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Image of Your Own Body, Sense of Isolation and Quality of Life in Patients with Gynecological Cancers 妇科癌症患者的身体形象、孤立感和生活质量
Pub Date : 2020-03-17 DOI: 10.29413/abs.2020-5.1.8
A. Ovchinnikov, A. Sultanova, T. Sycheva, S. V. Akimova, E. Tagiltseva, N. A. Savinkova
Aim: to study mental state of gynecological oncological patients, their attitude to the existing disease and quality of life.Material and methods. The study was conducted on the basis of the City Clinical Hospital No. 1 of Novosibirsk. The main group (17women aged 29 to 60 years) included patients with ovarian cancer, cancer of the external female genital organs, and uterine cancer; the comparison group was comprised of 20 people aged 29 to 63 years without a history of cancer.Results. In gynecological oncological patients, dissatisfaction with their own bodies is more pronounced; they perceive their body distorted, which may be due to the characteristics of the disease and the specifics of treatment. Patients with gynecological cancers have a more pronounced subjective feeling of loneliness, but it is at the upper limit of the norm, which may mean the fact that these patients turn in upon themselves, in their experiences, as well as the feeling of something lost in their inner world. Patients with gynecological cancers showed an average level of quality of life and low indicators of the mental component of health, which indicates reduced functioning and a significant effect of the patient’s physical and emotional state on daily activities.Conclusion. The mental state of the cancer patient, his ability to withstand stress, his attitude to the existing disease affect the treatment process and further quality of life.
目的:了解妇科肿瘤患者的心理状态、对疾病的态度及生活质量。材料和方法。这项研究是在新西伯利亚市第一临床医院的基础上进行的。主要人群(17名29岁至60岁的女性)包括卵巢癌、女性外生殖器癌和子宫癌患者;对照组由20名年龄在29至63岁之间、无癌症病史的人组成。在妇科肿瘤患者中,对自己身体的不满更为明显;他们觉得自己的身体扭曲了,这可能是由于疾病的特点和治疗的具体情况。妇科癌症患者有更明显的主观孤独感,但这是正常的上限,这可能意味着这些患者在他们的经历中转向自己,以及在他们的内心世界中感觉失去了什么。妇科癌症患者的生活质量一般,心理健康指标较低,这表明功能下降,患者的身体和情绪状态对日常活动有显著影响。癌症患者的精神状态,他承受压力的能力,他对现有疾病的态度都会影响治疗过程和进一步的生活质量。
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引用次数: 0
Psychopharmacotherapy of Suicidal Behavior in Schizophrenia and Schizophrenic Spectrum Disorders 精神分裂症和精神分裂症谱系障碍自杀行为的精神药物治疗
Pub Date : 2020-03-17 DOI: 10.29413/abs.2020-5.1.7
L. A. Ivanova
Background. Suicidal behavior in schizophrenia correlates with the severity of productive and negative personality symptoms.Aims. Study of the clinic, the effectiveness of psychopharmacotherapy of paranoid schizophrenia and schizotypal disorder with the presence of suicidal behavior.Material and methods. Patients with paranoid schizophrenia, episodic type of course (n = 19) and schizotypal disorder (n = 15) were studied, in the clinical picture of which various variants of suicidal behavior were revealed. Clinicalpsychopathological, clinical-anamnestic, and psychometric methods were used.Results. Suicidal behavior in patients with an actual attack of paranoid schizophrenia was represented by suicidal intentions to avoid persecution (42.1 %), exposure to “voices” with an order to end their lives (36.8 %), and suicidal attempts (21.1 %). In patients with schizotypal disorder, suicidal thoughts were detected (84.6 %) in the form of loss of meaning in life, and suicidal attempts (15.4 %). Psychopharmacotherapy of suicidal behavior in schizophrenia and schizotypal disorder included the use of antipsychotics (atypical and traditional), antidepressants, tranquilizers, and normotimics. Among patients with paranoid schizophrenia, a decrease in the overall score of the PANSS scale was detected by day 14 of therapy (p < 0.05). The effectiveness of therapy was due to the reduction of delirium, verbal hallucinosis, and deactualization of suicidal behavior. Among patients with schizotypal disorder, a statistically significant decrease in the overall score of the PANSS scale was observed by 21 days of therapy (p < 0.05). The favorable dynamics was characterized by a decrease in manifestations of depression, suicidal thoughts, loss of interests.Conclusion. Combined therapy (antipsychotic, antidepressant, normotimic) helps reduce mental disorders and suicidal tendencies in patients with schizophrenia and schizophrenic spectrum disorders.
