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Age-related differences in vertical jump height and handgrip strength measurements. 垂直跳跃高度和握力测量中与年龄有关的差异。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Kayla Sisneros, Pratibha Maurya, Evan Johnson, Benton Ford, T Y Palmer

Purpose: This study aimed to examine the effects of age on vertical jump height and handgrip strength measurements in women. A secondary aim was to investigate the correlations between vertical jump height and handgrip strength.

Methods: Twenty young (21.5 ± 2.8 years) and twenty older (67.0 ± 5.5 years) healthy women participated in this study. Handgrip contractions were used to assess strength measurements of peak force and rate of force development at different time intervals. Vertical jumps were performed on a jump mat. The jump mat measured vertical jump height based on flight time.

Results: The older women had lower vertical jump height (P < 0.001) and handgrip peak force (P = 0.028) and rate of force development values (P = 0.003-0.016) than the younger women. A larger difference was observed between the groups for vertical jump height (41%) than handgrip peak force and rate of force development (12-17%). Of all the strength measurements, handgrip rate of force development at 200 ms in the young (r = 0.502, P = 0.024) and older (r = 0.446, P = 0.049) women exhibited the strongest correlation with vertical jump height.

Conclusions: This investigation showed significantly lower vertical jump height and handgrip peak force and rate of force development values in older compared to younger women. Interestingly, the difference between age groups was larger for jump height than handgrip peak force and rate of force development. This suggests that vertical jump performance may be more severely affected by age than handgrip strength characteristics.

目的:本研究旨在探讨年龄对女性垂直跳跃高度和握力测量的影响。另一个目的是研究垂直跳跃高度和握力之间的相关性:二十名年轻(21.5±2.8 岁)和二十名年长(67.0±5.5 岁)的健康女性参加了此次研究。手握收缩用于评估不同时间间隔的峰值力量和力量发展速度。垂直跳跃在跳垫上进行。结果:结果:老年妇女的垂直跳跃高度(P < 0.001)、手握峰值力(P = 0.028)和力量发展速度值(P = 0.003-0.016)均低于年轻妇女。与手握峰值力和力量发展率(12%-17%)相比,在垂直跳跃高度(41%)方面观察到的组间差异更大。在所有力量测量中,年轻女性(r = 0.502,P = 0.024)和年长女性(r = 0.446,P = 0.049)在 200 毫秒时的手握力发展率与垂直跳跃高度的相关性最强:本次调查显示,与年轻女性相比,老年女性的垂直跳跃高度、手握峰值力量和力量发展速度值明显较低。有趣的是,年龄组之间在跳高高度上的差异要大于手握峰值力和力量发展率。这表明,垂直跳跃成绩受年龄的影响可能比手握力量特征更严重。
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引用次数: 0
Dynamic-passive correction of hallux valgus and associated static foot deformities. 动态-被动矫正足外翻及相关的足部静态畸形。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Jacek Dygut, Joanna Strąk, Jerzy Detyna, Monika Piwowar

Purpose: The aim of this paper was the application of a new dynamic-passive method of treatment in correction of hallux valgus and coexisting static deformities of the foot (transverse-plane and plano-valgus foot).

Methods: The study involved 50 patients; 26 with full big toe correction after the passive correction grip (group I) and 24 with big toe correction requiring additional passive abduction (group II). The patients regularly performed exercises using the designed device according to the planned schedule. The progress of the correction was assessed by a medical examination and additional tests.

Results: The cross-sectional area [cm2 ] of the abductor hallucis muscle in three-time points among I and II groups of patients with the hallux valgus was measured based on MRI images. The STIR examination showed, among others, the abductor hallucis muscle edema after exercises with the DPc device were carried out. It evidences that exercises with the new device activate the muscle. Alignment of the big toes of both feet in groups I and II were obtained with a statistically significant result ( p < 0.05). The percentage progression of correction for HV and I/II IM was calculated.

Conclusions: Based on the new correction approach the alignment of the big toe phalanges and the remaining toes was obtained. The passive setup of the tendons with their distal inserts at the level of the big toe phalanges to the correct path of their course with the withdrawal of articular subluxations was obtained. Simultaneously, the big toe's passive correction was dynamically consolidated through a specially selected set of exercises.

