyperglycemia,dyslipidemia and hypertension,posing a serious health problem.Exercise plays a pivotal role in preventing and treating metabolic syndrome:it can(1)reduce weight and improve the fat deposit in organs;(2)improve insulin sensitivity and glucose transporter4 level and down-regulate blood glucose by promoting muscle glucose utilization;(3)improve the vascular endothelial function,increase the secretion of nitric oxide,decrease the secretion of endothelin,and finally reduce blood pressure;and(4)decrease blood levels of triglyceride and low density lipoprotein cholesterol,and increase the level of high density lipoprotein cholesterol.This paper is to review the effect of exercise on metabolic syndrome in an all around manner.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69847473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00483
Qiuxiang Kang, Yi Chen, Guifang Yu, Xu Zhang, K. Zhu
Objective To explore the lipopolysaccharide(LPS)-induced changes of heat shock protein A12B(HSPA12B)expression and its effect on the permeability of human umbilical vein endothelial cells(HUVECs).Methods The HUVECs cultured in vitro were divided into four groups: control group(without any treatment); LPS group(1 μg / m L LPS); LPS + p IRES2-EGFPHSPA12B-3Flag group(The HSPA12 B gene overexpression plasmid was transiently transfected into HUVECs and then LPS of 1 μg / m L was added); and LPS + p IRES2-EGFP-3Flag group(The negative control plasmid was transiently transfected into HUVECs and then LPS of 1 μg / m L was added).The transendothelial electrical resistance(TEER) of HUVECs was measured by MERSST × 01 Electrode.The expression of VE-cadherin was studied by flow cytometry.RT-PCR and Western blotting analysis were used to examine the expression changes of HSPA12 B mRNA and protein in HUVECs stimulated with LPS at various time points.Results It was showed that after stimulated with LPS,HSPA12 B mRNA and protein were gradually upregulated,and peaked at 12 h.HSPA12 B significantly increased the TEER value of HUVECs(P 0.001),and it could completely offset the decline of TEER value induced by LPS(P 0.001).Besides,HSPA12 B could cause upregulation of VE-cadherin expression.Conclusion HSPA12 B can reduce the permeability of vascular endothelial cells by up-regulating the expression of VE-cadherin,thus protecting the vascular endothelial barrier function of endothelial cells.
目的探讨脂多糖(LPS)诱导热休克蛋白A12B(HSPA12B)表达的变化及其对人脐静脉内皮细胞(HUVECs)通透性的影响。方法将体外培养的HUVECs分为4组:对照组(未经处理);LPS组(1 μg / m L LPS);LPS + p IRES2-EGFPHSPA12B-3Flag组(将hspa12b基因过表达质粒瞬时转染HUVECs，然后加入1 μg / m L的LPS);LPS + p IRES2-EGFP-3Flag组(将阴性对照质粒瞬时转染HUVECs，然后加入1 μg / m L的LPS)。采用MERSST × 01电极测定HUVECs的跨内皮电阻(TEER)。流式细胞术检测VE-cadherin的表达。采用RT-PCR和Western blotting方法检测LPS刺激HUVECs不同时间点hspa12b mRNA和蛋白的表达变化。结果LPS刺激后，hspa12b mRNA和蛋白水平逐渐上调，并在12 h时达到峰值，hspa12b显著提高了HUVECs的TEER值(P 0.001)，完全抵消了LPS诱导的TEER值下降(P 0.001)。hspa12b可引起VE-cadherin表达上调。结论hspa12b可通过上调VE-cadherin的表达来降低血管内皮细胞的通透性，从而保护内皮细胞的血管内皮屏障功能。