背景。精神分裂症患者的自杀行为与生产性人格和消极人格症状的严重程度相关。临床、精神药物治疗偏执型精神分裂症及分裂型精神障碍伴自杀行为的有效性研究。材料和方法。对偏执型精神分裂症、发作型病程(n = 19)和分裂型障碍(n = 15)患者进行了研究,在临床图片中揭示了自杀行为的各种变体。采用了临床精神病理学、临床记忆学和心理测量学方法。实际发作的偏执型精神分裂症患者的自杀行为表现为逃避迫害的自杀意图(42.1%),暴露于命令结束生命的“声音”(36.8%)和自杀企图(21.1%)。在精神分裂型精神障碍患者中,有自杀念头(84.6%)表现为生活意义丧失,有自杀企图(15.4%)。精神分裂症和分裂型障碍患者自杀行为的精神药物治疗包括使用抗精神病药物(非典型和传统)、抗抑郁药、镇静剂和normmotimics。偏执型精神分裂症患者在治疗第14天PANSS量表总分下降(p < 0.05)。治疗的有效性是由于谵妄、言语幻觉和自杀行为去现实感的减少。精神分裂型精神障碍患者治疗21 d时,PANSS量表总分下降有统计学意义(p < 0.05)。良好的动态表现为抑郁、自杀念头和丧失兴趣的表现减少。联合治疗(抗精神病药、抗抑郁药、normmotimic)有助于减少精神分裂症和精神分裂症谱系障碍患者的精神障碍和自杀倾向。
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引用次数: 0
Obesity and Circadian Cycle of Sleep and Wakefulness: Common Points and Prospects of Therapy 肥胖与睡眠和觉醒的昼夜周期:共同点和治疗前景
Pub Date : 2020-03-17 DOI: 10.29413/abs.2020-5.1.3
O. Berdina, I. Madaeva, L. Rychkova
The prevalence of obesity in recent years has assumed the character of a non-communicable epidemic. Wherein, the standard approaches for its treatment are not always successful. Meanwhile, obesity remains one of the main causes of the formation of a number of some serious diseases, such as cardiovascular, diabetes, cancer, etc. and death from them. In search of alternative and more adequate methods of obesity treatment and preventing its complications, recent studies are aimed at further identifying new associations and revealing the pathophysiological mechanisms underlying excessive weight gain. It should be noted an increasing amount of chronobiological studies that raised awareness of the key role of the body’s circadian rhythms and its main regulator, melatonin, responsible for the temporary organization of the main physiological (including metabolism) processes throughout the 24-h day, in the development and progression of obesity. This review is devoted to the consideration of mutually directed interactions between the circadian system and metabolism; attempts have been made to explain the role of sleep-wake cycle disruptions in the excess accumulation of adipose tissue and the formation of obesity and its comorbidities, as well as detailed therapeutic principles based on normalizing disruption of body clocks using time-coordinated approaches to food intake, physical activity, the effects of non-drug methods and pharmacological substances (chronobiotics), which represents a novel and promising ways to prevent or treat obesity and associated diseases.
