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Utility of N-Bromosuccinimide as a Green Chemical Reagent for Determination of H2-Receptor Antagonists in their Pharmaceutical Dosage Forms n -溴代琥珀酰亚胺作为绿色化学试剂在测定h2受体拮抗剂剂型中的应用
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2019-06-01 DOI: 10.2478/achi-2019-0004
Ahmed I. Hassan
Abstract An environmentally safe, simple and robust spectrophotometric method has been developed for determination of H2-receptor antagonists namely: cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine hydrochloride (RAN). The method was depend on the reaction of the studied drugs with N-bromosuccinimide (NBS), environmentally friendly reagent, and the excess NBS was measured by its reaction with phloroglucinol to give a yellow chromogenic product (λmax at 435 nm). The absorption intensity decrease (ΔA) was correlated with drug concentrations in the sample solutions. By using of the optimum conditions, linear calibration curves with good correlation coefficients (0.9958–0.9998) were found between the measured ΔA values and the corresponding drugs concentrations in the range of 12-80 μg mL−1. Limits of detection were in the range 1.31-2.21 μg mL−1. The proposed method was validated and successfully applied for the analysis of the above mentioned drugs in their bulk and pharmaceutical dosage forms with good recoveries (98.5 ± 0.98 to 102.5 ± 0.79%). No interferences were obtained from the common excipients. The proposed method was successfully applied for the analysis of H2RAs in their dosage forms and the results were comparable with that obtained by the official methods.
建立了一种安全、简便、可靠的分光光度法测定h2受体拮抗剂西咪替丁(CIM)、法莫替丁(FAM)、尼扎替丁(NIZ)和盐酸雷尼替丁(RAN)的方法。该方法通过与环境友好试剂n -溴代琥珀酰亚胺(NBS)的反应,通过与间苯三酚的反应测定过量的NBS,得到在435 nm处λmax的黄色显色产物。吸收强度降低(ΔA)与样品溶液中的药物浓度有关。通过优化条件,在12 ~ 80 μg mL−1范围内,测得的ΔA值与相应药物浓度具有良好的线性校准曲线(0.9958 ~ 0.9998)。检出限为1.31 ~ 2.21 μ mL−1。该方法经验证,可用于上述药物原料药和制剂制剂的分析,回收率为98.5±0.98 ~ 102.5±0.79%。常用辅料均无干扰。该方法成功地应用于硫酸氢ras制剂的分析,结果与官方方法相当。
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引用次数: 2
Synthesis and Characterization of Co0.8-x Nix Zn0.2 Fe2O4 Ferrites by Williamson–Hall and Size–Strain Plot Methods Co0.8-x Nix Zn0.2 Fe2O4铁氧体的合成及尺寸-应变图表征
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2019-06-01 DOI: 10.2478/achi-2019-0006
R. Kolekar, S. B. Kapatkar, S. Mathad
Abstract The Co-Zn ferrite (x=0.00) and Nickel doped Co-Zn ferrites (x=0.24) was synthesized by low cost solid state reaction method and characterized by XRD technique. The X-ray diffraction results for the samples showed the formation of single phase cubic spinel. The lattice constant and particle size for Co-Zn ferrite(x=0.00) is found to be 8.3465 Å and 26.72 nm and for Nickel doped (x=0.24) it is 8.3440 Å and 24.21nm. Micro strain (ε), Dislocation density(ρD), Hopping lengths (LA and LB), Bond lengths (A - O and B-O), Ionic radii (rA and rB), Texture coefficients (Thkl) and Standard deviation (σ) are also reported. The particle size is confirmed by scanning electron microscope (SEM). The Williamson-Hall plot and stress-strain plot also employed to understand the mechanical properties of materials.