{"title":"Heat shock protein A12B decreases lipopolysaccharide-induced permeability of human umbilical vein endothelial cells","authors":"Qiuxiang Kang, Yi Chen, Guifang Yu, Xu Zhang, K. Zhu","doi":"10.3724/SP.J.1008.2015.00483","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00483","url":null,"abstract":"Objective To explore the lipopolysaccharide(LPS)-induced changes of heat shock protein A12B(HSPA12B)expression and its effect on the permeability of human umbilical vein endothelial cells(HUVECs).Methods The HUVECs cultured in vitro were divided into four groups: control group(without any treatment); LPS group(1 μg / m L LPS); LPS + p IRES2-EGFPHSPA12B-3Flag group(The HSPA12 B gene overexpression plasmid was transiently transfected into HUVECs and then LPS of 1 μg / m L was added); and LPS + p IRES2-EGFP-3Flag group(The negative control plasmid was transiently transfected into HUVECs and then LPS of 1 μg / m L was added).The transendothelial electrical resistance(TEER) of HUVECs was measured by MERSST × 01 Electrode.The expression of VE-cadherin was studied by flow cytometry.RT-PCR and Western blotting analysis were used to examine the expression changes of HSPA12 B mRNA and protein in HUVECs stimulated with LPS at various time points.Results It was showed that after stimulated with LPS,HSPA12 B mRNA and protein were gradually upregulated,and peaked at 12 h.HSPA12 B significantly increased the TEER value of HUVECs(P 0.001),and it could completely offset the decline of TEER value induced by LPS(P 0.001).Besides,HSPA12 B could cause upregulation of VE-cadherin expression.Conclusion HSPA12 B can reduce the permeability of vascular endothelial cells by up-regulating the expression of VE-cadherin,thus protecting the vascular endothelial barrier function of endothelial cells.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69847577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00472
Ru-juan Xin, Ting Zhao, Min Ni, Dong-Jie Li, F. Shen
Objective To investigate the effect of activating α7 nicotinic acetylcholine receptor(α7n AchR) on cerebral cortical neurons injury induced by oxygen-glucose deprivation(OGD) and the possible mechanism.Methods Cerebral cortical neurons cultured for 7 d were randomly divided into three groups: control group,OGD group(Cells experienced a 12 h oxygen-glucose deprivation) and OGD group treated with PNU-282987(Cells experienced a 12 h oxygen-glucose deprivation with PNU-282987 pretreatment for 24 h).Cell viability was determined by CCK-8 assay,lactate dehydrogenase(LDH) was examined to reflect cell injury,apoptosis and reactive oxygen species(ROS) production were analyzed by flow cytometry,and expression of hemeoxygenase-1(HO-1) and hypoxia inducible factor-1α(HIF-1α) were detected by Western blotting analysis.Results OGD resulted in cell death,LDH increase,and cell apoptosis.Compared with the OGD group,PNU-282987 pretreated group had significantly increased cell survival(P 0.05),significantly decreased LDH level and ROS production(P 0.05),and significantly inhibited cell apoptosis(P 0.05).Meanwhile,HO-1 protein expression was significantly increased and HIF-1α protein expression was significantly reduced in PNU-282987 pretreated group compared with the OGD group(P 0.05).Conclusion Activation of α7n AchR can protect cerebral cortical neurons against OGD-induced injury,which may be related to the anti-oxidative stress.