近年来,肥胖症的流行具有非传染性流行病的特征。其中,标准的治疗方法并不总是成功的。同时,肥胖仍然是一些严重疾病,如心血管、糖尿病、癌症等的形成和死亡的主要原因之一。为了寻找替代和更充分的肥胖治疗方法并预防其并发症,最近的研究旨在进一步确定新的关联并揭示过度体重增加的病理生理机制。值得注意的是,越来越多的时间生物学研究提高了人们对人体昼夜节律及其主要调节因子褪黑激素的关键作用的认识,褪黑激素负责24小时内主要生理(包括代谢)过程的临时组织,在肥胖的发生和发展中。这篇综述致力于考虑昼夜节律系统和新陈代谢之间相互指导的相互作用;人们试图解释睡眠-觉醒周期中断在脂肪组织的过度积累和肥胖及其合并症的形成中的作用,以及详细的治疗原则,这些原则是基于对食物摄入、身体活动、非药物方法和药理学物质(时间生物制剂)的影响使用时间协调方法使生物钟中断正常化。这代表了一种预防或治疗肥胖及相关疾病的新颖而有前途的方法。
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引用次数: 3
Infectious Complication of Revision Knee Replacement 改良膝关节置换术的感染并发症
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.10
S. Leonova, A. Kameka, A. N. Grishchuk
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引用次数: 0
Radiological and Functional Research Methods in the Diagnosis of Segmental Instability in Cervical Osteochondrosis and of Cervicobrachial Syndrome 颈椎骨软骨病和颈肱综合征节段性不稳诊断的影像学和功能研究方法
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.6
Z. Koshkareva, V. Sorokovikov, A. Zhivotenko, O. Sklyarenko, B. Damdinov, А. N. Kiriyenko
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引用次数: 0
Some Aspects of the Pathogenesis and Diagnosis of Osteochondrosis of the Cervical Spine (Literature Review) 颈椎骨软骨病发病机制及诊断的若干问题(文献复习)
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.7
C. V. Sklyarenko, V. Sorokovikov, Z. Koshkareva, A. Zhivotenko, B. Damdinov
The aim of this research was to study the most important problems in diagnosing a socially significant problem – os- teochondrosis of the cervical spine. According to some authors, in the structure of disability and disability associated with pathology of the spine, diseases of the cervical spine occupy one of the leading positions. The paper analyzes data from 41 sources of literature on the pathogenesis and diagnosis of osteochondrosis of the cervical spine. Due to the complexity and ambiguity of the approaches to the diagnosis of osteochondrosis of the cervical spine, this paper analyzes the most important research methods in the diagnosis of this pathology. Attention is focused on the main pathogenetic prerequisites for the occurrence of pain. According to literature data, the main attention in the diagnosis of osteochondrosis of the cervical spine is given to the basic methods: clinical and neurological examination, where the severity of the disorders is determined using scales that include not only an assessment of the intensity of the pain syndrome, but also the determination of a number of neurological disorders. The authors propose the use of a DN4 questionnaire, LANSS scales, neurological impairment scales (NIS); radiation research methods, such as survey spondylography of the cervical spine in direct and lateral pro- jections, functional spondylography of the cervical spine in the position of maximum flexion and extension, multispiral computed tomography, magnetic resonance imaging data, and neurophysiological studies. Radiation research methods can determine pathological changes in the bone tissue itself. Magnetic resonance imaging indices make it possible to assess the degree of pathological changes in the soft tissue anatomical structures of the spinal canal and intervertebral discs. According to the literature, much attention is paid to functional research methods, in particular, electroneuromyography, which allows to assess the level and degree of damage to nerve fiber, the dynamics of the pathological process. Attention is paid to the allocation of marker indicators. All methods are significant, evidence-based, objective and modern and do not exclude the possibility of using data from other research methods. The analysis of the presented literature once again convinces clinicians of the ambiguity and heterogeneity of approaches to the issues of pathogenesis and diagnosis of the cervical spine, which requires further improvement of the proposed methods for clarifying and objectifying the pathological process. An important and justified is a pathogeneti-cally grounded approach to their study.