目的:本文旨在应用一种新的动态-被动治疗方法来矫正拇外翻和同时存在的足部静态畸形(横平面和平面外翻足):研究涉及 50 名患者,其中 26 人在被动矫正握法后完全矫正了大脚趾(I 组),24 人矫正大脚趾后需要额外的被动外展(II 组)。患者按照计划时间表定期使用设计的装置进行锻炼。通过体检和其他测试评估矫正进度:结果:根据核磁共振成像,测量了拇指外翻患者 I 组和 II 组三个时间点的拇外展肌横截面积[cm2]。STIR 检查显示,在使用 DPc 设备进行锻炼后,内收肌出现水肿。这证明使用新装置进行的锻炼激活了肌肉。第一组和第二组患者双脚大脚趾的对齐情况具有统计学意义(P < 0.05)。计算了 HV 和 I/II IM 的矫正进展百分比:根据新的矫正方法,大脚趾趾骨和其余脚趾得到了对齐。大脚趾趾骨水平的肌腱及其远端插入物被动设置为正确的路径,同时关节脱位也被撤回。与此同时,通过一套专门挑选的练习来动态巩固大脚趾的被动矫正。
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引用次数: 0
Analysis of volleyball players' force generation during jump spike from the perspective of electromyographic characteristics. 从肌电图特征角度分析排球运动员在跳起扣球时的发力。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Z I Wang, Min Zhao

Purpose: The aim of this study was to investigate the force characteristics of novice athletes and professional athletes in completing a cross spike at position four from the perspective of electromyographic characteristics.

Methods: Ten novice and ten professional athletes were selected as subjects. The electromyographic characteristics of the athletes were obtained by the Noraxon Ultium electromyography (EMG) and compared.

Results: In the first stage, i.e., the takeoff stage, the activation level of the rectus abdominis and external abdominal obliques was significantly higher in the professional group (p<0.05). During the second stage, i.e., the stage of flying to hit the ball, the professional group had a higher integrated electromyography (iEMG) value in the trapezius. Moreover, it showed significantly higher muscle contribution from the rectus abdominis (5.59 ± 1.58%), external abdominal obliques (3.67 ± 1.21%), and trapezius (10.12 ± 2.61%) compared to the novice group (p<0.05). In the third stage, i.e., the stage of landing and buffering, p<0.05 in the comparison of the iEMG values of trapezius and gluteus maximus between the two groups. Moreover, the professional group exhibited higher muscle activation levels in all muscles except for the gastrocnemius, compared to the novice group (p<0.05).

Conclusions: Professional athletes display superior muscle coordination and more effective muscle force generation in the trunk and lower limbs during the execution of the jump spike action.

目的:本研究旨在从肌电图特征的角度研究新手运动员和专业运动员在完成四号位十字扣球时的用力特征:方法:选取 10 名新手运动员和 10 名专业运动员作为研究对象。方法:选取 10 名新手运动员和 10 名专业运动员作为研究对象,通过 Noraxon Ultium 肌电图(EMG)获取运动员的肌电图特征并进行比较:结果:在第一阶段,即起飞阶段,专业组运动员腹直肌和腹外斜肌的激活水平明显更高(p结论:专业组运动员的腹直肌和腹外斜肌的激活水平明显更高(p结论:专业组运动员的腹直肌和腹外斜肌的激活水平明显更高(p结论):专业运动员在执行起跳扣球动作时,躯干和下肢的肌肉协调性更好,肌肉发力更有效。
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引用次数: 0
Effect of pulse laser treatment at different process variables on mechanical behavior of carbon nanotubes electrophoretically deposited on titanium alloy. 不同工艺变量下的脉冲激光处理对电泳沉积在钛合金上的碳纳米管力学行为的影响
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Beata Majkowska-Marzec, Kacper Staszewski, Joanna Sypniewska

Purpose: Titanium and its alloys are widely used as biomaterials for long-term implants, but they are usually surface-modified due to their weak bioactivity and wear resistance. Laser processing was used to modify the surface layer, and elemental carbon was a component of the deposited coatings. This research aims to use a combination of both methods based on preliminary electrophoretic deposition of multi-wall carbon nanotubes (MWNCTs) followed by pulse laser treatment. Carbon nanotubes were chosen due to their mechanical and chemical stability as well as their tubular shape, resulting in enhanced mechanical properties of laser-modified layers.

