Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00851
Maoquan Li, Bi-Li Zhang, Xing-chun Zheng, Feng-Qiang Chen, Rang Li, Ming Shen
{"title":"Risk factor score for predicting in-hospital adverse cardiovascular events in elderly patients undergoing percutaneous coronary intervention","authors":"Maoquan Li, Bi-Li Zhang, Xing-chun Zheng, Feng-Qiang Chen, Rang Li, Ming Shen","doi":"10.3724/SP.J.1008.2015.00851","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00851","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69854770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00925
L. Fang, Wei-ming Xu, Guang-hua Chen, Guang’an Xiao, Tie Zhou
{"title":"Application of Sandwich balloon dilation for total ultrasound guided-percutaneous nephrolithotomy","authors":"L. Fang, Wei-ming Xu, Guang-hua Chen, Guang’an Xiao, Tie Zhou","doi":"10.3724/SP.J.1008.2015.00925","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00925","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69856770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00883
Ze-Min Yang, Jing Lin, Long-hui Chen, Min Zhang, Wei-wen Chen, Xiao-rong Yang
{"title":"Sex differences of salivary α-amylase activity, flow rate and pH value before and after acid stimulation","authors":"Ze-Min Yang, Jing Lin, Long-hui Chen, Min Zhang, Wei-wen Chen, Xiao-rong Yang","doi":"10.3724/SP.J.1008.2015.00883","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00883","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69855497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00914
Wenguang Huang, Li Chen, Chang-lian Wang, Shi-ju Gong, Xiong-gang Chen
{"title":"Targeted distribution of flurbiprofen axetil in hysteromyoma and its influence on prostaglandin E2","authors":"Wenguang Huang, Li Chen, Chang-lian Wang, Shi-ju Gong, Xiong-gang Chen","doi":"10.3724/SP.J.1008.2015.00914","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00914","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69856896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00929
Long-Fei Deng, C. Ding, W. Xie, Xin Zhang
{"title":"Inhibitory effect of PEP-1-mediated recombinant hepatocyte nuclear factor 4 alpha transduction on hepatocellular carcinoma cells","authors":"Long-Fei Deng, C. Ding, W. Xie, Xin Zhang","doi":"10.3724/SP.J.1008.2015.00929","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00929","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69856962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Construction of recombinant lentiviral vector harboring shRNA of ribosomal protein S3a and its effect on cell apoptosis","authors":"Ying-hua Li, Jing Wang, Lei Qiu, Jian-zhong Li, Zhen-lin Hu, Jun-ping Zhang","doi":"10.3724/SP.J.1008.2015.00947","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00947","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69857283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.01007
Xuelin Yang, Wei-Yu Tang, Yong-Quan Shi
{"title":"Detection and clinical significance of regulatory T cells in peripheral blood of elderly patients with type 2 diabetic peripheral neuropathy","authors":"Xuelin Yang, Wei-Yu Tang, Yong-Quan Shi","doi":"10.3724/SP.J.1008.2015.01007","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01007","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69857973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.01156
Jian Lin, Hong-zhi Li, Jian-chun Liu
{"title":"Tension band wiring fixation for the treatment of young patients with lumbar spondylolysis","authors":"Jian Lin, Hong-zhi Li, Jian-chun Liu","doi":"10.3724/SP.J.1008.2015.01156","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01156","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69858499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.01143
Yun Bian, Wei Chen, Zhang Shi, Yancai Zhu, Zhenli Gao, Yu Sheng, Xiao Li, Xu Fang, Li Wang
{"title":"Castleman disease: a comparative analysis of imaging and histopathologic features","authors":"Yun Bian, Wei Chen, Zhang Shi, Yancai Zhu, Zhenli Gao, Yu Sheng, Xiao Li, Xu Fang, Li Wang","doi":"10.3724/SP.J.1008.2015.01143","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01143","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69858830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.1167