{"title":"Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen-glucose deprivation","authors":"Ru-juan Xin, Ting Zhao, Min Ni, Dong-Jie Li, F. Shen","doi":"10.3724/SP.J.1008.2015.00472","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00472","url":null,"abstract":"Objective To investigate the effect of activating α7 nicotinic acetylcholine receptor(α7n AchR) on cerebral cortical neurons injury induced by oxygen-glucose deprivation(OGD) and the possible mechanism.Methods Cerebral cortical neurons cultured for 7 d were randomly divided into three groups: control group,OGD group(Cells experienced a 12 h oxygen-glucose deprivation) and OGD group treated with PNU-282987(Cells experienced a 12 h oxygen-glucose deprivation with PNU-282987 pretreatment for 24 h).Cell viability was determined by CCK-8 assay,lactate dehydrogenase(LDH) was examined to reflect cell injury,apoptosis and reactive oxygen species(ROS) production were analyzed by flow cytometry,and expression of hemeoxygenase-1(HO-1) and hypoxia inducible factor-1α(HIF-1α) were detected by Western blotting analysis.Results OGD resulted in cell death,LDH increase,and cell apoptosis.Compared with the OGD group,PNU-282987 pretreated group had significantly increased cell survival(P 0.05),significantly decreased LDH level and ROS production(P 0.05),and significantly inhibited cell apoptosis(P 0.05).Meanwhile,HO-1 protein expression was significantly increased and HIF-1α protein expression was significantly reduced in PNU-282987 pretreated group compared with the OGD group(P 0.05).Conclusion Activation of α7n AchR can protect cerebral cortical neurons against OGD-induced injury,which may be related to the anti-oxidative stress.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69847897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00577
Lei Wang, Yang Li, Jianhua Cheng, Qi-gao Zhang
{"title":"Type I Brugada syndrome in a Tibetan patient","authors":"Lei Wang, Yang Li, Jianhua Cheng, Qi-gao Zhang","doi":"10.3724/SP.J.1008.2015.00577","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00577","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69848865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00584
Fu-xiang Li, Cheng-zhong Li, F. Zhou, Zong-hai Hu, Zhi-hui Chen, C. Hao, Jian-Jun Yang, Chang-xing Guo, Ping Zhang, Ying Cai, Wangang Guo, J. Yin
Objective To analyze the clinical characteristics and prognoses of patients with confirmed Ebola virus disease(EVD)and to summarize the clinical treatment experience.Methods The epidemiologic history,symptoms,signs,treatment,and prognoses of 5confirmed EVD cases were summarized.And the relationship between clinical features and clinical outcomes was analyzed.Results The 5patients,2 men and 3women,ranged in age from 32-58 years old,with a median age of 46.Three were severe cases when they were admitted while the others were relatively mild.All the patients admitted the exposure history within 21 days before onset of the symptoms,with two patients(one medical staff)from the same transmission chain.The main symptoms included fever,weakness or fatigue,lack of appetite,diarrhea and red eyes,with one patient having gastrointestinal bleeding.The first test of PCR Ebola virus(EBOV)RNA was positive in all the 5cases.They were promptly isolated and treated with antipyretic and fluid replacement therapy.Meanwhile,prevention of complications and treatment of basic diseases were also conducted.Three patients survived at last and the other two died.Conclusion Prompt isolation of the infection source and tracing the contacts can effectively prevent the transmission of EVD.PCR assay is an effective,rapid and simple method to diagnose EVD.Early supporting treatment-centered multimodality therapy can improve the treatment outcome of EVD.
{"title":"Clinical characteristic analysis of 5 patients with confirmed Ebola virus disease","authors":"Fu-xiang Li, Cheng-zhong Li, F. Zhou, Zong-hai Hu, Zhi-hui Chen, C. Hao, Jian-Jun Yang, Chang-xing Guo, Ping Zhang, Ying Cai, Wangang Guo, J. Yin","doi":"10.3724/SP.J.1008.2015.00584","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00584","url":null,"abstract":"Objective To analyze the clinical characteristics and prognoses of patients with confirmed Ebola virus disease(EVD)and to summarize the clinical treatment experience.Methods The epidemiologic history,symptoms,signs,treatment,and prognoses of 5confirmed EVD cases were summarized.And the relationship between clinical features and clinical outcomes was analyzed.Results The 5patients,2 men and 3women,ranged in age from 32-58 years old,with a median age of 46.Three were severe cases when they were admitted while the others were relatively mild.All the patients admitted the exposure history within 21 days before onset of the symptoms,with two patients(one medical staff)from