采用低成本固相法合成了Co-Zn铁氧体(x=0.00)和掺杂镍的Co-Zn铁氧体(x=0.24),并用XRD技术对其进行了表征。样品的x射线衍射结果显示形成了单相立方尖晶石。Co-Zn铁氧体(x=0.00)的晶格常数和粒径分别为8.3465 Å和26.72 nm,掺杂镍(x=0.24)的晶格常数和粒径分别为8.3440 Å和24.21nm。还报道了微应变(ε)、位错密度(ρD)、跳跃长度(LA和LB)、键长(A -O和B-O)、离子半径(rA和rB)、织构系数(Thkl)和标准差(σ)。通过扫描电子显微镜(SEM)确定了颗粒的大小。采用Williamson-Hall图和应力-应变图来了解材料的力学性能。
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引用次数: 2
Forgotten Topological Index of Line Graphs of Some Chemical Structures in Drugs 药物中某些化学结构线形图被遗忘的拓扑索引
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0012
Gul E Mehak, A. A. Bhatti
Abstract A large number of drug experiments revealed that there exists strong inherent relation between the drugs molecular structures and the bio-medical and pharmacology characteristics. Due to the effectiveness for pharmaceutical and medical scientists of their ability to grasp the biological and chemical characteristics of new drugs, forgotten topological index was defined to analyze the drug molecular structures. This index is applicable for testing the chemical and pharmacological properties of drug molecular structures that can make up for lack of chemical experiments and can provide a theoretical basis for the manufacturing of drugs which is widely welcomed in developing areas. In this paper, based on the drug molecular structure analysis and vertex dividing technique with respect to their degrees, we present the forgotten topological index of the line graphs of several popular chemical structures which is quite common in drug molecular graphs.
大量的药物实验表明,药物分子结构与其生物医学和药理学特性之间存在着很强的内在联系。由于药剂学和医药学家掌握新药的生物学和化学特性的能力的有效性,定义了遗忘拓扑指数来分析药物的分子结构。该指标适用于检测药物分子结构的化学和药理学性质,可以弥补化学实验的不足,为药品的生产提供理论依据,在发展中地区广受欢迎。本文基于药物分子结构分析和按度分顶点技术,给出了药物分子图中常见的几种常用化学结构线形图的被遗忘拓扑指数。
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引用次数: 0
Hepatoprotective Effect of Quercetin on Bisphenol A-Induced Toxicity 槲皮素对双酚a毒性的保肝作用
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0013
Kinjal K. Kubavat, Sanman Samova, Hetal Doctor, G. Sindhav, R. Verma
Abstract One of the natural antioxidant flavonols -Quercetin is found in various food products and plants. Its anticancer properties have been proved by in vivo and in vitro experiments; it shows an attempt to examine toxic effects of Bisphenol A in the liver of mice and its alleviation by quercetin. For this inbred Swiss strain male albino mice were orally administered with quercetin (30, 60 and 90 mg/kg body weight/day) along with BPA (240 mg/kg body weight/day) for 45 days. On the completion of the treatment period, animals were sacrificed; organs were isolated and used for biochemical analysis. All these effects were dose-dependent. Co-treatment with quercetin (30, 60 and 90 mg/kg body weight) and BPA (240 mg/kg body weight) alleviates the changes in body weight, absolute and relative organ weights of mice. Biochemical analysis revealed significant (p < 0.05) and dose-dependent reduction in enzymatic antioxidants such as superoxide dismutase, Catalase and glutathione peroxidase and non-enzymatic antioxidants such as Glutathione and Total ascorbic acid content were also observed in Bisphenol A -treated groups as compared to control. The present results revealed that graded doses of BPA caused oxidative damage in the liver of mice, which is mitigated by quercetin.
摘要槲皮素是一种天然抗氧化剂黄酮醇,存在于各种食品和植物中。其抗癌作用已被体内和体外实验证明;它显示了一种检测双酚A在小鼠肝脏中的毒性作用和槲皮素减轻其毒性的尝试。对这只瑞士自交系雄性白化小鼠口服槲皮素(30、60和90 mg/kg体重/天)和BPA (240 mg/kg体重/天),持续45天。治疗期结束后,处死动物;分离器官用于生化分析。所有这些效应都是剂量依赖性的。槲皮素(30、60和90 mg/kg体重)和BPA (240 mg/kg体重)联合处理可减轻小鼠体重、绝对和相对脏器重量的变化。生化分析显示,与对照组相比,双酚A处理组的酶促抗氧化剂(如超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶)和非酶促抗氧化剂(如谷胱甘肽和总抗坏血酸)含量显著(p < 0.05)且呈剂量依赖性降低。目前的结果显示,分级剂量的双酚a引起小鼠肝脏氧化损伤,槲皮素减轻了这一损伤。
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引用次数: 1
Zagreb Connection Indices of Some Nanostructures 一些纳米结构的Zagreb连接指数
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0011
Saba Manzoor, N. Fatima, A. A. Bhatti, Akbar Ali
Abstract The first Zagreb index (occurred in an approximate formula of total π-electron energy, communicated in 1972) and the second Zagreb index (appeared in 1975, within the study of molecular branching) are among the most studied topological indices. Recently, three modified versions of the Zagreb indices were proposed independently in [A. Ali, N. Trinajstić, A novel/old modification of the first Zagreb index, arXiv:1705.10430 [math.CO], 2017] and [A. M. Naji, N. D. Soner, I. Gutman, On leap Zagreb indices of graphs, Commun. Comb. Optim., 2017, 2, 99–117], which were named as the Zagreb connection indices and the leap Zagreb indices, respectively. In this paper, we derive formulas for calculating these modified versions of the Zagreb indices of four well known nanostructures.