Methods: The pulse laser power and laser scanning speed were defined as variable process parameters. The microstructure, roughness Ra, nanohardness H, Young's modulus E, and indent depth values were measured, and the H/E, H 3/E2, and relative changes of all these values in comparison to MWCNTs-coated and non-coated surfaces, were calculated.

Results: The obtained results show that the best mechanical properties of MWCNTs-coated and laser-treated specimens are obtained at a laser power of 900 W and laser feed of 6 mm/s. The observed relations can be explained considering processes occurring on the surface such as deposition of carbon nanotubes, melting and re-crystallization of the surface layer, formation and possible partial decomposition of titanium carbides, and associated changes in local chemical composition, phase composition, and a level of residual stresses beneath the surface.

Conclusions: The developed process can substitute the time and money-consuming carbonization of titanium and its alloys.

目的:钛及其合金被广泛用作长期植入物的生物材料,但由于其生物活性和耐磨性较弱,通常需要对其进行表面改性。激光加工被用来修饰表层,元素碳是沉积涂层的成分之一。本研究的目的是在多壁碳纳米管(MWNCTs)初步电泳沉积和脉冲激光处理的基础上,将这两种方法结合使用。之所以选择碳纳米管,是因为它们具有机械和化学稳定性以及管状形状,可增强激光改性层的机械性能:方法:将脉冲激光功率和激光扫描速度定义为可变工艺参数。测量了微观结构、粗糙度 Ra、纳米硬度 H、杨氏模量 E 和压痕深度值,并计算了 H/E、H 3/E2 以及与 MWCNTs 涂层表面和非涂层表面相比所有这些值的相对变化:结果表明,当激光功率为 900 W、激光进给速度为 6 mm/s 时,MWCNT 涂层和激光处理试样的机械性能最佳。观察到的关系可以用表面发生的过程来解释,如碳纳米管的沉积、表层的熔化和再结晶、钛碳化物的形成和可能的部分分解,以及与之相关的局部化学成分、相组成和表面下残余应力水平的变化:结论:所开发的工艺可替代耗时耗钱的钛及其合金碳化工艺。
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引用次数: 0
Quantitative evaluation f stereoscopic augmented reality visualization using an optical see-through head-mounted display. 使用光学透视头戴式显示器对立体增强现实可视化进行定量评估。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Magdalena Żuk, Marcin Majak, Izabela Szczur, Michał Popek, Ewelina Świątek-Najwer

Purpose: The authors of the current study aimed to propose a calibration method for accurate augmented reality visualisation using an optical see-through head-mounted display, and to qualitatively evaluate visualisation accuracy for the application in computer assisted surgery.

Methods: An adaptation of stereo single-point active alignment method was proposed as the calibration procedure together with verification. Three tests were performed: display of points in 3D space, on the plane and on the surface of a skull phantom on inexperience users (5 participants) and experienced users (17 participants).

Results: The highest accuracy of visualization was obtained for skull phantom visualisation for an inexperienced user (3.00 mm, std 0.75 mm), while the lowest accuracy was obtained in a 3D visualisation test for an inexperienced user (22.95 mm, std 18.04 mm). The largest error was related to the depth component and amounted to 18.49 mm, std 18.10 mm for an inexperienced user.

Conclusions: It is possible to achieve relatively high visualisation accuracy (less than 5 mm for visualisation in space) for selected users but providing it for the group of inexperienced users seems to remain a major challenge. The accuracy of point indication can be substantially and statistically significantly increased by visualising objects on surfaces. The proposed methods and obtained results can serve as a basis for further implementation of augmented reality visualisation on an optical see-through head-mounted display in applications requiring high-quality augmented reality guidance of manual tasks.