the same transmission chain.The main symptoms included fever,weakness or fatigue,lack of appetite,diarrhea and red eyes,with one patient having gastrointestinal bleeding.The first test of PCR Ebola virus(EBOV)RNA was positive in all the 5cases.They were promptly isolated and treated with antipyretic and fluid replacement therapy.Meanwhile,prevention of complications and treatment of basic diseases were also conducted.Three patients survived at last and the other two died.Conclusion Prompt isolation of the infection source and tracing the contacts can effectively prevent the transmission of EVD.PCR assay is an effective,rapid and simple method to diagnose EVD.Early supporting treatment-centered multimodality therapy can improve the treatment outcome of EVD.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69849857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00634
Fan Hao, X. Tan, Wei-Zhong Wang, Mingjuan Xu
Objective To observe the expression ofβ-arrestin2 in cardiac tissues of ovariectomzied(OVX)rats,and to explore the role ofβ-arrestin2 in estrogen-mediated cardiovascular protection in OVX rats.Methods OVX rats were evaluated by monitoring the serum levels of estrogen and the ratio of uterine weight to body weight.The cardiovascular function of rats was assessed by measuring the ratio of heart weight to body weight,blood pressure and heart rate after estrogen replacement treatment for 4weeks,Western blotting analysis was performed to detect the protein expression ofβ-arrestin1,β-arrestin2 and angiotensin receptor type 1(AT1R)in the cardiac tissues.Results Compared with rats in the sham group,the serum estrogen level and the ratio of uterine weight to body weight in OVX rats were decreased significantly(P0.05);meanwhile,the cardiovascular parameters including blood pressure,heart rate and the ratio of heart weight to body weight were significantly increased(P0.05)in OVX rats,and they were attenuated after treatment with estrogen replacement.Compared with the sham controls,the cardiac expression ofβ-arrestin2 was decreased significantly in OVX rats(P0.05),with up-regulated estrogen expression and unchanged expression ofβ-arrestin1 and AT1R.Conclusion β-Arrestin2 expression is decreased in the cardiac tissues of OVX rats,which can be increased by estrogen replacement therapy.
目的观察β-arrestin2在卵巢切除(OVX)大鼠心脏组织中的表达，探讨β-arrestin2在雌激素介导的OVX大鼠心血管保护中的作用。方法通过监测OVX大鼠血清雌激素水平和子宫重量与体重之比对其进行评价。雌激素替代治疗4周后，通过测量大鼠的心重与体重之比、血压和心率来评估大鼠的心血管功能，采用Western blotting分析检测心脏组织中β-arrestin1、β-arrestin2和血管紧张素受体1型(angiotensin receptor type 1, AT1R)蛋白的表达。结果与假手术组比较，OVX大鼠血清雌激素水平、子宫重量/体重比均显著降低(P0.05); OVX大鼠血压、心率、心重/体重比均显著升高(P0.05)，经雌激素替代治疗后均有所降低。与假对照组相比，OVX大鼠心脏β-arrestin2表达显著降低(P0.05)，雌激素表达上调，β-arrestin1和AT1R表达不变。结论OVX大鼠心脏组织中β-Arrestin2表达降低，雌激素替代治疗可使其表达升高。
{"title":"Estrogen replacement increases β-arrestin2 expression in cardiac tissues in ovariectomized rats","authors":"Fan Hao, X. Tan, Wei-Zhong Wang, Mingjuan Xu","doi":"10.3724/SP.J.1008.2015.00634","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00634","url":null,"abstract":"Objective To observe the expression ofβ-arrestin2 in cardiac tissues of ovariectomzied(OVX)rats,and to explore the role ofβ-arrestin2 in estrogen-mediated cardiovascular protection in OVX rats.Methods OVX rats were evaluated by monitoring the serum levels of estrogen and the ratio of uterine weight to body weight.The cardiovascular function of rats was assessed by measuring the ratio of heart weight to body weight,blood pressure and heart rate after estrogen replacement treatment for 4weeks,Western blotting analysis was performed to detect the protein expression ofβ-arrestin1,β-arrestin2 and angiotensin receptor type 1(AT1R)in the cardiac tissues.Results Compared with rats in the sham group,the serum estrogen level and the ratio of uterine weight to body weight in OVX rats were decreased significantly(P0.05);meanwhile,the cardiovascular parameters including blood pressure,heart rate and the ratio of heart weight to body weight were significantly increased(P0.05)in OVX rats,and they were attenuated after treatment with estrogen replacement.Compared with the sham controls,the cardiac expression ofβ-arrestin2 was decreased significantly in OVX rats(P0.05),with up-regulated estrogen expression and unchanged expression ofβ-arrestin1 and AT1R.Conclusion β-Arrestin2 expression is decreased in the cardiac tissues of OVX rats,which can be increased by estrogen replacement therapy.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69850658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00649
Jian-fei Pang, Junhua Jiang, Xiao-dong Pan