本研究的目的是研究诊断一个具有社会意义的问题-颈椎软骨下垂的最重要的问题。一些作者认为,在与脊柱病理相关的残疾和残疾的结构中,颈椎疾病占据主导地位之一。本文分析了41篇文献对颈椎骨软骨病的发病机制和诊断的资料。由于颈椎软骨病诊断方法的复杂性和模糊性,本文分析了该病理诊断中最重要的研究方法。注意力集中在疼痛发生的主要病理先决条件上。根据文献资料,在诊断颈椎骨软骨病时,主要关注的是基本方法:临床和神经学检查,其中疾病的严重程度是通过量表来确定的,量表不仅包括对疼痛综合征强度的评估,还包括对一些神经学疾病的确定。作者建议使用DN4问卷、LANSS量表、神经功能障碍量表(NIS);放射研究方法,如颈椎正位和侧位的椎管造影、颈椎最大屈伸位置的功能椎管造影、多螺旋计算机断层扫描、磁共振成像数据和神经生理学研究。放射研究方法可以确定骨组织本身的病理变化。磁共振成像指标可以评估椎管和椎间盘软组织解剖结构的病理改变程度。根据文献,功能研究方法得到了很多关注,特别是神经肌电图,它可以评估神经纤维损伤的水平和程度,病理过程的动态。注意市场指标的配置。所有方法都是重要的、基于证据的、客观的和现代的,不排除使用其他研究方法数据的可能性。对现有文献的分析再次使临床医生相信,关于颈椎发病机制和诊断问题的方法存在歧义和异质性,这需要进一步改进所提出的方法,以澄清和客观化病理过程。一个重要的和合理的是对他们的研究病原学的基础方法。
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引用次数: 0
Method for Osteosynthesis of Long Tubular Bones Using a Distraction-Reposition Apparatus of External Fixation 外固定牵张-复位装置固定长管骨的方法
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.17
G. Palshin, S. S. Torduin, A. Maksimov, V. Levchenko
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引用次数: 0
Early Diagnosis and Treatment 早期诊断和治疗
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.9
А. В. Антонов, В. Е. Воловик
Aseptic necrosis of a femoral head - severe chronic orthopedic pathology (1.2-12 %), diagnostics of which presents considerable difficulties. Problems of fast diagnostics, identical clinical symptoms, rapid development of the disease leads to disability. Risk group includes young and middle-aged men. The cause of the disease is unknown, the possibilities of conservative treatment are applied only in the early stages with doubtful efficiency, and among surgical none is the best. The research is performed in the traumatology center of Khabarovsk - clinical base of a Postgraduate Institute for Public Health Workers. During 2014-2019, retrospective analysis of treatment results was carried out on the basis of statistical data of 97 medical maps of patients diagnosed with aseptic necrosis of a femoral head, pathomorphological study of 49 preparations of the femoral head; laboratory analysis of immunological indicators of cellular immunity and thyroid hormones in the operated group of patients was carried out. Detected immunological changes indicate the systemic nature of the disease. Method of minimally invasive two-stage decompression of femoral neck is developed. Minimum injury of the developed method of treatment provides undeniable advantages in contrast to previous methods of surgical treatment. The technique has been applied in 17 cases, with positive medium-term clinical results. Aseptic necrosis of a femoral head is a pathology with a polymorphologicpicture, diagnosis of which presents considerable difficulties, associated with high risk of development atyoung age, is a current problem and demands further studying for the purpose of achievement of permanent long remission, and, perhaps, and an absolute recovery of the patient.