目的:本研究的作者旨在提出一种使用光学透视头戴式显示器进行精确增强现实可视化的校准方法,并对计算机辅助手术应用中的可视化精度进行定性评估:方法:提出了一种改编的立体单点主动对齐方法,作为校准程序并进行了验证。进行了三项测试:在没有经验的用户(5 人参加)和有经验的用户(17 人参加)身上显示三维空间、平面和头骨模型表面上的点:没有经验的用户头骨模型可视化的准确度最高(3.00 毫米,标准偏差 0.75 毫米),而没有经验的用户三维可视化测试的准确度最低(22.95 毫米,标准偏差 18.04 毫米)。最大的误差与深度部分有关,为 18.49 毫米,无经验用户的标准误差为 18.10 毫米:对于选定的用户来说,实现相对较高的可视化精度(空间可视化精度小于 5 毫米)是可能的,但对于缺乏经验的用户来说,实现这一目标似乎仍是一项重大挑战。通过对物体表面进行可视化,可大大提高点指示的精确度,而且在统计学上也有显著提高。提出的方法和获得的结果可以作为进一步在光学透视头戴式显示器上实现增强现实可视化的基础,应用于需要高质量增强现实指导的手动任务中。
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引用次数: 0
Relationship of lumbar-hip kinematics during trunk flexion and sex, body mass index, and self-reported energy expenditure: a cross-sectional analysis. 躯干屈曲时腰部-臀部运动学与性别、体重指数和自我报告的能量消耗的关系:横断面分析。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Magdalena Zawadka, Jakub Smołka, Maria Skublewska-Paszkowska, Edyta Łukasik, Grzegorz Zieliński, Piotr Gawda

Purpose: Physical activity (PA) is a well-known, simple and effective preventive and therapeutic intervention for low back pain (LBP). In spite of the growing interest in active lifestyles and its benefits, more needs to be known about the relationship between energy expenditure, body mass and lumbar-pelvic kinematics during the forward bending movement in a group of young asymptomatic people who met PA guidelines. Young people can be identified as a future risk group of civilisation diseases and lumbar-hip kinematics can be considered as a predictor of LBP occurrence. The aim of this study was to identify the association of gender, self-reported energy expenditure, body mass index, and lumbar-hip kinematics in young people.

Methods: Sixty-four students at pre-employment stage participated in the study. They declared moderate-to-high PA and activity-induced energy expenditure (AEE) was self-reported. Kinematic data of the lumbar spine, pelvis and hip were collected during forward bending using a 3D motion capture system.

Results: Sex was found to be associated with pelvis (β = -0.38 p = 0.002) and lumbar mobility (β = 0.49, p < 0.001) during forward bending and BMI was related only to lumbar mobility (β = -0.41, p = 0.001). Recreation AEE significantly predicted hip flexion mobility (β = 0.38, p = 0.002).

Conclusions: This study showed that among a sample of physically active young people, BMI, self-reported AEE and sex can partially predict lumbar-hip kinematics during trunk flexion. Recreational PA can be regarded as improving hip mobility and thus making forward bending more effective and less prone to injury.

目的:体力活动(PA)是一种众所周知的、简单有效的预防和治疗腰背痛(LBP)的干预措施。尽管人们对积极的生活方式及其益处的兴趣与日俱增,但仍需进一步了解一组符合体力活动指南的无症状年轻人在前屈运动时的能量消耗、体重和腰椎-骨盆运动学之间的关系。年轻人可被视为未来文明病的高危人群,而腰臀运动学可被视为枸杞痛发生的预测因素。本研究旨在确定年轻人的性别、自我报告的能量消耗、体重指数和腰臀运动学之间的关联:方法:64 名处于就业前阶段的学生参与了研究。方法:64 名处于就业前阶段的学生参加了研究,他们申报了中度至高度的活动量,活动引起的能量消耗(AEE)为自我报告。使用三维运动捕捉系统收集了前屈时腰椎、骨盆和髋部的运动学数据:结果:性别与前屈时骨盆(β = -0.38 p = 0.002)和腰椎活动度(β = 0.49,p < 0.001)有关,而体重指数仅与腰椎活动度有关(β = -0.41,p = 0.001)。Recreation AEE可显著预测髋关节屈曲活动度(β = 0.38,p = 0.002):本研究表明,在体力活动量大的年轻人样本中,体重指数、自我报告的 AEE 和性别可部分预测躯干屈曲时的腰髋运动学。休闲体育锻炼可改善髋关节活动度,从而使前屈更有效、更不易受伤。
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引用次数: 0
Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants. 根据生物相容性对生物材料进行表征,专用于患者特异性手指植入物。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Adam Byrski, Magdalena Kopernik, Łukasz Major, Katarzyna Kasperkiewicz, Marcin Dyner, Juergen M Lackner, David B Lumenta, Roman Major

Purpose: The research was focused on determining basic mechanical properties, surface, and phase structure taking into consideration basic cytotoxicity analysis towards human cells.