第一个萨格勒布指数(出现于1972年的总π电子能量近似公式中)和第二个萨格勒布指数(出现于1975年的分子分支研究中)是目前研究最多的拓扑指数。最近,在[A]中分别提出了三个修改版本的Zagreb指数。[3]陈志强,张志强,张志强。一种基于数学模型的Zagreb指数[j] .中国科学:自然科学版。[c], 2017。M. Naji, N. D. Soner, I. Gutman,图的跳跃萨格勒布指数,公共。梳子。Optim。[j], 2017, 2, 99-117],分别命名为萨格勒布连接指数和飞跃萨格勒布指数。在本文中,我们推导了计算四种已知纳米结构的这些修正版本的萨格勒布指数的公式。
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引用次数: 9
Synthesis of 4-(2-Hydroxyaryl)-5-Methyl-1,3-Dithiol-2-Thiones 4-(2-羟基)-5-甲基-1,3-二硫醇-2-硫酮的合成
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0021
L. Bahrin
Abstract The synthesis of 4-(2-hydroxyaryl)-5-methyl-1,3-dithiol-2-thiones has been accomplished by the reaction of the corresponding 4-(2-hydroxyaryl)-5-methyl-1,3-dithiol-2-ylium perchlorates with sodium sulfide nonahydrate in ethanol at room temperature. The newly obtained derivatives were characterized by NMR and MS spectrometry and IR spectroscopy.
摘要采用相应的4-(2-羟基)-5-甲基-1,3-二硫醇-2-硫酮与非水合硫化钠在乙醇中室温反应合成了4-(2-羟基)-5-甲基-1,3-二硫醇-2-硫酮。用核磁共振、质谱和红外光谱对新合成的衍生物进行了表征。
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引用次数: 0
Surface Modification of Olive Stone Waste for Enhanced Sorption Properties of Cadmium and Lead Ions 橄榄石废料表面改性对镉、铅离子吸附性能的影响
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0018
M. Belalia, Meriem Bendjelloul, A. Aziz, E. Elandaloussi
Abstract This paper reports the synthesis and characterization of an efficient anionic olive stone waste-based material as new ion-exchanger adsorbent. The olive stone waste was subjected to an alkaline pretreatment in order to enhance their reactivity towards maleic anhydride. The maleate-derived material MOS was characterized by FTIR, 13C NMR, TGA and DSC. The resulting sodium form of material NaMOS was subjected to batch experiments in order to evaluate its cadmium and lead removal efficiency. Adsorption experimental data showed a uniform and rapid process. Both Langmuir and Freundlich isotherm models were found to fit adequately the equilibrium isotherm data. The sorption capacities reached 240.96 mg Cd g−1 and 127.38 mg Pb g−1. The thermodynamic parameters showed that the process was exothermic and the adsorption occurred spontaneously. The desorption experiments show a quantitative recovery of the metal ions from NaMOS material.
摘要本文报道了一种高效阴离子橄榄石废基材料的合成和表征。对橄榄石废渣进行碱性预处理,以提高其对马来酸酐的反应性。采用FTIR、13C NMR、TGA和DSC对马来酸衍生物MOS进行了表征。为了评价其对镉和铅的去除效果,对所得到的钠形式的材料NaMOS进行了批量实验。吸附实验数据表明,吸附过程均匀、快速。发现Langmuir和Freundlich等温线模型都能充分拟合平衡等温线数据。吸附量为240.96 mg Cd g−1和127.38 mg Pb g−1。热力学参数表明,该过程为放热过程,吸附是自发进行的。解吸实验表明,从NaMOS材料中可以定量回收金属离子。
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引用次数: 6
Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control Cinnamyl-Imine-Chitosan水凝胶。形态控制
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0014
A. Craciun
Abstract The study deals with the exploration of the possibilities to control the morphology of cinnamyl-imine-chitosan hydrogels in view of their bio-application. Three series of hydrogels were synthetized from chitosan of three different molecular weights and cinnamaldehyde, varying the molar ratio between the amine groups on chitosan and aldehyde functional groups. The hydrogel morphology has been monitored by scanning electron microscopy. The variation of the hydrogel morphology as a function of chitosan molecular weight, crosslinking degree, and incubation conditions has been monitored. It was concluded that there are multiple possibilities of tuning the morphology of these hydrogels in function of the targeted application.