股骨头无菌性坏死——严重的慢性骨科病理(1.2- 12%),诊断相当困难。诊断快的问题,临床症状千篇一律,疾病发展快导致残疾。高危人群包括中青年男性。本病的病因不明,保守治疗的可能性仅适用于早期,疗效可疑,在手术中没有一个是最好的。这项研究是在哈巴罗夫斯克创伤学中心进行的,该中心是公共卫生工作者研究生院的临床基地。2014-2019年,对97例诊断为股骨头无菌性坏死患者的医学图进行统计资料,对治疗结果进行回顾性分析,对49例股骨头制剂进行病理形态学研究;对手术组患者细胞免疫、甲状腺激素等免疫学指标进行实验室分析。检测到的免疫变化表明疾病的全身性。提出了一种微创两阶段股骨颈减压术。与以前的手术治疗方法相比,开发的最小损伤治疗方法具有不可否认的优势。该技术已应用于17例,中期临床效果良好。股骨头无菌性坏死是一种具有形态学特征的病理,其诊断相当困难,与年轻时的高风险相关,是当前的一个问题,需要进一步研究,以实现永久的长期缓解,甚至可能是患者的绝对康复。
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引用次数: 1
Results of the Application of the Original Method of Surgical Treatment of Patients with Severe Hallux Valgus 原术式在重度拇外翻手术治疗中的应用效果
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.15
V. V. Epishin, S. M. Goodi, V. Kuznetsov, S. Korochkin, S. V. Filatova, I. A. Pakhomov
Background. Traditional methods of surgical treatment of severe Hallux valgus (HV) lead to a large number of com- plications and poor results. In order to avoid complications and improve the quality of treatment, an original technique of double osteotomy of the first metatarsal bone has been proposed. The aim of the study was to conduct a comparative assessment of the results of applying the original technique in the treatment of patients with severe Hallux valgus. Materials and methods. A retrospective analysis of the treatment of 95 patients operated on at the Seversk Clinical Hospital for severe Hallux valgus in the period from 2008 to 2016 was performed. The study group included 60 patients who underwent surgery according to the original method. In a comparison group of 35 people, Logroshino’s surgery was performed. Clinical, radiological, surgical and statistical research methods were used. Results. The final assessment of the results 1 year after the operation showed an unacceptably high number of Hallux valgus relapses, complications, and unsatisfactory results in the comparison group. The use of original approaches for osteotomy of the first metatarsal bone in patients of the study group allowed to significantly improve treatment results and achieve good results in 85 % of cases. Conclusion. The proposed surgical technique is effective and shows statistically significantly better results 1 year after surgery. Application of the original technique will improve the results of surgical correction of the severe degree of Hallux valgus, which consists in reducing the number of complications and improving functional indicators. Original
背景。严重拇外翻的传统手术治疗方法并发症多,治疗效果差。为了避免并发症和提高治疗质量,我们提出了一种独创的第一跖骨双截骨术。该研究的目的是对应用原始技术治疗严重拇外翻患者的结果进行比较评估。材料和方法。回顾性分析2008 ~ 2016年在Seversk临床医院接受手术治疗的95例重度拇外翻患者的治疗情况。研究组包括60例按照原方法进行手术的患者。在35人的对照组中,Logroshino进行了手术。采用临床、放射学、外科和统计学研究方法。结果。术后1年的最终评估结果显示,对照组的拇外翻复发和并发症的发生率高得令人无法接受,结果也不令人满意。研究组患者第一跖骨截骨采用原始入路,治疗效果显著提高,85%的病例取得良好效果。结论。所建议的手术技术是有效的,并在术后1年显示统计学上显著更好的结果。原技术的应用将提高拇外翻严重程度的手术矫正效果,减少并发症的发生,改善功能指标。原始
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引用次数: 0
Single and Double Bundle Arthroscopic Reconstruction of Anterior Cruciate Ligament (Review of Literature) 单、双束关节镜下前交叉韧带重建(文献回顾)
Pub Date : 2019-12-17 DOI: 10.29413/abs.2019-4.6.14
D. B. Balzhinimaev, I. Mikhaylov, V. Monastyrev
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引用次数: 0
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Acta Biomedica Scientifica (East Siberian Biomedical Journal)
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