Methods: Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing.

Results: Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance increasing cell survivability by more than 10%.

Conclusions: Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testin.

目的:研究重点是确定基本机械性能、表面和相结构,同时考虑对人体细胞的基本细胞毒性分析:使用激光粉末床熔融技术(LB-PBF)生产的三维打印 Ti6Al4V 合金(Ti64)和光刻陶瓷制造技术(LCM)生产的氧化铝增韧氧化锆 20(ATZ20),对人 C-12302 成纤维细胞进行生物测试。表面修饰包括电抛光和羟基磷灰石或羟基磷灰石/锌涂层。使用 X 射线衍射、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和激光共聚焦扫描显微镜(CLSM)等多种技术进行了结构分析,然后使用纳米压痕测试进行了机械性能评估:结果:经过表面改性的样品在表面结构、相结构和机械性能方面表现出多样性。然而,测试细胞的细胞毒性并没有明显高于对照组。尽管如此,在所分析的材料中还是发现了一种趋势,表明在 Ti64 和 ATZ20 上进行 HAp/Zn 涂层可获得最佳生物性能,细胞存活率提高了 10%以上:Ti64 和 ATZ20 上的羟基磷灰石涂层具有最佳的生物特性。测试材料适合用于体内毒性测试。
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引用次数: 0
Effect of change in patellofemoral joint contact area by the decrease in vastus medialis muscle activation on joint stress. 髌股关节接触面积的变化对关节应力的影响(内侧阔肌活动减少)。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Takabayashi Tomoya, Edama Mutsuaki, Inai Takuma, Kubo Masayoshi

Purpose: Patellofemoral pain syndrome is a common orthopedic trauma among runners. It is unclear whether patellofemoral joint stress (PFJS) is the highest (or lowest) when the knee joint flexion angle and extension moment are in combination under the condition that vastus medialis (VM) activation decreases. This study aimed to investigate the effects of changes in the PFJ contact area by decreasing the activation of the VM muscle on PFJS.

Methods: A PFJ sagittal model was used to quantify PFJ reaction force and PFJS. The PFJ model and mathematical modelling procedure were used to quantify PFJS based on previous studies. The simulation ranges were set to knee joint flexion angles of 10-45° and extension moments of 0-240 Nm. PFJS was calculated for the normal condition (NC) and decrease condition (DC) in VM activation.

Results: When the knee joint angle and knee joint moment were at the maximum, the PFJS showed the maximum value under both conditions (NC; 14.9 N/cm2, DC; 16.4 N/cm2). PFJS was found to be higher in DC than that in NC for all simulation ranges.

Conclusion: Decreased VM activation may be involved in the mechanism of patellofemoral pain syndrome. In addition, the results of this study provide evidence that clinicians can enhance VM to relieve pain in patients with patellofemoral pain syndrome.

目的:髌骨股骨疼痛综合征是跑步者中常见的骨科创伤。目前尚不清楚在内侧肌(VM)激活减少的情况下,膝关节屈曲角和伸展力矩结合时髌股关节应力(PFJS)是否最大(或最小)。本研究旨在探讨通过减少 VM 肌肉的激活来改变 PFJ 接触面积对 PFJS 的影响:方法:使用 PFJ 矢状模型量化 PFJ 反作用力和 PFJS。根据先前的研究,PFJ 模型和数学建模程序用于量化 PFJS。模拟范围设定为膝关节屈曲角 10-45° 和伸展力矩 0-240 Nm。在 VM 激活的正常状态(NC)和减弱状态(DC)下计算 PFJS:当膝关节角度和膝关节力矩达到最大值时,PFJS 在两种条件下都显示出最大值(NC;14.9 牛/平方厘米,DC;16.4 牛/平方厘米)。在所有模拟范围内,DC 中的 PFJS 都高于 NC 中的 PFJS:结论:髌骨股骨痛综合征的发病机制可能与虚拟运动激活减少有关。此外,本研究结果还提供了证据,证明临床医生可以通过增强 VM 来缓解髌骨股骨疼痛综合征患者的疼痛。
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引用次数: 0
Effect of exercise rehabilitation on hemodynamic performance after carotid artery stenting: a numerical study. 运动康复对颈动脉支架术后血液动力学表现的影响:一项数值研究。
IF 1 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01
Jiashuai Liu, Zhenmin Fan, Xiao Liu, Xiao Xu, Mingyuan Liu, Xia Ye, Xiaoyan Deng