摘要:从肉桂酰亚胺-壳聚糖水凝胶的生物应用角度出发,探讨控制其形态的可能性。以三种不同分子量的壳聚糖和肉桂醛为原料,通过改变壳聚糖上胺基与醛官能团的摩尔比,合成了三个系列的水凝胶。用扫描电镜观察了水凝胶的形态。研究了壳聚糖分子量、交联度和培养条件对水凝胶形态的影响。结果表明,在目标应用的功能中,有多种可能调整这些水凝胶的形态。
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引用次数: 1
2-N,N-Dialkylamino-1,3-Dithiolium Salts 2-N, N-Dialkylamino-1,3-Dithiolium盐
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0010
L. Birsa
Abstract The synthesis of 2-N,N-dialkylamino-1,3-dithiolium salts is reviewed.
摘要综述了2-N, n -二烷基氨基-1,3-二硫鎓盐的合成方法。
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引用次数: 0
Magnetic and Antibacterial Studies of Nanoferrites Prepared by Self Propagating High-Temperature Synthesis Route 自扩散高温合成纳米铁氧体的磁性和抗菌研究
IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2018-12-01 DOI: 10.2478/achi-2018-0016
R. Bharamagoudar, A. S. Patil, S. Mathad, V. Kumbar, L. B. Kankanawadi
Abstract The main objective of the manuscript is the structural analysis, magnetic investigation and antimicrobial activity of Mn1−xZnxFe2O4 with stoichiometry (x = 0, 0.25, 0.5, 0.75, and 1.0). The Mn-Zn nanoferrites were synthesized by self propagating high-temperature synthesis using a mixture of fuels. The synthesized Mn-Zn nanoferrites were characterized by X-ray diffraction (XRD) that confirms cubic crystal structure with lattice constant in the range 8.372-8.432Ao. It is observed that saturation magnetization (Ms), remanence magnetization (Mr) and magneton number (Mr/Ms) decreased gradually with the increasing of Zn2+ concentration. The decrease in the saturation magnetization may be explained as, the Zn2+ concentration increases, the relative number of ferric ions on the A sites diminishes and this reduces the A–B interaction. Further, the synthesized Mn-Zn nanoferrites were tested for antibacterial activities against two-gram positive strains (Staphylococcus aureus ATCC No–12598, Lactobacillus amylovorus ATCC No– 12598), gram-negative strains E.coli ATCC No – 25922, Pseudomonas- ATCC No- 25619) and one fungal strain (C.albicans -ATCC No – 2091).
摘要本文的主要目的是利用化学计量学(x = 0, 0.25, 0.5, 0.75和1.0)对Mn1−xZnxFe2O4进行结构分析、磁性研究和抗菌活性研究。采用混合燃料自蔓延高温合成法合成了锰锌纳米铁氧体。采用x射线衍射(XRD)对合成的Mn-Zn纳米铁氧体进行了表征,证实了其立方晶体结构,晶格常数在8.372 ~ 8.432 ao之间。随着Zn2+浓度的增加,饱和磁化强度(Ms)、剩磁强度(Mr)和磁子数(Mr/Ms)逐渐减小。饱和磁化强度的降低可以解释为,Zn2+浓度增加,A位上的铁离子相对数量减少,从而降低了A - b相互作用。进一步,对合成的Mn-Zn纳米铁氧体对革兰氏阳性菌株(金黄色葡萄球菌ATCC No- 12598、淀粉样乳杆菌ATCC No- 12598)、革兰氏阴性菌株大肠杆菌ATCC No- 25922、假单胞菌ATCC No- 25619)和一种真菌(白色念珠菌ATCC No- 2091)的抑菌活性进行了测试。
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引用次数: 7
期刊
Acta Chemica Iasi
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