Hai Zhang, Wen Zhang, Feng-feng Sun, Jing Yu, Y. Chai, Guoqing Zhang
Objective To investigate the absorption behaviors of three kinds of sophora alkaloids(matrine,oxymatrine and sophocarpine)in Caco-2cells and their metabolic rates in rat liver microsomes.Methods Caco-2cell absorption model was used to analyze the absorption behaviors of three sophora alkaloids and rat liver microsomal model in vitro was used to investigate the metabolic rates of three sophora alkaloids.The contents of three kinds of sophora alkaloids were determined by HPLC-MS and the permeation rates and metabolic rates were calculated.The analytical conditions were as follows:chromatographic column:Agilent Zorbax SB-C18(3.0 mm×100 mm,3.5μm);mobile phase:acetonitrile/water(60∶40,V/V)with isocratic elution;injection volume:5μL;flow rate:0.8mL/min;temperature of column:30℃;and running time:9min.The selective ion monitoring(SIM)in positive ion mode was used in mass spectrometry,with drying gas temperature:350℃;capillary voltage:4 000V;drying gas flow rate:9.0L/min;and fragmentor voltage:90eV.Results In the Caco-2cell absorption model,matrine,oxymatrine and sophocarpine were separated with good linearity(r0.999 5)between0.050 5-10.01μmol/L,with the permeation rates being:matrine 1.251,oxymatrine 0.937 5,and sophocarpine 1.424.In rat liver microsomal model,matrine,oxymatrine and sophocarpine were separated with good linearity(r0.999 8)between0.050 1-1.001μmol/L,with the half-life period being:matrine 4.331 h,oxymatrine 1.084 h,and sophocarpine 2.478 h.The intra-day and inter-day precisions were 5%,the matrix effect was 80%,and the extraction recovery rate was 88%.Conclusion The three kinds of sophora alkaloids can easily pass the Caco-2cell absorption model,with active transport being the main way,and it is difficult for them to be metabolized in rat liver microsomes.
{"title":"Three alkaloids in Radix Sophorae flavescentis:metabolic rate in rat liver microsomes and absorption behavior in Caco-2 cells","authors":"Hai Zhang, Wen Zhang, Feng-feng Sun, Jing Yu, Y. Chai, Guoqing Zhang","doi":"10.3724/SP.J.1008.2015.1167","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.1167","url":null,"abstract":"Objective To investigate the absorption behaviors of three kinds of sophora alkaloids(matrine,oxymatrine and sophocarpine)in Caco-2cells and their metabolic rates in rat liver microsomes.Methods Caco-2cell absorption model was used to analyze the absorption behaviors of three sophora alkaloids and rat liver microsomal model in vitro was used to investigate the metabolic rates of three sophora alkaloids.The contents of three kinds of sophora alkaloids were determined by HPLC-MS and the permeation rates and metabolic rates were calculated.The analytical conditions were as follows:chromatographic column:Agilent Zorbax SB-C18(3.0 mm×100 mm,3.5μm);mobile phase:acetonitrile/water(60∶40,V/V)with isocratic elution;injection volume:5μL;flow rate:0.8mL/min;temperature of column:30℃;and running time:9min.The selective ion monitoring(SIM)in positive ion mode was used in mass spectrometry,with drying gas temperature:350℃;capillary voltage:4 000V;drying gas flow rate:9.0L/min;and fragmentor voltage:90eV.Results In the Caco-2cell absorption model,matrine,oxymatrine and sophocarpine were separated with good linearity(r0.999 5)between0.050 5-10.01μmol/L,with the permeation rates being:matrine 1.251,oxymatrine 0.937 5,and sophocarpine 1.424.In rat liver microsomal model,matrine,oxymatrine and sophocarpine were separated with good linearity(r0.999 8)between0.050 1-1.001μmol/L,with the half-life period being:matrine 4.331 h,oxymatrine 1.084 h,and sophocarpine 2.478 h.The intra-day and inter-day precisions were 5%,the matrix effect was 80%,and the extraction recovery rate was 88%.Conclusion The three kinds of sophora alkaloids can easily pass the Caco-2cell absorption model,with active transport being the main way,and it is difficult for them to be metabolized in rat liver microsomes.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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