Objective To design an emergency medical rescue simulation system,and to provide reference for optimizing rescue strategy and medical resource allocation by simulating different rescue conditions.Methods Firstly,Stateflow was used to build the main simulation unit,which included arrival of the wounded,classification of the wounded(emergent[type A]and non-emergent[type B]),and medical treatment modules,and then the related event and response function were appended.Secondly,the system parameter input unit and character display unit were set up in Simulink.Finally two different medical treatment strategies(strategy 1:type B wounded waiting for treatment in the rescue module with least waiting patients;strategy 2:type B wounded waiting for treatment in the rescue module with least workload)were simulated and the corresponding rescue strategies were analyzed.Results The system could simulate the medical rescue process of different strategies.The type A wounded could be rescued in a timely manner in both strategies.Type B wounded had a shorter waiting time in strategy 1,but the rescuers had a heavy work load;while they had a longer waiting time in strategy 2,and the rescuers had a lighter work load.Conclusion We have successfully designed a simulation system for emergency medical rescue and its feasibility and effectiveness are verified.Different rescue strategies have their respective advantages and disadvantages in the waiting time and work load,and the two strategies can be combined in practice in order to achieve a dynamic balance between the waiting time of the wounded and the work load of the rescuers.
{"title":"Stateflow and queuing theory-based design of emergency medical rescue simulation system","authors":"Jian-fei Pang, Junhua Jiang, Xiao-dong Pan","doi":"10.3724/SP.J.1008.2015.00649","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00649","url":null,"abstract":"Objective To design an emergency medical rescue simulation system,and to provide reference for optimizing rescue strategy and medical resource allocation by simulating different rescue conditions.Methods Firstly,Stateflow was used to build the main simulation unit,which included arrival of the wounded,classification of the wounded(emergent[type A]and non-emergent[type B]),and medical treatment modules,and then the related event and response function were appended.Secondly,the system parameter input unit and character display unit were set up in Simulink.Finally two different medical treatment strategies(strategy 1:type B wounded waiting for treatment in the rescue module with least waiting patients;strategy 2:type B wounded waiting for treatment in the rescue module with least workload)were simulated and the corresponding rescue strategies were analyzed.Results The system could simulate the medical rescue process of different strategies.The type A wounded could be rescued in a timely manner in both strategies.Type B wounded had a shorter waiting time in strategy 1,but the rescuers had a heavy work load;while they had a longer waiting time in strategy 2,and the rescuers had a lighter work load.Conclusion We have successfully designed a simulation system for emergency medical rescue and its feasibility and effectiveness are verified.Different rescue strategies have their respective advantages and disadvantages in the waiting time and work load,and the two strategies can be combined in practice in order to achieve a dynamic balance between the waiting time of the wounded and the work load of the rescuers.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69850746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00607
Jingxi Zhang, Cheng-zhong Li, Chong Bai
Ebola virus disease(EVD)caused by Ebora virus(EBOV)is one of the most violent infectious disease so far.It is so highly infective and fatal that there has been no effective treatment until now.Ebola viral infection can cause a series of immune responses.Specific and nonspecific antiviral innate immune deficiency in the hosts is a recognized important reason for EVD associated death.This paper reviews the influence of EBOV on innate immune reaction of humans and the corresponding countermeasures.
{"title":"Ebola virus and innate immunity","authors":"Jingxi Zhang, Cheng-zhong Li, Chong Bai","doi":"10.3724/SP.J.1008.2015.00607","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00607","url":null,"abstract":"Ebola virus disease(EVD)caused by Ebora virus(EBOV)is one of the most violent infectious disease so far.It is so highly infective and fatal that there has been no effective treatment until now.Ebola viral infection can cause a series of immune responses.Specific and nonspecific antiviral innate immune deficiency in the hosts is a recognized important reason for EVD associated death.This paper reviews the influence of EBOV on innate immune reaction of humans and the corresponding countermeasures.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69850856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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