A high in-stent restenosis rate and thrombosis have compromised clinical benefits after vascular stent placement. Exercise rehabilitation after stenting emerges as a promising and practical therapeutic strategy to improve the clinical performance of this therapy, although it remains controversial. The present study aimed to explore the impact of exercise training on hemodynamic performance after vascular stent implantation. Different 3-dimensional computational models based on the patient-specific carotids were constructed to calculate hemodynamic parameters, including flow velocity, time-averaged wall shear (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT). The results demonstrated that exercise training increased TAWSS but decreased OSI and RRT in some cases after the intervention, and high-intensity exercise further suppressed the adverse blood flow. However, exercise training remarkably reduced TAWSS and elevated OSI and RRT in patients with mild stenosis at upstream of stented segment. Additionally, we discovered that the hemodynamic environment change induced by exercise training was not significant compared to the stent position in some cases. Exercise had a less beneficial impact on the disturbed blood flow after the distal common carotid artery (CCA) stenting. These findings highlighted that exercise-induced hemodynamic changes differ under different conditions. The exercise training for the intervention patients should only be performed after a comprehensive vascular function assessment.

高支架内再狭窄率和血栓形成损害了血管支架置入术后的临床疗效。支架植入术后的运动康复是一种很有前景且切实可行的治疗策略,可改善该疗法的临床表现,但目前仍存在争议。本研究旨在探讨运动训练对血管支架植入术后血流动力学表现的影响。研究人员根据患者特异性颈动脉构建了不同的三维计算模型,以计算血流动力学参数,包括流速、时间平均壁剪切力(TAWSS)、振荡剪切力指数(OSI)和相对滞留时间(RRT)。结果表明,干预后运动训练增加了TAWSS,但在某些情况下降低了OSI和RRT,高强度运动进一步抑制了不利的血流。然而,在支架段上游轻度狭窄的患者中,运动训练明显降低了 TAWSS,升高了 OSI 和 RRT。此外,我们还发现,在某些病例中,运动训练引起的血流动力学环境变化与支架位置相比并不显著。在颈总动脉(CCA)远端支架植入术后,运动对紊乱血流的影响较小。这些发现突出表明,在不同条件下,运动引起的血流动力学变化有所不同。介入治疗患者的运动训练应在全面评估血管功能后进行。
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引用次数: 0
Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants 生物材料的特征,参考生物相容性,专用于患者特定的手指植入物
4区 医学 Q4 BIOPHYSICS Pub Date : 2023-01-01 DOI: 10.37190/abb-02156-2022-02
Adam Byrski, Magdalena Kopernik, Łukasz Major, Katarzyna Kasperkiewicz, Marcin Dyner, Juergen M. Lackner, David Lumenta, Roman Major
Purpose The research was focused on determining basic mechanical properties, surface and phase structure taking into consideration basic cytotoxicity analysis towards human cells. Methods Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing, and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing. Results Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance Conclusions Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.
目的:在对人体细胞进行基本细胞毒性分析的基础上,研究其基本力学性能、表面和相结构。方法采用激光粉末床熔融(LB-PBF)法制备Ti6Al4V合金(Ti64)和光刻陶瓷制造(LCM)法制备氧化铝增韧氧化锆20 (ATZ20),对人C-12302成纤维细胞进行生物实验。表面改性包括电抛光、羟基磷灰石或羟基磷灰石/锌涂层。使用x射线衍射、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和共聚焦激光扫描显微镜(CLSM)等多种技术进行了结构分析,随后使用纳米压痕测试进行了力学性能评估。结果经表面改性后的样品表面、相结构和力学性能呈现多样性。然而,对被试细胞的细胞毒性并不显著高于对照组。结论羟基磷灰石涂层在Ti64和ATZ20表面具有最佳的生物学性能。被试材料适用于体内毒性试验。
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引用次数: 0
期刊
Acta of bioengineering and biomechanics
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